Genomes and Genes
Experts and Doctors on mice in Okazaki, Aichi, Japan
Locale: Okazaki, Aichi, Japan
Publications127 found, 100 shown here
- Katoh Fukui Y, Owaki A, Toyama Y, Kusaka M, Shinohara Y, Maekawa M, et al. Mouse Polycomb M33 is required for splenic vascular and adrenal gland formation through regulating Ad4BP/SF1 expression. Blood. 2005;106:1612-20 pubmed..In agreement with these observations, chromatin immunoprecipitation assays with adrenocortical Y-1 cells revealed direct binding of the M33-containing PcG to the Ad4BP/SF1 gene locus. ..
- Inoue H, Okada Y. Roles of volume-sensitive chloride channel in excitotoxic neuronal injury. J Neurosci. 2007;27:1445-55 pubmed
- Noda M. Hydromineral neuroendocrinology: mechanism of sensing sodium levels in the mammalian brain. Exp Physiol. 2007;92:513-22 pubmed..Close communication between inexcitable glial cells and excitable neural cells thus appears to be the basis of the central control of salt homeostasis. ..
- Tanaka H, Ma J, Tanaka K, Takao K, Komada M, Tanda K, et al. Mice with altered myelin proteolipid protein gene expression display cognitive deficits accompanied by abnormal neuron-glia interactions and decreased conduction velocities. J Neurosci. 2009;29:8363-71 pubmed publisher..Our results implicate that abnormalities in the neuron-glia interactions at the paranodal junctions can result in reduced CV in the CNS, which then induces behavioral abnormalities related to schizophrenia. ..
- Kaneda K, Kasahara H, Matsui R, Katoh T, Mizukami H, Ozawa K, et al. Selective optical control of synaptic transmission in the subcortical visual pathway by activation of viral vector-expressed halorhodopsin. PLoS ONE. 2011;6:e18452 pubmed publisher..The method established here can most likely be applied to a variety of brain regions for studying the function of individual inputs to these regions. ..
- Nishihara E, Hiyama T, Noda M. Osmosensitivity of transient receptor potential vanilloid 1 is synergistically enhanced by distinct activating stimuli such as temperature and protons. PLoS ONE. 2011;6:e22246 pubmed publisher..Our findings thus indicate that TRPV1 integrates multiple different types of activating stimuli, and that TRPV1 is sensitive to hypertonic stimuli under physiologically relevant conditions. ..
- Uramoto H, Okada T, Okada Y. Protective role of cardiac CFTR activation upon early reperfusion against myocardial infarction. Cell Physiol Biochem. 2012;30:1023-38 pubmed publisher..Cardiac CFTR may serve as a target accessible even after ischemic attack for pharmacotherapeutic intervention in I/R-induced myocardial infarction. ..
- Komine Y, Takao K, Miyakawa T, Yamamori T. Behavioral abnormalities observed in Zfhx2-deficient mice. PLoS ONE. 2012;7:e53114 pubmed publisher..Moreover, considering their phenotypes, the Zfhx2-deficient mice may provide a novel model of human psychiatric disorders. ..
- Sano H, Chiken S, Hikida T, Kobayashi K, Nambu A. Signals through the striatopallidal indirect pathway stop movements by phasic excitation in the substantia nigra. J Neurosci. 2013;33:7583-94 pubmed publisher..These observations suggest that phasic late excitation in the SNr through the striatopallidal indirect pathway plays a key role in stopping movements. ..
- Mochii M, Agata K, Eguchi G. Complete sequence and expression of a cDNA encoding a chicken 115-kDa melanosomal matrix protein. Pigment Cell Res. 1991;4:41-7 pubmed..The presence of a specific sorting signal was suggested for localization of melanosomal proteins. Southern blot analysis has revealed that the homologues of the chicken MMP115 gene are found in many vertebrate genomes. ..
- Ebihara S, Obata K, Yanagawa Y. Mouse vesicular GABA transporter gene: genomic organization, transcriptional regulation and chromosomal localization. Brain Res Mol Brain Res. 2003;110:126-39 pubmed..These results suggest a possible mechanism for regulation of the expression of the mVGAT gene. ..
- Zubair M, Ishihara S, Oka S, Okumura K, Morohashi K. Two-step regulation of Ad4BP/SF-1 gene transcription during fetal adrenal development: initiation by a Hox-Pbx1-Prep1 complex and maintenance via autoregulation by Ad4BP/SF-1. Mol Cell Biol. 2006;26:4111-21 pubmed..Using transgenic mice with lacZ driven by the FAdE, we clearly identified a fetal adrenal cortex in mice, and the X zone is the fetal adrenal cells accumulated at the juxtamedullary region after birth. ..
- Mandadi S, Sokabe T, Shibasaki K, Katanosaka K, Mizuno A, Moqrich A, et al. TRPV3 in keratinocytes transmits temperature information to sensory neurons via ATP. Pflugers Arch. 2009;458:1093-102 pubmed publisher..This study provides evidence that ATP is a messenger molecule for mainly TRPV3-mediated thermotransduction in skin. ..
- Hiyama T, Matsuda S, Fujikawa A, Matsumoto M, Watanabe E, Kajiwara H, et al. Autoimmunity to the sodium-level sensor in the brain causes essential hypernatremia. Neuron. 2010;66:508-22 pubmed publisher..Our findings thus provide new insights into the pathogenesis of hypernatremia relevant to the sodium-level-sensing mechanism in humans. ..
- Akita T, Fedorovich S, Okada Y. Ca2+ nanodomain-mediated component of swelling-induced volume-sensitive outwardly rectifying anion current triggered by autocrine action of ATP in mouse astrocytes. Cell Physiol Biochem. 2011;28:1181-90 pubmed publisher..Thus the swelling-induced VSOR channel activation in mouse astrocytes is partly regulated via Ca(2+) nanodomains, whose generation is triggered by an autocrine action of ATP. ..
- Takahashi M, Yamagata M, Noda M. Specific expression of ezrin, a cytoskeletal-membrane linker protein, in a subset of chick retinotectal and sensory projections. Eur J Neurosci. 1999;11:545-58 pubmed
- Sabirov R, Dutta A, Okada Y. Volume-dependent ATP-conductive large-conductance anion channel as a pathway for swelling-induced ATP release. J Gen Physiol. 2001;118:251-66 pubmed..Thus, it is concluded that the volume- and voltage-dependent ATP-conductive large-conductance anion channel serves as a conductive pathway for the swelling-induced ATP release in C127i cells. ..
- Katsu Y, Lubahn D, Iguchi T. Expression of a novel C-type lectin in the mouse vagina. Endocrinology. 2003;144:2597-605 pubmed..Taken together, these data suggest that DDV10 encodes a novel, 17beta-estradiol-regulated, C-type lectin in the mouse vagina. DDV10 may play a role in the stratification and/or cornification of epithelial cells during differentiation. ..
- Tsunekawa N, Yanagawa Y, Obata K. Development of GABAergic neurons from the ventricular zone in the superior colliculus of the mouse. Neurosci Res. 2005;51:243-51 pubmed..At E12-13, bundles of commissural GFP-positive fibers which appeared to originate outside the SC were distributed at the superficial layer. These superficial fibers were no longer observed at the later stages. ..
- Takada R, Hijikata H, Kondoh H, Takada S. Analysis of combinatorial effects of Wnts and Frizzleds on beta-catenin/armadillo stabilization and Dishevelled phosphorylation. Genes Cells. 2005;10:919-28 pubmed
- Hatakeyama H, Kishimoto T, Nemoto T, Kasai H, Takahashi N. Rapid glucose sensing by protein kinase A for insulin exocytosis in mouse pancreatic islets. J Physiol. 2006;570:271-82 pubmed
- Liu H, Tashmukhamedov B, Inoue H, Okada Y, Sabirov R. Roles of two types of anion channels in glutamate release from mouse astrocytes under ischemic or osmotic stress. Glia. 2006;54:343-57 pubmed..We conclude that these two channels jointly represent a major conductive pathway for the release of glutamate from swollen and ischemia-challenged astrocytes, with the contribution of maxi-anion channels being predominant. ..
- Tanaka H, Ikenaka K, Isa T. Electrophysiological abnormalities precede apparent histological demyelination in the central nervous system of mice overexpressing proteolipid protein. J Neurosci Res. 2006;84:1206-16 pubmed..These results suggest that electrophysiological analysis can detect the abnormalities of the plp(tg/-) mice earlier than histological or behavioral measures. ..
- Shimizu H, Watanabe E, Hiyama T, Nagakura A, Fujikawa A, Okado H, et al. Glial Nax channels control lactate signaling to neurons for brain [Na+] sensing. Neuron. 2007;54:59-72 pubmed..These results suggest that the information on a physiological increase of the Na level in body fluids sensed by Na(x) in glial cells is transmitted to neurons by lactate as a mediator to regulate neural activities of the SFO. ..
- Tao H, Suzuki M, Kiyonari H, Abe T, Sasaoka T, Ueno N. Mouse prickle1, the homolog of a PCP gene, is essential for epiblast apical-basal polarity. Proc Natl Acad Sci U S A. 2009;106:14426-31 pubmed publisher..Our results demonstrate a role for mpk1 in AB polarity formation rather than expected role as a PCP gene. ..
- Fukumi Tominaga T, Mori Y, Matsuura A, Kaneko K, Matsui M, Ogata M, et al. DIP/WISH-deficient mice reveal Dia- and N-WASP-interacting protein as a regulator of cytoskeletal dynamics in embryonic fibroblasts. Genes Cells. 2009;14:1197-207 pubmed publisher..Thus, DIP/WISH is a negative regulator of Rho and modulates cell adhesion by controlling the integration of adhesion molecules. ..
- Fukata Y, Lovero K, Iwanaga T, Watanabe A, Yokoi N, Tabuchi K, et al. Disruption of LGI1-linked synaptic complex causes abnormal synaptic transmission and epilepsy. Proc Natl Acad Sci U S A. 2010;107:3799-804 pubmed publisher..Thus, LGI1 may serve as a major determinant of brain excitation, and the LGI1 gene-targeted mouse provides a good model for human epilepsy. ..
- Uchida K, Shiuchi T, Inada H, Minokoshi Y, Tominaga M. Metabolic adaptation of mice in a cool environment. Pflugers Arch. 2010;459:765-74 pubmed publisher..These adaptations can be interpreted as preparation for a further reduction in ambient temperature. ..
- Ishii H, Nakajo K, Yanagawa Y, Kubo Y. Identification and characterization of Cs(+) -permeable K(+) channel current in mouse cerebellar Purkinje cells in lobules 9 and 10 evoked by molecular layer stimulation. Eur J Neurosci. 2010;32:736-48 pubmed publisher..Taken together, these results show that KCNK13 is a legitimate candidate for the Cs(+)-permeable K(+) channel activated by GABA(B) receptors, presumably via G(??) subunits in Purkinje cells. ..
- Kasugai Y, Swinny J, Roberts J, Dalezios Y, Fukazawa Y, Sieghart W, et al. Quantitative localisation of synaptic and extrasynaptic GABAA receptor subunits on hippocampal pyramidal cells by freeze-fracture replica immunolabelling. Eur J Neurosci. 2010;32:1868-88 pubmed publisher..Assuming similar antibody access to all receptors, about 60% of these subunits are in extrasynaptic receptors. ..
- Sümegi M, Fukazawa Y, Matsui K, Lorincz A, Eyre M, Nusser Z, et al. Virus-mediated swapping of zolpidem-insensitive with zolpidem-sensitive GABA(A) receptors in cortical pyramidal cells. J Physiol. 2012;590:1517-34 pubmed publisher..In addition, this virus-based approach opens up the possibility of modifying multiple cell types in distinct brain regions and performing alternative recombination-based intersectional genetic manipulations. ..
- Ohashi R, Takao K, Miyakawa T, Shiina N. Comprehensive behavioral analysis of RNG105 (Caprin1) heterozygous mice: Reduced social interaction and attenuated response to novelty. Sci Rep. 2016;6:20775 pubmed publisher..These findings suggest that the RNG105 heterozygous knockout leads to a reduction in sociality, response to novelty and flexibility in learning, which are implicated in ASD-like behavior. ..
- Yoshikawa S, Tanimura T, Miyawaki A, Nakamura M, Yuzaki M, Furuichi T, et al. Molecular cloning and characterization of the inositol 1,4,5-trisphosphate receptor in Drosophila melanogaster. J Biol Chem. 1992;267:16613-9 pubmed..The present study points to the likely functional importance of the InsP3/Ca2+ signaling system in Drosophila. ..
- Inoue T, Tamura T, Furuichi T, Mikoshiba K. Isolation of complementary DNAs encoding a cerebellum-enriched nuclear factor I family that activates transcription from the mouse myelin basic protein promoter. J Biol Chem. 1990;265:19065-70 pubmed..NFI-B proteins translated in vitro could bind to the MBP NFI site. Furthermore, we demonstrated by transfection experiments that NFI-B activated transcription from transfected MBP promoter in neuronal/glial NG108-15 cells. ..
- Yamada H, Fukushima M, Koizumi K, Katakura H, Nakanishi H, Teshima S, et al. Regulation of dihydropyrimidine dehydrogenase gene expression in regenerating mouse liver. Int J Oncol. 2003;22:359-64 pubmed
- Yamagata Y, Kobayashi S, Umeda T, Inoue A, Sakagami H, Fukaya M, et al. Kinase-dead knock-in mouse reveals an essential role of kinase activity of Ca2+/calmodulin-dependent protein kinase IIalpha in dendritic spine enlargement, long-term potentiation, and learning. J Neurosci. 2009;29:7607-18 pubmed publisher..These results demonstrate that kinase activity of CaMKIIalpha is a common critical gate controlling structural, functional, and behavioral expression of synaptic memory. ..
- Fujimori T. Preimplantation development of mouse: a view from cellular behavior. Dev Growth Differ. 2010;52:253-62 pubmed publisher..Here, mouse preimplantation embryonic development is briefly summarized and our current understanding of this complex process based on recent observations is reviewed...
- Watakabe A, Komatsu Y, Ohsawa S, Yamamori T. Fluorescent in situ hybridization technique for cell type identification and characterization in the central nervous system. Methods. 2010;52:367-74 pubmed publisher..In this article, we describe the methodology of these techniques, taking examples from our analyses of the mammalian cerebral cortex. ..
- Budisantoso T, Matsui K, Kamasawa N, Fukazawa Y, Shigemoto R. Mechanisms underlying signal filtering at a multisynapse contact. J Neurosci. 2012;32:2357-76 pubmed publisher..We propose that the micrometer-order structure can ultimately affect the visual information processing. ..
- Hiyama T, Yoshida M, Matsumoto M, Suzuki R, Matsuda T, Watanabe E, et al. Endothelin-3 expression in the subfornical organ enhances the sensitivity of Na(x), the brain sodium-level sensor, to suppress salt intake. Cell Metab. 2013;17:507-19 pubmed..These results indicate that ET-3 expression in the SFO is tightly coupled with body-fluid homeostasis through modulation of the [Na(+)](o) sensitivity of Na(x). ..
- Fukata Y, Dimitrov A, Boncompain G, Vielemeyer O, Perez F, Fukata M. Local palmitoylation cycles define activity-regulated postsynaptic subdomains. J Cell Biol. 2013;202:145-61 pubmed publisher..Thus, the first genetically encoded antibody sensitive to palmitoylation reveals an instructive role of local palmitoylation machinery in creating activity-responsive PSD-95 nanodomains, contributing to the PSD (re)organization. ..
- Shih P, Savtchenko L, Kamasawa N, Dembitskaya Y, McHugh T, Rusakov D, et al. Retrograde synaptic signaling mediated by K+ efflux through postsynaptic NMDA receptors. Cell Rep. 2013;5:941-51 pubmed publisher..Our findings indicate that postsynaptic NMDAR-mediated K(+) efflux contributes to use-dependent synaptic facilitation, thus revealing a fundamental form of retrograde synaptic signaling. ..
- Suzuki R, Matsumoto M, Fujikawa A, Kato A, Kuboyama K, Yonehara K, et al. SPIG1 negatively regulates BDNF maturation. J Neurosci. 2014;34:3429-42 pubmed publisher..Together, these results suggest that SPIG1 negatively regulated BDNF maturation by binding to proBDNF, thereby suppressing axonal branching and spine formation. ..
- Funayama N, Nagafuchi A, Sato N, Tsukita S. Radixin is a novel member of the band 4.1 family. J Cell Biol. 1991;115:1039-48 pubmed..1 protein described in this study favors the idea that radixin plays a crucial role in the association of the barbed ends of actin filaments with the plasma membrane in the cell-to-cell adherens junction and the cleavage furrow. ..
- Morohashi K, Tsuboi Asai H, Matsushita S, Suda M, Nakashima M, Sasano H, et al. Structural and functional abnormalities in the spleen of an mFtz-F1 gene-disrupted mouse. Blood. 1999;93:1586-94 pubmed..Our results indicate that a lack of the mFtz-F1 gene in mice is associated with structural and functional abnormalities of the splenic vascular system. ..
- Li F, Endo T, Isa T. Presynaptic muscarinic acetylcholine receptors suppress GABAergic synaptic transmission in the intermediate grey layer of mouse superior colliculus. Eur J Neurosci. 2004;20:2079-88 pubmed..This may be an additional mechanism by which cholinergic inputs can facilitate tectofugal command generation. ..
- Toychiev A, Sabirov R, Takahashi N, Ando Akatsuka Y, Liu H, Shintani T, et al. Activation of maxi-anion channel by protein tyrosine dephosphorylation. Am J Physiol Cell Physiol. 2009;297:C990-1000 pubmed publisher..Thus it is concluded that activation of the maxi-anion channel involves protein dephosphorylation mediated by protein tyrosine phosphatases that include RPTPzeta in mouse fibroblasts, but not in C127 cells. ..
- Nagakura A, Hiyama T, Noda M. Na(x)-deficient mice show normal vasopressin response to dehydration. Neurosci Lett. 2010;472:161-5 pubmed publisher..All these results indicate that the information of Na+-level increase detected by Na(x) does not contribute to the control of VP production/release. ..
- Hira R, Ohkubo F, Ozawa K, Isomura Y, Kitamura K, Kano M, et al. Spatiotemporal dynamics of functional clusters of neurons in the mouse motor cortex during a voluntary movement. J Neurosci. 2013;33:1377-90 pubmed publisher..This higher fidelity of activity was related to higher trial-to-trial correlations of activities of pairs within the cluster. We propose that strong recurrent network clusters may represent the execution of voluntary movements. ..
- Murakoshi H, Shin M, Parra Bueno P, Szatmari E, Shibata A, Yasuda R. Kinetics of Endogenous CaMKII Required for Synaptic Plasticity Revealed by Optogenetic Kinase Inhibitor. Neuron. 2017;94:37-47.e5 pubmed publisher..Thus, we demonstrated that paAIP2 is useful to elucidate the temporal window of CaMKII activation required for synaptic plasticity and learning. ..
- Iwasaki Y, Hosoya T, Takebayashi H, Ogawa Y, Hotta Y, Ikenaka K. The potential to induce glial differentiation is conserved between Drosophila and mammalian glial cells missing genes. Development. 2003;130:6027-35 pubmed..The mammalian homolog of Drosophila gcm, mouse Gcm1, exhibits the potential to induce gliogenesis, but may function in the generation of a minor subpopulation of glial cells. ..
- Yamanaka H, Yanagawa Y, Obata K. Development of stellate and basket cells and their apoptosis in mouse cerebellar cortex. Neurosci Res. 2004;50:13-22 pubmed..Apoptosis of GABAergic interneurons was demonstrated in the ML and WM during the first two weeks. Their apoptotic loss will contribute to the adjustment of neuron number or elimination of any improper populations. ..
- Nakamura T, Katsu Y, Watanabe H, Iguchi T. Estrogen receptor subtypes selectively mediate female mouse reproductive abnormalities induced by neonatal exposure to estrogenic chemicals. Toxicology. 2008;253:117-24 pubmed publisher..In contrast, polyovular follicles were induced by neonatal treatment with both ERalpha and ERbeta ligands, suggesting that ovarian abnormalities are mediated through both ER subtypes. ..
- Toyoda S, Kawaguchi M, Kobayashi T, Tarusawa E, Toyama T, Okano M, et al. Developmental epigenetic modification regulates stochastic expression of clustered protocadherin genes, generating single neuron diversity. Neuron. 2014;82:94-108 pubmed publisher..They also suggest a mechanism for a rare human recessive disease, the ICF (Immunodeficiency, Centromere instability, and Facial anomalies) syndrome, which is caused by Dnmt3b mutations. ..
- Sasaki M, Takagi M, Okamura Y. A voltage sensor-domain protein is a voltage-gated proton channel. Science. 2006;312:589-92 pubmed publisher..Responses of voltage dependence to sequence changes suggest that mouse voltage-sensor domain-only protein is itself a channel, rather than a regulator of another channel protein...
- Shibuya H, Iwata H, Masuyama N, Gotoh Y, Yamaguchi K, Irie K, et al. Role of TAK1 and TAB1 in BMP signaling in early Xenopus development. EMBO J. 1998;17:1019-28 pubmed..These results thus suggest that xTAK1 and xTAB1 function in the BMP signal transduction pathway in Xenopus embryos in a cooperative manner. ..
- Fukada M, Watakabe I, Yuasa Kawada J, Kawachi H, Kuroiwa A, Matsuda Y, et al. Molecular characterization of CRMP5, a novel member of the collapsin response mediator protein family. J Biol Chem. 2000;275:37957-65 pubmed..This indicates that different complexes may have distinct functions in shaping the neural networks. ..
- Watanabe E, Fujikawa A, Matsunaga H, Yasoshima Y, Sako N, Yamamoto T, et al. Nav2/NaG channel is involved in control of salt-intake behavior in the CNS. J Neurosci. 2000;20:7743-51 pubmed..These findings suggest that the Na(v)2 channel plays an important role in the central sensing of body-fluid sodium level and regulation of salt intake behavior. ..
- Sabirov R, Sheiko T, Liu H, Deng D, Okada Y, Craigen W. Genetic demonstration that the plasma membrane maxianion channel and voltage-dependent anion channels are unrelated proteins. J Biol Chem. 2006;281:1897-904 pubmed..The lack of correlation between VDAC protein expression and maxianion channel activity strongly argues against the long held hypothesis of plasmalemmal VDAC being the maxianion channel. ..
- Fatchiyah -, Zubair M, Shima Y, Oka S, Ishihara S, Fukui Katoh Y, et al. Differential gene dosage effects of Ad4BP/SF-1 on target tissue development. Biochem Biophys Res Commun. 2006;341:1036-45 pubmed..This variation might be dependent on in part the protein expression levels among the tissues and in part on differential sensitivities to the gene dosage. ..
- Watanabe K, Tamamaki N, Furuta T, Ackerman S, Ikenaka K, Ono K. Dorsally derived netrin 1 provides an inhibitory cue and elaborates the 'waiting period' for primary sensory axons in the developing spinal cord. Development. 2006;133:1379-87 pubmed..These results are the first direct evidence that netrin 1 in the dorsal spinal cord acts as an inhibitory cue for primary sensory axons and is a crucial signal for the formation of sensory afferent neural networks. ..
- Fujikawa A, Chow J, Shimizu H, Fukada M, Suzuki R, Noda M. Tyrosine phosphorylation of ErbB4 is enhanced by PSD95 and repressed by protein tyrosine phosphatase receptor type Z. J Biochem. 2007;142:343-50 pubmed
- Sato Y, Baba T, Zubair M, Miyabayashi K, Toyama Y, Maekawa M, et al. Importance of forkhead transcription factor Fkhl18 for development of testicular vasculature. Mol Reprod Dev. 2008;75:1361-71 pubmed publisher..Considering that Fas ligand gene expression is activated by Foxs, the elevated activity of Foxs in the absence of Fkhl18 probably explains the marked apoptosis of periendothelial cells in Fkhl18 KO mice. ..
- Inada H, Kawabata F, Ishimaru Y, Fushiki T, Matsunami H, Tominaga M. Off-response property of an acid-activated cation channel complex PKD1L3-PKD2L1. EMBO Rep. 2008;9:690-7 pubmed publisher..The off-response property of PKD1L3-PKD2L1 channels might explain the physiological phenomena occurring during sour taste sensation. ..
- Nagatomo K, Kubo Y. Caffeine activates mouse TRPA1 channels but suppresses human TRPA1 channels. Proc Natl Acad Sci U S A. 2008;105:17373-8 pubmed publisher..Finally, we observed that caffeine does not activate human TRPA1; instead, it suppresses its activity. ..
- Fujita F, Uchida K, Moriyama T, Shima A, Shibasaki K, Inada H, et al. Intracellular alkalization causes pain sensation through activation of TRPA1 in mice. J Clin Invest. 2008;118:4049-57 pubmed publisher..These results suggest that alkaline pH causes pain sensation through activation of TRPA1 and may provide a molecular explanation for some of the human alkaline pH-related sensory disorders whose mechanisms are largely unknown. ..
- Chiken S, Shashidharan P, Nambu A. Cortically evoked long-lasting inhibition of pallidal neurons in a transgenic mouse model of dystonia. J Neurosci. 2008;28:13967-77 pubmed publisher..Long-lasting inhibition induced by cortical inputs in the internal pallidal segment may disinhibit thalamic and cortical activity, resulting in the motor hyperactivity observed in the transgenic mice. ..
- Uchida K, Miura Y, Nagai M, Tominaga M. Isothiocyanates from Wasabia japonica activate transient receptor potential ankyrin 1 channel. Chem Senses. 2012;37:809-18 pubmed publisher..These results indicate the following: 1) 6-MSITC and 6-MTITC activate both mTRPA1 and hTRPA1; 2) 6-MSITC activates mTRPV1; and 3) the pharmacological functions of these isothiocyanates could be derived from TRPA1 activation...
- Parajuli L, Nakajima C, Kulik A, Matsui K, Schneider T, Shigemoto R, et al. Quantitative regional and ultrastructural localization of the Ca(v)2.3 subunit of R-type calcium channel in mouse brain. J Neurosci. 2012;32:13555-67 pubmed..3 density was variable among similar-sized spine heads and did not correlate with the density in the parent dendrite, implying that spines are individual calcium compartments operating autonomously from their parent dendrites. ..
- Lim R, Anand A, Nishimiya Fujisawa C, Kobayashi S, Kai T. Analysis of Hydra PIWI proteins and piRNAs uncover early evolutionary origins of the piRNA pathway. Dev Biol. 2014;386:237-51 pubmed publisher..These results indicate that various conserved features of PIWI proteins, the piRNA pathway, and their associations with the nuage were likely established before the evolution of bilaterians. ..
- Coutinho E, Okamoto S, Ishikawa A, Yokota S, Wada N, Hirabayashi T, et al. Activation of SF1 Neurons in the Ventromedial Hypothalamus by DREADD Technology Increases Insulin Sensitivity in Peripheral Tissues. Diabetes. 2017;66:2372-2386 pubmed publisher..DREADD technology is thus an important tool for studies of the role of the brain in the regulation of insulin sensitivity in peripheral tissues. ..
- Kihara A, Kabeya Y, Ohsumi Y, Yoshimori T. Beclin-phosphatidylinositol 3-kinase complex functions at the trans-Golgi network. EMBO Rep. 2001;2:330-5 pubmed..Some PtdIns 3-kinase is also distributed in the late endosome. These results suggest that Beclin and PtdIns 3-kinase control autophagy as a complex at the TGN. ..
- Ishibashi T, Dupree J, Ikenaka K, Hirahara Y, Honke K, Peles E, et al. A myelin galactolipid, sulfatide, is essential for maintenance of ion channels on myelinated axon but not essential for initial cluster formation. J Neurosci. 2002;22:6507-14 pubmed..These results indicate a critical role for sulfatide in proper localization and maintenance of ion channels clusters, whereas they do not appear to be essential for initial cluster formation of Na+ channels. ..
- Shirahama Noda K, Yamamoto A, Sugihara K, Hashimoto N, Asano M, Nishimura M, et al. Biosynthetic processing of cathepsins and lysosomal degradation are abolished in asparaginyl endopeptidase-deficient mice. J Biol Chem. 2003;278:33194-9 pubmed..Thus, the AEP deficiency caused the accumulation of macromolecules in the lysosomes, highlighting a pivotal role of AEP in the endosomal/lysosomal degradation system. ..
- Shibasaki K, Suzuki M, Mizuno A, Tominaga M. Effects of body temperature on neural activity in the hippocampus: regulation of resting membrane potentials by transient receptor potential vanilloid 4. J Neurosci. 2007;27:1566-75 pubmed..We conclude that TRPV4 is activated by physiological temperature in hippocampal neurons and thereby controls their excitability. ..
- Shinohara Y, Hirase H, Watanabe M, Itakura M, Takahashi M, Shigemoto R. Left-right asymmetry of the hippocampal synapses with differential subunit allocation of glutamate receptors. Proc Natl Acad Sci U S A. 2008;105:19498-503 pubmed publisher..Our study demonstrates universal left-right asymmetry of hippocampal synapses with a fundamental relationship between synaptic area and the expression of glutamate receptor subunits. ..
- Uchida K, Tominaga M. TRPM2 modulates insulin secretion in pancreatic ?-cells. Islets. 2011;3:209-11 pubmed..Although further examination is needed to clarify the mechanism of TRPM2-mediated insulin secretion, TRPM2 may be a key player in regulation of insulin secretion and could represent a new target for diabetes therapy. ..
- Tsunematsu T, Kilduff T, Boyden E, Takahashi S, Tominaga M, Yamanaka A. Acute optogenetic silencing of orexin/hypocretin neurons induces slow-wave sleep in mice. J Neurosci. 2011;31:10529-39 pubmed publisher..The results presented here advance our understanding of the role of orexin neurons in the regulation of sleep/wakefulness and may be relevant to the mechanisms that underlie symptom progression in narcolepsy. ..
- Shintaku K, Uchida K, Suzuki Y, Zhou Y, Fushiki T, Watanabe T, et al. Activation of transient receptor potential A1 by a non-pungent capsaicin-like compound, capsiate. Br J Pharmacol. 2012;165:1476-86 pubmed publisher..Taken together, these results indicate that capsinoids activate TRPA1 by an as yet unknown mechanism, and TRPA1 could be involved in physiological phenomena associated with capsinoid treatment. ..
- Takayama Y, Shibasaki K, Suzuki Y, Yamanaka A, Tominaga M. Modulation of water efflux through functional interaction between TRPV4 and TMEM16A/anoctamin 1. FASEB J. 2014;28:2238-48 pubmed publisher..Thus, physical and functional interactions between TRPV4 and ANO1 can modulate water transport in the choroid plexus...
- Nagafuchi A, Ishihara S, Tsukita S. The roles of catenins in the cadherin-mediated cell adhesion: functional analysis of E-cadherin-alpha catenin fusion molecules. J Cell Biol. 1994;127:235-45 pubmed..The possible functions of beta catenin are discussed with a special reference to its role as a negative regulator for the cadherin-mediated cell adhesion system. ..
- Shintani T, Maeda N, Nishiwaki T, Noda M. Characterization of rat receptor-like protein tyrosine phosphatase gamma isoforms. Biochem Biophys Res Commun. 1997;230:419-25 pubmed..These molecules were similar to PTPzeta/RPTPbeta with regard not only to structure but also to the presence of both secretory and transmembrane forms. However, RPTPgamma isoforms were not expressed as proteoglycans. ..
- Maeda N, Ichihara Tanaka K, Kimura T, Kadomatsu K, Muramatsu T, Noda M. A receptor-like protein-tyrosine phosphatase PTPzeta/RPTPbeta binds a heparin-binding growth factor midkine. Involvement of arginine 78 of midkine in the high affinity binding to PTPzeta. J Biol Chem. 1999;274:12474-9 pubmed..These results suggested that Arg78 in midkine plays an essential role in high affinity binding to PTPzeta by interacting with the chondroitin sulfate portion of this receptor. ..
- Baba H, Akita H, Ishibashi T, Inoue Y, Nakahira K, Ikenaka K. Completion of myelin compaction, but not the attachment of oligodendroglial processes triggers K(+) channel clustering. J Neurosci Res. 1999;58:752-64 pubmed..In addition, postsynaptic density protein-95 (PSD-95) or its highly related protein was found colocalized with K(+) channels, suggesting that it may interact with K(+) channels to form clusters at juxtaparanodal regions...
- Sakuta H, Suzuki R, Takahashi H, Kato A, Shintani T, Iemura Si -, et al. Ventroptin: a BMP-4 antagonist expressed in a double-gradient pattern in the retina. Science. 2001;293:111-5 pubmed..Thus, the topographic retinotectal projection appears to be specified by the double-gradient molecule Ventroptin along the two axes. ..
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