Experts and Doctors on autoimmune diseases in Tokushima, Japan
Locale: Tokushima, Japan
Topic: autoimmune diseases
Ishimaru N, Yoneda T, Saegusa K, Yanagi K, Haneji N, Moriyama K, et al
. Severe destructive autoimmune lesions with aging in murine Sjögren's syndrome through Fas-mediated apoptosis. Am J Pathol. 2000;156:1557-64 pubmed
..These results indicate that age-associated dysregulation of CD4(+) T cells may play a crucial role on acceleration of organ-specific autoimmune lesions in a murine model for primary SS through Fas-mediated apoptosis. ..
Hayashi Y, Arakaki R, Ishimaru N. The role of caspase cascade on the development of primary Sjögren's syndrome. J Med Invest. 2003;50:32-8 pubmed
..Thus, an increased activity in caspase cascade may be involved in the progression of alpha-fodrin proteolysis and tissue destruction on the development of SS...
Niki S, Oshikawa K, Mouri Y, Hirota F, Matsushima A, Yano M, et al
. Alteration of intra-pancreatic target-organ specificity by abrogation of Aire in NOD mice. J Clin Invest. 2006;116:1292-301 pubmed
Ishimaru N, Saegusa K, Yanagi K, Haneji N, Saito I, Hayashi Y. Estrogen deficiency accelerates autoimmune exocrinopathy in murine Sjögren's syndrome through fas-mediated apoptosis. Am J Pathol. 1999;155:173-81 pubmed
Kajiura F, Sun S, Nomura T, Izumi K, Ueno T, Bando Y, et al
. NF-kappa B-inducing kinase establishes self-tolerance in a thymic stroma-dependent manner. J Immunol. 2004;172:2067-75 pubmed
Ishimaru N, Arakaki R, Yoshida S, Yamada A, Noji S, Hayashi Y. Expression of the retinoblastoma protein RbAp48 in exocrine glands leads to Sjögren's syndrome-like autoimmune exocrinopathy. J Exp Med. 2008;205:2915-27 pubmed publisher
..These results indicate a novel immunocompetent role of epithelial cells that can produce IFN-gamma, resulting in loss of local tolerance before developing gender-based autoimmunity...
Izawa T, Kondo T, Kurosawa M, Oura R, Matsumoto K, Tanaka E, et al
. Fas-independent T-cell apoptosis by dendritic cells controls autoimmune arthritis in MRL/lpr mice. PLoS ONE. 2012;7:e48798 pubmed publisher
..These results strongly suggest that a novel Fas-independent apoptosis pathway in T cells maintains peripheral tolerance and thus controls autoimmunity in MRL/lpr mice. ..
Kozai M, Kubo Y, Katakai T, Kondo H, Kiyonari H, Schaeuble K, et al
. Essential role of CCL21 in establishment of central self-tolerance in T cells. J Exp Med. 2017;214:1925-1935 pubmed publisher
..These results indicate a nonredundant role of CCL21Ser in the establishment of self-tolerance in T cells in the thymic medulla, and reveal a functional inequality among CCR7 ligands in vivo. ..