Experts and Doctors on cell proliferation in Wakayama, Japan


Locale: Wakayama, Japan
Topic: cell proliferation

Top Publications

  1. Imanishi T, Kobayashi K, Kuki S, Takahashi C, Akasaka T. Sirolimus accelerates senescence of endothelial progenitor cells through telomerase inactivation. Atherosclerosis. 2006;189:288-96 pubmed
    ..The inhibitory effects of sirolimus on circulating EPCs potently may affect re-endotheliazation after SES implantation. ..
  2. Kitano A, Okada Y, Yamanka O, Shirai K, Mohan R, Saika S. Therapeutic potential of trichostatin A to control inflammatory and fibrogenic disorders of the ocular surface. Mol Vis. 2010;16:2964-73 pubmed
    ..The mechanisms of action involve attenuation of Smad signal in mesenchymal cells and reduction in the activation and recruitment of macrophages. TSA has the potential to treat corneal scarring in vivo. ..
  3. Yamanaka O, Saika S, Ohnishi Y, Kim Mitsuyama S, Kamaraju A, Ikeda K. Inhibition of p38MAP kinase suppresses fibrogenic reaction in conjunctiva in mice. Mol Vis. 2007;13:1730-9 pubmed
    ..Inhibiting p38MAPK signal impairs the fibrogenic reaction induced by the subconjunctival fibroblasts in vivo and in vitro, suggesting its potential effectiveness in preventing excessive scarring following glaucoma filtering surgery. ..
  4. Saika S, Yamanaka O, Ikeda K, Kim Mitsuyama S, Flanders K, Yoo J, et al. Inhibition of p38MAP kinase suppresses fibrotic reaction of retinal pigment epithelial cells. Lab Invest. 2005;85:838-50 pubmed
    ..Gene transfer of DN-p38MAPK attenuated the post-retinal detachment fibrotic reaction of the retinal pigment epithelium in vivo in mice, supporting its effectiveness in preventing/treating PVR. ..
  5. Tanaka T, Wang C, Umesaki N. Remodeling of the human endometrial epithelium is regulated by laminin and type IV collagen. Int J Mol Med. 2009;23:173-80 pubmed
    ..These results indicate that the cyclic expression of laminin and COL-4 in basement membrane-like structures of endometrial epithelium may regulate the endometrial epithelial remodeling and embryo implantation during the menstrual cycle. ..
  6. Semba Y, Harada A, Maehara K, Oki S, Meno C, Ueda J, et al. Chd2 regulates chromatin for proper gene expression toward differentiation in mouse embryonic stem cells. Nucleic Acids Res. 2017;45:8758-8772 pubmed publisher
    ..These results suggest that Chd2 is essential in preventing suppressive chromatin formation for developmentally regulated genes and determines subsequent effects on developmental processes in the undifferentiated state. ..
  7. Muhammad J, Nanjo S, Ando T, Yamashita S, Maekita T, Ushijima T, et al. Autophagy impairment by Helicobacter pylori-induced methylation silencing of MAP1LC3Av1 promotes gastric carcinogenesis. Int J Cancer. 2017;140:2272-2283 pubmed publisher
    ..pylori infection. MAP1LC3Av1 is essential for autophagy and H. pylori-induced methylation silencing of MAP1LC3Av1 may impair autophagy, facilitating gastric carcinogenesis. ..
  8. Kitano A, Saika S, Yamanaka O, Ikeda K, Okada Y, Shirai K, et al. Emodin suppression of ocular surface inflammatory reaction. Invest Ophthalmol Vis Sci. 2007;48:5013-22 pubmed
    ..Additional studies are warranted to evaluate the therapeutic potential of emodin in lessening ocular tissue inflammation and resultant fibrosis after injury. ..
  9. Fukai J, Yokote H, Yamanaka R, Arao T, Nishio K, Itakura T. EphA4 promotes cell proliferation and migration through a novel EphA4-FGFR1 signaling pathway in the human glioma U251 cell line. Mol Cancer Ther. 2008;7:2768-78 pubmed publisher
    ..Thus, our results indicate that EphA4 plays an important role in malignant phenotypes of glioblastoma by enhancing cell proliferation and migration through accelerating a canonical FGFR signaling pathway. ..

More Information


  1. Fujiwara D, Tsubaki M, Takeda T, Tomonari Y, Koumoto Y, Sakaguchi K, et al. Statins induce apoptosis through inhibition of Ras signaling pathways and enhancement of Bim and p27 expression in human hematopoietic tumor cells. Tumour Biol. 2017;39:1010428317734947 pubmed publisher
    ..Therefore, our findings support the use of statins as potential anticancer agents or concomitant drugs of adjuvant therapy...
  2. Prakoura N, Politis P, Ihara Y, Michalak M, Charonis A. Epithelial calreticulin up-regulation promotes profibrotic responses and tubulointerstitial fibrosis development. Am J Pathol. 2013;183:1474-1487 pubmed publisher
  3. Kokado M, Okada Y, Goto M, Ishikawa K, Miyamoto T, Yamanaka O, et al. Increased fragility, impaired differentiation, and acceleration of migration of corneal epithelium of epiplakin-null mice. Invest Ophthalmol Vis Sci. 2013;54:3780-9 pubmed publisher
    ..The mechanism of acceleration of cell migration in the epiplakin-null corneal epithelium is to be further investigated, although suppression of expression of E-cadherin might be included. ..
  4. Shinozaki M, Okada Y, Kitano A, Ikeda K, Saika S, Shinozaki M. Impaired cutaneous wound healing with excess granulation tissue formation in TNFalpha-null mice. Arch Dermatol Res. 2009;301:531-7 pubmed publisher
    ..In conclusion, lacking TNFalpha potentiates Smad-mediated fibrogenic reaction in healing dermis and retards reepithelialization in a healing mouse cutaneous wound...
  5. Tanaka T, Umesaki N. Leptin regulates the proliferation and apoptosis of human endometrial epithelial cells. Int J Mol Med. 2008;22:683-9 pubmed
  6. Nishioka K, Itoh S, Suemoto H, Kanno S, Gai Z, Kawakatsu M, et al. Trps1 deficiency enlarges the proliferative zone of growth plate cartilage by upregulation of Pthrp. Bone. 2008;43:64-71 pubmed publisher
    ..Taken together, these data provide the first genetic evidence that lack of Trps1 leads to overexpression of PTHrP, and that Trps1 is required to maintain the normal organization of chondrocytes in the growth plate. ..
  7. Suemoto H, Muragaki Y, Nishioka K, Sato M, Ooshima A, Itoh S, et al. Trps1 regulates proliferation and apoptosis of chondrocytes through Stat3 signaling. Dev Biol. 2007;312:572-81 pubmed
    ..Altogether our findings identify Trps1 as a novel regulator of chondrocytes proliferation and survival through the control of Stat3 expression. ..
  8. Kitano A, Saika S, Yamanaka O, Ikeda K, Reinach P, Nakajima Y, et al. Genipin suppresses subconjunctival fibroblast migration, proliferation and myofibroblast transdifferentiation. Ophthalmic Res. 2006;38:355-60 pubmed
    ..Genipin suppresses injury-induced fibrogenic responses in SCFs. This result suggests that the herbal medicine Inchin-ko-to might have therapeutic value following trabeculotomy. ..
  9. Mabuchi Y, Yamoto M, Minami S, Umesaki N. The autocrine effect of activin A on human ovarian clear cell adenocarcinoma cells. Oncol Rep. 2006;16:373-9 pubmed
    ..Activin A significantly increased the expression of phosphorylated Smad2 in JHOC-5 cells. Therefore, it is possible that activin has autocrine roles in tumor growth of ovarian clear cell adenocarcinoma cells...
  10. Shirai K, Saika S, Tanaka T, Okada Y, Flanders K, Ooshima A, et al. A new model of anterior subcapsular cataract: involvement of TGFbeta/Smad signaling. Mol Vis. 2006;12:681-91 pubmed
    ..Topical alkali treatment of the ocular surface readily induces an EMT-type anterior subcapsular cataract. Smad3 signaling is involved, but not required, for achievement of EMT in the lens epithelium in this cataract model. ..
  11. Tanaka T, Bai T, Yukawa K, Utsunomiya T, Umesaki N. Reduced radiosensitivity and increased CD40 expression in cyclophosphamide-resistant subclones established from human cervical squamous cell carcinoma cells. Oncol Rep. 2005;14:941-8 pubmed
    ..Furthermore, CD40 activation signals may be associated with the multidrug- and radioresistance in these cyclophosphamide-resistant subclones. ..