Experts and Doctors on cell proliferation in Tokyo, Japan


Locale: Tokyo, Japan
Topic: cell proliferation

Top Publications

  1. Nakamura K, Harada C, Namekata K, Harada T. Expression of olig2 in retinal progenitor cells. Neuroreport. 2006;17:345-9 pubmed
    ..These results suggest that olig2 is involved in the maintenance of the undifferentiated state of retinal progenitor cells. ..
  2. Sasaki R, Aoki S, Yamato M, Uchiyama H, Wada K, Okano T, et al. Neurosphere generation from dental pulp of adult rat incisor. Eur J Neurosci. 2008;27:538-48 pubmed publisher
    ..These data suggest that the CD81 and nestin double-positive cells localized in the odontoblast layer of the apical portion of the dental pulp may have the ability to grow and form neurospheres...
  3. Yoneda M, Suzuki T, Nakamura T, Ajima R, Yoshida Y, Kakuta S, et al. Deficiency of antiproliferative family protein Ana correlates with development of lung adenocarcinoma. Cancer Sci. 2009;100:225-32 pubmed publisher
    ..Taken together, we propose that ana functions as a tumor suppressor and that its product inhibits tumor progression as well by suppressing angiogenesis, invasion, and metastasis. ..
  4. Furuiye M, Miyake S, Miyazaki Y, Ohtani Y, Inase N, Umino T, et al. Effect of cigarette smoking on the development of murine chronic pigeon breeder's lung. The difference between a short-term and a long-term exposure. J Med Dent Sci. 2007;54:87-95 pubmed
    ..These results suggest that a short-term cigarette smoking attenuates lung inflammation, but a long-term cigarette smoking enhances lung inflammation with fibrosis. ..
  5. Karasuyama H, Wada T, Yoshikawa S, Obata K. Emerging roles of basophils in protective immunity against parasites. Trends Immunol. 2011;32:125-30 pubmed publisher
  6. Saito Y, Kojima T, Takahashi N. Mab21l2 is essential for embryonic heart and liver development. PLoS ONE. 2012;7:e32991 pubmed publisher
    ..These findings demonstrate that Mab21l2 plays a crucial role in both heart and liver development through STM formation. ..
  7. Hiramoto K, Sugiyama D, Iizuka Y, Yamaguchi T. Sex differences regarding the amelioration of wrinkles due to skin dryness by the administration of tranexamic acid. Biomed Pharmacother. 2016;83:283-289 pubmed publisher
    ..These results suggest that the amelioration effect on wrinkles is stronger in female NOA mice than in males and that ?-endorphin produced by macrophages plays an important role in this sex difference. ..
  8. Hayashi N, Asano K, Suzuki H, Yamamoto T, Tanigawa N, Egawa S, et al. Adenoviral infection of survivin antisense sensitizes prostate cancer cells to etoposide in vivo. Prostate. 2005;65:10-9 pubmed
    ..The prominent synergy of this combination may provide a basis for clinical application of Ad.survivin-AS as a chemosensitizer of etoposide. ..
  9. Matsumoto T, Hosono Nishiyama K, Yamada H. Antiproliferative and apoptotic effects of butyrolactone lignans from Arctium lappa on leukemic cells. Planta Med. 2006;72:276-8 pubmed
    ..lappa. Of these active compounds, (-)-arctigenin showed the most potent antiproliferative activity against MH60 cells (IC (50) : 1.0 microM), and the activity was suggested to be due to apoptosis. ..

More Information

Publications360 found, 100 shown here

  1. Murakami D, Yamato M, Nishida K, Ohki T, Takagi R, Yang J, et al. Fabrication of transplantable human oral mucosal epithelial cell sheets using temperature-responsive culture inserts without feeder layer cells. J Artif Organs. 2006;9:185-91 pubmed
    ..These results suggest that temperature-responsive culture inserts can be useful in clinical settings that require the exclusion of xenogeneic factors. ..
  2. Omoteyama K, Inoue S. The variation in Fas localization and the changes in Fas expression level upon stimulation with growth factors. Biochem Biophys Res Commun. 2007;353:159-63 pubmed
    ..Conversely, Fas internalization may enable cancer cells to escape from apoptosis. Our results suggest that growth factor may contribute to the resistance of cancer cells to Fas-mediated apoptosis in an autocrine or paracrine fashion. ..
  3. Yamagami S, Yokoo S, Mimura T, Takato T, Araie M, Amano S. Distribution of precursors in human corneal stromal cells and endothelial cells. Ophthalmology. 2007;114:433-9 pubmed
  4. Tanaka T, Haneda S, Imakawa K, Sakai S, Nagaoka K. A microRNA, miR-101a, controls mammary gland development by regulating cyclooxygenase-2 expression. Differentiation. 2009;77:181-7 pubmed publisher
    ..Taken together, these results suggest that miR-101a regulates cell proliferation via altering Cox-2 expression, which is critical for controlling mammary gland development. ..
  5. Fujiki K, Kano F, Shiota K, Murata M. Expression of the peroxisome proliferator activated receptor gamma gene is repressed by DNA methylation in visceral adipose tissue of mouse models of diabetes. BMC Biol. 2009;7:38 pubmed publisher
  6. Furukawa K, Iida T, Shiba H, Fujiwara Y, Uwagawa T, Shimada Y, et al. Anti-tumor effect by inhibition of NF-kappaB activation using nafamostat mesilate for pancreatic cancer in a mouse model. Oncol Rep. 2010;24:843-50 pubmed
    ..These results suggested that nafamostat mesilate has anti-neoplastic property against experimental pancreatic cancer. ..
  7. Kato N, Kitaura J, Doki N, Komeno Y, Watanabe Okochi N, Togami K, et al. Two types of C/EBP? mutations play distinct but collaborative roles in leukemogenesis: lessons from clinical data and BMT models. Blood. 2011;117:221-33 pubmed publisher
    ..1, despite low expression levels of p30 protein generated by C/EBP?-N(m). Thus, 2 types of C/EBP? mutations are implicated in leukemo-genesis, involving different and cooperating molecular mechanisms. ..
  8. Harada Y, Ishii I, Hatake K, Kasahara T. Pyrvinium pamoate inhibits proliferation of myeloma/erythroleukemia cells by suppressing mitochondrial respiratory complex I and STAT3. Cancer Lett. 2012;319:83-8 pubmed publisher
    ..1.7-?(0) cells. Moreover, PP acted synergistically with dexamethasone to inhibit PCM6 cell proliferation. In conclusion, we identified PP as a potential anticancer drug directed against mitochondrial respiratory complex I/STAT3. ..
  9. Nakamura Ishizu A, Okuno Y, Omatsu Y, Okabe K, Morimoto J, Uede T, et al. Extracellular matrix protein tenascin-C is required in the bone marrow microenvironment primed for hematopoietic regeneration. Blood. 2012;119:5429-37 pubmed publisher
    ..These results identify TN-C as a critical component of the BM microenvironment that is required for hematopoietic regeneration. ..
  10. Jin X, Uchiyama M, Zhang Q, Watanabe T, Niimi M. The smell of Tokishakuyaku-san (TJ-23) induces generation of regulatory T cells and prolongation of survival of fully allogeneic cardiac grafts in mice. Transplant Proc. 2012;44:1070-2 pubmed publisher
    ..In conclusion naïve but not olfactory-dysfunctional CBA mice treated with fumigation of TJ-23 displayed prolonged survival of fully allogeneic cardiac allografts and generation of regulatory cells. ..
  11. Shinozuka E, Miyashita M, Mizuguchi Y, Akagi I, Kikuchi K, Makino H, et al. SnoN/SKIL modulates proliferation through control of hsa-miR-720 transcription in esophageal cancer cells. Biochem Biophys Res Commun. 2013;430:101-6 pubmed publisher
    ..These data demonstrate a novel mechanism of miRNA regulation, leading to changes in cell proliferation...
  12. Shishido Y, Ueno S, Yamazaki R, Nagaoka M, Matsuzaki T. ABCG2 inhibitor YHO-13351 sensitizes cancer stem/initiating-like side population cells to irinotecan. Anticancer Res. 2013;33:1379-86 pubmed
    ..The aim of this study was to determine the efficacy of the combination of irinotecan and newly-synthesized ABCG2 (breast cancer-resistant protein) inhibitor YHO-13351 in cancer chemotherapy...
  13. Migita T, Takayama K, Urano T, Obinata D, Ikeda K, Soga T, et al. ACSL3 promotes intratumoral steroidogenesis in prostate cancer cells. Cancer Sci. 2017;108:2011-2021 pubmed publisher
    ..These findings suggest that ACSL3 contributes to the growth of CRPC through intratumoral steroidogenesis (i.e. promoting androgen synthesis from DHEAS and preventing the catabolism of active androgens). ..
  14. Ishiwata T, Fujii T, Ishiwata S, Ikegawa S, Naito Z. Effect of morpholino antisense oligonucleotide against lumican mRNA in human embryonic kidney (HEK) 293 cells. Pathol Int. 2004;54:77-81 pubmed
    ..These findings may indicate that lumican protein has an inhibitory effect on HEK 293 cell growth in vitro. ..
  15. Fukushima Y, Matsui T, Saitoh T, Ichinose M, Tateishi K, Shindo T, et al. Unique roles of G protein-coupled histamine H2 and gastrin receptors in growth and differentiation of gastric mucosa. Eur J Pharmacol. 2004;502:243-52 pubmed
    ..These findings provide evidence that different G-protein coupled-receptors affect differentiation into different cell lineages derived from common stem cells in gastric mucosa. ..
  16. Yanagihara K, Takigahira M, Tanaka H, Komatsu T, Fukumoto H, Koizumi F, et al. Development and biological analysis of peritoneal metastasis mouse models for human scirrhous stomach cancer. Cancer Sci. 2005;96:323-32 pubmed
  17. Miyamoto K, Araki K, Naka K, Arai F, Takubo K, Yamazaki S, et al. Foxo3a is essential for maintenance of the hematopoietic stem cell pool. Cell Stem Cell. 2007;1:101-12 pubmed publisher
    ..Finally, HSC frequencies were significantly decreased in aged Foxo3a(-/-) mice compared to the littermate controls. Our results demonstrate that Foxo3a plays a pivotal role in maintaining the HSC pool. ..
  18. Dewan M, Tomita M, Katano H, Yamamoto N, Ahmed S, Yamamoto M, et al. An HIV protease inhibitor, ritonavir targets the nuclear factor-kappaB and inhibits the tumor growth and infiltration of EBV-positive lymphoblastoid B cells. Int J Cancer. 2009;124:622-9 pubmed publisher
    ..These data also suggest that this compound may have promise for treatment or prevention of EBV-associated lymphoproliferative diseases that occur in immunocompromised patients. ..
  19. Sato T, Shimazaki T, Naka H, Fukami S, Satoh Y, Okano H, et al. FRS2? regulates Erk levels to control a self-renewal target Hes1 and proliferation of FGF-responsive neural stem/progenitor cells. Stem Cells. 2010;28:1661-73 pubmed publisher
    ..Thus, FRS2? fine-tunes the FGF-signaling to control qualitatively different biological activities, self-renewal at least partly through Hes1 versus proliferation of NSPCs. ..
  20. Tao K, Watanabe S, Narita S, Tokuda H. A periplasmic LolA derivative with a lethal disulfide bond activates the Cpx stress response system. J Bacteriol. 2010;192:5657-62 pubmed publisher
    ..Moreover, LolCDE overproduction stabilized I93C/F140C and therefore caused an increase in its level. Taken together, these results indicate that oxidized I93C/F140C stably binds to LolCDE, which causes strong envelope stress. ..
  21. Murata T, Takayama K, Katayama S, Urano T, Horie Inoue K, Ikeda K, et al. miR-148a is an androgen-responsive microRNA that promotes LNCaP prostate cell growth by repressing its target CAND1 expression. Prostate Cancer Prostatic Dis. 2010;13:356-61 pubmed publisher
    ..CAND1 knockdown by small interfering RNA promoted the proliferation of LNCaP cells. Our study indicates the potential contribution of miR-148a to the growth of human prostate cancer. ..
  22. Nedachi T, Kawai T, Matsuwaki T, Yamanouchi K, Nishihara M. Progranulin enhances neural progenitor cell proliferation through glycogen synthase kinase 3? phosphorylation. Neuroscience. 2011;185:106-15 pubmed publisher
    ..In addition, a GSK3?-specific inhibitor enhanced NPC proliferation. Taken together, our observations indicate that PGRN enhanced NPC proliferation, at least in part, via inducing GSK3? phosphorylation. ..
  23. Sato S, Yoshida W, Soejima H, Nakabayashi K, Hata K. Methylation dynamics of IG-DMR and Gtl2-DMR during murine embryonic and placental development. Genomics. 2011;98:120-7 pubmed publisher
    ..These results add to the growing body of knowledge elucidating the mechanism whereby parent-of-origin-dependent DNA methylation at the IG-DMR leads to the imprinted expression of the Dlk1-Dio3 cluster. ..
  24. Hoshino T, Saito I, Takano H, Samejima K, Mabuchi K, Kato Y. Neurite outgrowth of PC12 cells on diX (parylene) family materials. Biotechnol Prog. 2012;28:587-90 pubmed publisher
    ..The result suggests that diX H may be advantageous as a biocompatible coating material for a scaffold, which can be used on virtually any substrate to get various configurations in neural devices. ..
  25. Nguyen H, Takata R, Akamatsu S, Shigemizu D, Tsunoda T, Furihata M, et al. IRX4 at 5p15 suppresses prostate cancer growth through the interaction with vitamin D receptor, conferring prostate cancer susceptibility. Hum Mol Genet. 2012;21:2076-85 pubmed publisher
  26. Shoji K, Oda K, Kashiyama T, Ikeda Y, Nakagawa S, Sone K, et al. Genotype-dependent efficacy of a dual PI3K/mTOR inhibitor, NVP-BEZ235, and an mTOR inhibitor, RAD001, in endometrial carcinomas. PLoS ONE. 2012;7:e37431 pubmed publisher
    ..Our data suggest that mutational statuses of PTEN and K-Ras might be useful predictors of sensitivity to NVP-BEZ235 in certain endometrial carcinomas...
  27. Taniai E, Yafune A, Hayashi H, Itahashi M, Hara Kudo Y, Suzuki K, et al. Aberrant activation of ubiquitin D at G2 phase and apoptosis by carcinogens that evoke cell proliferation after 28-day administration in rats. J Toxicol Sci. 2012;37:1093-111 pubmed
    ..Aberrant expression of Ubd at G(2) phase and increased apoptosis reflecting aberrant cell cycle regulation may be the common feature of these carcinogens. ..
  28. Funakoshi Tago M, Sumi K, Kasahara T, Tago K. Critical roles of Myc-ODC axis in the cellular transformation induced by myeloproliferative neoplasm-associated JAK2 V617F mutant. PLoS ONE. 2013;8:e52844 pubmed publisher
  29. Watanabe T, Oyama T, Asada M, Harada D, Ito Y, Inagawa M, et al. MAML1 enhances the transcriptional activity of Runx2 and plays a role in bone development. PLoS Genet. 2013;9:e1003132 pubmed publisher
    ..These observations suggest that chondrocyte maturation was impaired in MAML1(-/-) mice. MAML1 enhances the transcriptional activity of Runx2 and plays a role in bone development. ..
  30. Jung J, Jung H, Neupane S, Kim K, Kim J, Yamamoto H, et al. Involvement of PI3K and PKA pathways in mouse tongue epithelial differentiation. Acta Histochem. 2017;119:92-98 pubmed publisher
    ..Based on these results, we suggest that the tongue epithelium is differentiated into multiple epithelial cell layers via the PI3K and PKA pathways in tissue-specific manner during the epithelial-mesenchymal interactions. ..
  31. West A, Tang K, Tye H, Yu L, Deng N, Najdovska M, et al. Identification of a TLR2-regulated gene signature associated with tumor cell growth in gastric cancer. Oncogene. 2017;36:5134-5144 pubmed publisher
  32. Nagaoka M, Yashiro T, Uchida Y, Ando T, Hara M, Arai H, et al. The Orphan Nuclear Receptor NR4A3 Is Involved in the Function of Dendritic Cells. J Immunol. 2017;199:2958-2967 pubmed publisher
    ..Taken together, these results indicate that NR4A3 is involved in TLR-mediated activation and gene expression of DCs. ..
  33. Hashimoto A, Hirose K, Iino M. BAD detects coincidence of G2/M phase and growth factor deprivation to regulate apoptosis. J Biol Chem. 2005;280:26225-32 pubmed
    ..These results indicate that BAD induces apoptosis upon detecting the coincidence of G2/M phase and growth factor deprivation. ..
  34. Kimura N, Miyakawa Y, Kohmura K, Umezawa K, Ikeda Y, Kizaki M. Targeting NF-kappaB and induction of apoptosis by novel NF-kappaB inhibitor dehydroxymethylepoxyquinomicin (DHMEQ) in Burkitt lymphoma cells. Leuk Res. 2007;31:1529-35 pubmed
    ..Phosphorylation of ERK and JNK was induced by DHMEQ. In conclusion, these results demonstrate that NF-kappaB might be an ideal target to develop for new anti-cancer drugs for Burkitt lymphoma. ..
  35. Nukumi N, Iwamori T, Kano K, Naito K, Tojo H. Whey acidic protein (WAP) regulates the proliferation of mammary epithelial cells by preventing serine protease from degrading laminin. J Cell Physiol. 2007;213:793-800 pubmed
    ..We concluded that WAP plays some role in regulating the proliferation of mammary epithelial cells by preventing elastase-type serine protease from carrying out laminin degradation and thereby suppressing the MAP kinase signal pathway. ..
  36. Shinmura Y, Tsuchiya S, Hata K, Honda M. Quiescent epithelial cell rests of Malassez can differentiate into ameloblast-like cells. J Cell Physiol. 2008;217:728-38 pubmed publisher
    ..Moreover, positive staining for amelogenin was observed in the enamel-like tissues, indicating the presence of well-developed ameloblasts in the implants. These results suggest that ERM can differentiate into ameloblast-like cells. ..
  37. Suzuki K, Kaminuma O, Yang L, Motoi Y, Takai T, Ichikawa S, et al. Development of transgenic rice expressing mite antigen for a new concept of immunotherapy. Int Arch Allergy Immunol. 2009;149 Suppl 1:21-4 pubmed publisher
    ..These results suggest that the edible vaccines using Tg rice seeds are useful for the treatment of allergic disorders including bronchial asthma. ..
  38. Hirose Y, Itoh T, Miyajima A. Hedgehog signal activation coordinates proliferation and differentiation of fetal liver progenitor cells. Exp Cell Res. 2009;315:2648-57 pubmed publisher
  39. Hashimoto Y, Akiyama Y, Otsubo T, Shimada S, Yuasa Y. Involvement of epigenetically silenced microRNA-181c in gastric carcinogenesis. Carcinogenesis. 2010;31:777-84 pubmed publisher
    ..These results indicate that miR-181c may be silenced through methylation and play important roles in gastric carcinogenesis through its target genes, such as NOTCH4 and KRAS. ..
  40. Eto H, Suga H, Inoue K, Aoi N, Kato H, Araki J, et al. Adipose injury-associated factors mitigate hypoxia in ischemic tissues through activation of adipose-derived stem/progenitor/stromal cells and induction of angiogenesis. Am J Pathol. 2011;178:2322-32 pubmed publisher
    ..Treatment with AIC has many advantages over cell-based therapies regarding morbidity, cost, and physical risks and may be used as an alternative therapy for improving tissue oxygen. ..
  41. Fujii H, Ato M, Takahashi Y, Otake K, Hashimoto S, Kaji T, et al. HIV-1 Nef impairs multiple T-cell functions in antigen-specific immune response in mice. Int Immunol. 2011;23:433-41 pubmed publisher
    ..These results support a model, in which Nef expression does not cause T-cell hyperresponse in immune reaction, but instead reduces the T-cell activity, that may contribute to a low level of virus spread without viral cytopathic effects. ..
  42. Tsuruta T, Kozaki K, Uesugi A, Furuta M, Hirasawa A, Imoto I, et al. miR-152 is a tumor suppressor microRNA that is silenced by DNA hypermethylation in endometrial cancer. Cancer Res. 2011;71:6450-62 pubmed publisher
    ..Our findings define a central role for miR-152 in endometrial cancer, and they also suggest its use in new therapeutic strategies to treat this cancer. ..
  43. Kaneko E, Kawahara M, Ueda H, Nagamune T. Growth control of genetically modified cells using an antibody/c-Kit chimera. J Biosci Bioeng. 2012;113:641-6 pubmed publisher
    ..Since c-Kit is an important molecule in the expansion of hematopoietic stem cells (HSCs), this antibody/c-Kit chimera could be a promising tool for gene therapy targeting HSCs...
  44. Ishiwata T, Matsuda Y, Yamamoto T, Uchida E, Korc M, Naito Z. Enhanced expression of fibroblast growth factor receptor 2 IIIc promotes human pancreatic cancer cell proliferation. Am J Pathol. 2012;180:1928-41 pubmed publisher
  45. Uchiyama M, Jin X, Zhang Q, Amano A, Watanabe T, Niimi M. Music exposure induced prolongation of cardiac allograft survival and generated regulatory CD4? cells in mice. Transplant Proc. 2012;44:1076-9 pubmed publisher
    ..In conclusion, exposure to some types of music may induce prolonged survival of fully allogeneic cardiac allografts and generate CD4(+)CD25(+)Foxp3(+) regulatory cells. ..
  46. Akanuma G, Nanamiya H, Natori Y, Yano K, Suzuki S, Omata S, et al. Inactivation of ribosomal protein genes in Bacillus subtilis reveals importance of each ribosomal protein for cell proliferation and cell differentiation. J Bacteriol. 2012;194:6282-91 pubmed publisher
    ..These data provide the first evidence in B. subtilis that L1 and S21 are required for the progression of cellular differentiation. ..
  47. Fujii T, Horiguchi K, Sunaga H, Moriwaki Y, Misawa H, Kasahara T, et al. SLURP-1, an endogenous ?7 nicotinic acetylcholine receptor allosteric ligand, is expressed in CD205(+) dendritic cells in human tonsils and potentiates lymphocytic cholinergic activity. J Neuroimmunol. 2014;267:43-9 pubmed publisher
    ..These findings support the notion that SLURP-1 acts as a key modulator of immune responses...
  48. Sato M, Kawana K, Fujimoto A, Yoshida M, Nakamura H, Nishida H, et al. Clinical significance of Gremlin 1 in cervical cancer and its effects on cancer stem cell maintenance. Oncol Rep. 2016;35:391-7 pubmed publisher
    ..0184). Sphere-forming ability was increased when 1,000 Gremlin 1-exposed cells were seeded (P=0.0379). In cervical cancer, it is suggested that Gremlin 1 may have a role in clinical recurrence and maintaining CSC-like properties. ..
  49. Hiramoto K, Sugiyama D, Takahashi Y, Mafune E. The amelioration effect of tranexamic acid in wrinkles induced by skin dryness. Biomed Pharmacother. 2016;80:16-22 pubmed publisher
    ..These results indicate that tranexamic acid decreased the proliferation of mast cells and increases the proliferation of fibroblasts, subsequently improving wrinkles caused by skin dryness. ..
  50. Tanaka N, Mashima T, Mizutani A, Sato A, Aoyama A, Gong B, et al. APC Mutations as a Potential Biomarker for Sensitivity to Tankyrase Inhibitors in Colorectal Cancer. Mol Cancer Ther. 2017;16:752-762 pubmed publisher
    ..These observations exemplify the predictive importance of APC mutations, the most common genetic alteration in colorectal cancers, for molecular targeted therapeutics. Mol Cancer Ther; 16(4); 752-62. ©2017 AACR. ..
  51. Kawaguchi T, Komatsu S, Ichikawa D, Hirajima S, Nishimura Y, Konishi H, et al. Overexpression of TRIM44 is related to invasive potential and malignant outcomes in esophageal squamous cell carcinoma. Tumour Biol. 2017;39:1010428317700409 pubmed publisher
  52. Kwon H, Kawaguchi K, Kikuma T, Takegawa K, Kitamoto K, Higuchi Y. Analysis of an acyl-CoA binding protein in Aspergillus oryzae that undergoes unconventional secretion. Biochem Biophys Res Commun. 2017;493:481-486 pubmed publisher
    ..Thus, the filamentous fungus A. oryzae harbors two types of ACBPs, one of which appears to be essential for growth and undergoes unconventional secretion. ..
  53. Nagahara Y, Nagahara K. Relationship Between Structure and Antiproliferative Activity of Novel 5-amino-4-cyanopyrazole-1-formaldehydehydrazono Derivatives on HL-60RG Human Leukemia Cells. Anticancer Res. 2017;37:6329-6333 pubmed
    ..Here we synthesized and determined the anticancer effects of hydrazonopyrazole derivatives on a mammalian cancer cell line...
  54. Yoneyama H, Kai Y, Koyama J, Suzuki K, Kawachi H, Narumi S, et al. Neutralization of CXCL10 accelerates liver regeneration in carbon tetrachloride-induced acute liver injury. Med Mol Morphol. 2007;40:191-7 pubmed
    ..Thus, CXCL10 can be a novel therapeutic target for acute hepatocellular damage by regulating liver tissue remodeling. ..
  55. Dharel N, Kato N, Muroyama R, Taniguchi H, Otsuka M, Wang Y, et al. Potential contribution of tumor suppressor p53 in the host defense against hepatitis C virus. Hepatology. 2008;47:1136-49 pubmed publisher
    ..These observations underscore the potential contributions of the tumor suppressor p53 in cellular antiviral immunity against HCV with possible therapeutic implications. ..
  56. Seo S, Asai T, Saito T, Suzuki T, Morishita Y, Nakamoto T, et al. Crk-associated substrate lymphocyte type is required for lymphocyte trafficking and marginal zone B cell maintenance. J Immunol. 2005;175:3492-501 pubmed
    ..Thus, Cas-L affects homeostasis of MZB cells and peripheral lymphoid organs, which is considered to be relevant to impaired lymphocyte migration and adhesion. ..
  57. Hongo S, Watanabe T, Takahashi K, Miyazaki A. Ndrg4 enhances NGF-induced ERK activation uncoupled with Elk-1 activation. J Cell Biochem. 2006;98:185-93 pubmed
    ..Ndrg4 may play a role in supporting the activation of ERK and its target proteins needed for neuronal differentiation and in reducing the activation of Elk-1 implicated in cell growth. ..
  58. Chiba S, Suzuki M, Yamanouchi K, Nishihara M. Involvement of granulin in estrogen-induced neurogenesis in the adult rat hippocampus. J Reprod Dev. 2007;53:297-307 pubmed
  59. Yamada Y, Sakurada K, Takeda Y, Gojo S, Umezawa A. Single-cell-derived mesenchymal stem cells overexpressing Csx/Nkx2.5 and GATA4 undergo the stochastic cardiomyogenic fate and behave like transient amplifying cells. Exp Cell Res. 2007;313:698-706 pubmed
    ..Single-cell-derived mesenchymal stem cells overexpressing Csx/Nkx2.5 and GATA4 behaved like cardiac transient amplifying cells, and still retained their plasticity in vivo. ..
  60. Shitashige M, Naishiro Y, Idogawa M, Honda K, Ono M, Hirohashi S, et al. Involvement of splicing factor-1 in beta-catenin/T-cell factor-4-mediated gene transactivation and pre-mRNA splicing. Gastroenterology. 2007;132:1039-54 pubmed
    ..Identification of the interaction may shed light on a novel aspect of the Wnt signaling pathway. ..
  61. Maehama T. PTEN: its deregulation and tumorigenesis. Biol Pharm Bull. 2007;30:1624-7 pubmed
    ..This article will review the PTEN inactivation mechanism which is linked to human tumorigenesis, particularly focusing on recent research progress in PTEN regulators. ..
  62. Mizuno H, Ogura M, Saito Y, Sekine W, Sano R, Gotou T, et al. Changes in adhesive and migratory characteristics of hepatocellular carcinoma (HCC) cells induced by expression of alpha3beta1 integrin. Biochim Biophys Acta. 2008;1780:564-70 pubmed
    ..These results strongly suggest that enhanced expression of alpha3beta1 integrin on HCC cells is directly involved in their malignant phenotypes such as invasion and metastasis. ..
  63. Kim J, Kakusho N, Yamada M, Kanoh Y, Takemoto N, Masai H. Cdc7 kinase mediates Claspin phosphorylation in DNA replication checkpoint. Oncogene. 2008;27:3475-82 pubmed
    ..Consistent with this prediction, Cdc7 interacts with and phosphorylates Claspin. We propose that Cdc7 is required for activation of the ATR-Chk1 checkpoint pathway through regulation of Claspin. ..
  64. Zhao L, Yano T, Osuga Y, Nakagawa S, Oishi H, Wada Hiraike O, et al. Cellular mechanisms of growth inhibition of human endometrial cancer cell line by an antagonist of growth hormone-releasing hormone. Int J Oncol. 2008;32:593-601 pubmed
  65. Kitazawa Y, Fujino M, Sakai T, Azuma H, Kimura H, Isaka Y, et al. Foxp3-expressing regulatory T cells expanded with CD28 superagonist antibody can prevent rat cardiac allograft rejection. J Heart Lung Transplant. 2008;27:362-71 pubmed publisher
  66. Hirata M, Kugimiya F, Fukai A, Ohba S, Kawamura N, Ogasawara T, et al. C/EBPbeta Promotes transition from proliferation to hypertrophic differentiation of chondrocytes through transactivation of p57. PLoS ONE. 2009;4:e4543 pubmed publisher
  67. Niwa H, Satoh T, Matsushima Y, Hosoya K, Saeki K, Niki T, et al. Stable form of galectin-9, a Tim-3 ligand, inhibits contact hypersensitivity and psoriatic reactions: a potent therapeutic tool for Th1- and/or Th17-mediated skin inflammation. Clin Immunol. 2009;132:184-94 pubmed publisher
    ..This was accompanied by decreased skin lesion levels of IL-17 and IL-22. sGal-9 may be a unique and useful therapeutic tool for the treatment of Th1- and/or Th17-mediated skin inflammation. ..
  68. Yanaka S, Kudou M, Tanaka Y, Sasaki T, Takemoto S, Sakata A, et al. Contribution of the flexible loop region to the function of staphylococcal enterotoxin B. Protein Eng Des Sel. 2010;23:415-21 pubmed publisher
    ..These results highlight the importance of the flexible loop region for the functional, physical and chemical properties of WT SEB, thus providing insight into the nature of WT SEB that was unrevealed previously. ..
  69. Okae H, Iwakura Y. Neural tube defects and impaired neural progenitor cell proliferation in Gbeta1-deficient mice. Dev Dyn. 2010;239:1089-101 pubmed publisher
    ..These data indicate that Gbeta1 is required for normal embryonic neurogenesis. ..
  70. Shigoka M, Tsuchida A, Matsudo T, Nagakawa Y, Saito H, Suzuki Y, et al. Deregulation of miR-92a expression is implicated in hepatocellular carcinoma development. Pathol Int. 2010;60:351-7 pubmed publisher
    ..Thus, although the physiological significance of the decrease of miR-92a in plasma is still unknown, deregulation of miR-92 expression in cells and plasma should be implicated in the development of HCC. ..
  71. Ishii A, Oboki K, Nambu A, Morita H, Ohno T, Kajiwara N, et al. Development of IL-17-mediated delayed-type hypersensitivity is not affected by down-regulation of IL-25 expression. Allergol Int. 2010;59:399-408 pubmed publisher
    ..IL-25 is not essential for differentiation of Th1, Th2 and Th17 cells in the sensitization phase or induction of local inflammation in the elicitation phase of the mBSA-induced DTH reaction. ..
  72. Vu H, Beppu Y, Chi H, Sasaki K, Yamamoto H, Xinh P, et al. Green tea epigallocatechin gallate exhibits anticancer effect in human pancreatic carcinoma cells via the inhibition of both focal adhesion kinase and insulin-like growth factor-I receptor. J Biomed Biotechnol. 2010;2010:290516 pubmed publisher
    ..Our data suggests that blocking FAK and IGF-1R by EGCG could prove valuable for targeted therapy, which can be used in combination with other therapies, for pancreatic cancer. ..
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