Experts and Doctors on central nervous system in Tokyo, Japan


Locale: Tokyo, Japan
Topic: central nervous system

Top Publications

  1. Sugiura N, Uda A, Inoue S, Kojima D, Hamamoto N, Kaku Y, et al. Gene expression analysis of host innate immune responses in the central nervous system following lethal CVS-11 infection in mice. Jpn J Infect Dis. 2011;64:463-72 pubmed
    ..The presence of perforin and granzymes both in the Purkinje cells and CD3 T lymphocytes strongly suggested that apoptosis of the former cells was induced by the latter cells. ..
  2. Miyamoto K, Miyake S, Mizuno M, Oka N, Kusunoki S, Yamamura T. Selective COX-2 inhibitor celecoxib prevents experimental autoimmune encephalomyelitis through COX-2-independent pathway. Brain. 2006;129:1984-92 pubmed
    ..These results suggest that celecoxib may be useful as a new additional therapeutic agent for multiple sclerosis. ..
  3. Okano H. Strategies toward CNS-regeneration using induced pluripotent stem cells. Genome Inform. 2009;23:217-20 pubmed
    ..Surprisingly, SNSs derived from c-Myc minus iPS cells generated without drug selection showed robust tumorigenesis, in spite of their potential to contribute adult chimeric mice without tumor formation. ..
  4. Ikemura M, Saito Y, Sengoku R, Sakiyama Y, Hatsuta H, Kanemaru K, et al. Lewy body pathology involves cutaneous nerves. J Neuropathol Exp Neurol. 2008;67:945-53 pubmed publisher
    ..We demonstrate for the first time that the skin is involved and may be a highly specific and useful biopsy site for the pathological diagnosis of LB diseases. ..
  5. Saito R, Fujita N, Nagata S. Overexpression of Fyn tyrosine kinase causes abnormal development of primary sensory neurons in Xenopus laevis embryos. Dev Growth Differ. 2001;43:229-38 pubmed
    ..These results suggest that Fyn can modify signals regulating axonal guidance or fasciculation in the developing X. laevis nervous system and that contactin may affect this action of Fyn. ..
  6. Takamatsu Y, Nakagoshi H, Rachidi M, Lopes C, Nishida Y, Ohsako S. Characterization of the dCaMKII-GAL4 driver line whose expression is controlled by the Drosophila Ca2+/calmodulin-dependent protein kinase II promoter. Cell Tissue Res. 2002;310:237-52 pubmed
  7. Usui Aoki K, Mikawa Y, Yamamoto D. Species-specific patterns of sexual dimorphism in the expression of fruitless protein, a neural musculinizing factor in Drosophila. J Neurogenet. 2005;19:109-21 pubmed
    ..suzukii, but not in males and females of the 7 other species. These results indicate that sexually dimorphic expression of the Fru protein has been subjected to species-specific modulation during evolution. ..
  8. Ozawa H. Steroid Hormones, their receptors and neuroendocrine system. J Nippon Med Sch. 2005;72:316-25 pubmed
    ..Finally, the recent topics on the control system of feeding regulation in the central nervous system, which also closely involves steroid hormone action, are discussed. ..
  9. Matsumoto K, Umemoto H, Mori T, Akatsu R, Saito S, Tashima K, et al. Differences in the morphine-induced inhibition of small and large intestinal transit: Involvement of central and peripheral μ-opioid receptors in mice. Eur J Pharmacol. 2016;771:220-8 pubmed publisher

More Information


  1. Yamamoto T, Shibata N, Saito Y, Osawa M, Kobayashi M. Functions of fukutin, a gene responsible for Fukuyama type congenital muscular dystrophy, in neuromuscular system and other somatic organs. Cent Nerv Syst Agents Med Chem. 2010;10:169-79 pubmed
    ..Toward effective therapies with minimal side effects, precise evaluation of the pathomechanism of FCMD and the function of fukutin would be required. ..
  2. Isobe Y, Sugimoto K, Masuda A, Hamano Y, Oshimi K. Central nervous system is a sanctuary site for chronic myelogenous leukaemia treated with imatinib mesylate. Intern Med J. 2009;39:408-11 pubmed publisher
    ..It is important to consider isolated CNS blast crisis as a possible event in IM-treated CML patients. ..
  3. Makino K, Kohase H, Sanada T, Umino M. Phenylephrine suppresses the pain modulation of diffuse noxious inhibitory control in rats. Anesth Analg. 2010;110:1215-21 pubmed publisher
    ..Direct administration of PE close to the RMg inhibited DNIC, thereby affecting and modulating the intrinsic pain inhibition system. These findings suggest that the RMg may be involved in the regulation of DNIC. ..
  4. Hayashi M, Araki S, Arai N, Kumada S, Itoh M, Tamagawa K, et al. Oxidative stress and disturbed glutamate transport in spinal muscular atrophy. Brain Dev. 2002;24:770-5 pubmed
    ..These data suggest that oxidative stress and disturbed glutamate transport can partly be involved in the motor neuron devastation and/or latent thalamic degeneration in SMA type 1. ..
  5. Mang D, Shu M, Endo H, Yoshizawa Y, Nagata S, Kikuta S, et al. Expression of a sugar clade gustatory receptor, BmGr6, in the oral sensory organs, midgut, and central nervous system of larvae of the silkworm Bombyx mori. Insect Biochem Mol Biol. 2016;70:85-98 pubmed publisher
    ..These results suggest that BmGr6 functions not only as a taste receptor, but also as a chemical sensor such as for the regulation of gut movement, physiological conditions, and feeding behavior of larvae. ..
  6. Momose Sato Y, Honda Y, Sasaki H, Sato K. Optical imaging of large-scale correlated wave activity in the developing rat CNS. J Neurophysiol. 2005;94:1606-22 pubmed
    ..These characteristics of the wave activity are similar to those of the depolarization wave reported in the chick embryo, suggesting that the large-scale depolarization wave is globally generated across different species. ..
  7. Kadowaki T, Yamauchi T, Kubota N. The physiological and pathophysiological role of adiponectin and adiponectin receptors in the peripheral tissues and CNS. FEBS Lett. 2008;582:74-80 pubmed
    ..We propose a hypothesis on the physiological role of adiponectin: a starvation gene in the course of evolution by promoting fat storage on facing the loss of adiposity. ..
  8. Kotani M, Osanai T, Tajima Y, Kato H, Imada M, Kaneda H, et al. Identification of neuronal cell lineage-specific molecules in the neuronal differentiation of P19 EC cells and mouse central nervous system. J Neurosci Res. 2002;67:595-606 pubmed
  9. Kinoshita M, Hatada S, Asashima M, Noda M. HMG-X, a Xenopus gene encoding an HMG1 homolog, is abundantly expressed in the developing nervous system. FEBS Lett. 1994;352:191-6 pubmed
    ..Our data suggest that we have identified a gene for a member of the HMG1/2 family that could have an important role in neurogenesis. ..
  10. Narita M, Nakamura A, Ozaki M, Imai S, Miyoshi K, Suzuki M, et al. Comparative pharmacological profiles of morphine and oxycodone under a neuropathic pain-like state in mice: evidence for less sensitivity to morphine. Neuropsychopharmacology. 2008;33:1097-112 pubmed
    ..Furthermore, the reduction in G-protein activation induced by M-6-G may, at least in part, contribute to the suppression of the antinociceptive effect produced by morphine under a neuropathic pain-like state. ..
  11. Momose Sato Y, Sato K, Kinoshita M. Spontaneous depolarization waves of multiple origins in the embryonic rat CNS. Eur J Neurosci. 2007;25:929-44 pubmed
    ..This network possibly works as a self-distributing system that maintains the incidence and complicated patterns of the correlated activity in the developing CNS. ..
  12. Ikeshima Kataoka H, Shen J, Eto Y, Saito S, Yuasa S. Alteration of inflammatory cytokine production in the injured central nervous system of tenascin-deficient mice. In Vivo. 2008;22:409-13 pubmed
    ..Our findings suggest that TN helps to regulate production of inflammatory cytokines in the injured brain. ..
  13. Watanabe S, Kirino Y, Gelperin A. Neural and molecular mechanisms of microcognition in Limax. Learn Mem. 2008;15:633-42 pubmed publisher
    ..Since the isolated Limax brain can perform odor learning in vitro, the circuits and synapses causally linked to learning and memory formation are assessable for further detailed analysis. ..
  14. Aoyama K, Nakaki T. Neuroprotective properties of the excitatory amino acid carrier 1 (EAAC1). Amino Acids. 2013;45:133-42 pubmed publisher
    ..In recent years, however, several studies have revealed regulatory mechanisms of EAAC1 functions in the brain. This review will summarize the latest information on the EAAC1-regulated neuroprotective functions in the CNS. ..
  15. Yamaguchi M, Seki T, Imayoshi I, Tamamaki N, Hayashi Y, Tatebayashi Y, et al. Neural stem cells and neuro/gliogenesis in the central nervous system: understanding the structural and functional plasticity of the developing, mature, and diseased brain. J Physiol Sci. 2016;66:197-206 pubmed publisher
  16. Seiwa C, Yamamoto M, Tanaka K, Fukutake M, Ueki T, Takeda S, et al. Restoration of FcRgamma/Fyn signaling repairs central nervous system demyelination. J Neurosci Res. 2007;85:954-66 pubmed
    ..These results suggest that the restoration of FcRgamma/Fyn signaling represents a new approach for the treatment of demyelinating diseases. ..
  17. Enokido Y, Suzuki E, Iwasawa K, Namekata K, Okazawa H, Kimura H. Cystathionine beta-synthase, a key enzyme for homocysteine metabolism, is preferentially expressed in the radial glia/astrocyte lineage of developing mouse CNS. FASEB J. 2005;19:1854-6 pubmed
  18. Oishi K, Ito Dufros Y. Angiogenic potential of CD44+ CD90+ multipotent CNS stem cells in vitro. Biochem Biophys Res Commun. 2006;349:1065-72 pubmed
    ..These results indicate that CD44(+) CD90(+) cells have the ability to generate neurospheres and to form vascular tubes. ..
  19. Miyajima M, Arai H, Okuda O, Hishii M, Nakanishi H, Ishii H, et al. Effect of C-type natriuretic peptide (CNP) on water channel aquaporin-4 (AQP4) expression in cultured astrocytes. Brain Res Mol Brain Res. 2004;122:109-15 pubmed
    ..These results suggest that CNP, which is mainly produced by the neurons, effects the level of AQP4 in the astrocytes. Therefore, CNP may be a regulator of water homeostasis in the central nervous system. ..
  20. Shibata S, Kakuta S, Hamada K, Sokawa Y, Iwakura Y. Cloning of a novel 2',5'-oligoadenylate synthetase-like molecule, Oasl5 in mice. Gene. 2001;271:261-71 pubmed
    ..These findings suggest a novel function of Oasl5, which are independent of oligoadenylate synthetase activity, in the brain and developing embryos. ..
  21. Oyama S, Yamakawa H, Sasagawa N, Hosoi Y, Futai E, Ishiura S. Dysbindin-1, a schizophrenia-related protein, functionally interacts with the DNA- dependent protein kinase complex in an isoform-dependent manner. PLoS ONE. 2009;4:e4199 pubmed publisher
  22. Hayasaka D, Nagata N, Fujii Y, Hasegawa H, Sata T, Suzuki R, et al. Mortality following peripheral infection with tick-borne encephalitis virus results from a combination of central nervous system pathology, systemic inflammatory and stress responses. Virology. 2009;390:139-50 pubmed publisher
    ..We therefore conclude that in addition to the development of CNS disease, systemic inflammatory and stress responses contribute to induce a fatal infection following subcutaneous infection of mice with TBEV. ..
  23. Kawakami A, Nojima Y, Toyoda A, Takahoko M, Satoh M, Tanaka H, et al. The zebrafish-secreted matrix protein you/scube2 is implicated in long-range regulation of hedgehog signaling. Curr Biol. 2005;15:480-8 pubmed
    ..We further show that Bmp activity can be attenuated by the coexpression of Scube2. Our data support the idea that Scube2 can modulate the long-range action of Bmp-dependent signaling in the neural tube and somites. ..
  24. Ohtsuka Tsurumi E, Saito Y, Yamamoto T, Voit T, Kobayashi M, Osawa M. Co-localization of fukutin and alpha-dystroglycan in the mouse central nervous system. Brain Res Dev Brain Res. 2004;152:121-7 pubmed
    ..Further research into the physiological function of alpha-DG in migrating and mature neurons is required. ..
  25. Fukuda T, Akiyama N, Ikegami M, Takahashi H, Sasaki A, Oka H, et al. Expression of hydroxyindole-O-methyltransferase enzyme in the human central nervous system and in pineal parenchymal cell tumors. J Neuropathol Exp Neurol. 2010;69:498-510 pubmed publisher
    ..These results indicate that HIOMT immunohistochemistry may be useful for the diagnosis of PPTs and be a prognostic factor in PPTs. ..
  26. Jee Y, Yoon W, Okura Y, Tanuma N, Matsumoto Y. Upregulation of monocyte chemotactic protein-1 and CC chemokine receptor 2 in the central nervous system is closely associated with relapse of autoimmune encephalomyelitis in Lewis rats. J Neuroimmunol. 2002;128:49-57 pubmed
    ..Collectively, these findings suggest that high expression of MCP-1 and its receptor, CCR2, in the CNS play important roles in relapse of EAE. ..
  27. Sato A, Ohtaki H, Tsumuraya T, Song D, Ohara K, Asano M, et al. Interleukin-1 participates in the classical and alternative activation of microglia/macrophages after spinal cord injury. J Neuroinflammation. 2012;9:65 pubmed publisher
    ..Moreover, we suggest that IL-1 participates in both the classical and alternative activation of MG in in vivo and in vitro systems. ..
  28. Miyashita T, Oda Y, Horiuchi J, Yin J, Morimoto T, Saitoe M. Mg(2+) block of Drosophila NMDA receptors is required for long-term memory formation and CREB-dependent gene expression. Neuron. 2012;74:887-98 pubmed publisher
    ..Our results suggest that Mg(2+) block of NMDARs functions to suppress basal expression of a CREB repressor, thus permitting CREB-dependent gene expression upon LTM induction. ..
  29. Yonekawa Y, Harada A, Okada Y, Funakoshi T, Kanai Y, Takei Y, et al. Defect in synaptic vesicle precursor transport and neuronal cell death in KIF1A motor protein-deficient mice. J Cell Biol. 1998;141:431-41 pubmed
    ..Thus, our results demonstrate that KIF1A transports a synaptic vesicle precursor and that KIF1A-mediated axonal transport plays a critical role in viability, maintenance, and function of neurons, particularly mature neurons. ..
  30. Mizuguchi M, Takashima S, Kakita A, Yamada M, Ikeda K. Lissencephaly gene product. Localization in the central nervous system and loss of immunoreactivity in Miller-Dieker syndrome. Am J Pathol. 1995;147:1142-51 pubmed
    ..These results are consistent with the notion that a deficiency of LIS-1 protein is the direct cause of the brain malformation and that the protein plays a critical role in neuronal migration. ..
  31. Sakai T, Sato S, Ishimoto H, Kitamoto T. Significance of the centrally expressed TRP channel painless in Drosophila courtship memory. Learn Mem. 2012;20:34-40 pubmed publisher
    ..These results indicate that the Pain TRP channels in the MBs and IPCs control neuronal plasticity that is required for the formation of a certain type of long-lasting associative memory in Drosophila. ..
  32. Haga T. Molecular properties of muscarinic acetylcholine receptors. Proc Jpn Acad Ser B Phys Biol Sci. 2013;89:226-56 pubmed
    ..This paper summarizes the molecular properties of muscarinic receptors with reference to the historical background and bias to studies performed in our laboratories. ..
  33. Konishi Y, Kamegai M, Takahashi K, Kunishita T, Tabira T. Production of interleukin-3 by murine central nervous system neurons. Neurosci Lett. 1994;182:271-4 pubmed
    ..Thus, endogenous IL-3 might be produced by certain neurons in situ. ..
  34. Sakuma H, Park I, Kohyama K, Feng D, Matsumoto Y. Quantitation of myelin oligodendrocyte glycoprotein and myelin basic protein in the thymus and central nervous system and its relationship to the clinicopathologic features of autoimmune encephalomyelitis. J Neurosci Res. 2006;84:606-13 pubmed
    ..Furthermore, the lesion distribution, but not the clinical course, of EAE is related to the neuroantigen expression in the CNS. ..
  35. Kutsukake M, Komatsu A, Yamamoto D, Ishiwa Chigusa S. A tyramine receptor gene mutation causes a defective olfactory behavior in Drosophila melanogaster. Gene. 2000;245:31-42 pubmed
    ..This study provides the first step toward understanding of the molecular genetics of tyramine-mediated neural functions in Drosophila...
  36. Ida Hosonuma M, Iwasaki T, Yoshikawa T, Nagata N, Sato Y, Sata T, et al. The alpha/beta interferon response controls tissue tropism and pathogenicity of poliovirus. J Virol. 2005;79:4460-9 pubmed
    ..We consider that poliovirus replication was observed in the nontarget tissues of PVR-transgenic/Ifnar knockout mice because the IFN response was null in all tissues. ..
  37. Nishiyama A, Endo T, Takeda S, Imamura M. Identification and characterization of epsilon-sarcoglycans in the central nervous system. Brain Res Mol Brain Res. 2004;125:1-12 pubmed
    ..These results suggest that the two epsilon-SG isoforms might play different roles in synaptic functions of the central nervous system. ..
  38. Komatsu M, Waguri S, Chiba T, Murata S, Iwata J, Tanida I, et al. Loss of autophagy in the central nervous system causes neurodegeneration in mice. Nature. 2006;441:880-4 pubmed
    ..Our results indicate that autophagy is essential for the survival of neural cells, and that impairment of autophagy is implicated in the pathogenesis of neurodegenerative disorders involving ubiquitin-containing inclusion bodies. ..
  39. Madsen P, Pinto M, Patel S, McCarthy S, Gao H, Taherian M, et al. Mitochondrial DNA Double-Strand Breaks in Oligodendrocytes Cause Demyelination, Axonal Injury, and CNS Inflammation. J Neurosci. 2017;37:10185-10199 pubmed publisher
    ..Hence, PLP:mtPstI mice represent a unique tool to study the pathological consequences of mitochondrial dysfunction in oligodendrocytes, as well as an ideal platform to test remyelinating and neuroprotective agents. ..
  40. Koike M, Shibata M, Sunabori T, Yamaguchi J, Sakimura K, Komatsu M, et al. Purkinje Cells Are More Vulnerable to the Specific Depletion of Cathepsin D Than to That of Atg7. Am J Pathol. 2017;187:1586-1600 pubmed publisher
    ..These results suggested that PCs were more vulnerable to CTSD deficiency in lysosomes than to autophagy impairment, and this vulnerability does not depend on the severity of axonal swelling. ..
  41. Hoshino M, Matsuzaki F, Nabeshima Y, Hama C. hikaru genki, a CNS-specific gene identified by abnormal locomotion in Drosophila, encodes a novel type of protein. Neuron. 1993;10:395-407 pubmed
    ..In situ hybridization to embryos revealed that accumulation of the hig transcripts is restricted to subsets of cells in the CNS. Our data suggest that hig has a role in the development of CNS functions involved in locomotor activity. ..
  42. Murase S, Hayashi Y. Integrin alpha1 localization in murine central and peripheral nervous system. J Comp Neurol. 1998;395:161-76 pubmed
  43. Awasaki T, Saito M, Sone M, Suzuki E, Sakai R, Ito K, et al. The Drosophila trio plays an essential role in patterning of axons by regulating their directional extension. Neuron. 2000;26:119-31 pubmed
    ..Thus, Trio is essential in order for neurites to faithfully extend on the correct pathways. In addition, the localization of Trio in the adult brain suggests its postdevelopmental role in neurite terminals. ..
  44. Kamitori K, Machide M, Tomita K, Nakafuku M, Kohsaka S. Cell-type-specific expression of protein tyrosine kinase-related receptor RYK in the central nervous system of the rat. Brain Res Mol Brain Res. 2002;104:255-66 pubmed
    ..These findings show that expression of RYK in rat CNS is tightly regulated in a cell-type-specific manner. ..
  45. Huang J, Jarjour A, Nait Oumesmar B, Kerninon C, Williams A, Krezel W, et al. Retinoid X receptor gamma signaling accelerates CNS remyelination. Nat Neurosci. 2011;14:45-53 pubmed publisher
    ..Our results indicate that RXR-? is a positive regulator of endogenous oligodendrocyte precursor cell differentiation and remyelination and might be a pharmacological target for regenerative therapy in the CNS. ..
  46. Sugiyama D, Kusuhara H, Taniguchi H, Ishikawa S, Nozaki Y, Aburatani H, et al. Functional characterization of rat brain-specific organic anion transporter (Oatp14) at the blood-brain barrier: high affinity transporter for thyroxine. J Biol Chem. 2003;278:43489-95 pubmed
    ..Therefore, it may be speculated that Oatp14 plays a role in maintaining the concentration of T4 and, ultimately, T3 in the brain by transporting T4 from the circulating blood to the brain. ..
  47. Ishiura H, Morikawa M, Hamada M, Watanabe T, Kako S, Chiba S, et al. Lymphomatoid granulomatosis involving central nervous system successfully treated with rituximab alone. Arch Neurol. 2008;65:662-5 pubmed publisher
    ..Because central nervous system (CNS) involvement of LYG has been known to show poor prognosis, the establishment of an effective treatment for CNS LYG with mild adverse effects is desired...
  48. Ito D, Fujisawa T, Iida H, Suzuki N. Characterization of seipin/BSCL2, a protein associated with spastic paraplegia 17. Neurobiol Dis. 2008;31:266-77 pubmed publisher
    ..The present study provides new insights into the biology of seipin protein that should help our understanding of the pathogenesis of seipin-related diseases. ..
  49. Nakahara J, Seiwa C, Tan Takeuchi K, Gotoh M, Kishihara K, Ogawa M, et al. Involvement of CD45 in central nervous system myelination. Neurosci Lett. 2005;379:116-21 pubmed
    ..Our findings suggest that CD45 is a key phosphatase involved in OPC differentiation and provide a preliminary explanation for the previously reported CD45 mutations observed in some multiple sclerosis (MS) patients. ..
  50. Shimura H, Imai Y, Ishiyama M, Yoshinaga K, Shiseki M, Mori N, et al. [Long-term remission after nonmyeloablative allogeneic bone marrow transplantation in a relapsed Hodgkin lymphoma patient with CNS involvement]. Rinsho Ketsueki. 2012;53:1991-6 pubmed
    ..Our results in this case suggest that allogeneic stem cell transplantation could be a useful therapeutic option in relapsed CNS HL patients, if their CNS lesions are controlled before stem cell transplantation. ..
  51. Hamada T, Ui Tei K, Imaki J, Takahashi F, Onodera H, Mishima T, et al. The expression of SCDGF/PDGF-C/fallotein and SCDGF-B/PDGF-D in the rat central nervous system. Mech Dev. 2002;112:161-4 pubmed
    ..It was highly expressed in the cortex, pontine area and choroid plexus at E16. Contrary to SCDGF/PDGF-C/fallotein, SCDGF-B/PDGF-D expression was notable in several nuclei at adult. ..
  52. Kanno T, Yasutake K, Tanaka K, Hadano S, Ikeda J. A novel function of N-linked glycoproteins, alpha-2-HS-glycoprotein and hemopexin: Implications for small molecule compound-mediated neuroprotection. PLoS ONE. 2017;12:e0186227 pubmed publisher
  53. Ui Tei K, Sakuma M, Watanabe Y, Miyake T, Miyata Y. Chemical analysis of neurotransmitter candidates in clonal cell lines from Drosophila central nervous system, II: Neuropeptides and amino acids. Neurosci Lett. 1995;195:187-90 pubmed
    ..Therefore, the conspicuous expression of peptides or amino acids in some clones suggests that the substances have a special role in Drosophila CNS. ..
  54. Torii M, Matsuzaki F, Osumi N, Kaibuchi K, Nakamura S, Casarosa S, et al. Transcription factors Mash-1 and Prox-1 delineate early steps in differentiation of neural stem cells in the developing central nervous system. Development. 1999;126:443-56 pubmed
    ..Thus, we propose that induction of Mash-1 and Prox-1 is one of the critical molecular events that control early development of the CNS. ..
  55. Tomita N, Yokoyama M, Yamamoto W, Watanabe R, Shimazu Y, Masaki Y, et al. Central nervous system event in patients with diffuse large B-cell lymphoma in the rituximab era. Cancer Sci. 2012;103:245-51 pubmed publisher
    ..The efficacy and manner of CNS prophylaxis in patients for each involvement site should be evaluated further. ..
  56. Matsubara H, Makimoto A, Higa T, Kawamoto H, Sakiyama S, Hosono A, et al. A multidisciplinary treatment strategy that includes high-dose chemotherapy for metastatic retinoblastoma without CNS involvement. Bone Marrow Transplant. 2005;35:763-6 pubmed
    ..The two patients who died of disease had CNS involvement. No long-term sequelae of HDC have been noted. Our treatment strategy using HDC appears to be effective for treating metastatic retinoblastoma without CNS involvement. ..
  57. Kamakura S, Oishi K, Yoshimatsu T, Nakafuku M, Masuyama N, Gotoh Y. Hes binding to STAT3 mediates crosstalk between Notch and JAK-STAT signalling. Nat Cell Biol. 2004;6:547-54 pubmed
    ..These results suggest that direct protein-protein interactions coordinate cross-talk between the Notch-Hes and JAK-STAT pathways. ..
  58. Ikuta T, Saiga H. Dynamic change in the expression of developmental genes in the ascidian central nervous system: revisit to the tripartite model and the origin of the midbrain-hindbrain boundary region. Dev Biol. 2007;312:631-43 pubmed
    ..This motivates us to revisit to the tripartite ground plan and the origin of the midbrain-hindbrain boundary (MHB) region...
  59. Naka H, Nakamura S, Shimazaki T, Okano H. Requirement for COUP-TFI and II in the temporal specification of neural stem cells in CNS development. Nat Neurosci. 2008;11:1014-23 pubmed publisher
    ..These findings reveal a part of the timer mechanisms for generating diverse types of neurons and glial cells during CNS development. ..
  60. Suzuki S, Namiki J, Shibata S, Mastuzaki Y, Okano H. The neural stem/progenitor cell marker nestin is expressed in proliferative endothelial cells, but not in mature vasculature. J Histochem Cytochem. 2010;58:721-30 pubmed publisher
    ..Immunohistochemistry showed nestin expression in neovascular cells from two distinct murine models. Our results demonstrate that nestin can be used as a marker protein for neovascularization. ..
  61. Namekata K, Enokido Y, Iwasawa K, Kimura H. MOCA induces membrane spreading by activating Rac1. J Biol Chem. 2004;279:14331-7 pubmed
    ..These observations suggest that MOCA may induce cytoskeletal reorganization and changes in cell adhesion by regulating the activity of Rac1. ..
  62. Saegusa H, Matsuda Y, Tanabe T. Effects of ablation of N- and R-type Ca(2+) channels on pain transmission. Neurosci Res. 2002;43:1-7 pubmed
    ..3-/- mice, was also observed in the Ca(v)2.2-/- mice. Therefore, it is suggested that these mutant mice could provide novel models to delineate the nociceptive and antinociceptive mechanisms. ..
  63. Moriya Ito K, Osada T, Ishimatsu Y, Muramoto K, Kobayashi T, Ichikawa M. Maturation of vomeronasal receptor neurons in vitro by coculture with accessory olfactory bulb neurons. Chem Senses. 2005;30:111-9 pubmed
    ..Since the maturation of VRNs was not induced in one-well separate cultures, the nonspecific induction of OMP expression by CNS neurons suggests the involvement of a direct contact effect with CNS in VRN maturation. ..
  64. Mizutani R, Nakamura K, Yokoyama S, Sanbe A, Kusakawa S, Miyamoto Y, et al. Developmental expression of sorting nexin 3 in the mouse central nervous system. Gene Expr Patterns. 2011;11:33-40 pubmed publisher
    ..Thus, snx3 mRNA is expressed during neural development and in adult neural tissues, suggesting that SNX3 may play an important role in the development and function of the CNS. ..
  65. Muto E, Tabata Y, Taneda T, Aoki Y, Muto A, Arai K, et al. Identification and characterization of Veph, a novel gene encoding a PH domain-containing protein expressed in the developing central nervous system of vertebrates. Biochimie. 2004;86:523-31 pubmed
    ..On the other hand, homozygous knockout mice of Veph showed no significant defect in the CNS, pointing to possible different functions of Veph between the zebrafish and mouse. ..
  66. Takahashi K, Yamada M, Ohata H, Honda K, Yamada M. Ndrg2 promotes neurite outgrowth of NGF-differentiated PC12 cells. Neurosci Lett. 2005;388:157-62 pubmed
    ..Moreover, Ndrg2S and Ndrg2L overexpression promoted neurite elongation in NGF-differentiated PC12 cells. In conclusion, our findings offer novel insights into the physiological roles of Ndrg2 in the central nervous system. ..
  67. Inoue K, Tsuda M, Koizumi S. ATP- and adenosine-mediated signaling in the central nervous system: chronic pain and microglia: involvement of the ATP receptor P2X4. J Pharmacol Sci. 2004;94:112-4 pubmed
    ..Taken together, our results demonstrate that activation of P2X(4) or p38MAPK in spinal cord microglia is necessary for tactile allodynia after nerve injury. ..
  68. Ishii K, Komaki H, Ohkuma A, Nishino I, Nonaka I, Sasaki M. Central nervous system and muscle involvement in an adolescent patient with riboflavin-responsive multiple acyl-CoA dehydrogenase deficiency. Brain Dev. 2010;32:669-72 pubmed publisher
    ..Early diagnosis is important because riboflavin treatment has been effective in a significant number of patients with MADD. ..
  69. Kawano H, Kimura Kuroda J, Komuta Y, Yoshioka N, Li H, Kawamura K, et al. Role of the lesion scar in the response to damage and repair of the central nervous system. Cell Tissue Res. 2012;349:169-80 pubmed publisher
    ..To what extent these changes in the fibroblasts act via subsequent downstream actions on the astrocytes remains for future investigation. ..