Experts and Doctors on spinal cord in Okazaki, Aichi, Japan


Locale: Okazaki, Aichi, Japan
Topic: spinal cord

Top Publications

  1. Tanaka H, Ikenaka K, Isa T. Electrophysiological abnormalities precede apparent histological demyelination in the central nervous system of mice overexpressing proteolipid protein. J Neurosci Res. 2006;84:1206-16 pubmed
    ..These results suggest that electrophysiological analysis can detect the abnormalities of the plp(tg/-) mice earlier than histological or behavioral measures. ..
  2. Isa T. [Reconsidering somatotopy with respect to functional recovery from spinal cord injury]. Brain Nerve. 2009;61:1405-11 pubmed
    ..It will lead to understanding the relation between the structural change in the somatotopic representation map and its functional roles in the motor control. ..
  3. Seki K, Perlmutter S, Fetz E. Task-dependent modulation of primary afferent depolarization in cervical spinal cord of monkeys performing an instructed delay task. J Neurophysiol. 2009;102:85-99 pubmed publisher
    ..This facilitation started 400-900 ms before the onset of EMG activity. Such pre-EMG modulation is hard to explain by movement-induced reafference and probably is associated with descending motor commands. ..
  4. Satou C, Kimura Y, Kohashi T, Horikawa K, Takeda H, Oda Y, et al. Functional role of a specialized class of spinal commissural inhibitory neurons during fast escapes in zebrafish. J Neurosci. 2009;29:6780-93 pubmed publisher
    ..This study illustrates (1) a clear example of the behavioral role of a specialized class of interneurons and (2) the capacity of the spinal circuits to filter descending commands and thereby produce the appropriate behavior. ..
  5. Okigawa S, Mizoguchi T, Okano M, Tanaka H, Isoda M, Jiang Y, et al. Different combinations of Notch ligands and receptors regulate V2 interneuron progenitor proliferation and V2a/V2b cell fate determination. Dev Biol. 2014;391:196-206 pubmed publisher
    ..In conclusion, V2-IN cell progenitor proliferation and V2a/V2b cell fate determination involve signaling through different sets of Notch ligand-receptor combinations that occur concurrently during development in zebrafish. ..
  6. Satou C, Kimura Y, Hirata H, Suster M, Kawakami K, Higashijima S. Transgenic tools to characterize neuronal properties of discrete populations of zebrafish neurons. Development. 2013;140:3927-31 pubmed publisher
  7. Usui N, Watanabe K, Ono K, Tomita K, Tamamaki N, Ikenaka K, et al. Role of motoneuron-derived neurotrophin 3 in survival and axonal projection of sensory neurons during neural circuit formation. Development. 2012;139:1125-32 pubmed publisher
    ..Taken together, we show that the motoneuron is a functional source of Ntf3 and motoneuron-derived Ntf3 is an essential pre-target neurotrophin for survival and axonal projection of sensory neurons. ..
  8. Watanabe K, Tamamaki N, Furuta T, Ackerman S, Ikenaka K, Ono K. Dorsally derived netrin 1 provides an inhibitory cue and elaborates the 'waiting period' for primary sensory axons in the developing spinal cord. Development. 2006;133:1379-87 pubmed
    ..These results are the first direct evidence that netrin 1 in the dorsal spinal cord acts as an inhibitory cue for primary sensory axons and is a crucial signal for the formation of sensory afferent neural networks. ..
  9. Ogawa Y, Takebayashi H, Takahashi M, Osumi N, Iwasaki Y, Ikenaka K. Gliogenic radial glial cells show heterogeneity in the developing mouse spinal cord. Dev Neurosci. 2005;27:364-77 pubmed
    ..This raises the idea that astrocytes generated from different domains along the dorsoventral axis in the mouse spinal cord have distinct characteristics. ..

More Information


  1. Shimizu T, Kagawa T, Wada T, Muroyama Y, Takada S, Ikenaka K. Wnt signaling controls the timing of oligodendrocyte development in the spinal cord. Dev Biol. 2005;282:397-410 pubmed
    ..Addition of rmFz-8/Fc, a Wnt antagonist, increased the number of immature oligodendrocytes in the spinal cord explant culture, demonstrating that endogenous Wnt signaling controls oligodendrocyte development. ..
  2. Shibasaki K, Murayama N, Ono K, Ishizaki Y, Tominaga M. TRPV2 enhances axon outgrowth through its activation by membrane stretch in developing sensory and motor neurons. J Neurosci. 2010;30:4601-12 pubmed publisher
    ..Thus, for the first time we revealed that TRPV2 is an important regulator for axon outgrowth through its activation by membrane stretch during development. ..
  3. Gotoh H, Ono K, Takebayashi H, Harada H, Nakamura H, Ikenaka K. Genetically-defined lineage tracing of Nkx2.2-expressing cells in chick spinal cord. Dev Biol. 2011;349:504-11 pubmed publisher
    ..Moreover, the labeled OLs were found throughout the white matter in the spinal cord including the most dorsal spinal cord. Thus p3 domain directly generates spinal cord OLs in the chick spinal cord...
  4. Satou C, Kimura Y, Higashijima S. Generation of multiple classes of V0 neurons in zebrafish spinal cord: progenitor heterogeneity and temporal control of neuronal diversity. J Neurosci. 2012;32:1771-83 pubmed publisher
    ..These results suggest that multiple types of V0 neurons are produced by two distinct mechanisms; from heterogeneous p0 progenitors and from the same p0 progenitor, but in a time-dependent manner. ..
  5. Masahira N, Takebayashi H, Ono K, Watanabe K, Ding L, Furusho M, et al. Olig2-positive progenitors in the embryonic spinal cord give rise not only to motoneurons and oligodendrocytes, but also to a subset of astrocytes and ependymal cells. Dev Biol. 2006;293:358-69 pubmed
    ..These findings demonstrate that motoneurons and oligodendrocytes are not the only cell types originating from this domain. ..
  6. Kimura Y, Satou C, Fujioka S, Shoji W, Umeda K, Ishizuka T, et al. Hindbrain V2a neurons in the excitation of spinal locomotor circuits during zebrafish swimming. Curr Biol. 2013;23:843-9 pubmed publisher
    ..These results indicated that hindbrain reticulospinal V2a neurons play critical roles in providing excitation to the spinal locomotor circuits during swimming by providing both tonic and phasic inputs to the circuits. ..
  7. Ishibashi H, Hirao K, Yamaguchi J, Nabekura J. Inhibition of chloride outward transport by gadolinium in cultured rat spinal cord neurons. Neurotoxicology. 2009;30:155-9 pubmed publisher
    ..These results suggest that Gd3+ inhibits a KCC function and gives rise to increase in intracellular Cl- concentration. The reduction of outward chloride transport could be related to the neurotoxic effects of Gd3+. ..
  8. Kimura Y, Satou C, Higashijima S. V2a and V2b neurons are generated by the final divisions of pair-producing progenitors in the zebrafish spinal cord. Development. 2008;135:3001-5 pubmed publisher
    ..We report that the terminal division of pair-producing progenitor cells in vertebrate neurogenesis can reproducibly produce two distinct neurons through a mechanism that may not depend on the orientation of the division axis. ..