Experts and Doctors on amino acid sequence in Hirosaki, Aomori, Japan

Summary

Locale: Hirosaki, Aomori, Japan
Topic: amino acid sequence

Top Publications

  1. Kakizaki I, Tatara Y, Majima M, Kato Y, Endo M. Identification of proteoglycan from salmon nasal cartilage. Arch Biochem Biophys. 2011;506:58-65 pubmed publisher
    ..Based on cDNA analysis and amino acid analysis after ?-elimination, the ratio of serine attached to sugar chains was calculated to be approximately 37.7% of total serine, that is, 46 of 123 serine residues. ..
  2. Sakai K, Yamada M, Horiba N, Wakui M, Demura H, Suda T. The genomic organization of the human corticotropin-releasing factor type-1 receptor. Gene. 1998;219:125-30 pubmed
    ..Exon-intron boundaries are the same as that of the consensus sequence. Locations of introns in the coding sequence are similar to human CRF-R1, rat CRF-R1, human CRF-R2alpha and others belonging to the human glucagon receptor family. ..
  3. Ohguro H, Nakazawa M. Pathological roles of recoverin in cancer-associated retinopathy. Adv Exp Med Biol. 2002;514:109-24 pubmed
    ..Lastly, the antibody blocks recoverin function (inhibition of rhodopsin phosphorylation in a calcium dependent manner), and enhancement of rhodopsin phosphorylation induces retinal apoptosis. ..
  4. Kanai K, Hirose S, Oguni H, Fukuma G, Shirasaka Y, Miyajima T, et al. Effect of localization of missense mutations in SCN1A on epilepsy phenotype severity. Neurology. 2004;63:329-34 pubmed
    ..More severe sodium channel dysfunctions including abnormal ion selectivity that are caused by mutations in the pore regions may be involved in the pathogenesis of SMEI. ..
  5. Tomita H, Sasaki S, Osanai T, Nakano T, Higuma T, Yokoyama J, et al. Mutational analysis of Kir6.1 in Japanese patients with coronary spastic angina. Int J Mol Med. 2006;18:589-91 pubmed
    ..No mutation that alters primary structure of Kir6.1 was detected in Japanese patients with CSA. The results indicate that abnormality in the primary structure of Kir6.1 may not be involved in the genetic pathogenesis of CSA in humans. ..
  6. Wang A, Tan D, Takahashi A, Li T, Harada T. MdERFs, two ethylene-response factors involved in apple fruit ripening. J Exp Bot. 2007;58:3743-8 pubmed
    ..On the basis of concomitant analyses of the expression of some genes related to ripening, the functions of MdERFs and the role of ethylene in the ripening process are discussed. ..
  7. Nanashima N, Akita M, Yamada T, Shimizu T, Nakano H, Fan Y, et al. The hairless phenotype of the Hirosaki hairless rat is due to the deletion of an 80-kb genomic DNA containing five basic keratin genes. J Biol Chem. 2008;283:16868-75 pubmed publisher
    ..Kb25 was expressed in the cortex in HHRs, whereas it was in the medulla in SDRs. This study clearly illustrates the importance of hair keratin genes in hair growth. ..
  8. Ujiie H, Matsutani T, Tomatsu H, Fujihara A, Ushida C, Miwa Y, et al. Trans-translation is involved in the CcpA-dependent tagging and degradation of TreP in Bacillus subtilis. J Biochem. 2009;145:59-66 pubmed publisher
  9. Ozaki T, Yamashita T, Ishiguro S. Ca²+-induced release of mitochondrial m-calpain from outer membrane with binding of calpain small subunit and Grp75. Arch Biochem Biophys. 2011;507:254-61 pubmed publisher
    ..Our results showed that the activating mechanism of mitochondrial OM-bound m-calpain and the release of mitochondrial m-calpain from the OM have important implications in facilitating apoptotic cell death. ..

More Information

Publications14

  1. Tanaka T, Shima Y, Ogawa N, Nagayama K, Yoshida T, Ohmachi T. Expression, identification and purification of Dictyostelium acetoacetyl-coa thiolase expressed in Escherichia coli. Int J Biol Sci. 2010;7:9-17 pubmed
  2. Ozaki T, Nakazawa M, Yamashita T, Sorimachi H, Hata S, Tomita H, et al. Intravitreal injection or topical eye-drop application of a ?-calpain C2L domain peptide protects against photoreceptor cell death in Royal College of Surgeons' rats, a model of retinitis pigmentosa. Biochim Biophys Acta. 2012;1822:1783-95 pubmed publisher
    ..Topical application of 40mM HIV-N? also prevented apoptosis of retinal photoreceptors in RCS rats. Our results demonstrate that HIV-N?, a peptide inhibitor of mitochondrial ?-calpain, offers a new modality for treating RP...
  3. Maina E, Hu D, Asano K, Nakane A. Inhibition of emetic and superantigenic activities of staphylococcal enterotoxin A by synthetic peptides. Peptides. 2012;38:1-7 pubmed publisher
    ..These regions could be important targets for therapeutic intervention against SEA exposure. ..
  4. Tatara Y, Kakizaki I, Kuroda Y, Suto S, Ishioka H, Endo M. Epiphycan from salmon nasal cartilage is a novel type of large leucine-rich proteoglycan. Glycobiology. 2013;23:993-1003 pubmed publisher
    ..EPY is heavily substituted by chondroitin sulfate, giving an overall molecular weight of just under 2 × 10(6). EPY from salmon nasal cartilage is a novel type of large leucine-rich proteoglycan. ..
  5. Senoo H, Araki T, Fukuzawa M, Williams J. A new kind of membrane-tethered eukaryotic transcription factor that shares an auto-proteolytic processing mechanism with bacteriophage tail-spike proteins. J Cell Sci. 2013;126:5247-58 pubmed publisher