Experts and Doctors on core binding factor alpha 3 subunit in Okayama, Japan
Locale: Okayama, Japan
Topic: core binding factor alpha 3 subunit
Kataoka J, Shiraha H, Horiguchi S, Sawahara H, Uchida D, Nagahara T, et al
. Loss of Runt-related transcription factor 3 induces resistance to 5-fluorouracil and cisplatin in hepatocellular carcinoma. Oncol Rep. 2016;35:2576-82 pubmed publisher
..Importantly, loss of RUNX3 expression contributed to 5-FU and CDDP resistance by inducing MRP expression. These data have important implications in the study of chemotherapy resistance in HCC. ..
Nakanishi Y, Shiraha H, Nishina S, Tanaka S, Matsubara M, Horiguchi S, et al
. Loss of runt-related transcription factor 3 expression leads hepatocellular carcinoma cells to escape apoptosis. BMC Cancer. 2011;11:3 pubmed publisher
..RUNX3 expression enhanced serum starvation-induced apoptosis in HCC cell lines. RUNX3 is deleted or weakly expressed in HCC, which leads to tumorigenesis by escaping apoptosis. ..
Shiraha H, Nishina S, Yamamoto K. Loss of runt-related transcription factor 3 causes development and progression of hepatocellular carcinoma. J Cell Biochem. 2011;112:745-9 pubmed publisher
..RUNX3 is a promising candidate as a tumor suppressor gene for HCC. ..
Tanaka S, Shiraha H, Nakanishi Y, Nishina S, Matsubara M, Horiguchi S, et al
. Runt-related transcription factor 3 reverses epithelial-mesenchymal transition in hepatocellular carcinoma. Int J Cancer. 2012;131:2537-46 pubmed publisher
..These results suggest a novel mechanism by which loss or decreased expression of RUNX3 induces EMT via induction of JAG1 expression in low-EMT HCC. ..
Tsuchiya Y, Saito Y, Taniuchi S, Sakuma A, Maekawa T, Fukamachi H, et al
. Runx3 expression and its roles in mouse endometrial cells. J Reprod Dev. 2012;58:592-8 pubmed
..Thus, Runx3 is likely to be a regulatory factor responsible for endometrial growth. ..