Experts and Doctors on animals in Tokyo, Japan

Summary

Locale: Tokyo, Japan
Topic: animals

Top Publications

  1. Mishiro S, Hoshi Y, Takeda K, Yoshikawa A, Gotanda T, Takahashi K, et al. Non-A, non-B hepatitis specific antibodies directed at host-derived epitope: implication for an autoimmune process. Lancet. 1990;336:1400-3 pubmed
    ..Detection of anti-GOR would therefore help in the diagnosis of NANBH and in reducing the occurrence of post-transfusion hepatitis. ..
  2. Kawada M, Fukazawa H, Mizuno S, Uehara Y. Inhibition of anchorage-independent growth of ras-transformed cells on polyHEMA surface by antisense oligodeoxynucleotides directed against K-ras. Biochem Biophys Res Commun. 1997;231:735-7 pubmed
    ..Using polyHEMA plates, the direct addition of AS ODNs to the cells growing anchorage-independently and various treatment schedules of AS ODNs are now available to identify the most desirable conditions for AS ODNs treatment. ..
  3. Ou Z, Nakayama K, Doi N, Saito T, Natori Y. Effective methylprednisolone dose in experimental crescentic glomerulonephritis. Am J Kidney Dis. 2001;37:411-7 pubmed
  4. Kikuchi H, Amano H, Yamada S. Putative role of basement membrane for dentinogenesis in the mesenchyme of murine dental papillae in vitro. Cell Tissue Res. 2001;303:93-107 pubmed
    ..The BM therefore serves as a structural meshwork that acts as a foothold for cell immobilisation; its components act as ligands for RGD-dependent cell adhesion and it stores TGF-beta1, which regulates ECM production...
  5. Shiraishi A, Higashi S, Masaki T, Saito M, Ito M, Ikeda S, et al. A comparison of alfacalcidol and menatetrenone for the treatment of bone loss in an ovariectomized rat model of osteoporosis. Calcif Tissue Int. 2002;71:69-79 pubmed
    ..These results have important implications in understanding the characteristic actions of vitamin K and active vitamin D on bone metabolism. ..
  6. Kai H, Koine T, Baba M, Okuyama T. [Pharmacological effects of Daphne genkwa and Chinese medical prescription, "Jyu-So-To"]. Yakugaku Zasshi. 2004;124:349-54 pubmed
    ..The water extract of D. genkwa clearly inhibited the IPR ear swelling. These results suggest that D. genkwa and Jyu-So-To should be a promising source of antitumor, antiinflammatory, and antiallergy agents...
  7. Kato H, Tamamizu Kato S, Shibasaki F. Histone deacetylase 7 associates with hypoxia-inducible factor 1alpha and increases transcriptional activity. J Biol Chem. 2004;279:41966-74 pubmed
    ..Taken together, these results indicate that HDAC7 is a novel transcriptional activator of HIF-1alpha ..
  8. Kobayashi Y, Sakai R, Ohshiro N, Ohbayashi M, Kohyama N, Yamamoto T. Possible involvement of organic anion transporter 2 on the interaction of theophylline with erythromycin in the human liver. Drug Metab Dispos. 2005;33:619-22 pubmed
    ..Our present findings suggest that hOat2 may, at least in part, be involved in the theophylline-erythromycin interaction in the human liver. ..
  9. Yamauchi M, Miya M, Machida R, Nishida M. PCR-based approach for sequencing mitochondrial genomes of decapod crustaceans, with a practical example from kuruma prawn (Marsupenaeus japonicus). Mar Biotechnol (NY). 2004;6:419-29 pubmed
    ..As a practical example, the mitogenomic sequence for a kuruma prawn Marsupenaeus japonicus (Crustacea: Decapoda), was determined using the PCR-based approach. ..

More Information

Publications985 found, 100 shown here

  1. Kanuka H, Kuranaga E, Takemoto K, Hiratou T, Okano H, Miura M. Drosophila caspase transduces Shaggy/GSK-3beta kinase activity in neural precursor development. EMBO J. 2005;24:3793-806 pubmed
    ..These results imply a novel role for caspases in modulating cell signaling pathways through substrate cleavage in neural precursor development...
  2. Sakamoto T, Kondo K, Kashio A, Suzukawa K, Yamasoba T. Methimazole-induced cell death in rat olfactory receptor neurons occurs via apoptosis triggered through mitochondrial cytochrome c-mediated caspase-3 activation pathway. J Neurosci Res. 2007;85:548-57 pubmed
  3. Yao R, Natsume Y, Noda T. TACC3 is required for the proper mitosis of sclerotome mesenchymal cells during formation of the axial skeleton. Cancer Sci. 2007;98:555-62 pubmed
    ..Thus, in addition to spindle assembly, Tacc3 has critical roles in chromosome separation and cytokinesis, and is essential for the mitosis of sclerotome mesenchymal cells during axial formation in mammals. ..
  4. Matsumoto T, Shiina H, Kawano H, Sato T, Kato S. Androgen receptor functions in male and female physiology. J Steroid Biochem Mol Biol. 2008;109:236-41 pubmed publisher
    ..The physiological importance of AR function currently recognized in female reproduction also has been verified in mouse genetic model. Here we review functions of AR in male and female physiology as revealed by mice lacking AR. ..
  5. Morioka A, Asai T, Nitta H, Yamamoto K, Ogikubo Y, Takahashi T, et al. Recent trends in antimicrobial susceptibility and the presence of the tetracycline resistance gene in Actinobacillus pleuropneumoniae isolates in Japan. J Vet Med Sci. 2008;70:1261-4 pubmed
    ..In OTC-resistant isolates, tetB has been the most frequently isolated gene in Japan. It is likely that the dissemination of tetB has contributed to the increased OTC resistance of A. pleuropneumoniae in Japan. ..
  6. Kume H, Konishi Y, Murayama K, Kametani F, Araki W. Expression of reticulon 3 in Alzheimer's disease brain. Neuropathol Appl Neurobiol. 2009;35:178-88 pubmed publisher
    ..Our data also suggest that there is considerable colocalization of RTN3 with BACE1 at a subcellular level. ..
  7. Tanaka K, Kawahara M, Ueda H, Nagamune T. Selection and growth regulation of genetically modified cells with hapten-specific antibody/receptor tyrosine kinase chimera. Biotechnol Prog. 2009;25:1138-45 pubmed publisher
    ..This is the first study to show that our antigen-mediated genetically modified cell amplification (AMEGA) system could be applied to non-hematopoietic cells by utilizing antibody/RTK chimeras. ..
  8. Liu G, Moriyasu F, Hirokawa T, Rexiati M, Yamada M, Imai Y. Expression of heat shock protein 70 in rabbit liver after contrast-enhanced ultrasound and radiofrequency ablation. Ultrasound Med Biol. 2010;36:78-85 pubmed publisher
    ..47 in the RF group and 0.42 in the CEUS+ RF group, respectively. CEUS using Sonazoid may produce HSP70 expression in the normal liver parenchyma after CEUS examination and RF ablation. (E-mail: moriyasu@tokyo-med.ac.jp). ..
  9. Ichimura R, Shibutani M, Mizukami S, Suzuki T, Shimada Y, Mitsumori K. A case report of an uncommon sex-cord stromal tumor consisted of luteal and sertoli cells in a spayed bitch. J Vet Med Sci. 2010;72:229-34 pubmed
    ..WT1-expression pattern suggested the signature of the difference in the phenotype of these cell types...
  10. Kameoka S, Matsumoto K, Kai Y, Yonehara Y, Arai Y, Honda K. Establishment of temporomandibular joint puncture technique in rats using in vivo micro-computed tomography (R_mCT®). Dentomaxillofac Radiol. 2010;39:441-5 pubmed publisher
    ..These results suggest that ASPT assisted by R-mCT® is useful for basic research, including drug discovery and pathogenesis of TMJ diseases. ..
  11. Cui C, Miyoshi S, Tsuji H, Makino H, Kanzaki S, Kami D, et al. Dystrophin conferral using human endothelium expressing HLA-E in the non-immunosuppressive murine model of Duchenne muscular dystrophy. Hum Mol Genet. 2011;20:235-44 pubmed publisher
    ..These findings suggest that HLA-E-expressing cells with a myogenic potential represent a promising source for cell-based therapy of patients with muscular dystrophy. ..
  12. Arata S, Nakamachi T, Onimaru H, Hashimoto H, Shioda S. Impaired response to hypoxia in the respiratory center is a major cause of neonatal death of the PACAP-knockout mouse. Eur J Neurosci. 2013;37:407-16 pubmed publisher
    ..Thus, disorders of the catecholaminergic system involved with O(2) sensing could be implicated in underlying neuronal mechanisms responsible for SIDS. ..
  13. Yan X, Anzai A, Katsumata Y, Matsuhashi T, Ito K, Endo J, et al. Temporal dynamics of cardiac immune cell accumulation following acute myocardial infarction. J Mol Cell Cardiol. 2013;62:24-35 pubmed publisher
    ..In conclusion, these results provide important knowledge necessary for developing successful immunomodulatory therapies. ..
  14. Iwamoto C, Takenaka K, Urata S, Yamauchi T, Shima T, Kuriyama T, et al. The BALB/c-specific polymorphic SIRPA enhances its affinity for human CD47, inhibiting phagocytosis against human cells to promote xenogeneic engraftment. Exp Hematol. 2014;42:163-171.e1 pubmed publisher
    ..This information should be useful for developing a novel immunodeficient strain with superior efficiency for xenogeneic transplantation of human cells. ..
  15. Tojinbara K, Yamada A, Kakitani I, Kwan N, Sugiura K. Estimating the probability distribution of the incubation period for rabies using data from the 1948-1954 rabies epidemic in Tokyo. Prev Vet Med. 2016;123:102-105 pubmed publisher
    ..30 (95% CI: 23.46-31.55) days and standard deviation of 20.20 (15.27-26.31) days. There were no significant differences between the incubation periods for dogs and cats, or between those for male and female dogs. ..
  16. Aoki S, Su Q, Li H, Nishikawa K, Ayukawa K, Hara Y, et al. Identification of an axotomy-induced glycosylated protein, AIGP1, possibly involved in cell death triggered by endoplasmic reticulum-Golgi stress. J Neurosci. 2002;22:10751-60 pubmed
    ..Our results suggest that AIGP1 gene activation and protein accumulation in the Golgi complex in response to axotomy-induced ER-Golgi stress may contribute to signaling during programmed cell death in damaged neurons. ..
  17. Kamo H, Honda K, Kitagawa J, Tsuboi Y, Kondo M, Taira M, et al. Topical capsaicin application causes cold hypersensitivity in awake monkeys. J Oral Sci. 2008;50:175-9 pubmed
    ..The present findings suggest that topical application of capsaicin to the facial skin induces reversible hypersensitivity to a facial cold stimulus in behaving monkeys. ..
  18. Okuno Y, Nakamura Ishizu A, Kishi K, Suda T, Kubota Y. Bone marrow-derived cells serve as proangiogenic macrophages but not endothelial cells in wound healing. Blood. 2011;117:5264-72 pubmed publisher
    ..Our data show that the proangiogenic effects of macrophages, but not the endothelial differentiation, are the major contribution of BMDCs in wound healing. ..
  19. Yoshida M, Hama H, Ishikawa Sakurai M, Imamura M, Mizuno Y, Araishi K, et al. Biochemical evidence for association of dystrobrevin with the sarcoglycan-sarcospan complex as a basis for understanding sarcoglycanopathy. Hum Mol Genet. 2000;9:1033-40 pubmed
    ..It is thus considered that the sarcoglycan-sarcospan complex is linked to the signaling protein neuronal nitric oxide synthase via alpha-syntrophin associated with dystrobrevin. ..
  20. Uchida S, Kagitani F, Suzuki A, Aikawa Y. Effect of acupuncture-like stimulation on cortical cerebral blood flow in anesthetized rats. Jpn J Physiol. 2000;50:495-507 pubmed
  21. Ogihara T, Asano T, Ando K, Chiba Y, Sekine N, Sakoda H, et al. Insulin resistance with enhanced insulin signaling in high-salt diet-fed rats. Diabetes. 2001;50:573-83 pubmed
  22. Kobayashi T, Minowa O, Sugitani Y, Takai S, Mitani H, Kobayashi E, et al. A germ-line Tsc1 mutation causes tumor development and embryonic lethality that are similar, but not identical to, those caused by Tsc2 mutation in mice. Proc Natl Acad Sci U S A. 2001;98:8762-7 pubmed
    ..The Tsc1 knockout mouse described here will be a useful model to elucidate the function of Tsc1 and Tsc2 products as well as pathogenesis of TS. ..
  23. Chomchan P, Miranda G, Shirako Y. Detection of rice grassy stunt tenuivirus nonstructural proteins p2, p5 and p6 from infected rice plants and from viruliferous brown planthoppers. Arch Virol. 2002;147:2291-300 pubmed
    ..p5 may have an essential role in virus infection in both plant and insect hosts, whereas p2 may function in plants such as a cell-to-cell movement protein. ..
  24. Son H, Nishikawa A, Kanki K, Okazaki K, Kitamura Y, Lee K, et al. Synergistic interaction between excess caffeine and deficient iodine on the promotion of thyroid carcinogenesis in rats pretreated with N-bis(2-hydroxypropyl)nitrosamine. Cancer Sci. 2003;94:334-7 pubmed
  25. Cullingford T. The ketogenic diet; fatty acids, fatty acid-activated receptors and neurological disorders. Prostaglandins Leukot Essent Fatty Acids. 2004;70:253-64 pubmed
    ..Finally, the implications of the KD and activated brain PPARalpha will be discussed in the context of their potential involvement in a range of disorders of neuro-degeneration and neuro-inflammation. ..
  26. Hirama K, Goto Y, Uema M, Endo Y, Miura R, Kai C. Phylogenetic analysis of the hemagglutinin (H) gene of canine distemper viruses isolated from wild masked palm civets (Paguma larvata). J Vet Med Sci. 2004;66:1575-8 pubmed
    ..Phylogenetic analysis revealed that the CDV strains derived from masked palm civets were classified into the group of recent Japanese CDV isolates...
  27. Yamada M, Kurihara H, Kinoshita K, Sakai T. Temporal expression of alpha-smooth muscle actin and drebrin in septal interstitial cells during alveolar maturation. J Histochem Cytochem. 2005;53:735-44 pubmed
    ..Alpha-SMA- and drebrin-containing septal interstitial cells (termed septal myofibroblast-like cells) may play an important role in alveolar formation. ..
  28. Wakino S, Hayashi K, Tatematsu S, Hasegawa K, Takamatsu I, Kanda T, et al. Pioglitazone lowers systemic asymmetric dimethylarginine by inducing dimethylarginine dimethylaminohydrolase in rats. Hypertens Res. 2005;28:255-62 pubmed
    ..Since ADMA is one of the risk factors for cardiovascular events, this study provides compelling evidence that PPARgamma ligands have the potential for reducing cardiovascular risks. ..
  29. Matsumoto T, Hayasaki T, Nishimura Y, Nakamura M, Takeda T, Tabuchi Y, et al. Butyrate induces necrotic cell death in murine colonic epithelial cell MCE301. Biol Pharm Bull. 2006;29:2041-5 pubmed
  30. Ichimaru T, Mogi K, Ohkura S, Mori Y, Okamura H. Exposure to ram wool stimulates gonadotropin-releasing hormone pulse generator activity in the female goat. Anim Reprod Sci. 2008;106:361-8 pubmed
    ..Since exposure to male goat hair enhances pulsatile LH secretion in the ewe, it is likely that very similar, if not identical, molecules are contained in the male-effect pheromone in the sheep and goat...
  31. Tomio A, Schust D, Kawana K, Yasugi T, Kawana Y, Mahalingaiah S, et al. Prolactin can modulate CD4+ T-cell response through receptor-mediated alterations in the expression of T-bet. Immunol Cell Biol. 2008;86:616-21 pubmed publisher
    ..These data suggest that the divergent immune effects of low- and high-dose prolactin may involve modulation of T-bet and alterations in the balance of the prolactin/JAK2/Stat5 and the prolactin/SOCS1 and 3 pathways. ..
  32. Miyado K, Yoshida K, Yamagata K, Sakakibara K, Okabe M, Wang X, et al. The fusing ability of sperm is bestowed by CD9-containing vesicles released from eggs in mice. Proc Natl Acad Sci U S A. 2008;105:12921-6 pubmed publisher
    ..The CD9-containing vesicle release from unfertilized eggs provides insight into the mechanism required for fusion with sperm. ..
  33. Kato M, Sanada M, Kato I, Sato Y, Takita J, Takeuchi K, et al. Frequent inactivation of A20 in B-cell lymphomas. Nature. 2009;459:712-6 pubmed publisher
  34. Watanabe S, Ueda N, Iha K, Masangkay J, Fujii H, Alviola P, et al. Detection of a new bat gammaherpesvirus in the Philippines. Virus Genes. 2009;39:90-3 pubmed publisher
    ..Phylogenetic analysis showed that the sequence was novel and most similar to those of the subfamily Gammaherpesvirinae. ..
  35. Yoshioka W, Akagi T, Nishimura N, Shimizu H, Watanabe C, Tohyama C. Severe toxicity and cyclooxygenase (COX)-2 mRNA increase by lithium in the neonatal mouse kidney. J Toxicol Sci. 2009;34:519-25 pubmed
    ..The present results showed that the kidney of mouse neonates is vulnerable to lithium, and suggested the possibility that COX-2 upregulation is responsible for the severe renal toxicity including hydronephrosis. ..
  36. Kajikawa A, Masuda K, Katoh M, Igimi S. Adjuvant effects for oral immunization provided by recombinant Lactobacillus casei secreting biologically active murine interleukin-1{beta}. Clin Vaccine Immunol. 2010;17:43-8 pubmed publisher
    ..In this study, it was demonstrated that recombinant L. casei secreting bioactive murine IL-1beta provided adjuvant effects for intragastric immunization. ..
  37. Azuma M, Ritprajak P, Hashiguchi M. Topical application of siRNA targeting cutaneous dendritic cells in allergic skin disease. Methods Mol Biol. 2010;623:373-81 pubmed publisher
    ..Our method may be advantageous for the treatment of allergic skin diseases. ..
  38. Yasui T, Kadono Y, Nakamura M, Oshima Y, Matsumoto T, Masuda H, et al. Regulation of RANKL-induced osteoclastogenesis by TGF-? through molecular interaction between Smad3 and Traf6. J Bone Miner Res. 2011;26:1447-56 pubmed publisher
    ..In summary, TGF-? is indispensable in RANKL-induced osteoclastogenesis, and the binding of Smad3 to the TRAF6-TAB1-TAK1 complex is crucial for RANKL-induced osteoclastogenic signaling. ..
  39. Nanno M, Kato I, Kobayashi T, Shida K. Biological effects of probiotics: what impact does Lactobacillus casei shirota have on us?. Int J Immunopathol Pharmacol. 2011;24:45S-50S pubmed
    ..These findings suggest that LcS may help the reinforcement of our defense system against cancer by modulating innate immune functions...
  40. Nakamoto N, Ebinuma H, Kanai T, Chu P, Ono Y, Mikami Y, et al. CCR9+ macrophages are required for acute liver inflammation in mouse models of hepatitis. Gastroenterology. 2012;142:366-76 pubmed publisher
    ..CCR9(+) macrophages contribute to the induction of acute liver inflammation in mouse models of hepatitis. ..
  41. Kataoka M, Ochiai M, Yamamoto A, Horiuchi Y. A need for careful evaluation of endotoxin contents in acellular pertussis-based combination vaccines. Biologicals. 2012;40:49-54 pubmed publisher
    ..As an adequate in vitro test method could not be identified for controlling the safety of the interfering batch, an appropriate in vivo test would be required for testing such vaccines. ..
  42. Crump A, Morel C, Omura S. The onchocerciasis chronicle: from the beginning to the end?. Trends Parasitol. 2012;28:280-8 pubmed publisher
  43. Cho H, Shimazu T, Toyokawa G, Daigo Y, Maehara Y, Hayami S, et al. Enhanced HSP70 lysine methylation promotes proliferation of cancer cells through activation of Aurora kinase B. Nat Commun. 2012;3:1072 pubmed publisher
    ..We also find that methylated HSP70 has a growth-promoting effect in cancer cells. Our findings demonstrate a crucial role of HSP70 methylation in human carcinogenesis. ..
  44. Ohmori K, Nishikawa S, Oku K, Oida K, Amagai Y, Kajiwara N, et al. Circadian rhythms and the effect of glucocorticoids on expression of the clock gene period1 in canine peripheral blood mononuclear cells. Vet J. 2013;196:402-7 pubmed publisher
    ..Rhythmic expression of per1 in PBMCs could be used as a molecular marker for monitoring circadian rhythms and the effects of drugs on clock genes in dogs. ..
  45. Endo T, Kakeyama M, Uemura Y, Haijima A, Okuno H, Bito H, et al. Executive function deficits and social-behavioral abnormality in mice exposed to a low dose of dioxin in utero and via lactation. PLoS ONE. 2012;7:e50741 pubmed publisher
  46. Akbar S, Al Mahtab M, Uddin M, Khan M. HBsAg, HBcAg, and combined HBsAg/HBcAg-based therapeutic vaccines in treating chronic hepatitis B virus infection. Hepatobiliary Pancreat Dis Int. 2013;12:363-9 pubmed
    ..Immune therapy with HBV-related antigens (vaccine therapy) has been used in CHB patients. But there is a paucity of information about the design of HBV antigen-based immune therapy in these patients...
  47. Kisu I, Kato Y, Yamada Y, Matsubara K, Obara H, Emoto K, et al. Organ Perfusion for Uterus Transplantation in Non-Human Primates With Assumed Procurement of a Uterus From a Brain-Dead Donor. Transplant Proc. 2016;48:1266-9 pubmed publisher
    ..It was suggested that this technique could be useful for uterus transplantation assuming the procurement of a uterus from a brain-dead donor. ..
  48. Ohsugi T, Kiuchi Y, Shimoda K, Oguri S, Maejima K. Translocation of bacteria from the gastrointestinal tract in immunodeficient mice. Lab Anim. 1996;30:46-50 pubmed
    ..These results suggest that defence mechanisms other than T and B cell function are important in the inhibition of systemic infection from the GI tract. ..
  49. Venkateswaran K, Dohmoto N, Harayama S. Cloning and nucleotide sequence of the gyrB gene of Vibrio parahaemolyticus and its application in detection of this pathogen in shrimp. Appl Environ Microbiol. 1998;64:681-7 pubmed
    ..parahaemolyticus in all of 27 shrimp samples artificially inoculated with this bacterium. We present here a rapid, reliable, and sensitive protocol for the detection of V. parahaemolyticus in shrimp...
  50. Ishii S, Kuwaki T, Nagase T, Maki K, Tashiro F, Sunaga S, et al. Impaired anaphylactic responses with intact sensitivity to endotoxin in mice lacking a platelet-activating factor receptor. J Exp Med. 1998;187:1779-88 pubmed
    ..These mutant mice clearly show that PAF plays a dominant role in eliciting anaphylaxis, but that it is not essential for reproduction, brain development, or endotoxic shock. ..
  51. Hashimoto O, Yamato K, Koseki T, Ohguchi M, Ishisaki A, Shoji H, et al. The role of activin type I receptors in activin A-induced growth arrest and apoptosis in mouse B-cell hybridoma cells. Cell Signal. 1998;10:743-9 pubmed
    ..These results indicate that ActRI and ActRIB are distinct from each other and that the ActRI/ActRIB expression ratio could regulate cell-cycle arrest in the G1 phase and subsequent apoptosis in HS-72 cells induced by activin A. ..
  52. Gohda T, Makita Y, Shike T, Tanimoto M, Funabiki K, Horikoshi S, et al. Identification of epistatic interaction involved in obesity using the KK/Ta mouse as a Type 2 diabetes model: is Zn-alpha2 glycoprotein-1 a candidate gene for obesity?. Diabetes. 2003;52:2175-81 pubmed
    ..These results suggest that Azgp1 is a possible candidate gene for regulation of body weight, elucidation of polygenic inheritance, and age-dependent changes in the genetic control of obesity. ..
  53. Misawa H, Nakata K, Toda K, Matsuura J, Oda Y, Inoue H, et al. VAChT-Cre. Fast and VAChT-Cre.Slow: postnatal expression of Cre recombinase in somatomotor neurons with different onset. Genesis. 2003;37:44-50 pubmed
    ..The use of VAChT-Cre mice should allow us to deliver Cre to a subset of postnatal motor neurons, thereby bypassing lethality and facilitating analysis of gene function in adult motor neurons. ..
  54. Horiuchi T, Giniger E, Aigaki T. Alternative trans-splicing of constant and variable exons of a Drosophila axon guidance gene, lola. Genes Dev. 2003;17:2496-501 pubmed
    ..We demonstrate that at least one variable exon is transcribed from its own promoter,and trans-spliced to the constant exons transcribed separately. ..
  55. Watanabe T, Miyatani S, Katoh I, Kobayashi S, Ikawa Y. Expression of a novel secretory form (Crb1s) of mouse Crumbs homologue Crb1 in skin development. Biochem Biophys Res Commun. 2004;313:263-70 pubmed
    ..After Ca(2+)-induced differentiation, Crb1s became associated with focal adhesions and cell-cell contacts. Crb1s may play a role distinct from that of Crb1 in epidermal tissue morphogenesis. ..
  56. Nakai M, Shiotsuki T, Kunimi Y. An entomopoxvirus and a granulovirus use different mechanisms to prevent pupation of Adoxophyes honmai. Virus Res. 2004;101:185-91 pubmed
    ..honmai larvae. Thus, while AdhoEPV and AdhoGV both prevent pupation of A. honmai larvae, the mechanisms by which they do so appear to be different...
  57. Ko Y, Nishino K, Hattori N, Arai Y, Tanaka S, Shiota K. Stage-by-stage change in DNA methylation status of Dnmt1 locus during mouse early development. J Biol Chem. 2005;280:9627-34 pubmed
    ..The present study also suggested that the DNA methylation status of the gene region dynamically changes during embryogenesis independently of the change in the bulk DNA methylation status. ..
  58. Honda M, Sumita Y, Kagami H, Ueda M. Histological and immunohistochemical studies of tissue engineered odontogenesis. Arch Histol Cytol. 2005;68:89-101 pubmed
    ..These results suggest that the development of these engineered teeth closely parallels that of natural odontogenesis derived from the immature epithelial and mesenchymal cells. ..
  59. Hattori K, Uchino S, Isosaka T, Maekawa M, Iyo M, Sato T, et al. Fyn is required for haloperidol-induced catalepsy in mice. J Biol Chem. 2006;281:7129-35 pubmed
  60. Shiba K, Machida T, Uchida S, Hotta H. Effects of nicotine on regional blood flow in the olfactory bulb in rats. Eur J Pharmacol. 2006;546:148-51 pubmed
    ..Nicotine may be of therapeutic value in improving blood flow in the olfactory bulb...
  61. Yamada Y, Sakurada K, Takeda Y, Gojo S, Umezawa A. Single-cell-derived mesenchymal stem cells overexpressing Csx/Nkx2.5 and GATA4 undergo the stochastic cardiomyogenic fate and behave like transient amplifying cells. Exp Cell Res. 2007;313:698-706 pubmed
    ..Single-cell-derived mesenchymal stem cells overexpressing Csx/Nkx2.5 and GATA4 behaved like cardiac transient amplifying cells, and still retained their plasticity in vivo. ..
  62. Nakada T, Toyoda F, Iwata T, Yamamoto K, Conlon J, Kato T, et al. Isolation, characterization and bioactivity of a region-specific pheromone, [Val8]sodefrin from the newt Cynops pyrrhogaster. Peptides. 2007;28:774-80 pubmed
    ..It is speculated that the coevolution of a novel pheromone and its complementary receptor in the Nara newts may lead to reproductive isolation and eventual differentiation into a separate species...
  63. Ishino T, Kunieda T, Natori S, Sekimizu K, Kubo T. Identification of novel members of the Xenopus Ca2+ -dependent lectin family and analysis of their gene expression during tail regeneration and development. J Biochem. 2007;141:479-88 pubmed
    ..Thus, the presence of multifunctional Ca(2+)-dependent lectin family and the induction of the member gene in regenerating organs are conserved among insects and vertebrates. ..
  64. Nagase T, Nagase M, Machida M, Yamagishi M. Hedgehog signaling: a biophysical or biomechanical modulator in embryonic development?. Ann N Y Acad Sci. 2007;1101:412-38 pubmed
    ..In this review, we examine various examples in which biophysical and biomechanical aspects of hedgehog signaling in development are revealed, including our own data using the mouse whole embryo culture system. ..
  65. Ueda R, Kinoshita E, Ito R, Kawase T, Kawakami Y, Toda M. Induction of protective and therapeutic antitumor immunity by a DNA vaccine with a glioma antigen, SOX6. Int J Cancer. 2008;122:2274-9 pubmed publisher
    ..These results suggest that the SOX6 protein has multiple CTL and helper epitopes to induce antitumor activity and the effectiveness of SOX6-DNA vaccine for the prevention and treatment of glioma. ..
  66. Suzuki N, Shichiri M, Akashi T, Sato K, Sakurada M, Hirono Y, et al. Systemic distribution of salusin expression in the rat. Hypertens Res. 2007;30:1255-62 pubmed publisher
  67. Goyama S, Yamamoto G, Shimabe M, Sato T, Ichikawa M, Ogawa S, et al. Evi-1 is a critical regulator for hematopoietic stem cells and transformed leukemic cells. Cell Stem Cell. 2008;3:207-20 pubmed publisher
    ..Thus, Evi-1 is a common and critical regulator essential for proliferation of embryonic/adult HSCs and transformed leukemic cells. ..
  68. Matsuda S, Yuzaki M. Polarized sorting of AMPA receptors to the somatodendritic domain is regulated by adaptor protein AP-4. Neurosci Res. 2009;65:1-5 pubmed publisher
    ..In this Update Article, we discuss recent progress in studies of the mechanisms underlying the somatodendritic targeting of AMPA receptors in neurons. ..
  69. Kato K, Sudo A, Kobayashi K, Sugi T, Tohya Y, Akashi H. Characterization of Plasmodium falciparum calcium-dependent protein kinase 4. Parasitol Int. 2009;58:394-400 pubmed publisher
    ..Thus, PfCDPK4 phosphorylation is activated by an increase in Ca(2+) concentration or pH and by a decrease in temperature, and is associated with the Ca(2+) signals that facilitate P. falciparum gametogenesis...
  70. Nakajima A, Tsuboi Y, Suzuki I, Honda K, Shinoda M, Kondo M, et al. PKCgamma in Vc and C1/C2 is involved in trigeminal neuropathic pain. J Dent Res. 2011;90:777-81 pubmed publisher
    ..Taken together, these findings suggest that PKC? expression in the Vc played an important role in the mechanism of orofacial static mechanical allodynia following trigeminal nerve injury...
  71. Fukuhara K, Ohno A, Ando Y, Yamoto T, Okuda H. A 1H NMR-based metabolomics approach for mechanistic insight into acetaminophen-induced hepatotoxicity. Drug Metab Pharmacokinet. 2011;26:399-406 pubmed
  72. Okamoto M, Irii H, Tahara Y, Ishii H, Hirao A, Udagawa H, et al. Synthesis of a new [6]-gingerol analogue and its protective effect with respect to the development of metabolic syndrome in mice fed a high-fat diet. J Med Chem. 2011;54:6295-304 pubmed publisher
    ..Our findings indicate that A6G, rather than 6G, enhances energy metabolism and reduces the extent of lipogenesis by downregulating SREBP-1c and its related molecules, which leads to the suppression of body fat accumulation. ..
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