Experts and Doctors on apoptosis in Kyoto, Japan


Locale: Kyoto, Japan
Topic: apoptosis

Top Publications

  1. Kobara M, Noda K, Kitamura M, Okamoto A, Shiraishi T, Toba H, et al. Antibody against interleukin-6 receptor attenuates left ventricular remodelling after myocardial infarction in mice. Cardiovasc Res. 2010;87:424-30 pubmed publisher
    ..Neutralization of the IL-6 receptor is a potentially useful strategy for protecting hearts from LV remodelling after MI. ..
  2. Matsuno K, Iwata K, Matsumoto M, Katsuyama M, Cui W, Murata A, et al. NOX1/NADPH oxidase is involved in endotoxin-induced cardiomyocyte apoptosis. Free Radic Biol Med. 2012;53:1718-28 pubmed publisher
    ..Marked up-regulation of NOX1 may affect the risk of mortality under systemic inflammatory conditions. ..
  3. Kwon Y, Ueda S, Ueno M, Yodoi J, Masutani H. Mechanism of p53-dependent apoptosis induced by 3-methylcholanthrene: involvement of p53 phosphorylation and p38 MAPK. J Biol Chem. 2002;277:1837-44 pubmed
    ..The current study shows that both p53 and p38 MAPK activation are required for MC-induced apoptosis and provides a novel model of a functional regulation between p53 and p38 MAPK in chemical stress-induced apoptosis. ..
  4. Sakamaki K, Takagi C, Kominami K, Sakata S, Yaoita Y, Kubota H, et al. The adaptor molecule FADD from Xenopus laevis demonstrates evolutionary conservation of its pro-apoptotic activity. Genes Cells. 2004;9:1249-64 pubmed
    ..Thus, the structural and functional similarities between xFADD and mammalian FADD provide evidence that the apoptotic pathways are evolutionally conserved across vertebrate species. ..
  5. Komada M, Fujiyama F, Yamada S, Shiota K, Nagao T. Methylnitrosourea induces neural progenitor cell apoptosis and microcephaly in mouse embryos. Birth Defects Res B Dev Reprod Toxicol. 2010;89:213-22 pubmed publisher
    ..Our data suggest that prenatal exposure to MNU induces the excessive cell death of neural precursor/stem cells, and the defective development of the cerebral cortex, resulting in microcephalic abnormalities. ..
  6. Imao T, Nagata S. Apaf-1- and Caspase-8-independent apoptosis. Cell Death Differ. 2013;20:343-52 pubmed publisher
  7. Suzuki J, Denning D, Imanishi E, Horvitz H, Nagata S. Xk-related protein 8 and CED-8 promote phosphatidylserine exposure in apoptotic cells. Science. 2013;341:403-6 pubmed publisher
    ..Thus, Xk-family proteins have evolutionarily conserved roles in promoting the phagocytosis of dying cells by altering the phospholipid distribution in the plasma membrane. ..
  8. Narita T, Ishida T, Ito A, Masaki A, Kinoshita S, Suzuki S, et al. Cyclin-dependent kinase 9 is a novel specific molecular target in adult T-cell leukemia/lymphoma. Blood. 2017;130:1114-1124 pubmed publisher
    ..Collectively, this study indicates that BAY 1143572 showed strong potential as a novel treatment of ATL. ..
  9. Tsuji S, Hosotani R, Yonehara S, Masui T, Tulachan S, Nakajima S, et al. Endogenous decoy receptor 3 blocks the growth inhibition signals mediated by Fas ligand in human pancreatic adenocarcinoma. Int J Cancer. 2003;106:17-25 pubmed
    ..These results suggest that DcR3 is highly expressed in many pancreatic cancers and endogenous DcR3 blocks the growth inhibition signals mediated by mFasL. DcR3 can be a candidate target molecule for the therapeutic intervention. ..

More Information

Publications259 found, 100 shown here

  1. Sakurai T, Itoh K, Higashitsuji H, Nonoguchi K, Liu Y, Watanabe H, et al. Cirp protects against tumor necrosis factor-alpha-induced apoptosis via activation of extracellular signal-regulated kinase. Biochim Biophys Acta. 2006;1763:290-5 pubmed
    ..These data suggest that mild hypothermia protects cells from TNF-alpha-induced apoptosis, at least partly, via induction of Cirp, and that Cirp protects cells by activating the ERK pathway. ..
  2. Urao N, Okigaki M, Yamada H, Aadachi Y, Matsuno K, Matsui A, et al. Erythropoietin-mobilized endothelial progenitors enhance reendothelialization via Akt-endothelial nitric oxide synthase activation and prevent neointimal hyperplasia. Circ Res. 2006;98:1405-13 pubmed
    ..In conclusion, Epo treatment inhibits the neointimal hyperplasia after arterial injury in an NO-dependent manner by acting on the injured vessels and mobilizing EPCs to the neo-endothelium. ..
  3. Sugiyama N, Yokoyama T. Sustained cell proliferation of renal epithelial cells in mice with inv mutation. Genes Cells. 2006;11:1213-24 pubmed
    ..One of the inv protein functions may provide a stop signal for renal epithelial cell proliferation. ..
  4. Higashitsuji H, Higashitsuji H, Masuda T, Liu Y, Itoh K, Fujita J. Enhanced deacetylation of p53 by the anti-apoptotic protein HSCO in association with histone deacetylase 1. J Biol Chem. 2007;282:13716-25 pubmed
    ..Treatment of hepatocellular carcinomas that retain wild-type p53 and overexpress HSCO with anti-HSCO agents might re-establish the p53 response and revert chemoresistance. ..
  5. Furuta K, Nakayama K, Sugimoto Y, Ichikawa A, Tanaka S. Activation of histidine decarboxylase through post-translational cleavage by caspase-9 in a mouse mastocytoma P-815. J Biol Chem. 2007;282:13438-46 pubmed
    ..These results suggest that, in P-815 cells, histamine synthesis is augmented through the post-translational cleavage of HDC, which is mediated by caspase-9...
  6. Nagata S. Apoptosis and autoimmune diseases. Ann N Y Acad Sci. 2010;1209:10-6 pubmed publisher
    ..Data from these mutant mice and human patients indicate that defects in cell death or dead-cell clearance leads to autoimmunity. This review examines the cell death and clearance processes and briefly discusses the diseases they cause. ..
  7. Sakurai A, Morita S, Wakita K, Deharu Y, Nakano M, Handa T. Effects of cholesterol in chylomicron remnant models of lipid emulsions on apoE-mediated uptake and cytotoxicity of macrophages. J Lipid Res. 2005;46:2214-20 pubmed
    ..Trypan blue dye exclusion revealed that the uptake of Chol-containing emulsions induced cytotoxicity to J774 macrophages. This study proposes a mechanism of atherosclerosis induced by chylomicron remnants. ..
  8. Kondo N, Ishii Y, Kwon Y, Tanito M, Sakakura Nishiyama J, Mochizuki M, et al. Lipid raft-mediated uptake of cysteine-modified thioredoxin-1: apoptosis enhancement by inhibiting the endogenous thioredoxin-1. Antioxid Redox Signal. 2007;9:1439-48 pubmed
    ..These findings suggest that the cysteine at the active site of TRX plays a key role in the internalization and signal transduction of extracellular TRX into the cells. ..
  9. Okabe Y, Sano T, Nagata S. Regulation of the innate immune response by threonine-phosphatase of Eyes absent. Nature. 2009;460:520-4 pubmed publisher
  10. Kobayashi T, Kuroda J, Ashihara E, Oomizu S, Terui Y, Taniyama A, et al. Galectin-9 exhibits anti-myeloma activity through JNK and p38 MAP kinase pathways. Leukemia. 2010;24:843-50 pubmed publisher
    ..Finally, hGal9 potently inhibited the growth of human myeloma cells xenografted in nude mice. These suggest that hGal9 is a new therapeutic target for MM that may overcome resistance to conventional chemotherapy. ..
  11. Ozasa R, Okada T, Nadanaka S, Nagamine T, Zyryanova A, Harding H, et al. The antipsychotic olanzapine induces apoptosis in insulin-secreting pancreatic β cells by blocking PERK-mediated translational attenuation. Cell Struct Funct. 2013;38:183-95 pubmed
  12. Iwai Kanai E, Hasegawa K, Sawamura T, Fujita M, Yanazume T, Toyokuni S, et al. Activation of lectin-like oxidized low-density lipoprotein receptor-1 induces apoptosis in cultured neonatal rat cardiac myocytes. Circulation. 2001;104:2948-54 pubmed
  13. Yamori M, Yoshida M, Watanabe T, Shirai Y, Iizuka T, Kita T, et al. Antigenic activation of Th1 cells in the gastric mucosa enhances dysregulated apoptosis and turnover of the epithelial cells. Biochem Biophys Res Commun. 2004;316:1015-21 pubmed
    ..Thus, Th1 type T cells infiltrating into gastric mucosa play an independent role in controlling turnover of epithelial cells. ..
  14. Yamazaki T, Sasaki N, Nishi M, Takeshima H. Facilitation of DNA damage-induced apoptosis by endoplasmic reticulum protein mitsugumin23. Biochem Biophys Res Commun. 2010;392:196-200 pubmed publisher
    ..It is therefore suggested that MG23 is an essential component of ER-generated lethal signals provoked upon DNA damage, specifying cell fate under pathophysiological conditions. ..
  15. Horiguchi N, Arimoto K, Mizutani A, Endo Ichikawa Y, Nakada H, Taketani S. Galectin-1 induces cell adhesion to the extracellular matrix and apoptosis of non-adherent human colon cancer Colo201 cells. J Biochem. 2003;134:869-74 pubmed
    ..These results indicate that galectin-1 plays a role in both cell-matrix interactions and the inhibition of Colo201 cell proliferation, and suggest that galectin-1 expressed in cells could be associated with apoptosis. ..
  16. Sakurai T, Itoh K, Liu Y, Higashitsuji H, Sumitomo Y, Sakamaki K, et al. Low temperature protects mammalian cells from apoptosis initiated by various stimuli in vitro. Exp Cell Res. 2005;309:264-72 pubmed
    ..In conclusion, mild hypothermia protects cells from a variety of stress by p53-dependent and p53-independent mechanisms. ..
  17. Yoshino T, Nakase H, Honzawa Y, Matsumura K, Yamamoto S, Takeda Y, et al. Immunosuppressive effects of tacrolimus on macrophages ameliorate experimental colitis. Inflamm Bowel Dis. 2010;16:2022-33 pubmed publisher
    ..Tacrolimus suppresses the function of activated macrophages and promotes their apoptosis, which may lead to the amelioration of colonic inflammation. ..
  18. Watanabe M, Sowa Y, Yogosawa M, Sakai T. Novel MEK inhibitor trametinib and other retinoblastoma gene (RB)-reactivating agents enhance efficacy of 5-fluorouracil on human colon cancer cells. Cancer Sci. 2013;104:687-93 pubmed publisher
    ..In particular, we strongly expect trametinib, which was discovered in Japan and was recently submitted to FDA for approval, to be used together with established regimens for colorectal cancer. ..
  19. Shoji T, Tanaka F, Takata T, Yanagihara K, Otake Y, Hanaoka N, et al. Clinical significance of p21 expression in non-small-cell lung cancer. J Clin Oncol. 2002;20:3865-71 pubmed
    ..There was no significant correlation between p21 expression and p53 status, proliferative activity, or incidence of apoptosis. p21 expression was shown to be an independent prognostic factor in NSCLC. ..
  20. Oyamada N, Sone M, Miyashita K, Park K, Taura D, Inuzuka M, et al. The role of mineralocorticoid receptor expression in brain remodeling after cerebral ischemia. Endocrinology. 2008;149:3764-77 pubmed publisher
    ..By these beneficial effects, the infarct volume was significantly reduced in spironolactone-treated mice. Spironolactone may thus provide therapeutic neuroprotective effects in the ischemic brain after stroke. ..
  21. Nakaya M, Kitano M, Matsuda M, Nagata S. Spatiotemporal activation of Rac1 for engulfment of apoptotic cells. Proc Natl Acad Sci U S A. 2008;105:9198-203 pubmed publisher
    ..These results indicate that activated Rac1 is necessary to assemble F-actin, but closing the phagocytic cup requires Rac1 to be deactivated. ..
  22. Ikegawa M, Han H, Okamoto A, Matsui R, Tanaka M, Omi N, et al. Syndactyly and preaxial synpolydactyly in the single Sfrp2 deleted mutant mice. Dev Dyn. 2008;237:2506-17 pubmed publisher
    ..Although joint formation was not disrupted, chondrocyte maturation was preaxially disturbed. Our results suggest that the Sfrp2 deleted mice can be a useful animal model to study human syndactyly/preaxial synpolydactyly defects...
  23. Shinnoh M, Horinaka M, Yasuda T, Yoshikawa S, Morita M, Yamada T, et al. Clostridium butyricum MIYAIRI 588 shows antitumor effects by enhancing the release of TRAIL from neutrophils through MMP-8. Int J Oncol. 2013;42:903-11 pubmed publisher
    ..Taken together, these results strongly suggest that CBM588 is promising for a safer and more effective therapy against bladder cancer...
  24. Yanai G, Hayashi T, Zhi Q, Yang K, Shirouzu Y, Shimabukuro T, et al. Electrofusion of mesenchymal stem cells and islet cells for diabetes therapy: a rat model. PLoS ONE. 2013;8:e64499 pubmed publisher
    ..These results show that electrofusion between MSCs and islet cells yield special cells with ?-cell function and robustness of MSCs and seems feasible for novel therapeutic strategy for diabetes mellitus. ..
  25. Kobayashi S, Yamashita K, Takeoka T, Ohtsuki T, Suzuki Y, Takahashi R, et al. Calpain-mediated X-linked inhibitor of apoptosis degradation in neutrophil apoptosis and its impairment in chronic neutrophilic leukemia. J Biol Chem. 2002;277:33968-77 pubmed
    ..These observations suggest that calpain-mediated XIAP degradation contributes to initiation of apoptosis in normal neutrophils and dysfunction of this regulatory pathway can lead to pathological neutrophil accumulation. ..
  26. Sadamasa N, Nozaki K, Takagi Y, Moriwaki T, Kawanabe Y, Ishikawa M, et al. Cerebral aneurysm progression suppressed by blockage of endothelin B receptor. J Neurosurg. 2007;106:330-6 pubmed
    ..These results suggest that ETBR might play a significant role in the progression of cerebral aneurysms and have the potential to improve prevention and treatment of cerebral aneurysms. ..
  27. Takada Takatori Y, Kume T, Ohgi Y, Izumi Y, Niidome T, Fujii T, et al. Mechanism of neuroprotection by donepezil pretreatment in rat cortical neurons chronically treated with donepezil. J Neurosci Res. 2008;86:3575-83 pubmed publisher
    ..This study provides novel insight into the mechanism of donepezil-induced neuroprotection that involves nAChR up-regulation. ..
  28. Nagai R, Hashimoto R, Tanaka Y, Taguchi O, Sato M, Matsukage A, et al. Syntrophin-2 is required for eye development in Drosophila. Exp Cell Res. 2010;316:272-85 pubmed publisher
    ..This information should facilitate identification of Syn2 regulators in Drosophila and clarification of roles of Syn2 in eye development. ..
  29. Otani A, Kojima H, Guo C, Oishi A, Yoshimura N. Low-dose-rate, low-dose irradiation delays neurodegeneration in a model of retinitis pigmentosa. Am J Pathol. 2012;180:328-36 pubmed publisher
  30. Nagai H, Yasuda H, Hatachi Y, Xue D, Sasaki T, Yamaya M, et al. Nitric oxide (NO) enhances pemetrexed cytotoxicity via NO‑cGMP signaling in lung adenocarcinoma cells in vitro and in vivo. Int J Oncol. 2012;41:24-30 pubmed publisher
    ..These findings suggest that NO donors, such as NOC-18 and GTN, enhance the anticancer effects of PEM by increasing the RFC1 and FPGS expression and stimulating cGMP signaling pathways in cancer cells. ..
  31. Okumura N, Kitahara M, Okuda H, Hashimoto K, Ueda E, Nakahara M, et al. Sustained Activation of the Unfolded Protein Response Induces Cell Death in Fuchs' Endothelial Corneal Dystrophy. Invest Ophthalmol Vis Sci. 2017;58:3697-3707 pubmed publisher
    ..Prolonged ER stress-mediated cell death, occurring via the intrinsic apoptotic signaling pathway, therefore might be associated with the pathogenesis of FECD. ..
  32. Tamura A, Hirai H, Yokota A, Kamio N, Sato A, Shoji T, et al. C/EBPβ is required for survival of Ly6C- monocytes. Blood. 2017;130:1809-1818 pubmed publisher
    ..Collectively, these results indicate that C/EBPβ is a critical factor for Ly6C- monocyte survival, at least in part through upregulation of Csf1r. ..
  33. Paumen M, Ishida Y, Muramatsu M, Yamamoto M, Honjo T. Inhibition of carnitine palmitoyltransferase I augments sphingolipid synthesis and palmitate-induced apoptosis. J Biol Chem. 1997;272:3324-9 pubmed
    ..Inhibition of CPT I by etomoxir enhanced palmitate-induced cell death and led to a further increase in ceramide synthesis. ..
  34. Nakai A, Suzuki M, Tanabe M. Arrest of spermatogenesis in mice expressing an active heat shock transcription factor 1. EMBO J. 2000;19:1545-54 pubmed
    ..These results suggest that male infertility caused by thermal insult is at least partly due to the activation of HSF1, which induces the primary spermatocytes to undergo apoptosis. ..
  35. Harada H, Kizaka Kondoh S, Hiraoka M. Mechanism of hypoxia-specific cytotoxicity of procaspase-3 fused with a VHL-mediated protein destruction motif of HIF-1alpha containing Pro564. FEBS Lett. 2006;580:5718-22 pubmed
    ..These data demonstrated that the VHL-mediated protein destruction motif of HIF-1alpha endowed procaspase-3 with hypoxia-specific cytotoxicity. ..
  36. Naito Y, Yoshikawa T. Oxidative stress involvement and gene expression in indomethacin-induced gastropathy. Redox Rep. 2006;11:243-53 pubmed
  37. Miyagawa Hayashino A, Tsuruyama T, Egawa H, Haga H, Sakashita H, Okuno T, et al. FasL expression in hepatic antigen-presenting cells and phagocytosis of apoptotic T cells by FasL+ Kupffer cells are indicators of rejection activity in human liver allografts. Am J Pathol. 2007;171:1499-508 pubmed
    ..In conclusion, our data suggest that FasL expression on APCs and phagocytosis of apoptotic T cells by FasL(+) KCs are indicators of rejection activity in human liver allografts. ..
  38. Yamanaka Y, Heike T, Kumada T, Shibata M, Takaoka Y, Kitano A, et al. Loss of Borealin/DasraB leads to defective cell proliferation, p53 accumulation and early embryonic lethality. Mech Dev. 2008;125:441-50 pubmed publisher
    ..Our data show that Borealin/DasraB is essential for cell proliferation during early embryonic development, and its early embryonic lethality cannot be rescued by the loss of p53. ..
  39. Takai K, Sakamoto S, Sakai T, Yasunaga J, Komatsu K, Matsuoka M. A potential link between alternative splicing of the NBS1 gene and DNA damage/environmental stress. Radiat Res. 2008;170:33-40 pubmed publisher
    ..Thus alternative splicing of the NBS1 gene may be associated with the regulation of NBS1 in response to DSBs, DNA alkylation damage, and mitogenic response. ..
  40. Hatsugai N, Iwasaki S, Tamura K, Kondo M, Fuji K, Ogasawara K, et al. A novel membrane fusion-mediated plant immunity against bacterial pathogens. Genes Dev. 2009;23:2496-506 pubmed publisher
    ..Thus, this novel defense strategy through proteasome-regulating membrane fusion of the vacuolar and plasma membranes provides plants with a mechanism for attacking intercellular bacterial pathogens. ..
  41. Isodono K, Takahashi T, Imoto H, Nakanishi N, Ogata T, Asada S, et al. PARM-1 is an endoplasmic reticulum molecule involved in endoplasmic reticulum stress-induced apoptosis in rat cardiac myocytes. PLoS ONE. 2010;5:e9746 pubmed publisher
    ..These results suggested that PARM-1 is a novel ER transmembrane molecule involved in cardiac remodeling in hypertensive heart disease. ..
  42. Katano M, Numata T, Aguan K, Hara Y, Kiyonaka S, Yamamoto S, et al. The juvenile myoclonic epilepsy-related protein EFHC1 interacts with the redox-sensitive TRPM2 channel linked to cell death. Cell Calcium. 2012;51:179-85 pubmed publisher
  43. Tsukamoto T, Hama S, Kogure K, Tsuchiya H. Selenate induces epithelial-mesenchymal transition in a colorectal carcinoma cell line by AKT activation. Exp Cell Res. 2013;319:1913-21 pubmed publisher
    ..These results suggest that although sodium selenate is a potential anticancer drug, deleterious effects of EMT induction should be taken into careful consideration. ..
  44. Kuroki S, Akiyoshi M, Tokura M, Miyachi H, Nakai Y, Kimura H, et al. JMJD1C, a JmjC domain-containing protein, is required for long-term maintenance of male germ cells in mice. Biol Reprod. 2013;89:93 pubmed publisher
    ..Our studies demonstrated that JMJD1C contributes to the long-term maintenance of the male germ line. ..
  45. Kitamura Y, Koide M, Akakabe Y, Matsuo K, Shimoda Y, Soma Y, et al. Manipulation of cardiac phosphatidylinositol 3-kinase (PI3K)/Akt signaling by apoptosis regulator through modulating IAP expression (ARIA) regulates cardiomyocyte death during doxorubicin-induced cardiomyopathy. J Biol Chem. 2014;289:2788-800 pubmed publisher
    ..These studies, therefore, revealed a previously undescribed mode of manipulating cardiac PI3K/Akt signaling by ARIA, thus identifying ARIA as an attractive new target for the prevention of stress-induced myocardial dysfunction. ..
  46. Nemoto A, Saida S, Kato I, Kikuchi J, Furukawa Y, Maeda Y, et al. Specific Antileukemic Activity of PD0332991, a CDK4/6 Inhibitor, against Philadelphia Chromosome-Positive Lymphoid Leukemia. Mol Cancer Ther. 2016;15:94-105 pubmed publisher
  47. Hyoh Y, Ishizaka S, Horii T, Fujiwara A, Tegoshi T, Yamada M, et al. Activation of caspases in intestinal villus epithelial cells of normal and nematode infected rats. Gut. 2002;50:71-7 pubmed
    ..Caspase-3 may have an important role in the physiological replacement of IEC as well as in progression of IEC apoptosis induced by nematode infection. ..
  48. Kondo T, Kitano T, Iwai K, Watanabe M, Taguchi Y, Yabu T, et al. Control of ceramide-induced apoptosis by IGF-1: involvement of PI-3 kinase, caspase-3 and catalase. Cell Death Differ. 2002;9:682-92 pubmed
    ..In summary, these results suggest that IGF-1/PI-3 kinase inhibited C2-ceramide-induced apoptosis due to relieving oxidative damage, which resulted from the inhibition of catalase by activated caspase-3. ..
  49. Kim T, Nakagawa T, Endo T, Iguchi F, Murai N, Naito Y, et al. Alteration of E-cadherin and beta-catenin in mouse vestibular epithelia during induction of apoptosis. Neurosci Lett. 2002;329:173-6 pubmed
    ..These findings suggest that the E-cadherin-beta-catenin complex plays roles in degeneration and subsequent repair processes in vestibular epithelia affected by aminoglycosides. ..
  50. Harada S, Nakata T, Oguni A, Kido H, Hatta T, Fukuyama R, et al. Contrasting effects of angiotensin type 1 and 2 receptors on nitric oxide release under pressure. Hypertens Res. 2002;25:779-86 pubmed
    ..In addition, the increase of AT2R gene expression in ECs during exposure to pressure may compensate for the reduction of NO. ..
  51. Yu S, Tanabe T, Yoshimura N. A rat model of glaucoma induced by episcleral vein ligation. Exp Eye Res. 2006;83:758-70 pubmed
  52. Yoshida H, Nadanaka S, Sato R, Mori K. XBP1 is critical to protect cells from endoplasmic reticulum stress: evidence from Site-2 protease-deficient Chinese hamster ovary cells. Cell Struct Funct. 2006;31:117-25 pubmed
    ..We concluded that ATF6-mediated induction of XBP1 mRNA is important to the production of pXBP1(S), activation of XBP1-target genes, and protection of cells from ER stress. ..
  53. Fujimoto M, Takagi Y, Aoki T, Hayase M, Marumo T, Gomi M, et al. Tissue inhibitor of metalloproteinases protect blood-brain barrier disruption in focal cerebral ischemia. J Cereb Blood Flow Metab. 2008;28:1674-85 pubmed publisher
    ..These results suggest that TIMP-1 inhibits MMP-9 activity and can play a neuroprotective role in cerebral ischemia. ..
  54. Kawane K, Nagata S. Nucleases in programmed cell death. Methods Enzymol. 2008;442:271-87 pubmed publisher
    ..These techniques are useful for studying DNases that are involved in programmed cell death and for following the engulfment of apoptotic cells by phagocytes. ..
  55. Hasegawa G, Yamasaki M, Kadono M, Tanaka M, Asano M, Senmaru T, et al. Senescence marker protein-30/gluconolactonase deletion worsens glucose tolerance through impairment of acute insulin secretion. Endocrinology. 2010;151:529-36 pubmed publisher
    ..Decreased SMP30/GNL may contribute to the worsening of glucose tolerance that occurs in normal aging. ..
  56. Horinaka M, Yoshida T, Nakata S, Shiraishi T, Tomosugi M, Yoshikawa S, et al. Aclarubicin enhances tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis through death receptor 5 upregulation. Cancer Sci. 2012;103:282-7 pubmed publisher
    ..These results suggest the combination of TRAIL and ACR to be a promising treatment for malignant tumors. ..
  57. Saeki T, Yui S, Hirai T, Fujii T, Okada S, Kanamoto R. Ursodeoxycholic acid protects colon cancer HCT116 cells from deoxycholic acid-induced apoptosis by inhibiting apoptosome formation. Nutr Cancer. 2012;64:617-26 pubmed publisher
    ..Our results indicate that UDC protects colon cancer cells from apoptosis induced by hydrophobic bile acids, by inhibiting apoptosome formation independently of the survival signals mediated by the PI3K, MAPK, or cAMP pathways. ..
  58. Sakurai A, Matsuda M, Kiyokawa E. Activated Ras protein accelerates cell cycle progression to perturb Madin-Darby canine kidney cystogenesis. J Biol Chem. 2012;287:31703-11 pubmed publisher
    ..The system developed here can be applied to drug screening for various cancers originating from epithelial cells...
  59. Tona Y, Inaoka T, Ito J, Kawano S, Nakagawa T. Development of an electrode for the artificial cochlear sensory epithelium. Hear Res. 2015;330:106-12 pubmed publisher
    ..028). These findings indicated that the new electrodes efficiently fixed the device in the cochlea and were able to stimulate spiral ganglion neurons. ..
  60. Yu Z, Taniguchi J, Wei Y, Pandian G, Hashiya K, Bando T, et al. Antiproliferative and apoptotic activities of sequence-specific histone acetyltransferase inhibitors. Eur J Med Chem. 2017;138:320-327 pubmed publisher
    ..Our research on sequence-specific dual-target epigenetic repressor offers us an alternative way to modulate HAT-governed therapeutically important genes and contributes to offer a fresh insight into antitumor therapeutics. ..
  61. Kawahito Y, Kondo M, Tsubouchi Y, Hashiramoto A, Bishop Bailey D, Inoue K, et al. 15-deoxy-delta(12,14)-PGJ(2) induces synoviocyte apoptosis and suppresses adjuvant-induced arthritis in rats. J Clin Invest. 2000;106:189-97 pubmed
    ..These findings suggest that PPAR-gamma may be an important immunoinflammatory mediator and its ligands, especially 15d-PGJ(2), may be useful in the treatment of RA. ..
  62. Ehara N, Hasegawa K, Ono K, Kawamura T, Iwai Kanai E, Morimoto T, et al. Activators of PPARgamma antagonize protection of cardiac myocytes by endothelin-1. Biochem Biophys Res Commun. 2004;321:345-9 pubmed
    ..These findings demonstrate that activators of PPARgamma perturb the anti-apoptotic effects of ET-1 in cardiac myocytes and that this perturbation is, in part, based on functional transcriptional cross-talk between NFATc and PPARgamma. ..
  63. Shang D, Ito N, Kamoto T, Ogawa O. Demethylating agent 5-aza-2'-deoxycytidine enhances susceptibility of renal cell carcinoma to paclitaxel. Urology. 2007;69:1007-12 pubmed
  64. Murashima Suginami A, Takahashi K, Sakata T, Tsukamoto H, Sugai M, Yanagita M, et al. Enhanced BMP signaling results in supernumerary tooth formation in USAG-1 deficient mouse. Biochem Biophys Res Commun. 2008;369:1012-6 pubmed publisher
    ..Based upon these results, we conclude that enhanced BMP signaling results in supernumerary teeth and BMP signaling was modulated by Wnt signaling in the USAG-1 deficient mouse model. ..
  65. Zeng L, Ou G, Itasaka S, Harada H, Xie X, Shibuya K, et al. TS-1 enhances the effect of radiotherapy by suppressing radiation-induced hypoxia-inducible factor-1 activation and inducing endothelial cell apoptosis. Cancer Sci. 2008;99:2327-35 pubmed publisher
    ..Our findings strengthen the importance of both HIF-1 and its downstream gene, such as vascular endothelial cell growth factor, as therapeutic targets to enhance the effect of radiotherapy. ..
  66. Chen Z, Yoshihara E, Son A, Matsuo Y, Masutani H, Sugie K, et al. Differential roles of Annexin A1 (ANXA1/lipocortin-1/lipomodulin) and thioredoxin binding protein-2 (TBP-2/VDUP1/TXNIP) in glucocorticoid signaling of HTLV-I-transformed T cells. Immunol Lett. 2010;131:11-8 pubmed publisher
  67. Imanaka Y, Tsuchiya S, Sato F, Shimada Y, Shimizu K, Tsujimoto G. MicroRNA-141 confers resistance to cisplatin-induced apoptosis by targeting YAP1 in human esophageal squamous cell carcinoma. J Hum Genet. 2011;56:270-6 pubmed publisher
    ..Our study highlights an important regulatory role for miR-141 in the development of cisplatin resistance in ESCC. ..
  68. Akagami M, Kawada K, Kubo H, Kawada M, Takahashi M, Kaganoi J, et al. Transcriptional factor Prox1 plays an essential role in the antiproliferative action of interferon-? in esophageal cancer cells. Ann Surg Oncol. 2011;18:3868-77 pubmed publisher
    ..Prox1 mediates the antiproliferative effect by IFN-? in ESCC cells. Prox1 may be a candidate target for novel therapeutic strategies of ESCCs. ..
  69. Nagao R, Ashihara E, Kimura S, Strovel J, Yao H, Takeuchi M, et al. Growth inhibition of imatinib-resistant CML cells with the T315I mutation and hypoxia-adaptation by AV65--a novel Wnt/β-catenin signaling inhibitor. Cancer Lett. 2011;312:91-100 pubmed publisher
    ..The combination of AV65 with IM had a synergistic inhibitory effect on the proliferation of CML cells. These findings suggest that AV65 could be a novel therapeutic agent for the treatment of CML. ..
  70. Fukui M, Senmaru T, Hasegawa G, Yamazaki M, Asano M, Kagami Y, et al. 17?-Estradiol attenuates saturated fatty acid diet-induced liver injury in ovariectomized mice by up-regulating hepatic senescence marker protein-30. Biochem Biophys Res Commun. 2011;415:252-7 pubmed publisher
    ..These results suggest that E2 supplementation attenuates HSFD-induced liver apoptotic death in ovariectomized mice by up-regulating SMP30. ..
  71. Yamashiro C, Hirota T, Kurimoto K, Nakamura T, Yabuta Y, Nagaoka S, et al. Persistent Requirement and Alteration of the Key Targets of PRDM1 During Primordial Germ Cell Development in Mice. Biol Reprod. 2016;94:7 pubmed publisher
    ..Our findings provide critical insight into the mechanism for maintaining the transcriptional integrity of PGCs. ..
  72. Shimono K, Fujimoto A, Tsuyama T, Yamamoto Kochi M, Sato M, Hattori Y, et al. Multidendritic sensory neurons in the adult Drosophila abdomen: origins, dendritic morphology, and segment- and age-dependent programmed cell death. Neural Dev. 2009;4:37 pubmed publisher
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