Experts and Doctors on epidermal growth factor in Hiroshima, Japan
Locale: Hiroshima, Japan
Topic: epidermal growth factor
Yamashita Y, Shimada M. The release of EGF domain from EGF-like factors by a specific cleavage enzyme activates the EGFR-MAPK3/1 pathway in both granulosa cells and cumulus cells during the ovulation process. J Reprod Dev. 2012;58:510-4 pubmed
..Thus, TACE/ADAM17 is one of the key genes expressed in both granulosa cells and cumulus cells for induction of the ovulation process. ..
Nakashima S, Morinaka K, Koyama S, Ikeda M, Kishida M, Okawa K, et al
. Small G protein Ral and its downstream molecules regulate endocytosis of EGF and insulin receptors. EMBO J. 1999;18:3629-42 pubmed
Shigeishi H, Higashikawa K, Hiraoka M, Fujimoto S, Mitani Y, Ohta K, et al
. Expression of epiregulin, a novel epidermal growth factor ligand associated with prognosis in human oral squamous cell carcinomas. Oncol Rep. 2008;19:1557-64 pubmed
..05). These results indicate that human epiregulin is closely linked to the increased or abnormal cell proliferation in human oral SCC. ..
Uesaka T, Lu H, Katoh O, Watanabe H. Heparin-binding EGF-like growth factor gene transcription regulated by Cdx2 in the intestinal epithelium. Am J Physiol Gastrointest Liver Physiol. 2002;283:G840-7 pubmed
..These data indicate that HB-EGF gene expression can be regulated by Cdx2 and serves to mediate the control of Cdx2 of the proliferation and migration of IEC-6 cells. ..
Hamai Y, Matsumura S, Matsusaki K, Kitadai Y, Yoshida K, Yamaguchi Y, et al
. A single nucleotide polymorphism in the 5' untranslated region of the EGF gene is associated with occurrence and malignant progression of gastric cancer. Pathobiology. 2005;72:133-8 pubmed
..80, 1.98, 2.26 and 1.89, respectively). Our findings suggest that the A-G polymorphism of EGF is involved not only in the occurrence but also in the malignant progression of gastric cancer. ..
Hatano H, Shigeishi H, Kudo Y, Higashikawa K, Tobiume K, Takata T, et al
. RHAMM/ERK interaction induces proliferative activities of cementifying fibroma cells through a mechanism based on the CD44-EGFR. Lab Invest. 2011;91:379-91 pubmed publisher
..Here, we report the new machinery by which RHAMM/ERK interaction induces the proliferative activity of cementifying fibroma cells via a specific signaling pathway through the CD44-EGFR axis. ..