Experts and Doctors on cho cells in Tokyo, Japan


Locale: Tokyo, Japan
Topic: cho cells

Top Publications

  1. Shibata K, Hirasawa A, Moriyama N, Kawabe K, Ogawa S, Tsujimoto G. Alpha 1a-adrenoceptor polymorphism: pharmacological characterization and association with benign prostatic hypertrophy. Br J Pharmacol. 1996;118:1403-8 pubmed
    ..The study did not provide any evidence to support the hypothesis that alpha 1a-adrenoceptor gene polymorphism is associated with BPH. ..
  2. Yokomizo T, Kato K, Terawaki K, Izumi T, Shimizu T. A second leukotriene B(4) receptor, BLT2. A new therapeutic target in inflammation and immunological disorders. J Exp Med. 2000;192:421-32 pubmed
    ..BLT2 provides a novel target for antiinflammatory therapy and promises to expand our knowledge of LTB(4) function. The location of the gene suggests shared transcriptional regulation of these two receptors. ..
  3. Nakamura H, Fujii Y, Inoki I, Sugimoto K, Tanzawa K, Matsuki H, et al. Brevican is degraded by matrix metalloproteinases and aggrecanase-1 (ADAMTS4) at different sites. J Biol Chem. 2000;275:38885-90 pubmed
  4. Tanaka T, Takeno T, Watanabe Y, Uchiyama Y, Murakami T, Yamashita H, et al. The generation of monoclonal antibodies against human peroxisome proliferator-activated receptors (PPARs). J Atheroscler Thromb. 2002;9:233-42 pubmed
    ..This method is of potential utility in that it allows the production of valuable antibodies without the requirement of a protein purification step. ..
  5. Houjou T, Hayakawa J, Watanabe R, Tashima Y, Maeda Y, Kinoshita T, et al. Changes in molecular species profiles of glycosylphosphatidylinositol anchor precursors in early stages of biosynthesis. J Lipid Res. 2007;48:1599-606 pubmed
    ..Therefore, a specific feature of the PI moieties of mature GPI-APs, domination of alkyl (or alkenyl)/acyl type species over diacyl types, is established at the stage of GlcN-acyl-PI. ..
  6. Horiguchi Y, Araki M, Motojima K. Identification and characterization of the ER/lipid droplet-targeting sequence in 17beta-hydroxysteroid dehydrogenase type 11. Arch Biochem Biophys. 2008;479:121-30 pubmed publisher
  7. Cui Y, Liu X, Zhang W, Lin H, Ohwada T, Ido K, et al. The synthesis and BK channel-opening activity of N-acylaminoalkyloxime derivatives of dehydroabietic acid. Bioorg Med Chem Lett. 2016;26:283-287 pubmed publisher
    ..This research could guide the design and synthesis of novel abietane-based BK channel opener. ..
  8. Harada N, Iijima S, Kobayashi K, Yoshida T, Brown W, Hibi T, et al. Human IgGFc binding protein (FcgammaBP) in colonic epithelial cells exhibits mucin-like structure. J Biol Chem. 1997;272:15232-41 pubmed
    ..FcgammaBP mRNA is expressed only in placenta and colonic epithelial cells. These results suggest that FcgammaBP may play an important role in immune protection and inflammation in the intestines of primates. ..
  9. Emoto K, Kuge O, Nishijima M, Umeda M. Isolation of a Chinese hamster ovary cell mutant defective in intramitochondrial transport of phosphatidylserine. Proc Natl Acad Sci U S A. 1999;96:12400-5 pubmed
    ..These results indicate that the mutant is defective in PS transport between the outer and inner mitochondrial membrane and provide genetic evidence for the existence of a specific mechanism for intramitochondrial transport of PS. ..

More Information

Publications144 found, 100 shown here

  1. Emoto K, Umeda M. An essential role for a membrane lipid in cytokinesis. Regulation of contractile ring disassembly by redistribution of phosphatidylethanolamine. J Cell Biol. 2000;149:1215-24 pubmed
    ..These findings provide the first evidence that PE is required for completion of cytokinesis in mammalian cells, and suggest that redistribution of PE on the cleavage furrow may contribute to regulation of contractile ring disassembly. ..
  2. Kanda Y, Imai Nishiya H, Kuni Kamochi R, Mori K, Inoue M, Kitajima Miyama K, et al. Establishment of a GDP-mannose 4,6-dehydratase (GMD) knockout host cell line: a new strategy for generating completely non-fucosylated recombinant therapeutics. J Biotechnol. 2007;130:300-10 pubmed
    ..Our results demonstrate that GMD knockout is a new strategy applicable to the manufacture of non-fucosylated therapeutic antibodies, and completely O-fucose-negative therapeutics as well. ..
  3. Yamaguchi N, Koizumi H, Aoki J, Natori Y, Nishikawa K, Natori Y, et al. Type I platelet-activating factor acetylhydrolase catalytic subunits over-expression induces pleiomorphic nuclei and centrosome amplification. Genes Cells. 2007;12:1153-61 pubmed
    ..These results suggest that over-expression of the PAF-AH (I) catalytic subunits induces centrosomal amplification and microtubule disorganization by disturbing intracellular localization of LIS1. ..
  4. Kajitani T, Liu S, Maruyama T, Uchida H, Sakurai R, Masuda H, et al. Analysis of serum FSH bioactivity in a patient with an FSH-secreting pituitary microadenoma and multicystic ovaries: A case report. Hum Reprod. 2008;23:435-9 pubmed
    ..This was confirmed with a granulosa cell aromatase assay. This case report suggests that alternate explanations may exist for the OHSS phenotype seen in some FSHoma patients. ..
  5. Matsuki E, Miyakawa Y, Okamoto S. A novel factor XII mutation, FXII R84P, causing factor XII deficiency in a patient with hereditary spastic paraplegia. Blood Coagul Fibrinolysis. 2011;22:227-30 pubmed publisher
  6. Nakano N, Nishiyama C, Yagita H, Koyanagi A, Ogawa H, Okumura K. Notch1-mediated signaling induces MHC class II expression through activation of class II transactivator promoter III in mast cells. J Biol Chem. 2011;286:12042-8 pubmed publisher
    ..These findings indicate that activation of CIITA pIII plays an important role in MHC class II expression in mast cells. ..
  7. Yu Y, Miki H, Nakamura Y, Hanyuda A, Matsuzaki Y, Abe Y, et al. Curcumin and genistein additively potentiate G551D-CFTR. J Cyst Fibros. 2011;10:243-52 pubmed publisher
  8. Nomura W, Masuda A, Ohba K, Urabe A, Ito N, Ryo A, et al. Effects of DNA binding of the zinc finger and linkers for domain fusion on the catalytic activity of sequence-specific chimeric recombinases determined by a facile fluorescent system. Biochemistry. 2012;51:1510-7 pubmed publisher
    ..The results provide information relevant to the design of ZFRs that will be useful for sequence-specific genome modification. ..
  9. Kamata T, Handa M, Takakuwa S, Sato Y, Kawai Y, Ikeda Y, et al. Epitope mapping for monoclonal antibody reveals the activation mechanism for ?V?3 integrin. PLoS ONE. 2013;8:e66096 pubmed publisher
    ..Thus, a switchblade-like movement of the integrin leg is indispensable for the affinity regulation of ?V?3 integrin. ..
  10. Okuda T, Haga T, Kanai Y, Endou H, Ishihara T, Katsura I. Identification and characterization of the high-affinity choline transporter. Nat Neurosci. 2000;3:120-5 pubmed
    ..Expression of CHT1 mRNA is restricted to cholinergic neurons. The characteristics of CHT1-mediated choline uptake essentially match those of high-affinity choline uptake in rat brain synaptosomes. ..
  11. Chung D, Ohashi K, Watanabe M, Miyasaka N, Hirosawa S. Mannose trimming targets mutant alpha(2)-plasmin inhibitor for degradation by the proteasome. J Biol Chem. 2000;275:4981-7 pubmed
  12. Imamura M, Araishi K, Noguchi S, Ozawa E. A sarcoglycan-dystroglycan complex anchors Dp116 and utrophin in the peripheral nervous system. Hum Mol Genet. 2000;9:3091-100 pubmed
    ..These results demonstrated that Dp116 and utrophin are anchored to a novel membrane protein architecture, which consists of the SG and dystroglycan complexes, but not SPN, in the Schwann cell membrane. ..
  13. Noguchi K, Ishii S, Shimizu T. Identification of p2y9/GPR23 as a novel G protein-coupled receptor for lysophosphatidic acid, structurally distant from the Edg family. J Biol Chem. 2003;278:25600-6 pubmed
    ..These facts suggest that p2y9/GPR23 has evolved from different ancestor sequences from the Edg family. ..
  14. Murakami A, Kimura S, Fujiki K, Fujimaki T, Kanai A. Mutations in the membrane component, chromosome 1, surface marker 1 (M1S1) gene in gelatinous drop-like corneal dystrophy. Jpn J Ophthalmol. 2004;48:317-20 pubmed
    ..These data indicate that the K84X and C108R mutations in M1S1 cause GDLD. ..
  15. Hino N, Okazaki Y, Kobayashi T, Hayashi A, Sakamoto K, Yokoyama S. Protein photo-cross-linking in mammalian cells by site-specific incorporation of a photoreactive amino acid. Nat Methods. 2005;2:201-6 pubmed
    ..Cross-linked complexes with endogenous proteins were also detected. In vivo photo-cross-linking with pBpa incorporated in proteins will be useful for studying protein-protein interactions in mammalian cells. ..
  16. Kanno A, Ozawa T, Umezawa Y. Intein-mediated reporter gene assay for detecting protein-protein interactions in living mammalian cells. Anal Chem. 2006;78:556-60 pubmed
  17. Nakayama T, Kuroi N, Sano M, Tabara Y, Katsuya T, Ogihara T, et al. Mutation of the follicle-stimulating hormone receptor gene 5'-untranslated region associated with female hypertension. Hypertension. 2006;48:512-8 pubmed
    ..004). The SNP in the 5'-untranslated region of the FSHR gene affects levels of transcriptional activity and is a susceptibility mutation of EH in women. ..
  18. Matsushita S, Urase K, Komatsu A, Scotting P, Kuroiwa A, Yasugi S. Foregut endoderm is specified early in avian development through signal(s) emanating from Hensen's node or its derivatives. Mech Dev. 2008;125:377-95 pubmed publisher
  19. Sakai K, Ohte S, Ohshiro T, Matsuda D, Masuma R, Rudel L, et al. Selective inhibition of acyl-CoA:cholesterol acyltransferase 2 isozyme by flavasperone and sterigmatocystin from Aspergillus species. J Antibiot (Tokyo). 2008;61:568-72 pubmed publisher
    ..Among them, flavasperone and sterigmatocystin, having an angular skeleton, showed selective inhibition toward ACAT2 isozyme, while the others having a linear one had no selectivity in inhibition. ..
  20. Kawaguchi M, Uchida R, Ohte S, Miyachi N, Kobayashi K, Sato N, et al. New dinapinone derivatives, potent inhibitors of triacylglycerol synthesis in mammalian cells, produced by Talaromyces pinophilus FKI-3864. J Antibiot (Tokyo). 2013;66:179-89 pubmed publisher
    ..Dinapinone AB2 showed potent inhibition of triacylglycerol (TG) synthesis in intact mammalian cells with an IC50 value of 1.17 ?M, whereas the other dinapinones showed weak inhibition of TG synthesis. ..
  21. Yamamoto K, Suzuki T, Imamura R, Nagano T, Okabe T, Miyachi H. Synthesis of both enantiomers of 1,2,3,4-tetrahydroisoquinoline derivative IPPAM-1 and enantio-dependency of its positive allosteric modulation of prostacyclin receptor. Bioorg Med Chem Lett. 2017;27:2567-2570 pubmed publisher
    ..Assay of cAMP production by CHO-K1 cells stably expressing human IP clearly demonstrated that the IPPAM activity resides exclusively on the R-form of 1. ..
  22. Yoshikawa N, Makino Y, Okamoto K, Morimoto C, Makino I, Tanaka H. Distinct interaction of cortivazol with the ligand binding domain confers glucocorticoid receptor specificity: cortivazol is a specific ligand for the glucocorticoid receptor. J Biol Chem. 2002;277:5529-40 pubmed
    ..Thus, it is indicated that CVZ may not be only a molecular probe for the analysis of the redundancy between the GR and MR in vivo but also a useful reagent to clarify structure-function relationship of the GR LBD. ..
  23. Takagi S, Sato S, Oh hara T, Takami M, Koike S, Mishima Y, et al. Platelets promote tumor growth and metastasis via direct interaction between Aggrus/podoplanin and CLEC-2. PLoS ONE. 2013;8:e73609 pubmed publisher
    ..Our results indicate that molecular target drugs inhibiting specific platelet-tumor interactions can be developed as antitumor drugs that suppress both metastasis and proliferation of tumors such as lung squamous cell carcinoma. ..
  24. Shiina T, Kawasaki A, Nagao T, Kurose H. Interaction with beta-arrestin determines the difference in internalization behavor between beta1- and beta2-adrenergic receptors. J Biol Chem. 2000;275:29082-90 pubmed
    ..This is further supported by the finding that beta-arrestin can induce internalization of beta(1)AR when beta-arrestin 1 does not dissociate from beta(1)AR by fusing to the carboxyl tail of beta(1)AR. ..
  25. Kataoka M, Toyoizumi H, Yamamoto A, Ochiai M, Horiuchi Y. Chinese hamster ovary (CHO) cell clustering does not correlate with in vivo histamine-sensitization when measuring residual activity of aldehyde-treated pertussis toxin (PT). Biologicals. 2002;30:297-302 pubmed
    ..These findings suggested that CHO cell clustering test might have an efficacy limitation in predicting in vivo activity of aldehyde-treated PT. ..
  26. Suga H, Takeda S, Haga T, Okamura M, Takao K, Tatemoto K. Stimulation of increases in intracellular calcium and prostaglandin E2 generation in Chinese hamster ovary cells expressing receptor-Galpha16 fusion proteins. J Biochem. 2004;135:605-13 pubmed
  27. Shiga K, Yoshioka H, Matsumiya T, Kimura I, Takeda S, Imamura M. Zeta-sarcoglycan is a functional homologue of gamma-sarcoglycan in the formation of the sarcoglycan complex. Exp Cell Res. 2006;312:2083-92 pubmed
  28. Nishi K, Saigo K. Cellular internalization of green fluorescent protein fused with herpes simplex virus protein VP22 via a lipid raft-mediated endocytic pathway independent of caveolae and Rho family GTPases but dependent on dynamin and Arf6. J Biol Chem. 2007;282:27503-17 pubmed
    ..Internalized VP22 initially entered early endosomes and then moved to lysosomes and possibly recycling endosomes. ..
  29. Tian Y, Denda Nagai K, Kamata Sakurai M, Nakamori S, Tsukui T, Itoh Y, et al. Mucin 21 in esophageal squamous epithelia and carcinomas: analysis with glycoform-specific monoclonal antibodies. Glycobiology. 2012;22:1218-26 pubmed publisher
    ..Thus, these antibodies represent a useful tool to characterize squamous epithelial differentiation and carcinogenesis. ..
  30. Doi S, Mori T, Uzawa N, Arima T, Takahashi T, Uchida M, et al. Characterization of methadone as a ?-arrestin-biased ?-opioid receptor agonist. Mol Pain. 2016;12: pubmed publisher
  31. Suzuki M, Kato Nakano M, Kawamoto S, Furuya A, Abe Y, Misaka H, et al. Therapeutic antitumor efficacy of monoclonal antibody against Claudin-4 for pancreatic and ovarian cancers. Cancer Sci. 2009;100:1623-30 pubmed publisher
    ..05). These results suggest that mAb therapy against CLDN4 is promising for pancreatic and ovarian cancers. ..
  32. Miyachi H, Suzuki T, Imamura R, Nagano T, Okabe T. Structural development of 1,2,3,4-tetrahydroisoquinoline-type positive allosteric modulators of prostacyclin receptor (IPPAMs) to improve metabolic stability, and investigation of metabolic fate. Bioorg Med Chem Lett. 2017;27:3572-3575 pubmed publisher
    ..The primary metabolite 12 underwent further hydroxylation mainly on the 1,2,3,4-tetrahydroisoquinoline moiety. These findings should be helpful for design of IPPAMs with longer duration of action. ..
  33. Miyazaki Y, Matsufuji S, Hayashi S. Cloning and characterization of a rat gene encoding ornithine decarboxylase antizyme. Gene. 1992;113:191-7 pubmed
    ..In addition, we isolated a 12-kb EcoRI fragment, the other sequence hybridizable to the cDNA. Sequence analysis showed that it represented a processed Oaz pseudogene and was not able to encode any active protein. ..
  34. Fukushima Y, Otsuka H, Ishikawa M, Asano T, Anai M, Katsube T, et al. Potent and long-lasting action of lafutidine on the human histamine H(2) receptor. Digestion. 2001;64:155-60 pubmed
    ..78 x 10(-7) M lafutidine, but not with 10(-5) M famotidine, had marked inhibitory effects which persisted as long as after extensive washing. Lafutidine shows a potent and long-lasting antagonism on the human H(2)R. ..
  35. Mori H, Tomari T, Koshikawa N, Kajita M, Itoh Y, Sato H, et al. CD44 directs membrane-type 1 matrix metalloproteinase to lamellipodia by associating with its hemopexin-like domain. EMBO J. 2002;21:3949-59 pubmed
    ..The PEX domain of MT1-MMP was indispensable in promoting cell migration and CD44H shedding. ..
  36. Ikeno M, Suzuki N. Construction and use of a bottom-up HAC vector for transgene expression. Methods Mol Biol. 2011;738:101-10 pubmed publisher
    ..This technology for manipulating a transgene using a HAC vector could be used in applied biology. ..
  37. Shimizu K, Chiba S, Saito T, Kumano K, Hirai H. Physical interaction of Delta1, Jagged1, and Jagged2 with Notch1 and Notch3 receptors. Biochem Biophys Res Commun. 2000;276:385-9 pubmed
    ..All interactions between the DSL proteins and soluble Notch proteins were dependent on Ca(2+). Taken together, these results suggest that Delta1, Jagged1, and Jagged2 are ligands for Notch1 and Notch3 receptors. ..
  38. Hakuno F, Kurihara S, Watson R, Pessin J, Takahashi S. 53BP2S, interacting with insulin receptor substrates, modulates insulin signaling. J Biol Chem. 2007;282:37747-58 pubmed
    ..Together these data demonstrate that 53BP2S interacts and modulates the insulin signals mediated by IRSs. ..
  39. Tomishige N, Kumagai K, Kusuda J, Nishijima M, Hanada K. Casein kinase I{gamma}2 down-regulates trafficking of ceramide in the synthesis of sphingomyelin. Mol Biol Cell. 2009;20:348-57 pubmed publisher
    ..These results indicate that CKIgamma2 hyperphosphorylates the serine-repeat motif of CERT, thereby inactivating CERT and down-regulating the synthesis of sphingomyelin. ..
  40. Matsumoto A, Mitchell A, Kurata H, Pyle L, Kondo K, Itakura H, et al. Cloning and characterization of HB2, a candidate high density lipoprotein receptor. Sequence homology with members of the immunoglobulin superfamily of membrane proteins. J Biol Chem. 1997;272:16778-82 pubmed
  41. Aoki K, Ishida N, Kawakita M. Substrate recognition by UDP-galactose and CMP-sialic acid transporters. Different sets of transmembrane helices are utilized for the specific recognition of UDP-galactose and CMP-sialic acid. J Biol Chem. 2001;276:21555-61 pubmed
  42. Tayama S, Nakagawa Y, Tayama K. Genotoxic effects of environmental estrogen-like compounds in CHO-K1 cells. Mutat Res. 2008;649:114-25 pubmed
    ..Our findings also suggest that E2, DES and BPA have aneuploidogenic properties, and that the former two of chemicals also are polyploidy-inducing agents. ..
  43. Okumura A, Suzuki T, Miyatake H, Okabe T, Hashimoto Y, Miyakawa T, et al. Leukocyte cell-derived chemotaxin 2 is a zinc-binding protein. FEBS Lett. 2013;587:404-9 pubmed publisher
    ..Furthermore, the recombinant LECT2 was found to be self-oligomerized by disulfide bonds in vitro, but this was suppressed by addition of zinc. These results indicated that zinc stabilizes the LECT2 structure. ..
  44. Hashimoto Y, Jiang H, Niikura T, Ito Y, Hagiwara A, Umezawa K, et al. Neuronal apoptosis by apolipoprotein E4 through low-density lipoprotein receptor-related protein and heterotrimeric GTPases. J Neurosci. 2000;20:8401-9 pubmed
  45. Ishii S, Kihara Y, Shimizu T. Identification of T cell death-associated gene 8 (TDAG8) as a novel acid sensing G-protein-coupled receptor. J Biol Chem. 2005;280:9083-7 pubmed
    ..These results suggest that TDAG8 may play biological roles in immune response and cellular transformation under conditions accompanying tissue acidosis. ..
  46. Iwai M, Tateishi Y, Hattori M, Mizutani A, Nakamura T, Futatsugi A, et al. Molecular cloning of mouse type 2 and type 3 inositol 1,4,5-trisphosphate receptors and identification of a novel type 2 receptor splice variant. J Biol Chem. 2005;280:10305-17 pubmed
  47. Kanda Y, Yamane Ohnuki N, Sakai N, Yamano K, Nakano R, Inoue M, et al. Comparison of cell lines for stable production of fucose-negative antibodies with enhanced ADCC. Biotechnol Bioeng. 2006;94:680-8 pubmed
    ..Our results demonstrate that FUT8 knockout has the essential characteristics of host cells for robust manufacture of fucose-negative therapeutic antibodies with enhanced ADCC. ..
  48. Yuyama K, Sekino Suzuki N, Sanai Y, Kasahara K. Translocation of activated heterotrimeric G protein Galpha(o) to ganglioside-enriched detergent-resistant membrane rafts in developing cerebellum. J Biol Chem. 2007;282:26392-400 pubmed
    ..These results demonstrate the involvement of signal-dependent Galpha(o) translocation to the DRM in the growth cone behavior of cerebellar granule neurons. ..
  49. Shiomi K, Hagiwara Y, Sonoue K, Segawa T, Miyashita K, Maeda M, et al. Sensitive and specific new enzyme-linked immunosorbent assay for N-ERC/mesothelin increases its potential as a useful serum tumor marker for mesothelioma. Clin Cancer Res. 2008;14:1431-7 pubmed publisher
    ..N-ERC/mesothelin is a very promising tumor marker for mesothelioma, especially epithelioid mesothelioma. ..
  50. Sugiyama T, Yoneda M, Kuraishi T, Hattori S, Inoue Y, Sato H, et al. Measles virus selectively blind to signaling lymphocyte activation molecule as a novel oncolytic virus for breast cancer treatment. Gene Ther. 2013;20:338-47 pubmed publisher
    ..On the basis of these results, rMV-SLAMblind could be a promising candidate as a novel oncolytic virus for breast cancer treatment. ..
  51. Yoshida A, Takahashi M, Nishimura S, Takeshima H, Kokubun S. Cyclic AMP-dependent phosphorylation and regulation of the cardiac dihydropyridine-sensitive Ca channel. FEBS Lett. 1992;309:343-9 pubmed
    ..These results suggested that the cardiac DHP-sensitive Ca channel was regulated by cAMP-dependent phosphorylation of the alpha 1 subunit. ..
  52. Shimizu Hirota R, Sasamura H, Kuroda M, Kobayashi E, Saruta T. Functional characterization of podocan, a member of a new class in the small leucine-rich repeat protein family. FEBS Lett. 2004;563:69-74 pubmed
  53. Suzuki E, Niwa R, Saji S, Muta M, Hirose M, Iida S, et al. A nonfucosylated anti-HER2 antibody augments antibody-dependent cellular cytotoxicity in breast cancer patients. Clin Cancer Res. 2007;13:1875-82 pubmed
    ..This preliminary study suggests that the use of fucose-negative antibodies may improve the therapeutic effects of anti-HER2 therapy for patients independent of clinical backgrounds. ..
  54. Koeberle A, Shindou H, Harayama T, Shimizu T. Role of lysophosphatidic acid acyltransferase 3 for the supply of highly polyunsaturated fatty acids in TM4 Sertoli cells. FASEB J. 2010;24:4929-38 pubmed publisher
  55. Hotta Y, Inana G. Expression of human ornithine aminotransferase (OAT) in OAT-deficient Chinese hamster ovary cells and fibroblasts of gyrate atrophy patient. Jpn J Ophthalmol. 1992;36:28-32 pubmed
    ..Despite the limited success, the ability to express active OAT in these OAT-deficient cells using an expression vector offers possibilities of replacement gene therapy for gyrate atrophy...
  56. Tanida I, Komatsu M, Ueno T, Kominami E. GATE-16 and GABARAP are authentic modifiers mediated by Apg7 and Apg3. Biochem Biophys Res Commun. 2003;300:637-44 pubmed
    ..These results indicate that GATE-16 and GABARAP are authentic modifiers, but that they have different biochemical characteristics from those of LC3. ..
  57. Katsura Y, Sasaki S, Sato M, Yamaoka K, Suzukawa K, Nagasawa T, et al. Involvement of Ku80 in microhomology-mediated end joining for DNA double-strand breaks in vivo. DNA Repair (Amst). 2007;6:639-48 pubmed
    ..The results suggest that the increase in DSBs makes the cell more predominant for MMEJ. MMEJ might function as a salvage pathway for DSBs that cannot be repaired by NHEJ. ..
  58. Nakazawa Y, Arai H, Fujita N. The novel metastasis promoter Merm1/Wbscr22 enhances tumor cell survival in the vasculature by suppressing Zac1/p53-dependent apoptosis. Cancer Res. 2011;71:1146-55 pubmed publisher
    ..Our findings show that Merm1 enhances cancer cell survival in the vasculature by suppressing Zac1/p53-dependent apoptosis, thereby enhancing metastasis. ..
  59. Ikenoya M, Yoshinaka Y, Kobayashi H, Kawamine K, Shibuya K, Sato F, et al. A selective ACAT-1 inhibitor, K-604, suppresses fatty streak lesions in fat-fed hamsters without affecting plasma cholesterol levels. Atherosclerosis. 2007;191:290-7 pubmed
  60. Tsuga H, Kameyama K, Haga T, Honma T, Lameh J, Sadee W. Internalization and down-regulation of human muscarinic acetylcholine receptor m2 subtypes. Role of third intracellular m2 loop and G protein-coupled receptor kinase 2. J Biol Chem. 1998;273:5323-30 pubmed
  61. Tamura Y, Adachi H, Osuga J, Ohashi K, Yahagi N, Sekiya M, et al. FEEL-1 and FEEL-2 are endocytic receptors for advanced glycation end products. J Biol Chem. 2003;278:12613-7 pubmed
    ..FEEL-1, which is expressed by the liver and vascular tissues, may recognize AGEs, thereby contributing to the development of diabetic vascular complications and atherosclerosis. ..
  62. Arai K, Maruyama Y, Nishida M, Tanabe S, Takagahara S, Kozasa T, et al. Differential requirement of G alpha12, G alpha13, G alphaq, and G beta gamma for endothelin-1-induced c-Jun NH2-terminal kinase and extracellular signal-regulated kinase activation. Mol Pharmacol. 2003;63:478-88 pubmed
    ..Thus, ERK was activated by G alpha(i)- and G beta gamma-dependent pathways. These results clearly demonstrate that differential pathways activate JNK and ERK. ..
  63. Kaihara A, Kawai Y, Sato M, Ozawa T, Umezawa Y. Locating a protein-protein interaction in living cells via split Renilla luciferase complementation. Anal Chem. 2003;75:4176-81 pubmed
    ..It was thereby found that the insulin-stimulated interaction occurred near the plasma membrane in the cytosol. ..
  64. Natsume A, In M, Takamura H, Nakagawa T, Shimizu Y, Kitajima K, et al. Engineered antibodies of IgG1/IgG3 mixed isotype with enhanced cytotoxic activities. Cancer Res. 2008;68:3863-72 pubmed publisher
  65. Ohtaki N, Takahashi H, Kaneko K, Gomi Y, Ishikawa T, Higashi Y, et al. Immunogenicity and efficacy of two types of West Nile virus-like particles different in size and maturation as a second-generation vaccine candidate. Vaccine. 2010;28:6588-96 pubmed publisher
    ..These results indicate that F-VLPs more closely resemble the virions and take a better immunogenic form than S-VLPs as WNV vaccine candidates. ..
  66. Ishijima N, Suzuki M, Ashida H, Ichikawa Y, Kanegae Y, Saito I, et al. BabA-mediated adherence is a potentiator of the Helicobacter pylori type IV secretion system activity. J Biol Chem. 2011;286:25256-64 pubmed publisher
    ..pylori can exploit BabA-Le(b) binding to trigger TFSS-dependent host cell signaling to induce the transcription of genes that enhance inflammation, development of intestinal metaplasia, and associated precancerous transformations. ..
  67. Iizuka Y, Yokomizo T, Terawaki K, Komine M, Tamaki K, Shimizu T. Characterization of a mouse second leukotriene B4 receptor, mBLT2: BLT2-dependent ERK activation and cell migration of primary mouse keratinocytes. J Biol Chem. 2005;280:24816-23 pubmed
    ..Furthermore, Compound A and LTB4 induced chemotaxis in primary mouse keratinocytes. These data suggest the presence of functional BLT2 in primary keratinocytes. ..
  68. Iida S, Misaka H, Inoue M, Shibata M, Nakano R, Yamane Ohnuki N, et al. Nonfucosylated therapeutic IgG1 antibody can evade the inhibitory effect of serum immunoglobulin G on antibody-dependent cellular cytotoxicity through its high binding to FcgammaRIIIa. Clin Cancer Res. 2006;12:2879-87 pubmed
    ..Hence, nonfucosylated IgG1 exhibits strong therapeutic potential through dramatically enhanced ADCC at low doses in humans in vivo. ..
  69. Oyama F, Kotliarova S, Harada A, Ito M, Miyazaki H, Ueyama Y, et al. Gem GTPase and tau: morphological changes induced by gem GTPase in cho cells are antagonized by tau. J Biol Chem. 2004;279:27272-7 pubmed
    ..Taken together, the present results indicate that the level of Gem GTPase and its cell elongation activity are modulated by tau and suggest that tau may be involved in a Gem GTPase-mediated signal transduction pathway. ..
  70. Irukayama Tomobe Y, Tanaka H, Yokomizo T, Hashidate Yoshida T, Yanagisawa M, Sakurai T. Aromatic D-amino acids act as chemoattractant factors for human leukocytes through a G protein-coupled receptor, GPR109B. Proc Natl Acad Sci U S A. 2009;106:3930-4 pubmed publisher
    ..These results suggest that these aromatic D-amino acids elicit a chemotactic response in human neutrophils via activation of GPR109B. ..
  71. Kitajima K, Minehata K, Sakimura K, Nakano T, Hara T. In vitro generation of HSC-like cells from murine ESCs/iPSCs by enforced expression of LIM-homeobox transcription factor Lhx2. Blood. 2011;117:3748-58 pubmed publisher
  72. Yamanashi Y, Takada T, Shoda J, Suzuki H. Novel function of Niemann-Pick C1-like 1 as a negative regulator of Niemann-Pick C2 protein. Hepatology. 2012;55:953-64 pubmed publisher
  73. Nakano N, Nishiyama C, Yagita H, Koyanagi A, Akiba H, Chiba S, et al. Notch signaling confers antigen-presenting cell functions on mast cells. J Allergy Clin Immunol. 2009;123:74-81.e1 pubmed publisher
    ..Dll1/Notch signaling confers the functions as an antigen-presenting cell on mast cells, which preferentially induce the differentiation of T(H)2. ..
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