Experts and Doctors on dna damage in Nagasaki, Japan


Locale: Nagasaki, Japan
Topic: dna damage

Top Publications

  1. Makino N, Oyama J, Maeda T, Koyanagi M, Higuchi Y, Shimokawa I, et al. FoxO1 signaling plays a pivotal role in the cardiac telomere biology responses to calorie restriction. Mol Cell Biochem. 2016;412:119-30 pubmed publisher
  2. Kawakatsu M, Urata Y, Goto S, Ono Y, Li T. Placental extract protects bone marrow-derived stem/progenitor cells against radiation injury through anti-inflammatory activity. J Radiat Res. 2013;54:268-76 pubmed publisher
    ..Placental extract significantly attenuated the acute radiation injury to bone marrow-derived stem/progenitor cells, and this protection is likely to be related to the anti-inflammatory activity of the placental extract. ..
  3. Luo L, Kawakatsu M, Guo C, Urata Y, Huang W, Ali H, et al. Effects of antioxidants on the quality and genomic stability of induced pluripotent stem cells. Sci Rep. 2014;4:3779 pubmed publisher
    ..Long-term culture will be necessary to confirm whether low dose antioxidants improve the quality and genomic stability of iPS cells. ..
  4. Nakamura T, Hosoyama T, Kawamura D, Takeuchi Y, Tanaka Y, Samura M, et al. Influence of aging on the quantity and quality of human cardiac stem cells. Sci Rep. 2016;6:22781 pubmed publisher
    ..Our data suggest that the impact of age on the quantity and quality of CDCs is quite limited. These findings have important clinical implications for autologous stem cell transplantation in elderly patients. ..
  5. Nanashima A, Izumino H, Sumida Y, Tominaga T, Wakata K, Hidaka S, et al. Relationship Between Urinary 8-hydroxydeoxyguanine (8-OHdG) Levels and Clinicopathological Findings in Hepatobiliary Malignancies. Anticancer Res. 2016;36:3899-903 pubmed
    ..Further studies are necessary to clarify the relationship between node metastasis and oxidative stress as a prognostic marker. ..
  6. Tashiro S, Sumi T, Uozumi N, Shimizu T, Nakamura T. B-Myb-dependent regulation of c-Myc expression by cytosolic phospholipase A2. J Biol Chem. 2004;279:17715-22 pubmed
    ..These findings provide new insights into the function of cPLA(2) in B-Myb-dependent gene expression. ..
  7. Akulevich N, Saenko V, Rogounovitch T, Drozd V, Lushnikov E, Ivanov V, et al. Polymorphisms of DNA damage response genes in radiation-related and sporadic papillary thyroid carcinoma. Endocr Relat Cancer. 2009;16:491-503 pubmed publisher
    ..32, 95% CI 1.57-6.99). The results indicate that polymorphisms of DNA damage response genes may be potential risk modifiers of ionizing radiation-induced or sporadic PTCs. ..
  8. Yoshida T, Goto S, Kawakatsu M, Urata Y, Li T. Mitochondrial dysfunction, a probable cause of persistent oxidative stress after exposure to ionizing radiation. Free Radic Res. 2012;46:147-53 pubmed publisher
    ..Although further experiments are required, results in this study support the hypothesis that mitochondrial dysfunction causes persistent oxidative stress that may contribute to promote radiation-induced genomic instability. ..
  9. Nakazawa Y, Sasaki K, Mitsutake N, Matsuse M, Shimada M, Nardo T, et al. Mutations in UVSSA cause UV-sensitive syndrome and impair RNA polymerase IIo processing in transcription-coupled nucleotide-excision repair. Nat Genet. 2012;44:586-92 pubmed publisher
    ..Our findings provide mechanistic insights into the processing of stalled RNA polymerase and explain the different clinical features across these TC-NER–deficient disorders. ..

More Information


  1. Suzuki K, Yamashita S. Low-dose radiation exposure and carcinogenesis. Jpn J Clin Oncol. 2012;42:563-8 pubmed publisher
    ..This review summarizes our current knowledge of the physical and biological features of low-dose radiation and discusses the possibilities of induction of cancer by low-dose radiation...