Experts and Doctors on biological clocks in Kyoto, Japan


Locale: Kyoto, Japan
Topic: biological clocks

Top Publications

  1. Kageyama R, Niwa Y, Isomura A, Gonzalez A, Harima Y. Oscillatory gene expression and somitogenesis. Wiley Interdiscip Rev Dev Biol. 2012;1:629-41 pubmed publisher
    ..It is likely that these oscillator networks constitute the core of the segmentation clock, but it remains to be determined whether as yet unknown oscillators function behind the scenes. ..
  2. Hirata H, Yoshiura S, Ohtsuka T, Bessho Y, Harada T, Yoshikawa K, et al. Oscillatory expression of the bHLH factor Hes1 regulated by a negative feedback loop. Science. 2002;298:840-3 pubmed
    ..Because Hes1 oscillation can be seen in many cell types, this clock may regulate timing in many biological systems. ..
  3. Bessho Y, Hirata H, Masamizu Y, Kageyama R. Periodic repression by the bHLH factor Hes7 is an essential mechanism for the somite segmentation clock. Genes Dev. 2003;17:1451-6 pubmed
    ..Thus, periodic repression by Hes7 protein is critical for the cyclic transcription of Hes7 and Lfng, and this negative feedback represents a molecular basis for the segmentation clock. ..
  4. Yoshida T, Katoh A, Ohtsuki G, Mishina M, Hirano T. Oscillating Purkinje neuron activity causing involuntary eye movement in a mutant mouse deficient in the glutamate receptor delta2 subunit. J Neurosci. 2004;24:2440-8 pubmed
  5. Uchio N, Doi M, Matsuo M, Yamazaki F, Mizoro Y, Hondo M, et al. Circadian characteristics of mice depleted with GPR7. Biomed Res. 2009;30:357-64 pubmed
    ..These results indicate that the role of GPR7 may be subtle or limited in relation to the circadian clock despite its robust expression in the SCN. ..
  6. Ito H, Maldonado P, Gray C. Dynamics of stimulus-evoked spike timing correlations in the cat lateral geniculate nucleus. J Neurophysiol. 2010;104:3276-92 pubmed publisher
    ..These findings show that stimulus-evoked synchronous activity within the LGN is often rhythmic, highly nonstationary, and modulated by endogenous processes that are not tightly correlated with firing rate. ..
  7. Gonzalez A, Manosalva I, Liu T, Kageyama R. Control of Hes7 expression by Tbx6, the Wnt pathway and the chemical Gsk3 inhibitor LiCl in the mouse segmentation clock. PLoS ONE. 2013;8:e53323 pubmed publisher
    ..Our data suggest that Tbx6 and the Wnt pathway cooperatively regulate proper Hes7 expression. Furthermore, proper Hes7 promoter activity and expression is important for the normal pace of oscillation. ..
  8. Harima Y, Kageyama R. Oscillatory links of Fgf signaling and Hes7 in the segmentation clock. Curr Opin Genet Dev. 2013;23:484-90 pubmed publisher
    ..In addition, Fgf signaling was found to be a primary target for hypoxia, which causes phenotypic variations of heterozygous mutations in Hes7 or Mesp2, suggesting gene-environment interaction through this signaling. ..
  9. Hirayama J, Nakamura H, Ishikawa T, Kobayashi Y, Todo T. Functional and structural analyses of cryptochrome. Vertebrate CRY regions responsible for interaction with the CLOCK:BMAL1 heterodimer and its nuclear localization. J Biol Chem. 2003;278:35620-8 pubmed
    ..These findings show that both nuclear localization and interaction with the CLOCK:BMAL heterodimer are essential for transcriptional repression by CRY. ..

More Information


  1. Naruse Y, Oh hashi K, Iijima N, Naruse M, Yoshioka H, Tanaka M. Circadian and light-induced transcription of clock gene Per1 depends on histone acetylation and deacetylation. Mol Cell Biol. 2004;24:6278-87 pubmed
    ..Taken together, these data indicate that the rhythmic transcription and light induction of clock genes are regulated by histone acetylation and deacetylation. ..
  2. Niwa Y, Masamizu Y, Liu T, Nakayama R, Deng C, Kageyama R. The initiation and propagation of Hes7 oscillation are cooperatively regulated by Fgf and notch signaling in the somite segmentation clock. Dev Cell. 2007;13:298-304 pubmed
    ..We thus propose that Hes7 oscillation is initiated by Fgf signaling and propagated/maintained anteriorly by Notch signaling. ..
  3. Shimojo H, Ohtsuka T, Kageyama R. Oscillations in notch signaling regulate maintenance of neural progenitors. Neuron. 2008;58:52-64 pubmed publisher
    ..These results suggest that Hes1 oscillation regulates Ngn2 and Dll1 oscillations, which in turn lead to maintenance of neural progenitors by mutual activation of Notch signaling. ..
  4. Takashima Y, Ohtsuka T, Gonzalez A, Miyachi H, Kageyama R. Intronic delay is essential for oscillatory expression in the segmentation clock. Proc Natl Acad Sci U S A. 2011;108:3300-5 pubmed publisher
    ..These results indicate that introns are indeed required for Hes7 oscillations and point to the significance of intronic delays in dynamic gene expression...
  5. Harima Y, Takashima Y, Ueda Y, Ohtsuka T, Kageyama R. Accelerating the tempo of the segmentation clock by reducing the number of introns in the Hes7 gene. Cell Rep. 2013;3:1-7 pubmed publisher
    ..These results suggest that the number of introns is important for the appropriate tempo of oscillatory expression and that Hes7 is a key regulator of the pace of the segmentation clock...
  6. Matsumiya M, Tomita T, Yoshioka Kobayashi K, Isomura A, Kageyama R. ES cell-derived presomitic mesoderm-like tissues for analysis of synchronized oscillations in the segmentation clock. Development. 2018;145: pubmed publisher
    ..This method is applicable to chemical-library screening and will facilitate the analysis of the molecular nature of the segmentation clock. ..