Experts and Doctors on animals in Chiba, Japan


Locale: Chiba, Japan
Topic: animals

Top Publications

  1. Sato S, Seki N, Hotta Y, Tabata S. Expression profiles of a human gene identified as a structural homologue of meiosis-specific recA-like genes. DNA Res. 1995;2:183-6 pubmed
    ..The result strongly suggests that the mRNA species coding for the putative meiosis-specific RecA-like protein in human is predominantly expressed in testis possibly as an alternative splicing product of a ubiquitously expressed gene. ..
  2. Takahashi S, Sonehara K, Takagi K, Miwa T, Horikomi K, Mita N, et al. Pharmacological profile of MS-377, a novel antipsychotic agent with selective affinity for sigma receptors. Psychopharmacology (Berl). 1999;145:295-302 pubmed
    ..Therefore, MS-377 could be a novel antipsychotic agent with clinical efficacy for overall symptoms of schizophrenia including its negative symptoms and without EPS liability. ..
  3. Terada N, Hamano N, Nomura T, Numata T, Hirai K, Nakajima T, et al. Interleukin-13 and tumour necrosis factor-alpha synergistically induce eotaxin production in human nasal fibroblasts. Clin Exp Allergy. 2000;30:348-55 pubmed
    ..These results strongly indicate that IL-13, as well as IL-4, may be important in eotaxin-mediated eosinophilic inflammation in nasal mucosa. In addition, in nasal mucosa, fibroblasts are the major cell source for eotaxin. ..
  4. Konishi Y, Matsu ura T, Mikoshiba K, Tamura T. Stimulation of gene expression of NeuroD-related factor in the mouse brain following pentylenetetrazol-induced seizures. Brain Res Mol Brain Res. 2001;97:129-36 pubmed
    ..NDRF is thought to be involved in long-lasting neuronal activation. ..
  5. Hirobe T, Wakamatsu K, Ito S, Abe H, Kawa Y, Mizoguchi M. Stimulation of the proliferation and differentiation of mouse pink-eyed dilution epidermal melanocytes by excess tyrosine in serum-free primary culture. J Cell Physiol. 2002;191:162-72 pubmed
    ..These results suggest that p/p melanocytes in the primary culture are induced to synthesize eumelanin by excess L-Tyr, but difficult to accumulate them in melanosomes. ..
  6. Okazaki N, Takahashi N, Kojima S, Masuho Y, Koga H. Protocadherin LKC, a new candidate for a tumor suppressor of colon and liver cancers, its association with contact inhibition of cell proliferation. Carcinogenesis. 2002;23:1139-48 pubmed
    ..Our results suggest that Protocadherin LKC, which directly binds PDZ protein, is a molecular switch for contact inhibition of epithelial cells in the liver, kidney and colon tissues. ..
  7. Matsu ura T, Konishi Y, Aoki T, Naranjo J, Mikoshiba K, Tamura T. Seizure-mediated neuronal activation induces DREAM gene expression in the mouse brain. Brain Res Mol Brain Res. 2002;109:198-206 pubmed
    ..The results of the present study demonstrate that DREAM is a neural activity-stimulated late gene and suggest its involvement in adaptation to long-lasting neuronal activity. ..
  8. Tokumasa N, Suto A, Kagami S, Furuta S, Hirose K, Watanabe N, et al. Expression of Tyk2 in dendritic cells is required for IL-12, IL-23, and IFN-gamma production and the induction of Th1 cell differentiation. Blood. 2007;110:553-60 pubmed
  9. Nakayama T, Yamashita M. Critical role of the Polycomb and Trithorax complexes in the maintenance of CD4 T cell memory. Semin Immunol. 2009;21:78-83 pubmed publisher
    ..Therefore, in memory CD4 T cells, PcG and TrxG genes appear to control distinct processes in a distinct manner, which indicates a novel regulatory feature of the PcG/TrxG genes. ..

More Information

Publications510 found, 100 shown here

  1. Ohashi S, Atsumi M, Kobayashi S. HSP60 interacts with YB-1 and affects its polysome association and subcellular localization. Biochem Biophys Res Commun. 2009;385:545-50 pubmed publisher
    ..These results suggest that HSP60 interacts with YB-1 at the YB-NLS region and acts as a regulator of polysome association and the subcellular distribution of YB-1. ..
  2. Kondrashov N, Pusic A, Stumpf C, Shimizu K, Hsieh A, Ishijima J, et al. Ribosome-mediated specificity in Hox mRNA translation and vertebrate tissue patterning. Cell. 2011;145:383-397 pubmed publisher
    ..Collectively, these findings suggest that RP activity may be highly regulated to impart a new layer of specificity in the control of gene expression and mammalian development. ..
  3. Yamauchi K, Kasuya Y, Kuroda F, Tanaka K, Tsuyusaki J, Ishizaki S, et al. Attenuation of lung inflammation and fibrosis in CD69-deficient mice after intratracheal bleomycin. Respir Res. 2011;12:131 pubmed publisher
    ..The present study clearly demonstrates that CD69 plays an important role in the progression of lung injury induced by BLM. ..
  4. Tsuneoka Y, Irie M, Tanaka Y, Sugimoto T, Kobayashi Y, Kusakabe T, et al. Permissive role of reduced inwardly-rectifying potassium current density in the automaticity of the guinea pig pulmonary vein myocardium. J Pharmacol Sci. 2017;133:195-202 pubmed publisher
    ..These results indicate that the pulmonary vein cardiomyocytes have a reduced density of the inwardly-rectifying potassium current, which plays a permissive role in their intracellular Ca2+-dependent automaticity. ..
  5. Yamazaki H, Bujo H, Kusunoki J, Seimiya K, Kanaki T, Morisaki N, et al. Elements of neural adhesion molecules and a yeast vacuolar protein sorting receptor are present in a novel mammalian low density lipoprotein receptor family member. J Biol Chem. 1996;271:24761-8 pubmed
    ..The identification of this highly conserved and superbly complex protein offers the opportunity to gain new insights into the emergence of multifunctional mosaic proteins akin to the ever expanding LDL receptor gene family. ..
  6. Kamata K, Kiyota M, Naoe A, Nakatani S, Yamamoto Y, Hayashi M, et al. New bisindole alkaloids isolated from Myxomycetes Arcyria cinerea and Lycogala epidendrum. Chem Pharm Bull (Tokyo). 2005;53:594-7 pubmed
    ..The structures of the new compounds were elucidated by spectral data. Among these bisindole alkaloids, compound 12 showed cytotoxicity against cultured tumor cell lines...
  7. Dobashi T, Tanabe S, Jin H, Mimura N, Yamamoto T, Nishino T, et al. BiP, an endoplasmic reticulum chaperone, modulates the development of morphine antinociceptive tolerance. J Cell Mol Med. 2010;14:2816-26 pubmed publisher
  8. Owada T, Watanabe N, Oki M, Oya Y, Saito Y, Saito T, et al. Activation-induced accumulation of B and T lymphocyte attenuator at the immunological synapse in CD4+ T cells. J Leukoc Biol. 2010;87:425-32 pubmed publisher
  9. Hamada M, Kiryu H, Iwasaki W, Asai K. Generalized centroid estimators in bioinformatics. PLoS ONE. 2011;6:e16450 pubmed publisher
    ..Not only the concept presented in this paper gives a useful framework to design MEA-based estimators but also it is highly extendable and sheds new light on many problems in bioinformatics. ..
  10. Okita N, Ishikawa N, Mizunoe Y, Oku M, Nagai W, Suzuki Y, et al. Inhibitory effect of p53 on mitochondrial content and function during adipogenesis. Biochem Biophys Res Commun. 2014;446:91-7 pubmed publisher
  11. Takayanagi I, Hisayama T, Iwase M, Sakuma N, Nagai H. Pharmacological properties of tiropramide, an antispasmodic drug. Gen Pharmacol. 1989;20:335-9 pubmed
    ..4. Tiropramide is considered to be useful to inhibit the contractile response of the urinary bladder, as this organ is mainly innervated by noncholinergic excitatory neurons. ..
  12. Nomura N, Nagase T, Miyajima N, Sazuka T, Tanaka A, Sato S, et al. Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1 (supplement). DNA Res. 1994;1:251-62 pubmed
  13. Saito T, Matsuda Y, Suzuki T, Hayashi A, Yuan X, Saito M, et al. Comparative gene mapping of the human and mouse TEP1 genes, which encode one protein component of telomerases. Genomics. 1997;46:46-50 pubmed
    ..7 cM distal to D14Mit18 and D14Mit134 and 2.0 cM proximal to D14Mit5 on mouse chromosome 14, where conserved linkage homology with human chromosome 14q11-q12 has been identified. ..
  14. Horinouchi T, Tsujitani M, Koike K. [Pharmacological analysis of atypical beta-adrenoceptors in the guinea pig gastrointestinal tissue systems]. Nihon Yakurigaku Zasshi. 1999;114 Suppl 1:118P-122P pubmed
    ..There is not a tissue difference in atypical beta-adrenoceptors in the guinea pig gastrointestinal tissue systems between stomach and ileum...
  15. Morita M, Suzuki T. The identification of the sympathetic neurons innervating the hamster submandibular gland and their electrophysiological membrane properties. Bull Tokyo Dent Coll. 2001;42:15-33 pubmed
    ..The delayed rectifiers, A channels, and BK and SK (slowly Ca2+-activated) channels were involved in generation of spike-AHP. Muscarine suppressed the Ca2+ component of spike via muscarinic receptors...
  16. Toyohara J, Hayashi A, Sato M, Tanaka H, Haraguchi K, Yoshimura Y, et al. Rationale of 5-(125)I-iodo-4'-thio-2'-deoxyuridine as a potential iodinated proliferation marker. J Nucl Med. 2002;43:1218-26 pubmed
    ..Radioiodine-labeled ITdU is potentially useful as a proliferation-imaging agent, and further studies should clarify the usefulness of this compound as a tumor-imaging agent. ..
  17. Matsumoto M, Miki T, Shibasaki T, Kawaguchi M, Shinozaki H, Nio J, et al. Noc2 is essential in normal regulation of exocytosis in endocrine and exocrine cells. Proc Natl Acad Sci U S A. 2004;101:8313-8 pubmed
    ..Thus, Noc2, a critical effector of Rab3, is essential in normal regulation of exocytosis in both endocrine and exocrine cells. ..
  18. Ito T, Komiya Ito A, Okuda K, Minaguchi K, Saitoh E, Yamada S, et al. Murine monoclonal antibody which can distinguish cystatins SA1 and SA2. Mol Immunol. 2005;42:1259-63 pubmed
    ..In conclusion, we have succeeded in producing two antibodies that discriminate the structural differences between salivary cystatins S and SN, which share more than 90% identity in amino acid sequence with cystatin SA. ..
  19. Namekata I, Nakamura H, Shimada H, Tanaka H, Shigenobu K. Cardioprotection without cardiosuppression by SEA0400, a novel inhibitor of Na+-Ca2+ exchanger, during ischemia and reperfusion in guinea-pig myocardium. Life Sci. 2005;77:312-24 pubmed
    ..The present results indicate that inhibition of Na+-Ca2+ exchanger either during ischemia or during reperfusion exerts cardioprotective effects and enhances the recovery of myocardial contractile function. ..
  20. Hosoda M, Ozaki T, Miyazaki K, Hayashi S, Furuya K, Watanabe K, et al. UFD2a mediates the proteasomal turnover of p73 without promoting p73 ubiquitination. Oncogene. 2005;24:7156-69 pubmed
  21. Fukuda S, Ikeda M, Anzai K, Suzuki M, Katoh A, Kontoghiorghes G. Radiation protection by deferiprone in animal models. Hemoglobin. 2006;30:201-8 pubmed
    ..The results were inconclusive...
  22. Iwamuro S, Yamada M, Kato M, Kikuyama S. Effects of bisphenol A on thyroid hormone-dependent up-regulation of thyroid hormone receptor alpha and beta and down-regulation of retinoid X receptor gamma in Xenopus tail culture. Life Sci. 2006;79:2165-71 pubmed
  23. Hasegawa H, Takano H, Kohro T, Ueda K, Niitsuma Y, Aburatani H, et al. Amelioration of hypertensive heart failure by amlodipine may occur via antioxidative effects. Hypertens Res. 2006;29:719-29 pubmed
    ..Approximately 48% of the genes were changed in similar fashion in AMLO and TEMP rats, suggesting that amlodipine shows beneficial effects on heart failure mainly via antioxidative mechanisms. ..
  24. Saito Y, Imazeki H, Miura S, Yoshimura T, Okutsu H, Harada Y, et al. A peptide derived from tenascin-C induces beta1 integrin activation through syndecan-4. J Biol Chem. 2007;282:34929-37 pubmed
    ..A lateral interaction of beta1 integrin with the extracellular region of the syndecan-4 molecule may be involved in this conformation change. ..
  25. Sawai S, Kanai K, Nakata M, Hiraga A, Misawa S, Isose S, et al. Changes in excitability properties associated with axonal regeneration in human neuropathy and mouse Wallerian degeneration. Clin Neurophysiol. 2008;119:1097-105 pubmed publisher
    ..The aim of this study was to investigate changes in excitability properties associated with axonal regeneration in human neuropathy and a mouse Wallerian degeneration model...
  26. Yokota S, Mizuo K, Moriya N, Oshio S, Sugawara I, Takeda K. Effect of prenatal exposure to diesel exhaust on dopaminergic system in mice. Neurosci Lett. 2009;449:38-41 pubmed publisher
    ..The present study provides the possibility that maternally inhaled DE might influence the development of central dopaminergic system and result in behavior disorder. ..
  27. Suzuki Toyota F, Ito C, Maekawa M, Toyama Y, Toshimori K. Adhesion between plasma membrane and mitochondria with linking filaments in relation to migration of cytoplasmic droplet during epididymal maturation in guinea pig spermatozoa. Cell Tissue Res. 2010;341:429-40 pubmed publisher
    ..The filaments might also stabilize the flagellum against hypo-osmotic stress encountered during ejaculation and within the female tract. ..
  28. Kawamura K, Akiyama M, Yui J, Yamasaki T, Hatori A, Kumata K, et al. In vivo evaluation of limiting brain penetration of probes for ?(2C)-adrenoceptor using small-animal positron emission tomography. ACS Chem Neurosci. 2010;1:520-8 pubmed publisher
    ..7-fold higher and that of [(11)C]JP-1302 was approximately 1.6-fold higher than those in wild-type mice. These results indicate that brain penetration of the two PET probes was affected by modulation of P-gp and Bcrp functions...
  29. Kadota R, Koda M, Kawabe J, Hashimoto M, Nishio Y, Mannoji C, et al. Granulocyte colony-stimulating factor (G-CSF) protects oligodendrocyte and promotes hindlimb functional recovery after spinal cord injury in rats. PLoS ONE. 2012;7:e50391 pubmed publisher
    ..As a result, G-CSF attenuates white matter loss and promotes hindlimb functional recovery. ..
  30. Komai T, Poupin J. Records of the hermit crab genus Pagurixus Melin, 1939 (Crustacea: Decapoda: Anomura: Paguridae) from Europa Island, Western Indian Ocean, with descriptions of two new species. Zootaxa. 2013;3608:191-203 pubmed publisher
    ..Pagurixus annulus n. sp. and P. europa n. sp. are referred to the P. boninensis (Melin, 1939) species group and P. anceps (Forest, 1954) group, respectively. Diagnostic characters of these two new species are discussed. ..
  31. Kojima S, Negishi Y, Tsukimoto M, Takenouchi T, Kitani H, Takeda K. Purinergic signaling via P2X7 receptor mediates IL-1? production in Kupffer cells exposed to silica nanoparticle. Toxicology. 2014;321:13-20 pubmed publisher
    ..The ROS causes activation of inflammasomes, leading to caspase-1-dependent processing of IL-1?...
  32. Nakayama Y, Soeda S, Ikeuchi M, Kakae K, Yamaguchi N. Cytokinesis Failure Leading to Chromosome Instability in v-Src-Induced Oncogenesis. Int J Mol Sci. 2017;18: pubmed publisher
    ..We also discuss the relationship between v-Src-induced chromosome instability and growth suppression in v-Src-induced oncogenesis. ..
  33. Takayanagi I, Hisayama T, Kiuchi Y, Sudo H. Propylbenzilylcholine mustard discriminates between two subtypes of muscarinic cholinoceptors in guinea-pig taenia caecum. Arch Int Pharmacodyn Ther. 1989;298:210-9 pubmed
    ..The responses to nicotine and to electrical stimulation were inhibited by the 50-min treatment with PrBCM, suggesting that PrBCM-sensitive receptors might play a physiological role...
  34. Matsuda Y, Saito T, Fujimoto J, Yamamoto T. Chromosomal mapping of the mouse and rat brt genes. Genomics. 1997;40:181-4 pubmed
    ..1, where a conserved linkage homology has been identified between the two species. Interspecific backcross analysis genetically demonstrated no recombination between the mouse BRT locus and D2Mit63. ..
  35. Nenoi M, Mita K, Ichimura S, Kawano A. Higher frequency of concerted evolutionary events in rodents than in man at the polyubiquitin gene VNTR locus. Genetics. 1998;148:867-76 pubmed
    ..3 x 10(-5) per year and that of UbC at no more than 5.0 x 10(-7) per year...
  36. Oshima N. Direct reception of light by chromatophores of lower vertebrates. Pigment Cell Res. 2001;14:312-9 pubmed
    ..This article reviews light-sensitive chromatophores of lower vertebrates. Photoreceptive molecules (visual pigments) and signal transduction of light via a GTP-binding protein (G protein) are also discussed...
  37. Yoshino N, Hisayoshi T, Sasaki T, Yamauchi S, Oaki Y, Hino M. Human pulmonary dirofilariasis in a patient whose clinical condition altered during follow-up. Jpn J Thorac Cardiovasc Surg. 2003;51:211-3 pubmed
    ..The parasites had the characteristic morphological features of Dirofilaria immitis. Immunological studies produced a positive test result for the anti-dirofilaria immitis antibody; hence a diagnosis of pulmonary dirofilariasis was made...
  38. Oka Y, Omura M, Kataoka H, Touhara K. Olfactory receptor antagonism between odorants. EMBO J. 2004;23:120-6 pubmed
    ..The current study also provides insight into strategies to modulate perceived odorant quality. ..
  39. Shimono M, Ishikawa T, Enokiya Y, Muramatsu T, Matsuzaka K, Inoue T, et al. Biological characteristics of the junctional epithelium. J Electron Microsc (Tokyo). 2003;52:627-39 pubmed
    ..Long junctional epithelium can be produced rapidly during wound healing, due to high proliferative activity. Peri-implant epithelium might be a poorly adhered and permeable epithelium...
  40. Fujitani M, Honda A, Hata K, Yamagishi S, Tohyama M, Yamashita T. Biological activity of neurotrophins is dependent on recruitment of Rac1 to lipid rafts. Biochem Biophys Res Commun. 2005;327:150-4 pubmed
    ..Proper recruitment of activated Rac1 to lipid rafts, structures that represent specialized signaling organelles, is of fundamental importance in determining neurotrophins' bioactivity. ..
  41. Ishihara H, Tanaka I, Ishihara F, Suzuki K, Yoshino C, Cheeramakara C, et al. Transient reporter RNA assay: quantification of reporter gene mRNA during immediate early response in mammalian cells based on real-time reverse transcription polymerase chain reaction. Anal Biochem. 2005;341:369-71 pubmed
  42. Tomonaga T, Matsushita K, Ishibashi M, Nezu M, Shimada H, Ochiai T, et al. Centromere protein H is up-regulated in primary human colorectal cancer and its overexpression induces aneuploidy. Cancer Res. 2005;65:4683-9 pubmed
    ..These results suggest that the aberrant expression and localization of a kinetochore protein CENP-H plays an important role in the aneuploidy frequently observed in colorectal cancers. ..
  43. Ishibashi M. Isolation of bioactive natural products from myxomycetes. Med Chem. 2005;1:575-90 pubmed
  44. Maeda J, Higuchi M, Inaji M, Ji B, Haneda E, Okauchi T, et al. Phase-dependent roles of reactive microglia and astrocytes in nervous system injury as delineated by imaging of peripheral benzodiazepine receptor. Brain Res. 2007;1157:100-11 pubmed
    ..The present findings collectively support the utility of PBR in identifying a unique temporal pattern of astrocytic and microglial activation that conventional glial markers hardly pursue. ..
  45. Inoue K, Saito M, Kanai T, Kawata T, Shigematsu N, Uno T, et al. Anti-tumor effects of water-soluble propolis on a mouse sarcoma cell line in vivo and in vitro. Am J Chin Med. 2008;36:625-34 pubmed
    ..05). Furthermore, histological findings revealed a significant reduction in mitotic cells and tumor invasion of the muscular tissue at both dose-levels of WSP. ..
  46. Iida A, Yoshidome H, Shida T, Takano S, Takeuchi D, Kimura F, et al. Hepatocyte nuclear factor-kappa beta (NF-kappaB) activation is protective but is decreased in the cholestatic liver with endotoxemia. Surgery. 2010;148:477-89 pubmed publisher
    ..After prolonged OJ, exposure to endotoxemia was associated with a decrease in hepatocyte NF-kappaB activation and an increase in hepatocyte apoptosis and secondary necrosis, thus resulting in liver dysfunction. ..
  47. Wang B, Tanaka K, Vares G, Shang Y, Fujita K, Ninomiya Y, et al. X-ray-induced radioresistance against high-LET radiations from accelerated heavy ions in mice. Radiat Res. 2010;174:532-6 pubmed publisher
    ..These findings would provide new insight into the radiation-induced adaptive response in vivo. ..
  48. Yamasaki T, Kawamura K, Hatori A, Yui J, Yanamoto K, Yoshida Y, et al. PET study on mice bearing human colon adenocarcinoma cells using [11C]GF120918, a dual radioligand for P-glycoprotein and breast cancer resistance protein. Nucl Med Commun. 2010;31:985-93 pubmed publisher
    ..A PET study combining the administration of [C]GF120918 with unlabeled GF120918 may be a useful tool for evaluating the functions of Pgp and BCRP in tumors. ..
  49. Saijo T, Maeda J, Okauchi T, Maeda J, Morio Y, Kuwahara Y, et al. Presynaptic selectivity of a ligand for serotonin 1A receptors revealed by in vivo PET assays of rat brain. PLoS ONE. 2012;7:e42589 pubmed publisher
  50. Koizumi K, Takano K, Kaneyasu A, Watanabe Takano H, Tokuda E, Abe T, et al. RhoD activated by fibroblast growth factor induces cytoneme-like cellular protrusions through mDia3C. Mol Biol Cell. 2012;23:4647-61 pubmed publisher
    ..Knockdown of mDia3 obstructed RhoD-induced protrusion formation. These results imply that RhoD activated by FGF signaling forms cytoneme-like protrusions through activation of mDia3C, which induces actin filament formation. ..
  51. Sugyo A, Tsuji A, Sudo H, Nagatsu K, Koizumi M, Ukai Y, et al. Evaluation of (89)Zr-labeled human anti-CD147 monoclonal antibody as a positron emission tomography probe in a mouse model of pancreatic cancer. PLoS ONE. 2013;8:e61230 pubmed publisher
    ..89)Zr]059-053 is a promising PET probe for imaging CD147 expression in pancreatic cancer and has the potential to select appropriate patients with CD147-expressing tumors who could gain benefit from anti-CD147 therapy. ..
  52. Muto T, Sashida G, Oshima M, Wendt G, Mochizuki Kashio M, Nagata Y, et al. Concurrent loss of Ezh2 and Tet2 cooperates in the pathogenesis of myelodysplastic disorders. J Exp Med. 2013;210:2627-39 pubmed publisher
    ..Our findings provide the first evidence of the tumor suppressor function of EZH2 in myeloid malignancies and highlight the cooperative effect of concurrent gene mutations in the pathogenesis of myelodysplastic disorders. ..
  53. Mitome Mishima Y, Oishi H, Yamamoto M, Yatomi K, Nonaka S, Miyamoto N, et al. Differences in tissue proliferation and maturation between Matrix2 and bare platinum coil embolization in experimental swine aneurysms. J Neuroradiol. 2016;43:43-50 pubmed publisher
    ..Matrix2 coils may not be superior to BP coils for preventing aneurysmal recanalization after endovascular treatment of cerebral aneurysms. ..
  54. Fujimori H, Sato A, Kikuhara S, Wang J, Hirai T, Sasaki Y, et al. A comprehensive analysis of radiosensitization targets; functional inhibition of DNA methyltransferase 3B radiosensitizes by disrupting DNA damage regulation. Sci Rep. 2015;5:18231 pubmed publisher
    ..Downregulation of DNMT3B, one of the targets identified using this method, radiosensitizes cancer cells by disturbing multiple DNA damage responses. ..
  55. Chiba T, Kondo N, Takahara A. Influences of rapid pacing-induced electrical remodeling on pharmacological manipulation of the atrial refractoriness in rabbits. J Pharmacol Sci. 2016;130:170-6 pubmed publisher
  56. Sakurai T, Nakagawa S, Bai H, Bai R, Kusama K, Ideta A, et al. Novel endogenous retrovirus-derived transcript expressed in the bovine placenta is regulated by WNT signaling. Biochem J. 2017;474:3499-3512 pubmed publisher
    ..BERV-K3 is in the latter case, likely providing functions unique to ruminant gestation. ..
  57. Matsuda Y, Nara K, Watanabe Y, Saito T, Sanai Y. Chromosome mapping of the GD3 synthase gene (SIAT8) in human and mouse. Genomics. 1996;32:137-9 pubmed
    ..The human GD3 synthase gene was mapped to p12.1-p11.2 of chromosome 12. The mouse homologue was mapped 2.8 cM distal to D6Mit52 and 4.3 cM proximal to D6Mit25; this region is syntenic to the short arm of human chromosome 12. ..
  58. Vohra M, Komiyama M, Hayakawa K, Obinata T, Shimada Y. Subcellular localization of dystrophin and vinculin in cardiac muscle fibers and fibers of the conduction system of the chicken ventricle. Cell Tissue Res. 1998;294:137-43 pubmed
    ..These data suggest that the distribution patterns of dystrophin reflect the degree of association between the sarcolemma and underlying myofibrils. ..
  59. Suzuki K, Susaki H, Okuno S, Sugiyama Y. Renal drug targeting using a vector "alkylglycoside". J Pharmacol Exp Ther. 1999;288:57-64 pubmed
    ..In addition, these renally targeted derivatives inhibited the binding of [3H]Glc-S-C7-Me to the kidney membrane fraction. Our findings allow us to conclude that the alkylglycoside is a suitable candidate vector for renal targeting. ..
  60. Yuasa S, Nakajima M, Aizawa H, Sahara N, Koizumi K, Sakai T, et al. Impaired cell cycle control of neuronal precursor cells in the neocortical primordium of presenilin-1-deficient mice. J Neurosci Res. 2002;70:501-13 pubmed
    ..These findings suggest that PS-1 is involved in the differentiation and the cell cycle control of neuronal precursor cells in the ventricular proliferating zone of the neocortical primordium. ..
  61. Aoki H, Ahsan M, Matsuo K, Hagiwara T, Watabe S. Purification and characterization of collagenolytic proteases from the hepatopancreas of northern shrimp (Pandalus eous). J Agric Food Chem. 2003;51:777-83 pubmed
    ..5. Both enzymes were strongly inhibited by PMSF and antipain, which suggests that they belong to collagenolytic serine proteases...
  62. Toyama Y, Maekawa M, Yuasa S. Ectoplasmic specializations in the Sertoli cell: new vistas based on genetic defects and testicular toxicology. Anat Sci Int. 2003;78:1-16 pubmed
  63. Sakate R, Osada N, Hida M, Sugano S, Hayasaka I, Shimohira N, et al. Analysis of 5'-end sequences of chimpanzee cDNAs. Genome Res. 2003;13:1022-6 pubmed publisher
    ..As for amino acids, the average sequence identity was 99.44%. The average synonymous (K(S)) and nonsynonymous (K(A)) divergences were estimated to be 1.33% and 0.28%, respectively...
  64. Hosomi O, Ohe Y, Takeya A, Hosaka K, Okubo T, Iyobe S, et al. Nucleotide and protein sequences of a proteinase inhibitor from the vitelline envelope of dace (Tribolodon hakonensis) eggs. J Exp Zool A Comp Exp Biol. 2004;301:756-66 pubmed
    ..A possible binding-site for serine proteinases, Arg-Ile, was contained in three domains. ..
  65. Saiki A, Murano T, Watanabe F, Oyama T, Miyashita Y, Shirai K. Pitavastatin enhanced lipoprotein lipase expression in 3T3-L1 preadipocytes. J Atheroscler Thromb. 2005;12:163-8 pubmed
    ..Statins, especially pitavastatin, increased the expression of LPL in 3T3-L1 preadipocytes. The TG-lowering effect of pitavastatin might be mediated by enhancement of LPL production in adipocytes. ..
  66. Kunieda T, Minamino T, Nishi J, Tateno K, Oyama T, Katsuno T, et al. Angiotensin II induces premature senescence of vascular smooth muscle cells and accelerates the development of atherosclerosis via a p21-dependent pathway. Circulation. 2006;114:953-60 pubmed
    ..Our results suggest a critical role of p21-dependent premature senescence of VSMCs in the pathogenesis of atherosclerosis. ..
  67. Kurabe N, Katagiri K, Komiya Y, Ito R, Sugiyama A, Kawasaki Y, et al. Deregulated expression of a novel component of TFTC/STAGA histone acetyltransferase complexes, rat SGF29, in hepatocellular carcinoma: possible implication for the oncogenic potential of c-Myc. Oncogene. 2007;26:5626-34 pubmed
    ..These results show that rSGF29 is a novel component of TFTC/STAGA complexes and could be involved in the c-Myc-mediated malignant transformation. ..
  68. Yamanaka N, Yamamoto S, Zitnan D, Watanabe K, Kawada T, Satake H, et al. Neuropeptide receptor transcriptome reveals unidentified neuroendocrine pathways. PLoS ONE. 2008;3:e3048 pubmed publisher
    ..This work illustrates how using a combinatorial approach employing bioinformatic, molecular, biochemical and physiological methods can help solve recalcitrant problems in neuropeptide research. ..
  69. Wakashin H, Hirose K, Maezawa Y, Kagami S, Suto A, Watanabe N, et al. IL-23 and Th17 cells enhance Th2-cell-mediated eosinophilic airway inflammation in mice. Am J Respir Crit Care Med. 2008;178:1023-32 pubmed publisher
    ..IL-23 and Th17 cells not only induce Th17-cell-mediated neutrophilic airway inflammation but also up-regulate Th2-cell-mediated eosinophilic airway inflammation. ..
  70. Hanamura T, Uchida E, Aoki H. Skin-lightening effect of a polyphenol extract from Acerola (Malpighia emarginata DC.) fruit on UV-induced pigmentation. Biosci Biotechnol Biochem. 2008;72:3211-8 pubmed
    ..An oral ingestion of C-AP may therefore be efficacious for reducing UVB-induced hyper-pigmentation by inhibiting the tyrosinase in melanocytes. ..
  71. Shimozato O, Sato A, Kawamura K, Chiyo M, Ma G, Li Q, et al. The secreted form of p28 subunit of interleukin (IL)-27 inhibits biological functions of IL-27 and suppresses anti-allogeneic immune responses. Immunology. 2009;128:e816-25 pubmed publisher
    ..We propose that p28 can be a regulatory subunit for IL-27-mediated cellular immune responses and a possible therapeutic agent to suppress unfavourable immune responses. ..
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    ..Taken together, these findings should facilitate an understanding of the regulation of TEX101 expression during gametogenesis. ..
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