Experts and Doctors on cytosol in Kanagawa, Japan


Locale: Kanagawa, Japan
Topic: cytosol

Top Publications

  1. Shindoh H, Nakano K, Yoshida T, Ishigai M. Comparison of in vitro metabolic conversion of capecitabine to 5-FU in rats, mice, monkeys and humans--toxicological implications. J Toxicol Sci. 2011;36:411-22 pubmed
  2. Tateishi T, Watanabe M, Nakura H, Tanaka M, Kumai T, Sakata S, et al. Dihydropyrimidine dehydrogenase activity and fluorouracil pharmacokinetics with liver damage induced by bile duct ligation in rats. Drug Metab Dispos. 1999;27:651-4 pubmed
  3. Kaisho T. Type I interferon production by nucleic acid-stimulated dendritic cells. Front Biosci. 2008;13:6034-42 pubmed
    ..Therefore, clarifying the molecular mechanisms for type I IFN induction by nucleic acids should contribute to the development of treatment not only for viral infection but also for autoimmune diseases. ..
  4. Yokoyama T, Amano M, Sekine M, Homma H, Tokuda M, Sato M. Immunohistochemical localization of endogenous D-Aspartate in the marine brown Alga Sargassum fusiforme. Biosci Biotechnol Biochem. 2011;75:1481-4 pubmed
    ..fusiforme cells, and excludes the possibility that it is derived from attached or symbiotic organisms such as marine bacteria. This is the first report describing the localization of free D-aspartate in plant cells. ..
  5. Itoh R. Enzymatic properties and physiological roles of cytosolic 5'-nucleotidase II. Curr Med Chem. 2013;20:4260-84 pubmed
    ..However, for the tissues, in which the expression of cN-I is very low or undetectable, e.g. liver or brain tissues, results have been obtained that suggest the participation of cN-II in intracellular dephosphorylation of AMP. ..
  6. Suematsu N, Okamoto K, Shibata K, Nakanishi Y, Isohashi F. Molecular cloning and functional expression of rat liver cytosolic acetyl-CoA hydrolase. Eur J Biochem. 2001;268:2700-9 pubmed
    ..Database searching shows no homology to other known proteins, but reveals high similarities to two mouse expressed sequence tags (91% and 93% homology) and human mRNA for KIAA0707 hypothetical protein (50% homology) of unknown function. ..
  7. Suematsu N, Okamoto K, Isohashi F. Mouse cytosolic acetyl-CoA hydrolase, a novel candidate for a key enzyme involved in fat metabolism: cDNA cloning, sequencing and functional expression. Acta Biochim Pol. 2002;49:937-45 pubmed
    ..The discovery of mouse CACH cDNA is an important step towards genetic studies on the functional analysis of this enzyme by gene-knockout and transgenic approaches. ..
  8. Suematsu N, Isohashi F. Molecular cloning and functional expression of human cytosolic acetyl-CoA hydrolase. Acta Biochim Pol. 2006;53:553-61 pubmed
    ..A consensus peroxisome proliferator responsive element (PPRE) present in the rodent CACH promoter regions supports marked CACH induction in rat liver by peroxisome proliferator (PP). ..
  9. Hiratsuka K, Yin S, Ohtomo T, Fujita M, Ohtsuki K, Isaka H, et al. Intratesticular localization of the organic solute carrier protein, OSCP1, in spermatogenic cells in mice. Mol Reprod Dev. 2008;75:1495-504 pubmed publisher
    ..These results suggest that mouse testis OSCP1 may indirectly mediate substrate uptake into meiotic and spermiogenic germ cells, within the cytosol. ..

More Information


  1. Yamashita A, Kumazawa T, Koga H, Suzuki N, Oka S, Sugiura T. Generation of lysophosphatidylinositol by DDHD domain containing 1 (DDHD1): Possible involvement of phospholipase D/phosphatidic acid in the activation of DDHD1. Biochim Biophys Acta. 2010;1801:711-20 pubmed publisher
    ..Similar observations for the production of arachidonic acid-containing LPI in neuroblastoma cells suggest the DDHD1-LPI-GPR55 axis to be involved in functions in the brain. ..
  2. Suzuki R, Oda Y, Utoguchi N, Maruyama K. Progress in the development of ultrasound-mediated gene delivery systems utilizing nano- and microbubbles. J Control Release. 2011;149:36-41 pubmed publisher
    ..This review focuses on the current ultrasound-mediated gene delivery system using nano/microbubbles. We discuss about the feasibility of this gene delivery system as novel non-viral vector system. ..