Experts and Doctors on glutathione peroxidase in Nagoya, Aichi, Japan
Locale: Nagoya, Aichi, Japan
Topic: glutathione peroxidase
Naiki Ito A, Asamoto M, Hokaiwado N, Takahashi S, Yamashita H, Tsuda H, et al
. Gpx2 is an overexpressed gene in rat breast cancers induced by three different chemical carcinogens. Cancer Res. 2007;67:11353-8 pubmed
..Thus, these data suggested that GPX2 may be involved in mammary carcinogenesis and cell proliferation in both rats and humans, indicating that GPX2 may be a novel target for the prevention and therapy of breast cancer. ..
Monji A, Mitsui T, Bando Y, Aoyama M, Shigeta T, Murohara T. Glucagon-like peptide-1 receptor activation reverses cardiac remodeling via normalizing cardiac steatosis and oxidative stress in type 2 diabetes. Am J Physiol Heart Circ Physiol. 2013;305:H295-304 pubmed publisher
..In conclusion, GLP-1R agonism reverses cardiac remodeling and dysfunction observed in T2DM via normalizing imbalance of lipid metabolism and related inflammation/oxidative stress. ..
Suzuki S, Pitchakarn P, Ogawa K, Naiki Ito A, Chewonarin T, Punfa W, et al
. Expression of glutathione peroxidase 2 is associated with not only early hepatocarcinogenesis but also late stage metastasis. Toxicology. 2013;311:115-23 pubmed publisher
..Together with immunohistochemical findings of elevated expression in rat and also human liver lesions, the results point to important roles in hepatocarcinogenesis. ..
Tran T, Mai H, Shin E, Nam Y, Nguyen B, Lee Y, et al
. Repeated exposure to far infrared ray attenuates acute restraint stress in mice via inhibition of JAK2/STAT3 signaling pathway by induction of glutathione peroxidase-1. Neurochem Int. 2016;94:9-22 pubmed publisher
..Our results indicate that exposure to FIR significantly protects ARS-induced increases in c-Fos-IR and oxidative burdens via inhibition of JAK2/STAT3 signaling by induction of GPx-1. ..
Kuzuya M, Ando F, Iguchi A, Shimokata H. Glutathione peroxidase 1 Pro198Leu variant contributes to the metabolic syndrome in men in a large Japanese cohort. Am J Clin Nutr. 2008;87:1939-44 pubmed
..15) in men but not in women; there were no differences in other components of MetS between the CC and CT/TT genotypes in either sex. GPX1 Pro198Leu variants are associated with the prevalence of MetS in Japanese men but not in women. ..