Experts and Doctors on caenorhabditis elegans proteins in Tokyo, Japan


Locale: Tokyo, Japan
Topic: caenorhabditis elegans proteins

Top Publications

  1. Saitoh Y, Katane M, Kawata T, Maeda K, Sekine M, Furuchi T, et al. Spatiotemporal localization of D-amino acid oxidase and D-aspartate oxidases during development in Caenorhabditis elegans. Mol Cell Biol. 2012;32:1967-83 pubmed publisher
    ..This work provides novel and useful insights into the physiological functions of these enzymes and D-amino acids in multicellular organisms. ..
  2. Sato A, Watanabe Y, Suzuki T, Komiyama M, Watanabe K, Ohtsuki T. Identification of the residues involved in the unique serine specificity of Caenorhabditis elegans mitochondrial EF-Tu2. Biochemistry. 2006;45:10920-7 pubmed
    ..Thus, these three approaches reveal the critical residues essential for the unique serine specificity of C. elegans mitochondrial EF-Tu2. ..
  3. Iwasa H, Kuroyanagi H, Maimaiti S, Ikeda M, Nakagawa K, Hata Y. Characterization of RSF-1, the Caenorhabditis elegans homolog of the Ras-association domain family protein 1. Exp Cell Res. 2013;319:1-11 pubmed publisher
    ..Although we could not detect the direct physical interaction of LET-60 with RSF-1, rsf-1 mutants suppress the multivulva phenotype of the active let-60 mutants, suggesting that rsf-1 genetically interacts with the Ras signaling. ..
  4. Setou M, Nakagawa T, Seog D, Hirokawa N. Kinesin superfamily motor protein KIF17 and mLin-10 in NMDA receptor-containing vesicle transport. Science. 2000;288:1796-802 pubmed
    ..This interaction, specific for a neurotransmitter receptor critically important for plasticity in the postsynaptic terminal, may be a regulatory point for synaptic plasticity and neuronal morphogenesis. ..
  5. Obinata T, Ono K, Ono S. Troponin I controls ovulatory contraction of non-striated actomyosin networks in the C. elegans somatic gonad. J Cell Sci. 2010;123:1557-66 pubmed publisher
    ..Our results demonstrate that troponin I regulates contraction of non-striated actomyosin networks and is an essential cytoskeletal component of the C. elegans reproductive system. ..
  6. Hayashi Y, Hirotsu T, Iwata R, Kage Nakadai E, Kunitomo H, Ishihara T, et al. A trophic role for Wnt-Ror kinase signaling during developmental pruning in Caenorhabditis elegans. Nat Neurosci. 2009;12:981-7 pubmed publisher
    ..These results reveal the trophic role of an atypical Wnt pathway and reinforce the classical model of developmental pruning. ..
  7. Yamada K, Hirotsu T, Matsuki M, Kunitomo H, Iino Y. GPC-1, a G protein gamma-subunit, regulates olfactory adaptation in Caenorhabditis elegans. Genetics. 2009;181:1347-57 pubmed publisher
    ..Our analyses place goa-1 Goalpha and let-60 Ras in parallel to gpc-1. In contrast, a gain-of-function mutation in egl-30 Gqalpha was epistatic to gpc-1, suggesting the possibility that gpc-1 Ggamma may act upstream of egl-30 Gqalpha. ..
  8. Honda Y, Tanaka M, Honda S. Modulation of longevity and diapause by redox regulation mechanisms under the insulin-like signaling control in Caenorhabditis elegans. Exp Gerontol. 2008;43:520-9 pubmed publisher
    ..We thus conclude that the MnSOD systems in C. elegans fine-tune the insulin-like-signaling based regulation of both longevity and dauer formation by acting not as antioxidants but as physiological-redox-signaling modulators. ..
  9. Kunitomo H, Iino Y. Caenorhabditis elegans DYF-11, an orthologue of mammalian Traf3ip1/MIP-T3, is required for sensory cilia formation. Genes Cells. 2008;13:13-25 pubmed publisher
    ..We further show that Traf3ip1/MIP-T3, the mammalian orthologue of DYF-11, localizes to cilia in the MDCK renal epithelial cells. ..

More Information


  1. Delawary M, Nakazawa T, Tezuka T, Sawa M, Iino Y, Takenawa T, et al. Molecular characterization of a novel RhoGAP, RRC-1 of the nematode Caenorhabditis elegans. Biochem Biophys Res Commun. 2007;357:377-82 pubmed
    ..These data contribute toward understanding the roles of Rho family GTPases in C. elegans. ..
  2. Honda Y, Tanaka M, Honda S. Trehalose extends longevity in the nematode Caenorhabditis elegans. Aging Cell. 2010;9:558-69 pubmed publisher
    ..Trehalose may be a lead compound for potential nutraceutical intervention of the aging process. ..
  3. Baba T, Shimizu T, Suzuki Y, Ogawara M, Isono K, Koseki H, et al. Estrogen, insulin, and dietary signals cooperatively regulate longevity signals to enhance resistance to oxidative stress in mice. J Biol Chem. 2005;280:16417-26 pubmed
    ..Collectively, we show that three distinct signals; insulin, estrogen, and dietary signals work in independent and cooperative ways to enhance the resistance to oxidative stress in mice. ..
  4. Kuwahara T, Koyama A, Koyama S, Yoshina S, Ren C, Kato T, et al. A systematic RNAi screen reveals involvement of endocytic pathway in neuronal dysfunction in alpha-synuclein transgenic C. elegans. Hum Mol Genet. 2008;17:2997-3009 pubmed publisher
    ..Collectively, these findings raise a novel pathogenic link between endocytic pathway and alpha-synuclein-induced neurotoxicity in synucleinopathy. ..
  5. Ohno G, Ono K, Togo M, Watanabe Y, Ono S, Hagiwara M, et al. Muscle-specific splicing factors ASD-2 and SUP-12 cooperatively switch alternative pre-mRNA processing patterns of the ADF/cofilin gene in Caenorhabditis elegans. PLoS Genet. 2012;8:e1002991 pubmed publisher
  6. Kumar S, Kinoshita M, Noda M, Copeland N, Jenkins N. Induction of apoptosis by the mouse Nedd2 gene, which encodes a protein similar to the product of the Caenorhabditis elegans cell death gene ced-3 and the mammalian IL-1 beta-converting enzyme. Genes Dev. 1994;8:1613-26 pubmed
    ..Our data suggest that Nedd2 is an important component of the mammalian programmed cell death machinery. ..
  7. Kuroyanagi H, Kobayashi T, Mitani S, Hagiwara M. Transgenic alternative-splicing reporters reveal tissue-specific expression profiles and regulation mechanisms in vivo. Nat Methods. 2006;3:909-15 pubmed
    ..This transgenic reporter system can be a powerful experimental tool for the comprehensive study of expression profiles and regulation mechanisms of alternative splicing in metazoans. ..
  8. Yin J, Huang Y, Guo P, Hu S, Yoshina S, Xuan N, et al. GOP-1 promotes apoptotic cell degradation by activating the small GTPase Rab2 in C. elegans. J Cell Biol. 2017;216:1775-1794 pubmed publisher
    ..Loss of gop-1 also abolishes association of UNC-108 with endosomes, causing defects in endosome and dense core vesicle maturation. Thus, GOP-1 is an activator of UNC-108/Rab2 in multiple processes. ..
  9. Miyadera H, Amino H, Hiraishi A, Taka H, Murayama K, Miyoshi H, et al. Altered quinone biosynthesis in the long-lived clk-1 mutants of Caenorhabditis elegans. J Biol Chem. 2001;276:7713-6 pubmed
    ..The accumulation of DMQ(9) and its use in mutant mitochondria indicate, for the first time in any organism, a link between the alteration in the quinone species used in respiration and life span. ..
  10. Morio H, Honda Y, Toyoda H, Nakajima M, Kurosawa H, Shirasawa T. EXT gene family member rib-2 is essential for embryonic development and heparan sulfate biosynthesis in Caenorhabditis elegans. Biochem Biophys Res Commun. 2003;301:317-23 pubmed
    ..These results indicate that rib-2 is essential for embryonic development and heparan sulfate biosynthesis in C. elegans. ..
  11. Sawa M, Takenawa T. Caenorhabditis elegans WASP-interacting protein homologue WIP-1 is involved in morphogenesis through maintenance of WSP-1 protein levels. Biochem Biophys Res Commun. 2006;340:709-17 pubmed
    ..Our results suggest that C. elegans WIP-1 may function in hypodermal cell migration during ventral enclosure by maintaining levels of WSP-1. ..
  12. Sugiura M, Fuke S, Suo S, Sasagawa N, Van Tol H, Ishiura S. Characterization of a novel D2-like dopamine receptor with a truncated splice variant and a D1-like dopamine receptor unique to invertebrates from Caenorhabditis elegans. J Neurochem. 2005;94:1146-57 pubmed
    ..Reporter gene assay showed that DOP-4 stimulates cAMP accumulation in response to dopamine stimulation. These two receptors provide new opportunities to understand dopaminergic signaling at the molecular level. ..
  13. Ohno H, Kato S, Naito Y, Kunitomo H, Tomioka M, Iino Y. Role of synaptic phosphatidylinositol 3-kinase in a behavioral learning response in C. elegans. Science. 2014;345:313-7 pubmed publisher
    ..Thus, synaptic PI3K is crucial for the behavioral switch caused by learning. ..
  14. Hasegawa M, Toma Fukai S, Kim J, Fukamizu A, Shimizu T. Protein arginine methyltransferase 7 has a novel homodimer-like structure formed by tandem repeats. FEBS Lett. 2014;588:1942-8 pubmed publisher
    ..Mutagenesis demonstrated that only the N-terminal catalytic site of PRMT7 is responsible for cofactor binding. ..
  15. Kuroyanagi H, Watanabe Y, Hagiwara M. CELF family RNA-binding protein UNC-75 regulates two sets of mutually exclusive exons of the unc-32 gene in neuron-specific manners in Caenorhabditis elegans. PLoS Genet. 2013;9:e1003337 pubmed publisher
    ..Taken together, UNC-75 is the neuron-specific splicing factor and regulates both sets of the mutually exclusive exons of the unc-32 gene...
  16. Yoshina S, Sakaki K, Yonezumi Hayashi A, Gengyo Ando K, Inoue H, Iino Y, et al. Identification of a novel ADAMTS9/GON-1 function for protein transport from the ER to the Golgi. Mol Biol Cell. 2012;23:1728-41 pubmed publisher
    ..elegans. We propose a novel function of ADAMTS9 and GON-1 in the ER that promotes protein transport from the ER to the Golgi. This function is GON-domain dependent but protease activity independent. ..
  17. Imae R, Inoue T, Nakasaki Y, Uchida Y, Ohba Y, Kono N, et al. LYCAT, a homologue of C. elegans acl-8, acl-9, and acl-10, determines the fatty acid composition of phosphatidylinositol in mice. J Lipid Res. 2012;53:335-47 pubmed publisher
    ..Furthermore, expression of mouse LYCAT rescued the phenotype of C. elegans acl-8 acl-9 acl-10 triple mutants. Our data indicate that LYCAT is a determinant of PI molecular species and its function is conserved in C. elegans and mammals. ..
  18. Yamada K, Hirotsu T, Matsuki M, Butcher R, Tomioka M, Ishihara T, et al. Olfactory plasticity is regulated by pheromonal signaling in Caenorhabditis elegans. Science. 2010;329:1647-50 pubmed publisher
    ..These results suggest that population density information is transmitted through the external pheromone and endogenous peptide signaling to modulate chemotactic behavior. ..
  19. Adachi T, Kunitomo H, Tomioka M, Ohno H, Okochi Y, Mori I, et al. Reversal of salt preference is directed by the insulin/PI3K and Gq/PKC signaling in Caenorhabditis elegans. Genetics. 2010;186:1309-19 pubmed publisher
    ..A putative salt receptor GCY-22 guanylyl cyclase is required in ASER for both salt attraction and avoidance. Our results suggest that ASEL and ASER use distinct molecular mechanisms to regulate salt chemotaxis plasticity. ..
  20. Imae R, Inoue T, Kimura M, Kanamori T, Tomioka N, Kage Nakadai E, et al. Intracellular phospholipase A1 and acyltransferase, which are involved in Caenorhabditis elegans stem cell divisions, determine the sn-1 fatty acyl chain of phosphatidylinositol. Mol Biol Cell. 2010;21:3114-24 pubmed publisher
    ..We propose that the sn-1 fatty acid of PI is determined by ipla-1 and acl-8, -9, -10 and crucial for asymmetric divisions. ..
  21. Nakae I, Fujino T, Kobayashi T, Sasaki A, Kikko Y, Fukuyama M, et al. The arf-like GTPase Arl8 mediates delivery of endocytosed macromolecules to lysosomes in Caenorhabditis elegans. Mol Biol Cell. 2010;21:2434-42 pubmed publisher
    ..These findings suggest that ARL-8 mediates delivery of endocytosed macromolecules to lysosomes by facilitating late endosome-lysosome fusion. ..
  22. Aoyama Y, Urushiyama S, Yamada M, Kato C, Ide H, Higuchi S, et al. MFB-1, an F-box-type ubiquitin ligase, regulates TGF-beta signalling. Genes Cells. 2004;9:1093-101 pubmed
    ..We propose that MFB-1 is a novel F-box protein that negatively regulates dauer formation in concert with the DAF-7 signalling pathway in C. elegans. ..
  23. Maekawa M, Inoue T, Kobuna H, Nishimura T, Gengyo Ando K, Mitani S, et al. Functional analysis of GS28, an intra-Golgi SNARE, in Caenorhabditis elegans. Genes Cells. 2009;14:1003-13 pubmed publisher
    ..We also demonstrated that GS28 and Ykt6 act redundantly for the proper expression of Golgi-resident proteins in adult intestinal cells. This study reveals the in vivo importance of the Golgi-localized SNAREs GS28 and Ykt6. ..
  24. Takahashi K, Yoshina S, Masashi M, Ito W, Inoue T, Shiwaku H, et al. Nematode homologue of PQBP1, a mental retardation causative gene, is involved in lipid metabolism. PLoS ONE. 2009;4:e4104 pubmed publisher
    ..1 is involved in lipid metabolism of intestinal cells. Dysfunction of lipid metabolism might underlie lean body, one of the most frequent symptoms associating with PQBP1-linked MR patients. ..
  25. Hasegawa E, Karashima T, Sumiyoshi E, Yamamoto M. C. elegans CPB-3 interacts with DAZ-1 and functions in multiple steps of germline development. Dev Biol. 2006;295:689-99 pubmed
    ..Taken together, CPEB appears to have a conserved role in the early phase of meiosis and in the sperm/oocyte specification, in addition to its reported function during meiotic progression. ..
  26. Mimoto A, Fujii M, Usami M, Shimamura M, Hirabayashi N, Kaneko T, et al. Identification of an estrogenic hormone receptor in Caenorhabditis elegans. Biochem Biophys Res Commun. 2007;364:883-8 pubmed
    ..Semi-quantitative RT-PCR showed that vitellogenin expression was significantly reduced in the mutant. This suggests that NHR-14 is a C. elegans estrogenic hormone receptor and that it controls gene expression in response to estrogen. ..
  27. Gengyo Ando K, Kuroyanagi H, Kobayashi T, Murate M, Fujimoto K, Okabe S, et al. The SM protein VPS-45 is required for RAB-5-dependent endocytic transport in Caenorhabditis elegans. EMBO Rep. 2007;8:152-7 pubmed
    ..Our results indicate that VPS-45 is a key molecule that functions downstream from RAB-5, cooperating with RABS-5, to regulate the dynamics of the endocytic system in multicellular organisms. ..
  28. Matsubara Y, Kawasaki I, Urushiyama S, Yasuda T, Shirakata M, Iino Y, et al. The adaptor-like protein ROG-1 is required for activation of the Ras-MAP kinase pathway and meiotic cell cycle progression in Caenorhabditis elegans. Genes Cells. 2007;12:407-20 pubmed
    ..Thus, ROG-1 is a key positive regulator of the Ras-MAP kinase pathway that permits germ cells to exit from pachytene. ..
  29. Yamada K, Tsuchiya J, Iino Y. Mutations in the pqe-1 gene enhance transgene expression in Caenorhabditis elegans. G3 (Bethesda). 2012;2:741-51 pubmed publisher
    ..We propose that pqe-1 mutants can be used to increase the expression of various useful transgenes. ..
  30. Kobuna H, Inoue T, Shibata M, Gengyo Ando K, Yamamoto A, Mitani S, et al. Multivesicular body formation requires OSBP-related proteins and cholesterol. PLoS Genet. 2010;6: pubmed publisher
    ..Our in vivo findings suggest that the proper cholesterol level of late endosomes/lysosomes generated by ORPs is required for normal MVB formation and MVB-mediated membrane protein degradation. ..
  31. Katane M, Saitoh Y, Seida Y, Sekine M, Furuchi T, Homma H. Comparative characterization of three D-aspartate oxidases and one D-amino acid oxidase from Caenorhabditis elegans. Chem Biodivers. 2010;7:1424-34 pubmed publisher
    ..Collectively, our results indicate that C. elegans contains at least three genes that encode functional DDOs, and one gene encoding a functional DAO, and that these enzymes have different and distinctive properties. ..
  32. Kuroyanagi H, Ohno G, Mitani S, Hagiwara M. The Fox-1 family and SUP-12 coordinately regulate tissue-specific alternative splicing in vivo. Mol Cell Biol. 2007;27:8612-21 pubmed
    ..These results establish an in vivo model that coordination of the two families of RNA-binding proteins regulates tissue-specific alternative splicing of a specific target gene. ..
  33. Lee H, Inoue T, Imae R, Kono N, Shirae S, Matsuda S, et al. Caenorhabditis elegans mboa-7, a member of the MBOAT family, is required for selective incorporation of polyunsaturated fatty acids into phosphatidylinositol. Mol Biol Cell. 2008;19:1174-84 pubmed
    ..mboa-7 encodes a member of the membrane-bound O-acyltransferase family, suggesting that mboa-7 is LPIAT. Finally, mboa-7 mutants had significantly lower EPA levels in PI, and they exhibited larval arrest and egg-laying defects. ..
  34. Kage E, Hayashi Y, Takeuchi H, Hirotsu T, Kunitomo H, Inoue T, et al. MBR-1, a novel helix-turn-helix transcription factor, is required for pruning excessive neurites in Caenorhabditis elegans. Curr Biol. 2005;15:1554-9 pubmed
    ..These findings provide an important clue for further genetic dissection of neurite pruning. ..
  35. Kanamori T, Inoue T, Sakamoto T, Gengyo Ando K, Tsujimoto M, Mitani S, et al. Beta-catenin asymmetry is regulated by PLA1 and retrograde traffic in C. elegans stem cell divisions. EMBO J. 2008;27:1647-57 pubmed publisher
    ..We propose that membrane trafficking regulated by ipla-1 provides a mechanism to control the cortical asymmetry of beta-catenin. ..
  36. Sasaki A, Nakae I, Nagasawa M, Hashimoto K, Abe F, Saito K, et al. Arl8/ARL-8 functions in apoptotic cell removal by mediating phagolysosome formation in Caenorhabditis elegans. Mol Biol Cell. 2013;24:1584-92 pubmed publisher
    ..Collectively our findings reveal that ARL-8 facilitates apoptotic cell removal in vivo by mediating phagosome-lysosome fusion during phagocytosis. ..
  37. Ohba Y, Sakuragi T, Kage Nakadai E, Tomioka N, Kono N, Imae R, et al. Mitochondria-type GPAT is required for mitochondrial fusion. EMBO J. 2013;32:1265-79 pubmed publisher
    ..We postulate from these results that LPA produced by Mt-GPAT functions not only as a precursor for glycerolipid synthesis but also as an essential factor of mitochondrial fusion...
  38. Inaoka H, Fukuoka Y, Kohane I. Lower expression of genes near microRNA in C. elegans germline. BMC Bioinformatics. 2006;7:112 pubmed
    ..Because there is mounting evidence for the localized component of transcriptional control, we investigated if there is a distance-dependent effect of miRNA...
  39. Igaki T, Miura M. Role of Bcl-2 family members in invertebrates. Biochim Biophys Acta. 2004;1644:73-81 pubmed
    ..The ancestral role of the Bcl-2 family protein may be pro-apoptotic, and the evolution of the functions of this family of proteins may be closely linked with the contribution of mitochondria to the cell death pathway. ..
  40. Ikeda D, Duan Y, Matsuki M, Kunitomo H, Hutter H, Hedgecock E, et al. CASY-1, an ortholog of calsyntenins/alcadeins, is essential for learning in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2008;105:5260-5 pubmed publisher
    ..These results suggest that learning is modulated by the released ectodomain of CASY-1. ..
  41. Otori M, Karashima T, Yamamoto M. The Caenorhabditis elegans homologue of deleted in azoospermia is involved in the sperm/oocyte switch. Mol Biol Cell. 2006;17:3147-55 pubmed
    ..Conversely, a mutation in gld-3, a gene that functionally counteracts FBF, could partially restore oogenesis in the daz-1 mutant. Together, we propose that daz-1 plays a role upstream of the pathway for germ cell sex determination. ..
  42. Hanazawa M, Kawasaki I, Kunitomo H, Gengyo Ando K, Bennett K, Mitani S, et al. The Caenorhabditis elegans eukaryotic initiation factor 5A homologue, IFF-1, is required for germ cell proliferation, gametogenesis and localization of the P-granule component PGL-1. Mech Dev. 2004;121:213-24 pubmed
  43. Matsuki M, Kunitomo H, Iino Y. Goalpha regulates olfactory adaptation by antagonizing Gqalpha-DAG signaling in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2006;103:1112-7 pubmed
    ..Our results suggest that down-regulation of EGL-30-DAG signaling by GOA-1 underlies olfactory adaptation and plasticity of chemotaxis. ..
  44. Katane M, Seida Y, Sekine M, Furuchi T, Homma H. Caenorhabditis elegans has two genes encoding functional d-aspartate oxidases. FEBS J. 2007;274:137-49 pubmed
    ..The two C. elegans DASPOs differ in their substrate specificities and possibly also in their subcellular localization. ..
  45. Tomioka M, Adachi T, Suzuki H, Kunitomo H, Schafer W, Iino Y. The insulin/PI 3-kinase pathway regulates salt chemotaxis learning in Caenorhabditis elegans. Neuron. 2006;51:613-25 pubmed
    ..These results suggest that INS-1 secreted from AIA interneurons provides feedback to ASER to generate plasticity of chemotaxis. ..
  46. Iwasa H, Maimaiti S, Kuroyanagi H, Kawano S, Inami K, Timalsina S, et al. Yes-associated protein homolog, YAP-1, is involved in the thermotolerance and aging in the nematode Caenorhabditis elegans. Exp Cell Res. 2013;319:931-45 pubmed publisher
    ..In short, YAP-1 partially shares basal characters with mammalian YAP and plays a role in thermal stress response and healthy aging. ..
  47. Kobayashi T, Gengyo Ando K, Ishihara T, Katsura I, Mitani S. IFT-81 and IFT-74 are required for intraflagellar transport in C. elegans. Genes Cells. 2007;12:593-602 pubmed
    ..Thus, we conclude that IFT-81 and IFT-74 coordinately act in IFT in C. elegans sensory cilia. ..
  48. Tsuda M, Sugiura T, Ishii T, Ishii N, Aigaki T. A mev-1-like dominant-negative SdhC increases oxidative stress and reduces lifespan in Drosophila. Biochem Biophys Res Commun. 2007;363:342-6 pubmed
    ..The transgenic flies should serve as a model for studying the biological processes associated with increased levels of oxidative stress and mitochondrial dysfunction in Drosophila. ..
  49. Awasaki T, Tatsumi R, Takahashi K, Arai K, Nakanishi Y, Ueda R, et al. Essential role of the apoptotic cell engulfment genes draper and ced-6 in programmed axon pruning during Drosophila metamorphosis. Neuron. 2006;50:855-67 pubmed
    ..These findings suggest that glial cells engulf degenerating axons through drpr and ced-6. We propose that apoptotic cells and degenerating axons of living neurons are removed by a similar molecular mechanism. ..
  50. Kume H, Murayama K, Araki W. The two-hydrophobic domain tertiary structure of reticulon proteins is critical for modulation of beta-secretase BACE1. J Neurosci Res. 2009;87:2963-72 pubmed publisher
  51. Sasagawa N, Ohno E, Kino Y, Watanabe Y, Ishiura S. Identification of Caenorhabditis elegans K02H8.1 (CeMBL), a functional ortholog of mammalian MBNL proteins. J Neurosci Res. 2009;87:1090-7 pubmed publisher
    ..The expression of GFP driven by the K02H8.1 promoter was absent in muscle; however, significant GFP expression was detected in the neurons around the pharynx. ..
  52. Ohno G, Hagiwara M, Kuroyanagi H. STAR family RNA-binding protein ASD-2 regulates developmental switching of mutually exclusive alternative splicing in vivo. Genes Dev. 2008;22:360-74 pubmed publisher
    ..We propose that the developmental switching between alternative sequences of intron removal determines the ratio between the mature let-2 mRNA isoforms. ..
  53. Hayakawa T, Kato K, Hayakawa R, Hisamoto N, Matsumoto K, Takeda K, et al. Regulation of anoxic death in Caenorhabditis elegans by mammalian apoptosis signal-regulating kinase (ASK) family proteins. Genetics. 2011;187:785-92 pubmed publisher
    ..These results suggest that the TIR-1-NSY-1-SEK-1-PMK-1 pathway plays important roles in the reponse to anoxia in C. elegans. ..
  54. Nishioka S, Aikawa J, Ida M, Matsumoto I, Street M, Tsujimoto M, et al. Ligand-binding activity and expression profile of annexins in Caenorhabditis elegans. J Biochem. 2007;141:47-55 pubmed
    ..Differentiated expression profiles and ligand-binding properties of NEX-1, -2, -3 and -4, shown in our study, may represent distinctive roles for each C. elegans annexins. ..
  55. Kuroyanagi H, Watanabe Y, Suzuki Y, Hagiwara M. Position-dependent and neuron-specific splicing regulation by the CELF family RNA-binding protein UNC-75 in Caenorhabditis elegans. Nucleic Acids Res. 2013;41:4015-25 pubmed publisher
    ..elegans. This study thus reveals the repertoire of target events for the CELF family in the living organism...
  56. Hamahashi S, Onami S, Kitano H. Detection of nuclei in 4D Nomarski DIC microscope images of early Caenorhabditis elegans embryos using local image entropy and object tracking. BMC Bioinformatics. 2005;6:125 pubmed
    ..elegans embryos. The system will facilitate genomic and computational analyses of C. elegans embryos. ..
  57. Minami M, Shinozaki F, Suzuki M, Yoshimatsu K, Ichikawa Y, Minami Y. The proteasome activator PA28 functions in collaboration with Hsp90 in vivo. Biochem Biophys Res Commun. 2006;344:1315-9 pubmed
    ..Taking these results together, we conclude that PA28 is likely to function in collaboration with Hsp90 in vivo. ..