Experts and Doctors on binding sites in Hyōgo, Japan

Summary

Locale: Hyōgo, Japan
Topic: binding sites

Top Publications

  1. Rehse P, Tahirov T. Structure of a putative 2'-5' RNA ligase from Pyrococcus horikoshii. Acta Crystallogr D Biol Crystallogr. 2005;61:1207-12 pubmed
    ..However, the size of the active-site cleft is smaller and less positively charged than that of the T. thermophilus homologue, suggesting that the actual substrate may be smaller than that previously postulated for the latter. ..
  2. Okada Y, Nishikawa J, Semma M, Ichikawa A. Induction of integrin ?3 in PGE?-stimulated adhesion of mastocytoma P-815 cells to the Arg-Gly-Asp-enriched fragment of fibronectin. Biochem Pharmacol. 2011;81:866-72 pubmed publisher
    ..These results suggest that de novo synthesis of the integrin ?3 subunit plays a pivotal role in PGE?-induced adhesion of P-815 cells to the RGD-enriched matrix through EP4-mediated cAMP signaling...
  3. Bagautdinov B, Kunishima N. Crystal structures of shikimate dehydrogenase AroE from Thermus thermophilus HB8 and its cofactor and substrate complexes: insights into the enzymatic mechanism. J Mol Biol. 2007;373:424-38 pubmed publisher
    ..The ternary complex TtAroE:NADP(H):shikimate allows unambiguous visualization of the SDH permitting elucidation of the roles of conserved residues Lys64 and Asp100 in the hydride ion transfer between NADP(H) and shikimate...
  4. Lokanath N, Ohshima N, Takio K, Shiromizu I, Kuroishi C, Okazaki N, et al. Crystal structure of novel NADP-dependent 3-hydroxyisobutyrate dehydrogenase from Thermus thermophilus HB8. J Mol Biol. 2005;352:905-17 pubmed publisher
    ..A kinetic study confirms that this enzyme has strict substrate specificity for 3-hydroxyisobutyrate and serine, but it cannot distinguish the chirality of the substrates. Lys165 is likely the catalytic residue of the enzyme...
  5. Bagautdinov B, Kuroishi C, Sugahara M, Kunishima N. Crystal structures of biotin protein ligase from Pyrococcus horikoshii OT3 and its complexes: structural basis of biotin activation. J Mol Biol. 2005;353:322-33 pubmed publisher
  6. Uekama N, Aoki T, Maruoka T, Kurisu S, Hatakeyama A, Yamaguchi S, et al. Influence of membrane curvature on the structure of the membrane-associated pleckstrin homology domain of phospholipase C-delta1. Biochim Biophys Acta. 2009;1788:2575-83 pubmed publisher
  7. Yamada S, Sugimoto H, Kobayashi M, Ohno A, Nakamura H, Shiro Y. Structure of PAS-linked histidine kinase and the response regulator complex. Structure. 2009;17:1333-44 pubmed publisher
  8. Tsuchida M, Emi Y, Kida Y, Sakaguchi M. Human ABC transporter isoform B6 (ABCB6) localizes primarily in the Golgi apparatus. Biochem Biophys Res Commun. 2008;369:369-75 pubmed publisher
    ..Laser scanning microscopic observation revealed that ABCB6 did not co-localize with mitochondrial staining. Rather, it localized in the ER-derived and brefeldin A-sensitive perinuclear compartments, mainly in the Golgi apparatus...
  9. Yonekura K, Maki Yonekura S, Homma M. Structure of the flagellar motor protein complex PomAB: implications for the torque-generating conformation. J Bacteriol. 2011;193:3863-70 pubmed publisher
    ..We propose a model for how PomAB units are placed around the flagellar basal body to function as torque generators. ..

More Information

Publications62

  1. Ebihara A, Yao M, Masui R, Tanaka I, Yokoyama S, Kuramitsu S. Crystal structure of hypothetical protein TTHB192 from Thermus thermophilus HB8 reveals a new protein family with an RNA recognition motif-like domain. Protein Sci. 2006;15:1494-9 pubmed publisher
    ..This report shows that TTHB192 and its sequence homologs adopt an RNA recognition motif-like domain and provides the first testable functional hypothesis for this protein family...
  2. Rehse P, Kitao T, Tahirov T. Structure of a closed-form uroporphyrinogen-III C-methyltransferase from Thermus thermophilus. Acta Crystallogr D Biol Crystallogr. 2005;61:913-9 pubmed publisher
    ..The T. thermophilus structure has this site restricted by the interaction of a flexible loop structure with a highly conserved residue, suggesting a mechanistic role. This structure represents the ;closed' form of the protein...
  3. Yonekura K, Watanabe M, Kageyama Y, Hirata K, Yamamoto M, Maki Yonekura S. Post-transcriptional regulator Hfq binds catalase HPII: crystal structure of the complex. PLoS ONE. 2013;8:e78216 pubmed publisher
    ..The proximal and distal surfaces are known to specifically bind different sRNAs, and binding of HPII could affect Hfq function. Hfq-HPII complexation has no effect on catalase HPII activity. ..
  4. Razzaque M, Masuda N, Maeda Y, Endo Y, Tsukamoto T, Osumi T. Estrogen receptor-related receptor gamma has an exceptionally broad specificity of DNA sequence recognition. Gene. 2004;340:275-82 pubmed
    ..Finally, we found that SHP efficiently represses the transcriptional activity of ERRgamma, even at a far lower concentration than that of ERRgamma. ..
  5. Rehse P, Ohshima N, Nodake Y, Tahirov T. Crystallographic structure and biochemical analysis of the Thermus thermophilus osmotically inducible protein C. J Mol Biol. 2004;338:959-68 pubmed publisher
    ..The active site consists of two cysteine residues from one monomer and an arginine and glutamic acid from the other. Enzymatic assays have revealed that T.thermophilus OsmC has a hydroperoxide peroxidase activity...
  6. Tsukamoto T, Miura S, Nakai T, Yokota S, Shimozawa N, Suzuki Y, et al. Peroxisome assembly factor-2, a putative ATPase cloned by functional complementation on a peroxisome-deficient mammalian cell mutant. Nat Genet. 1995;11:395-401 pubmed
    ..Fibroblasts derived from patients deficient in peroxisome biogenesis (complementation group C) were also complemented with PAF-2 cDNA, indicating that PAF-2 is a strong candidate for the pathogenic gene of group C peroxisome deficiency. ..
  7. Nakai T, Nakagawa N, Maoka N, Masui R, Kuramitsu S, Kamiya N. Ligand-induced conformational changes and a reaction intermediate in branched-chain 2-oxo acid dehydrogenase (E1) from Thermus thermophilus HB8, as revealed by X-ray crystallography. J Mol Biol. 2004;337:1011-33 pubmed publisher
    ..MOPA and of E1(ceim).lipoamide built from the above structures suggest that His273alpha and His129beta' are potential proton donors to the carbonyl group of a BCOA and to the proximal sulfur atom on the lipoamide, respectively...
  8. Luo F, Shinzawa Itoh K, Hagimoto K, Shimada A, Shimada S, Yamashita E, et al. Structure of bovine cytochrome c oxidase crystallized at a neutral pH using a fluorinated detergent. Acta Crystallogr F Struct Biol Commun. 2017;73:416-422 pubmed publisher
    ..The influence of pH on the molecular surface is likely to contribute to the pH dependency of the aerobic oxidation of ferrocytochrome c. ..
  9. Thiruselvam V, Sivaraman P, Kumarevel T, Ponnuswamy M. Crystal structure of the single-stranded RNA binding protein HutP from Geobacillus thermodenitrificans. Biochem Biophys Res Commun. 2014;446:945-51 pubmed publisher
    ..The addition of 0.5 M EDTA does not affect the overall metal-ion mediated ternary complex structure and however, the metal ions at the non-specific binding sites are chelated, as evidenced from the results of structural features. ..
  10. Meshcheryakov V, Nitanai Y, Maytum R, Geeves M, Maeda Y. Crystallization and preliminary X-ray crystallographic analysis of full-length yeast tropomyosin 2 from Saccharomyces cerevisiae. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008;64:528-30 pubmed publisher
    ..8, b = 49.9, c = 104.0 A, alpha = gamma = 90.0, beta = 124.0 degrees and two molecules in the asymmetric unit. A complete native X-ray diffraction data set was collected to 3.5 A resolution using synchrotron radiation. ..
  11. Iino H, Shimizu N, Goto M, Ebihara A, Fukui K, Hirotsu K, et al. Crystal structure of the tandem-type universal stress protein TTHA0350 from Thermus thermophilus HB8. J Biochem. 2011;150:295-302 pubmed publisher
    ..The loop interacting with ATP in the C-terminal domain is in a conformation quite different from that in the N-terminal domain...
  12. Vassylyev D, Sekine S, Laptenko O, Lee J, Vassylyeva M, Borukhov S, et al. Crystal structure of a bacterial RNA polymerase holoenzyme at 2.6 A resolution. Nature. 2002;417:712-9 pubmed publisher
    ..The holoenzyme structure provides insight into the structural organization of transcription intermediate complexes and into the mechanism of transcription initiation...
  13. Fukunaga Y, Matsubara M, Nagai R, Miyazawa A. The interaction between PSD-95 and Ca2+/calmodulin is enhanced by PDZ-binding proteins. J Biochem. 2005;138:177-82 pubmed
    ..The binding of ligands to the PDZ domain may change the conformation of PSD-95 and affect the interaction between PSD-95 and calmodulin. ..
  14. Komori H, Nitta Y, Ueno H, Higuchi Y. Structural study reveals that Ser-354 determines substrate specificity on human histidine decarboxylase. J Biol Chem. 2012;287:29175-83 pubmed publisher
    ..These data provide insight into the molecular basis of substrate recognition among the group II pyridoxal-5'-phosphate-dependent decarboxylases. ..
  15. Nakai T, Ishijima J, Masui R, Kuramitsu S, Kamiya N. Structure of Thermus thermophilus HB8 H-protein of the glycine-cleavage system, resolved by a six-dimensional molecular-replacement method. Acta Crystallogr D Biol Crystallogr. 2003;59:1610-8 pubmed
    ..Meanwhile, the lipoyl-lysine arm of the T. thermophilus H-protein was found to be more flexible than that of the pea H-protein, supporting the hypothesis that H-protein does not form a stable complex with L-protein during the reaction. ..
  16. Shibata N, Masuda J, Tobimatsu T, Toraya T, Suto K, Morimoto Y, et al. A new mode of B12 binding and the direct participation of a potassium ion in enzyme catalysis: X-ray structure of diol dehydratase. Structure. 1999;7:997-1008 pubmed
    ..On the basis of unique direct interactions between the potassium ion and the two hydroxyl groups of the substrate, direct participation of a potassium ion in enzyme catalysis is strongly suggested. ..
  17. Asada Y, Kuroishi C, Ukita Y, Sumii R, Endo S, Matsunaga T, et al. Dimeric crystal structure of rabbit L-gulonate 3-dehydrogenase/lambda-crystallin: insights into the catalytic mechanism. J Mol Biol. 2010;401:906-20 pubmed publisher
    ..Proper orientation of the substrate-binding residues for catalysis is likely to be maintained by an interprotomer hydrogen-bonding network of residues Asn196, Gln199, and Arg231, suggesting a network-based substrate recognition of GDH. ..
  18. Yamamoto H, Miwa H, Kunishima N. Crystal structure of glucose-6-phosphate isomerase from Thermus thermophilus HB8 showing a snapshot of active dimeric state. J Mol Biol. 2008;382:747-62 pubmed publisher
    ..From these results, it is suggested that transient dimer formation is sufficient for the catalytic function and that the TtGPI protomer itself has intrinsically higher thermal stability. ..
  19. Nakai T, Nakagawa N, Maoka N, Masui R, Kuramitsu S, Kamiya N. Structure of P-protein of the glycine cleavage system: implications for nonketotic hyperglycinemia. EMBO J. 2005;24:1523-36 pubmed publisher
    ..These results provide insights into the molecular basis of nonketotic hyperglycinemia...
  20. Sekine S, Nureki O, Shimada A, Vassylyev D, Yokoyama S. Structural basis for anticodon recognition by discriminating glutamyl-tRNA synthetase. Nat Struct Biol. 2001;8:203-6 pubmed publisher
    ..The mutation of Arg 358 to Gln resulted in a GluRS that does not discriminate between the Glu and Gln anticodons. This change mimics the reverse course of GluRS evolution from anticodon 'non-dicsriminating' to 'discriminating'...
  21. Saino H, Ukita Y, Ago H, Irikura D, Nisawa A, Ueno G, et al. The catalytic architecture of leukotriene C4 synthase with two arginine residues. J Biol Chem. 2011;286:16392-401 pubmed publisher
    ..In this study enzymatic assay with mutant enzymes demonstrates that Arg-104 is required for the binding and activation of GSH and that Arg-31 is needed for catalysis probably by activating the epoxide group of LTA(4). ..
  22. Lokanath N, Pampa K, Takio K, Kunishima N. Structures of dimeric nonstandard nucleotide triphosphate pyrophosphatase from Pyrococcus horikoshii OT3: functional significance of interprotomer conformational changes. J Mol Biol. 2008;375:1013-25 pubmed
    ..A combination of the exceptional interdomain and interprotomer relocations is most likely the reason for the observed asymmetric IMP binding that might be necessary for PhNTPase to release the reaction product IMP. ..
  23. Hoseki J, Okamoto A, Masui R, Shibata T, Inoue Y, Yokoyama S, et al. Crystal structure of a family 4 uracil-DNA glycosylase from Thermus thermophilus HB8. J Mol Biol. 2003;333:515-26 pubmed
    ..coli MUG (family 2). These results suggest that the mechanism by which family 4 UDGs remove uracils from DNA is similar to that of family 1 enzymes...
  24. Iwasaki W, Miki K. Crystal structure of the stationary phase survival protein SurE with metal ion and AMP. J Mol Biol. 2007;371:123-36 pubmed publisher
    ..The structural features and the absence of negative cooperativity imply the half-of-the-sites reactivity mechanism resulting from a pre-existing tendency toward structural asymmetry...
  25. Ago H, Oda M, Takahashi M, Tsuge H, Ochi S, Katunuma N, et al. Structural basis of the sphingomyelin phosphodiesterase activity in neutral sphingomyelinase from Bacillus cereus. J Biol Chem. 2006;281:16157-67 pubmed publisher
    ..In addition, the structural features and site-directed mutagenesis suggest that the specific beta-hairpin with the aromatic amino acid residues participates in binding to the membrane-bound sphingomyelin substrate...
  26. Shimizu M, Yamashita D, Yamaguchi T, Hirose F, Osumi T. Aspects of the regulatory mechanisms of PPAR functions: analysis of a bidirectional response element and regulation by sumoylation. Mol Cell Biochem. 2006;286:33-42 pubmed
    ..In addition, phosphorylation at a specific site in the amino-terminal region represses the transactivation by PPARgamma2 possibly through enhancing sumoylation. ..
  27. Yoshikawa S, Muramoto K, Shinzawa Itoh K, Mochizuki M. Structural studies on bovine heart cytochrome c oxidase. Biochim Biophys Acta. 2012;1817:579-89 pubmed publisher
    ..These functions of the pathway have been confirmed by site-directed mutagenesis of bovine CcO expressed in HeLa cells...
  28. Miyamoto K, Uechi A, Saito K. The zinc finger domain of RING finger protein 141 reveals a unique RING fold. Protein Sci. 2017;26:1681-1686 pubmed publisher
    ..Therefore, structural analysis may allow RFP141C to be used for designing an artificial RING finger possessing specific ubiquitin-conjugating enzyme (E2)-binding capabilities. ..
  29. Kim S, Hisano T, Iwasaki W, Ebihara A, Miki K. Crystal structure of the flavin reductase component (HpaC) of 4-hydroxyphenylacetate 3-monooxygenase from Thermus thermophilus HB8: Structural basis for the flavin affinity. Proteins. 2008;70:718-30 pubmed
  30. Kim S, Hisano T, Takeda K, Iwasaki W, Ebihara A, Miki K. Crystal structure of the oxygenase component (HpaB) of the 4-hydroxyphenylacetate 3-monooxygenase from Thermus thermophilus HB8. J Biol Chem. 2007;282:33107-17 pubmed publisher
    ..Arg-100 is located adjacent to the putative oxygen-binding site and may be involved in the formation and stabilization of the C4a-hydroperoxyflavin intermediate...
  31. Matoba Y, Kihara S, Muraki Y, Bando N, Yoshitsu H, Kuroda T, et al. Activation Mechanism of the Streptomyces Tyrosinase Assisted by the Caddie Protein. Biochemistry. 2017;56:5593-5603 pubmed publisher
    ..Aggregation of the caddie protein, which is triggered by the conversion of the Tyr98 residue to dopaquinone, may ensure the generation of fully activated tyrosinase...
  32. Ago H, Kanaoka Y, Irikura D, Lam B, Shimamura T, Austen K, et al. Crystal structure of a human membrane protein involved in cysteinyl leukotriene biosynthesis. Nature. 2007;448:609-12 pubmed
  33. Kimura Y, Sakai F, Nakano O, Kisaki O, Sugimoto H, Sawamura T, et al. The newly identified human nuclear protein NXP-2 possesses three distinct domains, the nuclear matrix-binding, RNA-binding, and coiled-coil domains. J Biol Chem. 2002;277:20611-7 pubmed
    ..The RNA-binding, nuclear matrix-binding, and coiled-coil domains are structurally separated, suggesting that NXP-2 plays important roles in diverse nuclear functions, including RNA metabolism and maintenance of nuclear architecture. ..
  34. Sugimoto H, Shinkyo R, Hayashi K, Yoneda S, Yamada M, Kamakura M, et al. Crystal structure of CYP105A1 (P450SU-1) in complex with 1alpha,25-dihydroxyvitamin D3. Biochemistry. 2008;47:4017-27 pubmed publisher
    ..These results provide the structural basis for understanding the mechanism of the two-step hydroxylation that activates VD 3. ..
  35. Nakatsu T, Ichiyama S, Hiratake J, Saldanha A, Kobashi N, Sakata K, et al. Structural basis for the spectral difference in luciferase bioluminescence. Nature. 2006;440:372-6 pubmed
    ..Our results indicate that the degree of molecular rigidity of the excited state of oxyluciferin, which is controlled by a transient movement of Ile 288, determines the colour of bioluminescence during the emission reaction...
  36. Kumarevel T, Nakano N, Ponnuraj K, Gopinath S, Sakamoto K, Shinkai A, et al. Crystal structure of glutamine receptor protein from Sulfolobus tokodaii strain 7 in complex with its effector L-glutamine: implications of effector binding in molecular association and DNA binding. Nucleic Acids Res. 2008;36:4808-20 pubmed publisher
  37. Tahirov T, Inagaki E, Ohshima N, Kitao T, Kuroishi C, Ukita Y, et al. Crystal structure of purine nucleoside phosphorylase from Thermus thermophilus. J Mol Biol. 2004;337:1149-60 pubmed publisher
    ..The obtained experimental data suggest that the catalytic properties of the T.thermophilus enzyme are reminiscent of the trimeric rather than hexameric purine nucleoside phosphorylases...
  38. Masuda N, Yasumo H, Furusawa T, Tsukamoto T, Sadano H, Osumi T. Nuclear receptor binding factor-1 (NRBF-1), a protein interacting with a wide spectrum of nuclear hormone receptors. Gene. 1998;221:225-33 pubmed
    ..NRBF-1 has a significant homology to the yeast protein MRF1, a putative transcription factor regulating the expression of mitochondrial respiratory proteins. NRBF-1 might be another type of nuclear receptor co-operator. ..
  39. Aoyama H, Muramoto K, Shinzawa Itoh K, Hirata K, Yamashita E, Tsukihara T, et al. A peroxide bridge between Fe and Cu ions in the O2 reduction site of fully oxidized cytochrome c oxidase could suppress the proton pump. Proc Natl Acad Sci U S A. 2009;106:2165-9 pubmed publisher
    ..The structural difference between the 2 fully oxidized forms suggests that the bound peroxide in the O(2) reduction site suppresses the proton pumping function. ..
  40. Hirano S, Asamizu S, Onaka H, Shiro Y, Nagano S. Crystal structure of VioE, a key player in the construction of the molecular skeleton of violacein. J Biol Chem. 2008;283:6459-66 pubmed publisher
    ..Based on these results, we propose that VioE traps the highly reactive substrate within the surface pocket to suppress CPA formation and promote protodeoxyviolaceinic acid formation caused by proximity and orientation effects. ..
  41. Omi R, Goto M, Miyahara I, Manzoku M, Ebihara A, Hirotsu K. Crystal structure of monofunctional histidinol phosphate phosphatase from Thermus thermophilus HB8. Biochemistry. 2007;46:12618-27 pubmed
  42. Sugahara M, Ohshima N, Ukita Y, Sugahara M, Kunishima N. Structure of ATP-dependent phosphoenolpyruvate carboxykinase from Thermus thermophilus HB8 showing the structural basis of induced fit and thermostability. Acta Crystallogr D Biol Crystallogr. 2005;61:1500-7 pubmed
    ..A bound calcium observed in the N-terminal domain of TtPEPCK probably contributes to the thermal stability. A combination of hydrophobic effects, ion pairs and entropic effects might also contribute to the thermostability of TtPEPCK. ..
  43. Kunishima N, Asada Y, Sugahara M, Ishijima J, Nodake Y, Sugahara M, et al. A novel induced-fit reaction mechanism of asymmetric hot dog thioesterase PAAI. J Mol Biol. 2005;352:212-28 pubmed publisher
  44. Takahashi H, Inagaki E, Kuroishi C, Tahirov T. Structure of the Thermus thermophilus putative periplasmic glutamate/glutamine-binding protein. Acta Crystallogr D Biol Crystallogr. 2004;60:1846-54 pubmed
    ..thermophilus HB8 molecule is most likely to be an L-glutamate and/or an L-glutamine-binding protein related to the cluster 3 periplasmic receptors. However, the geometry of ligand binding is unique to the T. thermophilus HB8 molecule. ..
  45. Hamada K, Ago H, Sugahara M, Nodake Y, Kuramitsu S, Miyano M. Oxyanion hole-stabilized stereospecific isomerization in ribose-5-phosphate isomerase (Rpi). J Biol Chem. 2003;278:49183-90 pubmed publisher
    ..R5P bound as the ring-opened reaction intermediate clarified the high stereoselectivity of the catalysis and is consistent with an aldose-ketose conversion by Rpi that proceeds via a cis-enediolate intermediate...
  46. Sekine S, Nureki O, Dubois D, Bernier S, Ch nevert R, Lapointe J, et al. ATP binding by glutamyl-tRNA synthetase is switched to the productive mode by tRNA binding. EMBO J. 2003;22:676-88 pubmed publisher
    ..Therefore, tRNA binding to GluRS switches the ATP-binding mode. The interactions of the three tRNA(Glu) regions with GluRS cause conformational changes around the ATP-binding site, and allow ATP to bind to the 'productive' subsite...
  47. Kamiya N, Shen J. Crystal structure of oxygen-evolving photosystem II from Thermosynechococcus vulcanus at 3.7-A resolution. Proc Natl Acad Sci U S A. 2003;100:98-103 pubmed publisher
    ..In particular, the C terminus of D1 polypeptide was shown to be connected to the Mn cluster directly. The structural information obtained here provides important insights into the mechanism of PSII reactions...
  48. Ihara M, Okajima T, Yamashita A, Oda T, Hirata K, Nishiwaki H, et al. Crystal structures of Lymnaea stagnalis AChBP in complex with neonicotinoid insecticides imidacloprid and clothianidin. Invert Neurosci. 2008;8:71-81 pubmed publisher
    ..Yet, the NH at position 1 of CTD makes a hydrogen bond with the backbone carbonyl of Trp143, offering an explanation for the diverse actions of neonicotinoids on nAChRs. ..
  49. Shomura Y, Komori H, Miyabe N, Tomiyama M, Shibata N, Higuchi Y. Crystal structures of hydrogenase maturation protein HypE in the Apo and ATP-bound forms. J Mol Biol. 2007;372:1045-54 pubmed publisher
    ..A glutamate residue is found close to the thiol group as well, which is suggestive of deprotonation of the carbamoyl group at the beginning of the reactions...
  50. Taka J, Ogasahara K, Jeyakanthan J, Kunishima N, Kuroishi C, Sugahara M, et al. Stabilization due to dimer formation of phosphoribosyl anthranilate isomerase from Thermus thermophilus HB8: X-ray Analysis and DSC experiments. J Biochem. 2005;137:569-78 pubmed
  51. Kumar S, Pampa K, Manjula M, Abdoh M, Kunishima N, Lokanath N. Crystal structure studies of NADP+ dependent isocitrate dehydrogenase from Thermus thermophilus exhibiting a novel terminal domain. Biochem Biophys Res Commun. 2014;449:107-13 pubmed publisher
    ..Overall, the TtIDH structure with novel terminal domain may be categorized as a first structure of subfamily of type IV. ..
  52. Fukui K, Iino H, Baba S, Kumasaka T, Kuramitsu S, Yano T. Crystal structure and DNA-binding property of the ATPase domain of bacterial mismatch repair endonuclease MutL from Aquifex aeolicus. Biochim Biophys Acta. 2017;1865:1178-1187 pubmed publisher
    ..On the basis of the model structure and further experimental results, we concluded that the two separate DNA-binding sites in the full-length A. aeolicus MutL simultaneously bind a dsDNA molecule. ..
  53. Usui D, Inaba S, Sekiguchi H, Sasaki Y, Tanaka T, Oda M. First observation of metal ion-induced structural fluctuations of ?-helical peptides by using diffracted X-ray tracking. Biophys Chem. 2017;228:81-86 pubmed publisher
    ..The metal-binding energies determined using the angular diffusion coefficients were in good agreement with those determined using isothermal titration calorimetry. ..