Experts and Doctors on map kinase kinase kinases in Nagoya, Aichi, Japan


Locale: Nagoya, Aichi, Japan
Topic: map kinase kinase kinases

Top Publications

  1. Yamaguchi K, Nagai S, Ninomiya Tsuji J, Nishita M, Tamai K, Irie K, et al. XIAP, a cellular member of the inhibitor of apoptosis protein family, links the receptors to TAB1-TAK1 in the BMP signaling pathway. EMBO J. 1999;18:179-87 pubmed
    ..These results suggest that XIAP participates in the BMP signaling pathway as a positive regulator linking the BMP receptors and TAB1-TAK1. ..
  2. Kondo M, Osada H, Uchida K, Yanagisawa K, Masuda A, Takagi K, et al. Molecular cloning of human TAK1 and its mutational analysis in human lung cancer. Int J Cancer. 1998;75:559-63 pubmed
  3. Morioka S, Inagaki M, Komatsu Y, Mishina Y, Matsumoto K, Ninomiya Tsuji J. TAK1 kinase signaling regulates embryonic angiogenesis by modulating endothelial cell survival and migration. Blood. 2012;120:3846-57 pubmed publisher
    ..Our results show that endothelial TAK1 signaling is important for 2 biologic processes in angiogenesis: inhibiting TNF-dependent endothelial cell death and promoting TNF-independent angiogenic cell migration. ..
  4. Matsuguchi T, Masuda A, Sugimoto K, Nagai Y, Yoshikai Y. JNK-interacting protein 3 associates with Toll-like receptor 4 and is involved in LPS-mediated JNK activation. EMBO J. 2003;22:4455-64 pubmed
    ..7 cells, JIP3 associates MEKK-1, but not with TAK-1. Finally, JIP3 also associates with TLR2 and TLR9, but not with TLR1 or TLR6. Altogether, our data indicate the involvement of JIP3 in JNK activation in downstream signals of some TLRs. ..
  5. Kajino T, Omori E, Ishii S, Matsumoto K, Ninomiya Tsuji J. TAK1 MAPK kinase kinase mediates transforming growth factor-beta signaling by targeting SnoN oncoprotein for degradation. J Biol Chem. 2007;282:9475-81 pubmed
    ..Inactivation of TAK1 prevented TGF-beta-induced SnoN degradation and impaired induction of the TGF-beta-responsive genes. These data suggest that TAK1 modulates TGF-beta-dependent cellular responses by targeting SnoN for degradation. ..
  6. Kishimoto K, Matsumoto K, Ninomiya Tsuji J. TAK1 mitogen-activated protein kinase kinase kinase is activated by autophosphorylation within its activation loop. J Biol Chem. 2000;275:7359-64 pubmed
    ..These results suggest that IL-1 and ectopic expression of TAB1 both activate TAK1 via autophosphorylation of Ser-192. ..
  7. Ninomiya Tsuji J, Kajino T, Ono K, Ohtomo T, Matsumoto M, Shiina M, et al. A resorcylic acid lactone, 5Z-7-oxozeaenol, prevents inflammation by inhibiting the catalytic activity of TAK1 MAPK kinase kinase. J Biol Chem. 2003;278:18485-90 pubmed
    ..Furthermore, in vivo 5Z-7-oxozeaenol was able to inhibit picryl chloride-induced ear swelling. Thus, 5Z-7-oxozeaenol blocks proinflammatory signaling by selectively inhibiting TAK1 MAPKKK. ..
  8. Kikuchi T, Yoshikai Y, Miyoshi J, Katsuki M, Musikacharoen T, Mitani A, et al. Cot/Tpl2 is essential for RANKL induction by lipid A in osteoblasts. J Dent Res. 2003;82:546-50 pubmed
    ..These findings indicate that Cot/Tpl2 is essential for LPS-induced ERK activation and RANKL induction in osteoblasts. ..
  9. Yaomura T, Tsuboi N, Urahama Y, Hobo A, Sugimoto K, Miyoshi J, et al. Serine/threonine kinase, Cot/Tpl2, regulates renal cell apoptosis in ischaemia/reperfusion injury. Nephrology (Carlton). 2008;13:397-404 pubmed publisher
    ..Cot/Tpl2 did not function as a member of MAPK family, but as a promoter of apoptosis in IRI. These results suggest that Cot/Tpl2 could be a possible therapeutic target in IRI. ..

More Information


  1. Uemura N, Kajino T, Sanjo H, Sato S, Akira S, Matsumoto K, et al. TAK1 is a component of the Epstein-Barr virus LMP1 complex and is essential for activation of JNK but not of NF-kappaB. J Biol Chem. 2006;281:7863-72 pubmed
    ..These results suggest that an LMP1-associated complex containing TRAF6, TAB2, and TAK1 plays an essential role in the activation of JNK. However, TAK1 is not an exclusive intermediate for NF-kappaB activation in LMP1 signaling. ..
  2. Suzuki S, Shiraga K, Sato S, Punfa W, Naiki Ito A, Yamashita Y, et al. Apocynin, an NADPH oxidase inhibitor, suppresses rat prostate carcinogenesis. Cancer Sci. 2013;104:1711-7 pubmed publisher
    ..These data suggest that apocynin possesses chemopreventive potential against prostate cancer. ..
  3. Pastuhov S, Fujiki K, Nix P, Kanao S, Bastiani M, Matsumoto K, et al. Endocannabinoid-Go? signalling inhibits axon regeneration in Caenorhabditis elegans by antagonizing Gq?-PKC-JNK signalling. Nat Commun. 2012;3:1136 pubmed publisher
    ..Our results show that arachidonoyl ethanolamide induction of a G protein signal transduction pathway has a role in the inhibition of post-development axon regeneration...
  4. Ito J, Nagayasu Y, Okumura Noji K, Lu R, Nishida T, Miura Y, et al. Mechanism for FGF-1 to regulate biogenesis of apoE-HDL in astrocytes. J Lipid Res. 2007;48:2020-7 pubmed
    ..The PI3K/Akt pathway upregulates secretion of apoE/apoE-HDL, the MEK/ERK pathway stimulates cholesterol biosynthesis, and an unknown pathway enhances apoE transcription. ..
  5. Ishitani T, Ninomiya Tsuji J, Matsumoto K. Regulation of lymphoid enhancer factor 1/T-cell factor by mitogen-activated protein kinase-related Nemo-like kinase-dependent phosphorylation in Wnt/beta-catenin signaling. Mol Cell Biol. 2003;23:1379-89 pubmed
    ..These results suggest that NLK phosphorylation on these sites contributes to the down-regulation of LEF-1/TCF transcriptional activity. ..
  6. Takaesu G, Ninomiya Tsuji J, Kishida S, Li X, Stark G, Matsumoto K. Interleukin-1 (IL-1) receptor-associated kinase leads to activation of TAK1 by inducing TAB2 translocation in the IL-1 signaling pathway. Mol Cell Biol. 2001;21:2475-84 pubmed
    ..Formation of this complex is an essential step in the activation of TAK1 in the IL-1 signaling pathway. ..
  7. Kajino T, Ren H, Iemura S, Natsume T, Stefansson B, Brautigan D, et al. Protein phosphatase 6 down-regulates TAK1 kinase activation in the IL-1 signaling pathway. J Biol Chem. 2006;281:39891-6 pubmed
    ..Our results demonstrate that PP6 specifically down-regulates TAK1 through dephosphorylation of Thr-187 in the activation loop, which is likely important for suppressing inflammatory responses via TAK1 signaling pathways. ..
  8. Chikamatsu S, Furuno T, Kinoshita Y, Inoh Y, Hirashima N, Teshima R, et al. Effects of Cot expression on the nuclear translocation of NF-kappaB in RBL-2H3 cells. Mol Immunol. 2007;44:1490-7 pubmed
    ..This finding gives a new insight into the role of Cot in the FcvarepsilonRI-mediated NF-kappaB activation in mast cells. ..
  9. Mizuno T, Hisamoto N, Terada T, Kondo T, Adachi M, Nishida E, et al. The Caenorhabditis elegans MAPK phosphatase VHP-1 mediates a novel JNK-like signaling pathway in stress response. EMBO J. 2004;23:2226-34 pubmed
    ..These results suggest that VHP-1 plays a pivotal role in the integration and fine-tuning of the stress response regulated by the KGB-1 MAPK pathway. ..
  10. Ito M, Natsume A, Takeuchi H, Shimato S, Ohno M, Wakabayashi T, et al. Type I interferon inhibits astrocytic gliosis and promotes functional recovery after spinal cord injury by deactivation of the MEK/ERK pathway. J Neurotrauma. 2009;26:41-53 pubmed publisher
    ..These results suggest that liposome-mediated IFN-beta gene delivery inhibits glial scar formation after SCI and promotes functional recovery. ..
  11. Takahashi Y, Soyano T, Kosetsu K, Sasabe M, Machida Y. HINKEL kinesin, ANP MAPKKKs and MKK6/ANQ MAPKK, which phosphorylates and activates MPK4 MAPK, constitute a pathway that is required for cytokinesis in Arabidopsis thaliana. Plant Cell Physiol. 2010;51:1766-76 pubmed publisher
    ..Thus cytokinesis in A. thaliana is controlled by a pathway that consists of ANP MAPKKKs that can be activated by HIK and MKK6/ANQ MAPKK, with MPK4 MAPK being a probable target of MKK6/ANQ. ..
  12. Sasabe M, Boudolf V, De Veylder L, Inze D, Genschik P, Machida Y. Phosphorylation of a mitotic kinesin-like protein and a MAPKKK by cyclin-dependent kinases (CDKs) is involved in the transition to cytokinesis in plants. Proc Natl Acad Sci U S A. 2011;108:17844-9 pubmed publisher
    ..Thus, timely and coordinated phosphorylation by CDKs and dephosphorylation of cytokinetic regulators from prophase to anaphase appear to be critical for the appropriate onset and/or progression of cytokinesis. ..
  13. Tanaka Hino M, Sagasti A, Hisamoto N, Kawasaki M, Nakano S, Ninomiya Tsuji J, et al. SEK-1 MAPKK mediates Ca2+ signaling to determine neuronal asymmetric development in Caenorhabditis elegans. EMBO Rep. 2002;3:56-62 pubmed
    ..Thus, the NSY-1-SEK-1-MAPK cascade is activated by Ca2+ signaling through CaMKII and establishes asymmetric cell fate decision during neuronal development. ..