Experts and Doctors on adult in Tokyo, Japan


Locale: Tokyo, Japan
Topic: adult

Top Publications

  1. Tsuda H, Satarug S, Bhudhisawasdi V, Kihana T, Sugimura T, Hirohashi S. Cholangiocarcinomas in Japanese and Thai patients: difference in etiology and incidence of point mutation of the c-Ki-ras proto-oncogene. Mol Carcinog. 1992;6:266-9 pubmed
    ..On the other hand, point-mutational activation of the c-Ki-ras proto-oncogene may be involved in cholangiocarcinogenesis in liver without preexisting liver-fluke or viral infection. ..
  2. Iwamoto J, Matsu K, Takeda T, Ichimura S, Uzawa M. Effects of treatment with etidronate and alfacalcidol for osteogenesis imperfecta type I: a case report. J Orthop Sci. 2003;8:243-7 pubmed
    ..This report provides evidence indicating that treatment with intermittent cyclical oral etidronate and alfacalcidol has potential use in adult patients with OI type I. ..
  3. Iwasa S, Jin X, Okada K, Mitsumata M, Ooi A. Increased expression of seprase, a membrane-type serine protease, is associated with lymph node metastasis in human colorectal cancer. Cancer Lett. 2003;199:91-8 pubmed
    ..These results suggested that an abundant expression of seprase in colorectal cancer tissue is associated with lymph node metastasis. ..
  4. Murai Y, Kominami S, Kobayashi S, Mizunari T, Teramoto A. The long-term effects of transluminal balloon angioplasty for vasospasms after subarachnoid hemorrhage: analyses of cerebral blood flow and reactivity. Surg Neurol. 2005;64:122-6; discussion 127 pubmed
    ..0817). Transluminal balloon angioplasty increased proximal vessel diameters but showed no significant influence on CBF or vascular reactivity 3 weeks later. Benefits presumably were short term, but the procedure was clinically safe. ..
  5. Tomiyama H, Hashimoto H, Hirayama Y, Yambe M, Yamada J, Koji Y, et al. Synergistic acceleration of arterial stiffening in the presence of raised blood pressure and raised plasma glucose. Hypertension. 2006;47:180-8 pubmed
    ..This synergistic progression may contribute to the additive increases in the risk of cardiovascular events, at least in part. ..
  6. Ogura K, Ishi K, Matsumoto T, Kina K, Nojima M, Suda K. Human papillomavirus localization in cervical adenocarcinoma and adenosquamous carcinoma using in situ polymerase chain reaction: review of the literature of human papillomavirus detection in these carcinomas. Pathol Int. 2006;56:301-8 pubmed
    ..HPV infection in the underlying squamous epithelium might be related to the carcinogenesis, even in cervical adenocarcinoma. HPV-DNA localization was different in each component of adenosquamous carcinoma...
  7. Matsumoto Y, Dogru M, Sato E, Katono Y, Uchino Y, Shimmura S, et al. The application of in vivo confocal scanning laser microscopy in the management of Acanthamoeba keratitis. Mol Vis. 2007;13:1319-26 pubmed
  8. Kawabe H, Saito I. Reproducibility of masked hypertension determined from morning and evening home blood pressure measurements over a 6-month period. Hypertens Res. 2007;30:845-51 pubmed
    ..In conclusion, the reproducibility of masked hypertension over a 6-month period was moderate in an urban Japanese population when evaluated by morning home blood pressure. ..
  9. Miyamoto J, Nakajima T, Nagasao T, Konno E, Okabe K, Tanaka T, et al. Full-thickness reconstruction of the eyelid with rotation flap based on orbicularis oculi muscle and palatal mucosal graft: long-term results in 12 cases. J Plast Reconstr Aesthet Surg. 2009;62:1389-94 pubmed publisher
    ..Minimal shrinkage of palatal mucosal grafts prevents the reconstructed eyelid from sagging. In only one case, poor design of the flap led to flap congestion. However, this complication can be avoided with the proper design. ..

More Information

Publications773 found, 100 shown here

  1. Yoshimura T, Yoshikawa M, Otori N, Haruna S, Moriyama H. Correlation between the prostaglandin D(2)/E(2) ratio in nasal polyps and the recalcitrant pathophysiology of chronic rhinosinusitis associated with bronchial asthma. Allergol Int. 2008;57:429-36 pubmed
    ..We may therefore say that the PGD(2)/PGE(2) ratio reflects the intractable nature of CRS. ..
  2. Yonemori K, Tsuta K, Shimizu C, Hatanaka Y, Hashizume K, Ono M, et al. Immunohistochemical expression of PTEN and phosphorylated Akt are not correlated with clinical outcome in breast cancer patients treated with trastuzumab-containing neo-adjuvant chemotherapy. Med Oncol. 2009;26:344-9 pubmed publisher
    ..Except among patients with pathological complete remission, the persistent over-expression of HER2/neu may be a poor prognostic factor. ..
  3. Katada Y, Isogai J, Ina H, Tezuka M, Umehara I, Shibuya H. Potential extraperitoneal space continuous with the peri-intestinal space: CT evidence and anatomical evaluation in patients with pneumatosis intestinalis without intestinal ischemia. Surg Radiol Anat. 2009;31:707-13 pubmed publisher
    ..Here, we evaluated potential anatomical extraperitoneal spaces based on the extraluminal gas distribution in patients with pneumatosis intestinalis without intestinal ischemia...
  4. Hirai H, Omura K, Harada H, Tohara H. Sequential evaluation of swallowing function in patients with unilateral neck dissection. Head Neck. 2010;32:896-904 pubmed publisher
    ..However, it is unknown whether neck dissection can cause dysphagia. The aim of this study was to evaluate swallowing function after neck dissection...
  5. Sekine T, Konno M, Sasaki S, Moritani S, Miura T, Wong W, et al. Patients with Epstein-Fechtner syndromes owing to MYH9 R702 mutations develop progressive proteinuric renal disease. Kidney Int. 2010;78:207-14 pubmed publisher
    ..Thus, MYH9 R702 mutations display a strict genotype-phenotype correlation, and lead to the rapid deterioration of podocyte structure. Our results highlight the critical role of NMMHC-IIA in the development of FSGS. ..
  6. Nomura K, Yano E, Fukui T. Gender differences in clinical confidence: a nationwide survey of resident physicians in Japan. Acad Med. 2010;85:647-53 pubmed publisher
    ..This nationwide resident survey demonstrated gender differences in clinical confidence levels. Future studies require careful monitoring of self-confidence and its impact on physicians' professional development. ..
  7. Shirokane M, Kikuchi F, Satomi M, Suzuki S. Isolated torsion of a left normal fallopian tube during pregnancy. J Nippon Med Sch. 2011;78:40-1 pubmed
    ..Although uncommon, especially on the left side, torsion of the fallopian tube should be included in the differential diagnosis of abdominal pain during pregnancy...
  8. Mori T, Kato J, Yamane A, Aisa Y, Kawata Y, Ichimura M, et al. Prevention of cytarabine-induced kerato-conjunctivitis by eye rinse in patients receiving high-dose cytarabine and total body irradiation as a conditioning for hematopoietic stem cell transplantation. Int J Hematol. 2011;94:261-265 pubmed publisher
    ..00001, respectively). These results strongly suggest that eye rinse effectively reduces the incidence and severity of cytarabine-induced kerato-conjunctivitis in HSCT recipients who receive high-dose cytarabine following TBI. ..
  9. Tsunoda K, Harihara S, Tanabe Y, Dashnyam B. Polymorphism of the apolipoprotein B gene and association with plasma lipid and lipoprotein levels in the Mongolian Buryat. Biochem Genet. 2012;50:249-68 pubmed publisher
    ..Significant associations of genotypes were shown with the triglyceride level only at the AluI and XbaI sites. The lipid level of A-A+ females or X-X+ males was higher than that of A-A- females or X-X- males, respectively. ..
  10. Hirokawa S, Matsumoto T, Katsumata Y, Kitani M, Akazawa M, Takahashi Y, et al. Psychosocial and psychiatric characteristics of suicide completers with psychiatric treatment before death: a psychological autopsy study of 76 cases. Psychiatry Clin Neurosci. 2012;66:292-302 pubmed publisher
    ..In addition, a higher proportion of the treatment cases suffered from schizophrenia. ..
  11. Ohtaki U, Ozawa H, Ishizuka T, Kamiishi A, Sasaki K, Nakajima S, et al. [Evaluation of serum total carnitine values in persons with severe motor and intellectual disabilities with enteral (tube) feeding]. No To Hattatsu. 2012;44:374-7 pubmed
  12. Hattori T, Hata M, Sezai A, Wakui S, Shiono M. Surgical treatment of atrial septal defect in a patient with familial antithrombin-III deficiency. Ann Thorac Cardiovasc Surg. 2013;19:323-5 pubmed
    ..In patients with familial antithrombin-III deficiency, administration of antithrombin-III concentrate is effective when cardiopulmonary bypass is required. ..
  13. Yoshida T, Matsuwaki Y, Asaka D, Hama T, Otori N, Moriyama H. The expression of protease-activated receptors in chronic rhinosinusitis. Int Arch Allergy Immunol. 2013;161 Suppl 2:138-46 pubmed publisher
    ..Differences in the expression of PAR-2 and PAR-3 on epithelial cells, eosinophils and neutrophils may be involved in the pathogenesis of CRS. CRS may be able to be treated by targeting PAR-2 and PAR-3. ..
  14. Oda H, Sato T, Kunishima S, Nakagawa K, Izawa K, Hiejima E, et al. Exon skipping causes atypical phenotypes associated with a loss-of-function mutation in FLNA by restoring its protein function. Eur J Hum Genet. 2016;24:408-14 pubmed publisher
    ..This study expands the diversity of the phenotypes associated with loss-of-function mutations in FLNA. ..
  15. Lucas E, Dyer N, Murakami K, Lee Y, Chan Y, Grimaldi G, et al. Loss of Endometrial Plasticity in Recurrent Pregnancy Loss. Stem Cells. 2016;34:346-56 pubmed publisher
    ..Our findings indicate that stem cell deficiency and accelerated stromal senescence limit the differentiation capacity of the endometrium and predispose for pregnancy failure. ..
  16. Ogawa M, Anan T, Suzuki T, Okuma M, Ichihara K, Hasegawa T, et al. Initial Report of Phase II Study on Bi-weekly SOX plus Cetuximab Treatment for Wild-type K-RAS Advanced and Recurrent Colorectal Cancer. Anticancer Res. 2016;36:2505-11 pubmed
    ..These regimens seem to be promising for conversion therapy (4 out of 18 patients) because of good outcomes and an early response. ..
  17. Ichida K, Amaya Y, Kamatani N, Nishino T, Hosoya T, Sakai O. Identification of two mutations in human xanthine dehydrogenase gene responsible for classical type I xanthinuria. J Clin Invest. 1997;99:2391-7 pubmed
    ..Thus, in three subjects with type I xanthinuria, the primary genetic defects were confirmed to be in the xanthine dehydrogenase gene. ..
  18. Negishi K, Tezuka Y, Kushikata N, Wakamatsu S. Photorejuvenation for Asian skin by intense pulsed light. Dermatol Surg. 2001;27:627-31; discussion 632 pubmed
    ..Photorejuvenation using IPL is a completely safe and effective procedure even for Asian skin. It will be increasingly used for skin rejuvenation in the future. ..
  19. Uramatsu M, Saida Y, Nagao J, Takase M, Sai K, Okumura C, et al. Omental cyst: report of a case. Surg Today. 2001;31:1104-6 pubmed
    ..Pathological examination of the surgical specimen revealed endothelial cells on its internal wall and colonies of lymphocytes, confirming a diagnosis of lymphangioma, which is the most common type of omental cyst. ..
  20. Naito M, Kawashima A, Akiba T, Takanashi M, Nihei H. Effects of an angiotensin II receptor antagonist and angiotensin-converting enzyme inhibitors on burst forming units-erythroid in chronic hemodialysis patients. Am J Nephrol. 2003;23:287-93 pubmed
    ..The ACE inhibitors produced a smaller effect than the AT1 receptor antagonist. AT1 receptor blockade can directly inhibit erythropoiesis in vitro. ..
  21. Kurata A, Nonaka T, Arimura Y, Nunokawa M, Terado Y, Sudo K, et al. Multiple ulcers with perforation of the small intestine in buerger's disease: a case report. Gastroenterology. 2003;125:911-6 pubmed
    ..Nevertheless, the manifestation of regularly distanced skip intestinal ulcers in Buerger's disease is apparently unique. In addition, detailed pathological findings delineated this rare condition. ..
  22. Ogawa T, Hirose H, Miyashita K, Saito I, Saruta T. GPR40 gene Arg211His polymorphism may contribute to the variation of insulin secretory capacity in Japanese men. Metabolism. 2005;54:296-9 pubmed
    ..These results suggest that the Arg211His polymorphism in the GPR40 gene may contribute to the variation of insulin secretory capacity in Japanese men. ..
  23. Mitsuo A, Morimoto S, Nakiri Y, Suzuki J, Kaneko H, Tokano Y, et al. Decreased CD161+CD8+ T cells in the peripheral blood of patients suffering from rheumatic diseases. Rheumatology (Oxford). 2006;45:1477-84 pubmed
    ..This result suggests that there is also an abnormality of NKT cells in the CD8(+) population. ..
  24. Hasegawa J, Matsuoka R, Ichizuka K, Fujikawa H, Sekizawa A, Okai T. Umbilical cord insertion to the lower uterine segment is a risk factor for vasa previa. Fetal Diagn Ther. 2007;22:358-60 pubmed
    ..It should be considered that umbilical cord insertion to the lower uterine segment is a high risk for vasa previa. Ultrasound screening for cord insertion will make it possible to do efficient and certain detection of vasa previa. ..
  25. Shimada H, Nakashizuka H, Hattori T, Mori R, Mizutani Y, Yuzawa M. 25-Gauge peripheral iridectomy during vitrectomy. Eur J Ophthalmol. 2007;17:857-9 pubmed
    ..To report peripheral iridectomy using a 25-gauge vitreous cutter in a 42-year-old man with pupillary block due to adhesion of the internal iris surface to the continuous circular capsulorhexis...
  26. Matsuda N, Katsube K, Mikami S, Katsuki Y, Iseki H, Mukai M, et al. E-cadherin expression in the subepithelial nevus cells of the giant congenital nevocellular nevi (GCNN) correlates with their migration ability in vitro. J Dermatol Sci. 2008;52:21-30 pubmed publisher
    ..Giant congenital nevocellular nevi (GCNN) are histologically characterized by the broad distribution of nevus cells in the epidermis and dermis...
  27. Hibi T, Sameshima Y, Sekiguchi Y, Hisatome Y, Maruyama F, Moriwaki K, et al. Treating ulcerative colitis by Adacolumn therapeutic leucocytapheresis: clinical efficacy and safety based on surveillance of 656 patients in 53 centres in Japan. Dig Liver Dis. 2009;41:570-7 pubmed publisher
    ..Baseline granulocyte count was convincingly an independent predictor of clinical response. ..
  28. Saito T, Fujii T, Kanatani Y, Saijo M, Morikawa S, Yokote H, et al. Clinical and immunological response to attenuated tissue-cultured smallpox vaccine LC16m8. JAMA. 2009;301:1025-33 pubmed publisher
  29. Ohyashiki J, Hisatomi H, Shimizu S, Sugaya M, Ohyashiki K. Detection of low allele burden of JAK2 exon 12 mutations using TA-cloning in patients with erythrocytosis. Jpn J Clin Oncol. 2009;39:509-13 pubmed publisher
  30. Nakagawa T, Kanai Y, Komiyama M, Fujimoto H, Kakizoe T. Characteristics of prostate cancers found in specimens removed by radical cystoprostatectomy for bladder cancer and their relationship with serum prostate-specific antigen level. Cancer Sci. 2009;100:1880-4 pubmed publisher
    ..PSA still appears to be a useful screening tool for detecting prostate cancers with significant volume. ..
  31. Fujimoto H, Kobayashi H, Ohno M. Age-induced reduction in mitochondrial manganese superoxide dismutase activity and tolerance of macrophages against apoptosis induced by oxidized low density lipoprotein. Circ J. 2010;74:353-60 pubmed
    ..mtMnSOD activity decreases with age, thereby reducing the tolerance of macrophages against oxLDL-induced apoptosis. Our data may provide an important clue to clarify the mechanisms of age-induced atherosclerosis. ..
  32. Uno S, Zembutsu H, Hirasawa A, Takahashi A, Kubo M, Akahane T, et al. A genome-wide association study identifies genetic variants in the CDKN2BAS locus associated with endometriosis in Japanese. Nat Genet. 2010;42:707-10 pubmed publisher
    ..66 x 10(-6), odds ratio = 1.20). Our findings suggest that these regions are new susceptibility loci for endometriosis. ..
  33. Kikuta K, Tochigi N, Saito S, Shimoda T, Morioka H, Toyama Y, et al. Peroxiredoxin 2 as a chemotherapy responsiveness biomarker candidate in osteosarcoma revealed by proteomics. Proteomics Clin Appl. 2010;4:560-7 pubmed publisher
    ..These results establish PRDX 2 as a candidate for chemotherapy responsiveness marker in OS. Measuring PRDX 2 in biopsy samples before treatment may contribute to more effective management of OS. ..
  34. Tanaka T, Morita A, Kato M, Hirai T, Mizoue T, Terauchi Y, et al. Congener-specific polychlorinated biphenyls and the prevalence of diabetes in the Saku Control Obesity Program (SCOP). Endocr J. 2011;58:589-96 pubmed
  35. Jwa S, Arata N, Sakamoto N, Watanabe N, Aoki H, Kurauchi Mito A, et al. Prediction of pregnancy-induced hypertension by a shift of blood pressure class according to the JSH 2009 guidelines. Hypertens Res. 2011;34:1203-8 pubmed publisher
    ..05). Within JSH 2009 Classes I, II and III, a shift in BP from a low to a high class between 16 and 20 weeks of gestation predicts the subsequent development of PIH. ..
  36. Sato K, Sadamoto T, Hirasawa A, Oue A, Subudhi A, Miyazawa T, et al. Differential blood flow responses to CO? in human internal and external carotid and vertebral arteries. J Physiol. 2012;590:3277-90 pubmed publisher
  37. Nakamura Y, Matsumoto S, Matsushita A, Yoshioka M, Shimizu T, Yamahatsu K, et al. Pancreaticojejunostomy with closure of the pancreatic stump by endoscopic linear stapler in laparoscopic pancreaticoduodenectomy: a reliable technique and benefits for pancreatic resection. Asian J Endosc Surg. 2012;5:191-4 pubmed publisher
    ..Our pancreaticojejunostomy with closure of the pancreatic stump by endoscopic linear stapler is a feasible procedure in Lap-PD and has produced positive results over a short time frame. ..
  38. Kissane L, Ikeda B, Akizuki R, Nozaki S, Yoshimura K, Ikegami N. End-of-life preferences of the general public: Results from a Japanese national survey. Health Policy. 2015;119:1472-81 pubmed publisher
    ..Few people preferred to die at home, while a preference for hospital was largely determined by factors other than preference for LST. ..
  39. Hattori S, Kikuchi E, Kosaka T, Miyazaki Y, Tanaka N, Miyajima A, et al. Relationship Between Increased Expression of the Axl/Gas6 Signal Cascade and Prognosis of Patients with Upper Tract Urothelial Carcinoma. Ann Surg Oncol. 2016;23:663-70 pubmed publisher
    ..The protein expression of Axl and its ligand Gas6 may be a useful indicator for a worse clinical outcome in UTUC patients, especially patients with pT ≥ 2, who underwent radical nephroureterectomy. ..
  40. Matsumura N, Oki S, Ogawa K, Iwamoto T, Ochi K, Sato K, et al. Three-dimensional anthropometric analysis of the glenohumeral joint in a normal Japanese population. J Shoulder Elbow Surg. 2016;25:493-501 pubmed publisher
    ..The present results would be useful to determine the size of implants and to improve the design of shoulder prostheses that reflect the normal anatomy of the Asian glenohumeral joint. ..
  41. Sakurai D, Yonekura S, Iinuma T, Sakurai T, Morimoto Y, Mita Y, et al. Sublingual immunotherapy for allergic rhinitis: subjective versus objective tools to evaluate its success. Rhinology. 2016;54:221-30 pubmed publisher
    ..The number of JC pollen-specific IL-10+Foxp3+ cells increased only in these good responders. Changes in levels of allergen-specific Th2 cytokine-producing cells and IL-10+Foxp3+ cells could be objective biomarkers for SLIT. ..
  42. Hira D, Komase Y, Koshiyama S, Oguma T, Hiramatsu T, Shiraki A, et al. Problems of elderly patients on inhalation therapy: Difference in problem recognition between patients and medical professionals. Allergol Int. 2016;65:444-449 pubmed publisher
  43. Ushigome Y, Sato Y, Shimoda Y, Yamazaki Y, Shiohara T. Localized hypohidrosis is an unrecognized sequela of herpes zoster. J Am Acad Dermatol. 2017;76:160-162 pubmed publisher
  44. Kaneko K, Aoki M, Hattori S, Sato M, Kawana S. Successful treatment of Kimura's disease with cyclosporine. J Am Acad Dermatol. 1999;41:893-4 pubmed
    ..The patient was reassessed 18 months after the cessation of treatment and there was no evidence of recurrence of the disease. We speculate that the effects of cyclosporine on T helper-2 cells improves Kimura's disease. ..
  45. Jishage M, Fujino T, Yamazaki Y, Kuroda H, Nakamura T. Identification of target genes for EWS/ATF-1 chimeric transcription factor. Oncogene. 2003;22:41-9 pubmed
    ..Moreover, induction of POSH brought apoptotic cell death to KAS, the clear cell sarcoma (CCS) cell line, suggesting that repressed expression of POSH in CCS may be relevant to the normal signaling pathway in apoptosis. ..
  46. Arimoto T, Katagiri T, Oda K, Tsunoda T, Yasugi T, Osuga Y, et al. Genome-wide cDNA microarray analysis of gene-expression profiles involved in ovarian endometriosis. Int J Oncol. 2003;22:551-60 pubmed
    ..These data should provide useful information for finding candidate genes whose products might serve as molecular targets for diagnosis or treatment of endometriosis...
  47. Kawano Y, Ishizaki S, Sasamoto S, Katoh Y, Kobayashi S. Effect of meals with milk on body iron stores and improvement of dietary habit during weight loss in female rhythmic gymnasts. J Nutr Sci Vitaminol (Tokyo). 2002;48:395-400 pubmed
    ..Further, milk intake with meals is related to keeping regular meal times and frequency. ..
  48. Suzuki H, Yamadera H, Asayama K, Kudo Y, Ito T, Tamura Y, et al. Study of nocturnal sleep and the carryover effects of triazolam and brotizolam using neurophysiological and subjective methods. Neuropsychobiology. 2003;47:158-64 pubmed
    ..05) compared with PLA. TRZ (0.125 and 0.25 mg) and 0.25 mg BRZ exerted different effects on SLT. We suggest that these different effects are attributable to differences in the half-life of these hypnotics. ..
  49. Sakai T, Shikishima K, Mizobuchi T, Yoshida M, Kitahara K. Bilateral tonic pupils associated with neurosyphilis. Jpn J Ophthalmol. 2003;47:368-71 pubmed
    ..To describe 4 patients with bilateral tonic pupils in neurosyphilis...
  50. Nomoto N, Konno S, Sugimoto H, Kurihara T, Wakata N. Wallenberg syndrome with SIADH. Eur Neurol. 2005;53:35-6 pubmed
  51. Maeda Y, Tsuchida M, Fukaya T. Extensive endoscopic sinus surgery from the viewpoint of out-patients in a metropolitan area. J Laryngol Otol. 2005;119:23-6 pubmed
    ..Nine (53 per cent) had some unexpected problems post-operatively. The establishment of a care pathway may improve the outcome of extensive FESS on an out-patient basis...
  52. Mito K, Kaneko K, Makabe H, Takanokura M, Sakamoto K. Comparison of experimental and numerical muscle fiber conduction velocity (MFCV) distribution around the end-plate zone and fiber endings. Med Sci Monit. 2006;12:BR115-23 pubmed
    ..Therefore, it is demonstrated by experimental and theoretical studies that MFCV, Rxy(Ts), and AMPratio are influenced by irregular waveform properties depending on both positions of the end-plate and fiber endings. ..
  53. Hayashi T, Gekka T, Takeuchi T, Goto Omoto S, Kitahara K. A novel homozygous GRK1 mutation (P391H) in 2 siblings with Oguchi disease with markedly reduced cone responses. Ophthalmology. 2007;114:134-41 pubmed
    ..The objective of this study was to describe the ophthalmic features and a novel mutation in the GRK1 (rhodopsin kinase) gene in 2 Japanese patients with Oguchi disease...
  54. Adachi M, Ishihara K, Inoue H, Kudo K, Takahashi K, Morita Y, et al. Efficacy and safety of inhaled ciclesonide compared with chlorofluorocarbon beclomethasone dipropionate in adults with moderate to severe persistent asthma. Respirology. 2007;12:573-80 pubmed
    ..In adult patients with moderate to severe asthma, 800 microg/day of HFA-ciclesonide was significantly more effective than 800 microg/day of CFC-BDP. Ciclesonide at doses of 400 microg/day and 800 microg/day was safe and well tolerated. ..
  55. Yano Y, Nagahama M, Sugino K, Ito K, Kameyama K, Ito K. Paraganglioma of the thyroid: report of a male case with ultrasonographic imagings, cytologic, histologic, and immunohistochemical features. Thyroid. 2007;17:575-8 pubmed
    ..The definitive diagnosis of paraganglioma is made on the basis of the results of immunohistochemical staining. The diagnosis of thyroid paraganglioma is difficult to make both preoperatively and postoperatively. ..
  56. Sekita Y, Takeshita K, Tani M, Okamura N, Chida T, Kawano T, et al. Microbiological evaluation after gastrectomy and reconstruction for gastric cancer. Int Surg. 2007;92:355-60 pubmed
    ..Some patients after jejunal pouch reconstruction worried about their halitosis. Therefore, elimination of anaerobes may relieve it and improve postoperative quality of life...
  57. Akhter M, Inoue M, Kurahashi N, Iwasaki M, Sasazuki S, Tsugane S. Reproductive factors, exogenous female hormone use and colorectal cancer risk: the Japan Public Health Center-based Prospective Study. Eur J Cancer Prev. 2008;17:515-24 pubmed publisher
    ..59). In contrast, no statistically significant association was found for rectal cancer. These findings suggest that late age at first birth is associated with a reduced risk of colon cancer in postmenopausal Japanese women. ..
  58. Hirata T, Osuga Y, Fujimoto A, Oishi H, Hiroi H, Fujiwara T, et al. Conjoined twins in a triplet pregnancy after intracytoplasmic sperm injection and blastocyst transfer: case report and review of the literature. Fertil Steril. 2009;91:933.e9-12 pubmed publisher
    ..Our case is unique in that the transferred embryos were blastocysts that might have had additional damage on the zona pellucida from the longer culture. ..
  59. Kawasaki H, Morinushi T, Yakushiji M, Takigawa M. Nonlinear dynamical analysis of the effect by six stimuli on electroencephalogram. J Clin Neurophysiol. 2009;26:24-38 pubmed publisher
    ..We confirmed that the change observed in the complexity in response to which the chewing stimulus relates in our present study is the model that best fits that theory of the change on complexity suggested by Stam CJ...
  60. Isoda T, Ford A, Tomizawa D, van Delft F, De Castro D, Mitsuiki N, et al. Immunologically silent cancer clone transmission from mother to offspring. Proc Natl Acad Sci U S A. 2009;106:17882-5 pubmed publisher
    ..e., foreign to the infant), suggesting a possible mechanism for immune evasion. ..
  61. Tobinai K, Ogura M, Itoh K, Kinoshita T, Hotta T, Watanabe T, et al. Randomized phase II study of concurrent and sequential combinations of rituximab plus CHOP (cyclophosphamide, doxorubicin, vincristine and prednisolone) chemotherapy in untreated indolent B-cell non-Hodgkin lymphoma: 7-year follow-up results. Cancer Sci. 2010;101:2579-85 pubmed publisher
  62. Kosaka T, Kikuchi E, Mikami S, Miyajima A, Shirotake S, Ishida M, et al. Expression of snail in upper urinary tract urothelial carcinoma: prognostic significance and implications for tumor invasion. Clin Cancer Res. 2010;16:5814-23 pubmed publisher
    ..Snail-induced EMT represents a clinically relevant mechanism of UTUC progression and an attractive target for the treatment of patients with UTUC. ..
  63. Ono M, Tsuda H, Shimizu C, Yamamoto S, Shibata T, Yamamoto H, et al. Tumor-infiltrating lymphocytes are correlated with response to neoadjuvant chemotherapy in triple-negative breast cancer. Breast Cancer Res Treat. 2012;132:793-805 pubmed publisher
    ..Although the whole analysis was exploratory, the degree of TIL correlated with immune response appear to play a substantial role in the response to NAC in TNBC. ..
  64. Kojima S, Hirata M, Shinohara H, Ueno E. Reproducibility of scan prescription in follow-up brain MRI: manual versus automatic determination. Radiol Phys Technol. 2013;6:375-84 pubmed publisher
    ..05). We conclude that, in follow-up brain MRI, automatic positioning should be used, because manual positioning decreases the reproducibility of the scan prescription even if the same operator performs the second scan. ..
  65. Ikeda Y, Oda K, Hiraike Wada O, Koso T, Miyasaka A, Kashiyama T, et al. Cyclin D1 harboring the T286I mutation promotes oncogenic activation in endometrial cancer. Oncol Rep. 2013;30:584-8 pubmed publisher
    ..In conclusion, we identified an unreported CCND1 mutation (T286I) in two endometrial cancers and revealed that the mutation was functional for inducing cell proliferation in human cells. ..
  66. Kuboki Y, Matsusaka S, Minowa S, Shibata H, Suenaga M, Shinozaki E, et al. Circulating tumor cell (CTC) count and epithelial growth factor receptor expression on CTCs as biomarkers for cetuximab efficacy in advanced colorectal cancer. Anticancer Res. 2013;33:3905-10 pubmed
    ..These results suggest that the assessment of CTCs might provide with important prognostic information for such patients. ..
  67. Hayamizu F, Yamazaki Y. [Effects of optic disc size on progression of visual field defects in normal-tension glaucoma]. Nippon Ganka Gakkai Zasshi. 2013;117:609-15 pubmed
    ..In clinical factors, no statistically significant difference except disc area was found between the two groups. These findings suggest that optic disc area is associated with the progression of VF defects in patients with NTG. ..
  68. Takatsu Y, Hiki N, Nunobe S, Ohashi M, Honda M, Yamaguchi T, et al. Clinicopathological features of gastric cancer in young patients. Gastric Cancer. 2016;19:472-8 pubmed publisher
    ..Early-onset gastric cancer is likely to present lymph node metastases. The survival rate of gastric cancer in young patients was equivalent to that in patients in their 60s, which is the typical age at onset. ..
  69. Ishida N, Araki K, Sakai T, Kobayashi K, Kobayashi T, Fukada I, et al. Fulvestrant 500 mg in postmenopausal patients with metastatic breast cancer: the initial clinical experience. Breast Cancer. 2016;23:617-23 pubmed publisher
    ..Patients with acquired resistance to endocrine therapies might be good candidates for fulvestrant therapy regardless of the number of prior endocrine treatments. ..
  70. Meltzer E, Chervinsky P, Busse W, Ohta K, Bardin P, Bredenbröker D, et al. Roflumilast for asthma: Efficacy findings in placebo-controlled studies. Pulm Pharmacol Ther. 2015;35 Suppl:S20-7 pubmed publisher
    ..All studies were funded by Takeda. Trial registration numbers available on NCT00073177, NCT00076076, NCT00163527. ..
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