Experts and Doctors on actin depolymerizing factors in Tokyo, Japan


Locale: Tokyo, Japan
Topic: actin depolymerizing factors

Top Publications

  1. Aizawa H, Katadae M, Maruya M, Sameshima M, Murakami Murofushi K, Yahara I. Hyperosmotic stress-induced reorganization of actin bundles in Dictyostelium cells over-expressing cofilin. Genes Cells. 1999;4:311-24 pubmed
    ..Cofilin plays a pivotal role in concert with Aip1/Wrp2 in the reorganization of actin architectures into bundles that contract in a myosin-II-independent manner, in response to hyperosmotic stress. ..
  2. Nakano K, Satoh K, Morimatsu A, Ohnuma M, Mabuchi I. Interactions among a fimbrin, a capping protein, and an actin-depolymerizing factor in organization of the fission yeast actin cytoskeleton. Mol Biol Cell. 2001;12:3515-26 pubmed
    ..Finally, genetic studies suggested that Fim1 may function in cytokinesis in cooperation with Cdc15 (PSTPIP) and Rng2 (IQGAP), respectively. ..
  3. Nakano K, Mabuchi I. Actin-capping protein is involved in controlling organization of actin cytoskeleton together with ADF/cofilin, profilin and F-actin crosslinking proteins in fission yeast. Genes Cells. 2006;11:893-905 pubmed
    ..In addition, CP is likely involved in assembling the F-actin contractile ring and F-actin patch with F-actin-crosslinking proteins. ..
  4. Adachi R, Takeuchi K, Suzuki K. Antisense oligonucleotide to cofilin enhances respiratory burst and phagocytosis in opsonized zymosan-stimulated mouse macrophage J774.1 cells. J Biol Chem. 2002;277:45566-71 pubmed
    ..Furthermore, phagocytosis of OZ was enhanced by the antisense. These results show that cofilin plays an essential role in the control of phagocyte function through regulation of actin filament dynamics. ..
  5. Taoka M, Ichimura T, Wakamiya Tsuruta A, Kubota Y, Araki T, Obinata T, et al. V-1, a protein expressed transiently during murine cerebellar development, regulates actin polymerization via interaction with capping protein. J Biol Chem. 2003;278:5864-70 pubmed
  6. Yahara I, Aizawa H, Moriyama K, Iida K, Yonezawa N, Nishida E, et al. A role of cofilin/destrin in reorganization of actin cytoskeleton in response to stresses and cell stimuli. Cell Struct Funct. 1996;21:421-4 pubmed
    ..Functional roles of cofilin/actin in the nucleus remain to be elucidated. 7. Tertiary structure of destrin (cofilin) resembles that of gelsolin segment 1 and well explains its functions such as Ca(2+)-independent actin binding activity. ..
  7. Aizawa H, Kishi Y, Iida K, Sameshima M, Yahara I. Cofilin-2, a novel type of cofilin, is expressed specifically at aggregation stage of Dictyostelium discoideum development. Genes Cells. 2001;6:913-21 pubmed
    ..We also found that cofilin-2 did not rescue Deltacof1 yeast cells, whereas cofilin-1 did. Cofilin-2 may play a distinct role from that of cofilin-1 in destabilization of the actin cytoskeleton during Dictyostelium development. ..
  8. Moriyama K, Yahara I. Human CAP1 is a key factor in the recycling of cofilin and actin for rapid actin turnover. J Cell Sci. 2002;115:1591-601 pubmed
    ..Thus, CAP1 plays a key role in speeding up the turnover of actin filaments by effectively recycling cofilin and actin and through its effect on both ends of actin filament. ..
  9. Makioka A, Kumagai M, Hiranuka K, Kobayashi S, Takeuchi T. Entamoeba invadens: identification of ADF/cofilin and their expression analysis in relation to encystation and excystation. Exp Parasitol. 2011;127:195-201 pubmed publisher

More Information


  1. Iida K, Yahara I. Cooperation of two actin-binding proteins, cofilin and Aip1, in Saccharomyces cerevisiae. Genes Cells. 1999;4:21-32 pubmed
    ..Thick and long fibres stained with anti-cofilin antibody were detected in Deltascf1/aip1 cells, but not in SCF1/AIP1 cells. These results suggest the cooperative modulation of the actin cytoskeleton by cofilin and Aip1. ..
  2. Kusui K, Sasaki H, Adachi R, Matsui S, Yamamoto K, Yamaguchi T, et al. Ribosomal protein S18 identified as a cofilin-binding protein by using phage display library. Mol Cell Biochem. 2004;262:187-93 pubmed
    ..These results suggest that some cofilin molecules bind the ribosomal S18 protein under physiological conditions. ..
  3. Nakano K, Mabuchi I. Actin-depolymerizing protein Adf1 is required for formation and maintenance of the contractile ring during cytokinesis in fission yeast. Mol Biol Cell. 2006;17:1933-45 pubmed
    ..Tropomyosin was shown to antagonize the function of Adf1 in the contractile ring. We propose that formation and maintenance of the contractile ring are achieved by a balanced collaboration of these proteins. ..
  4. Koyanagi S, Hamasaki H, Sekiguchi S, Hara K, Ishii Y, Kyuwa S, et al. Effects of ubiquitin C-terminal hydrolase L1 deficiency on mouse ova. Reproduction. 2012;143:271-9 pubmed publisher
    ..In an ultrastructural study, gad mouse ova contained less ER in the cortex than in wild-type mice. These results provide new insights into the role of UCHL1 in the mechanism of polyspermy block in mouse ova. ..
  5. Ohno G, Ono K, Togo M, Watanabe Y, Ono S, Hagiwara M, et al. Muscle-specific splicing factors ASD-2 and SUP-12 cooperatively switch alternative pre-mRNA processing patterns of the ADF/cofilin gene in Caenorhabditis elegans. PLoS Genet. 2012;8:e1002991 pubmed publisher
  6. Toshima J, Horikomi C, Okada A, Hatori M, Nagano M, Masuda A, et al. Srv2/CAP is required for polarized actin cable assembly and patch internalization during clathrin-mediated endocytosis. J Cell Sci. 2016;129:367-79 pubmed publisher
    ..These results demonstrate the in vivo roles of Srv2p in the regulation of the actin cytoskeleton during clathrin-mediated endocytosis. ..