Experts and Doctors on gene expression in Nagoya, Aichi, Japan


Locale: Nagoya, Aichi, Japan
Topic: gene expression

Top Publications

  1. Ito T, Niwa J, Hishikawa N, Ishigaki S, Doyu M, Sobue G. Dorfin localizes to Lewy bodies and ubiquitylates synphilin-1. J Biol Chem. 2003;278:29106-14 pubmed
  2. Yoshizato H, Tanaka M, Nakai N, Nakao N, Nakashima K. Growth hormone (GH)-stimulated insulin-like growth factor I gene expression is mediated by a tyrosine phosphorylation pathway depending on C-terminal region of human GH receptor in human GH receptor-expressing Ba/F3 cells. Endocrinology. 2004;145:214-20 pubmed
    ..These results suggest that the JAK-STAT5 pathway and the novel tyrosine phosphorylation pathway, dependent on signaling from the C-terminal region of hGHR, might be involved in the GH-stimulated IGF-I gene expression in Ba/F3 cells. ..
  3. Maeda M, Hasegawa H, Hyodo T, Ito S, Asano E, Yuang H, et al. ARHGAP18, a GTPase-activating protein for RhoA, controls cell shape, spreading, and motility. Mol Biol Cell. 2011;22:3840-52 pubmed publisher
    ..Furthermore, ARHGAP18 was required for the polarization of cells for migration. Our results define ARHGAP18 as one of the crucial factors for the regulation of RhoA for the control of cell shape, spreading, and migration. ..
  4. Maeda K, Enomoto A, Hara A, Asai N, Kobayashi T, Horinouchi A, et al. Identification of Meflin as a Potential Marker for Mesenchymal Stromal Cells. Sci Rep. 2016;6:22288 pubmed publisher
    ..These preliminary data suggest that Meflin is a potential marker for cultured MSCs and their source cells in vivo. ..
  5. Dunning A, Michailidou K, Kuchenbaecker K, Thompson D, French J, Beesley J, et al. Breast cancer risk variants at 6q25 display different phenotype associations and regulate ESR1, RMND1 and CCDC170. Nat Genet. 2016;48:374-86 pubmed publisher
  6. Nakamura K, Sasaki T, Cheng X, Iguchi A, Sato K, Kuzuya M. Statin prevents plaque disruption in apoE-knockout mouse model through pleiotropic effect on acute inflammation. Atherosclerosis. 2009;206:355-61 pubmed publisher
    ..In summary, fluvastatin was found to prevent plaque disruption through pleiotropic effect on acute inflammation in an animal model using apolipoprotein E-deficient mice. ..
  7. Nishida Y. [Oncogene research using Drosophila as a model system]. Jpn J Genet. 1990;65:121-34 pubmed
  8. Miyazu M, Tanimura T, Sokabe M. Molecular cloning and characterization of a putative cyclic nucleotide-gated channel from Drosophila melanogaster. Insect Mol Biol. 2000;9:283-92 pubmed
    ..These results suggest a possible role of the putative CNGL channel in the processing of visual and olfactory information in the nervous system of Drosophila. ..
  9. Tsuboi N, Yoshikai Y, Matsuo S, Kikuchi T, Iwami K, Nagai Y, et al. Roles of toll-like receptors in C-C chemokine production by renal tubular epithelial cells. J Immunol. 2002;169:2026-33 pubmed
    ..Thus, MTECs have a distinct expression pattern of TLR and secrete C-C chemokines in response to direct stimulation with a set of bacterial components. ..

More Information

Publications156 found, 100 shown here

  1. Umemura M, Nishimura H, Yajima T, Wajjwalk W, Matsuguchi T, Takahashi M, et al. Overexpression of interleukin-15 prevents the development of murine retrovirus-induced acquired immunodeficiency syndrome. FASEB J. 2002;16:1755-63 pubmed
    ..These results indicate that IL-15 prevents the progression of MAIDS and may provide insight into an immunotherapeutic approach using the IL-15 gene for controlling retrovirus-induced immunodeficiency...
  2. Tetsuka T, Uranishi H, Sanda T, Asamitsu K, Yang J, Wong Staal F, et al. RNA helicase A interacts with nuclear factor kappaB p65 and functions as a transcriptional coactivator. Eur J Biochem. 2004;271:3741-51 pubmed
    ..These data suggest that RHA is an essential component of the transactivation complex by mediating the transcriptional activity of NF-kappaB. ..
  3. Sakamoto R, Byrd D, Brown H, Hisamoto N, Matsumoto K, Jin Y. The Caenorhabditis elegans UNC-14 RUN domain protein binds to the kinesin-1 and UNC-16 complex and regulates synaptic vesicle localization. Mol Biol Cell. 2005;16:483-96 pubmed
    ..Our data support a model whereby UNC-16 and UNC-14 function together as kinesin-1 cargos and regulators for the transport or localization of synaptic vesicle components. ..
  4. Kashiwagi T, Matsushita T, Ito Y, Hirashima K, Sanda N, Fujimori Y, et al. L1503R is a member of group I mutation and has dominant-negative effect on secretion of full-length VWF multimers: an analysis of two patients with type 2A von Willebrand disease. Haemophilia. 2008;14:556-63 pubmed publisher
    ..Protein instability of L1503R may be responsible for its intracellular retention and perhaps the larger VWF multimers, containing more mutant VWF subunits, are likely to be mal-processed and retained within the cell. ..
  5. Mizuno T, Mohri K, Nasu S, Danjo K, Okamoto H. Dual imaging of pulmonary delivery and gene expression of dry powder inhalant by fluorescence and bioluminescence. J Control Release. 2009;134:149-54 pubmed publisher
    ..In conclusion, the dry powder containing both ICG and pCMV-Luc was useful as a dual imaging system to visualize pulmonary delivery and gene expression in mice. ..
  6. Itoh Y, Hatano N, Hayashi H, Onozaki K, Miyazawa K, Muraki K. An environmental sensor, TRPV4 is a novel regulator of intracellular Ca2+ in human synoviocytes. Am J Physiol Cell Physiol. 2009;297:C1082-90 pubmed publisher
    ..Treatment of RA but not MH7A cells with 4alphaPDD for 24 h reduced their production of IL-8. These results suggest that an environmental sensor, TRPV4, is a novel regulator of intracellular Ca(2+) in human synoviocytes. ..
  7. Naruse K, Sato J, Funakubo M, Hata M, Nakamura N, Kobayashi Y, et al. Transplantation of bone marrow-derived mononuclear cells improves mechanical hyperalgesia, cold allodynia and nerve function in diabetic neuropathy. PLoS ONE. 2011;6:e27458 pubmed publisher
    ..These results suggest that autologous transplantation of BM-MNCs could be a novel strategy for the treatment of painful diabetic neuropathy. ..
  8. Sakaidani Y, Ichiyanagi N, Saito C, Nomura T, Ito M, Nishio Y, et al. O-linked-N-acetylglucosamine modification of mammalian Notch receptors by an atypical O-GlcNAc transferase Eogt1. Biochem Biophys Res Commun. 2012;419:14-9 pubmed publisher
    ..These results suggest that Eogt1 encodes EGF domain O-GlcNAc transferase and that O-GlcNAcylation reaction in the secretory pathway is a fundamental biochemical process conserved through evolution. ..
  9. Saito S, Hosoda N, Hoshino S. The Hbs1-Dom34 protein complex functions in non-stop mRNA decay in mammalian cells. J Biol Chem. 2013;288:17832-43 pubmed publisher
    ..These findings demonstrate that the NSD mechanism exists in mammalian cells and involves Hbs1, Dom34, and the exosome-Ski complex. ..
  10. Demachi Okamura A, Ito Y, Akatsuka Y, Tsujimura K, Morishima Y, Takahashi T, et al. Epstein-Barr virus (EBV) latent membrane protein-1-specific cytotoxic T lymphocytes targeting EBV-carrying natural killer cell malignancies. Eur J Immunol. 2006;36:593-602 pubmed
    ..Overall, these data suggest that immunotherapy targeting LMP1 in EBV-associated NK lymphomas and CAEBV might serve as an alternative treatment modality. ..
  11. Lu R, Ito J, Iwamoto N, Nishimaki Mogami T, Yokoyama S. FGF-1 induces expression of LXRalpha and production of 25-hydroxycholesterol to upregulate the apoE gene in rat astrocytes. J Lipid Res. 2009;50:1156-64 pubmed publisher
    ..We concluded that FGF-1-induced apoE expression in astrocytes depends on LXRalpha being mediated by both LXRalpha expression and an LXRalpha ligand biosynthesis. ..
  12. Naiki T, Asamoto M, Toyoda Hokaiwado N, Naiki Ito A, Tozawa K, Kohri K, et al. Organ specific Gst-pi expression of the metastatic androgen independent prostate cancer cells in nude mice. Prostate. 2012;72:533-41 pubmed publisher
    ..Gst-pi expression of the prostate cancers are dependent on metastatic site, and that Gst-pi has an important role in adapting prostate cancer for growth and metastasis involving an alteration of ROS signals. ..
  13. Mirza R, Hayasaka S, Kambe F, Maki K, Kaji T, Murata Y, et al. Increased expression of aquaporin-3 in the epidermis of DHCR24 knockout mice. Br J Dermatol. 2008;158:679-84 pubmed publisher
    ..This is the first demonstration that elevated AQP3 results in the retention of epidermal water, causing the taut, wrinkle-free skin phenotype of the DHCR24-/- mice. ..
  14. Aihara N, Imamura N, Kimura T, Yamada K, Hida H, Nishino H, et al. Intracerebral hemorrhage upregulates Na(+)/myo-inositol cotransporter in the rat brain. Neurosci Lett. 2002;327:21-4 pubmed
    ..These results suggest that the expression of SMIT must be regulated not only by osmolality but also by unknown factors. ..
  15. Suzuki M, Kondo F, Ito Y, Matsumoto M, Hata M, Oka H, et al. Identification of a Shiga-toxin type I variant containing an IS1203-like element, from Shiga-toxin producing Escherichia coli O157:H7. FEMS Microbiol Lett. 2004;234:63-7 pubmed publisher
    ..Toxicity of the Stx1 was confirmed by Vero cell assay. IS1203v(1) hardly affected the stx(1) gene in either its expression or the toxicity of its product...
  16. Morikami A, Matsunaga R, Tanaka Y, Suzuki S, Mano S, Nakamura K. Two cis-acting regulatory elements are involved in the sucrose-inducible expression of the sporamin gene promoter from sweet potato in transgenic tobacco. Mol Genet Genomics. 2005;272:690-9 pubmed
    ..These results suggest that the TGGACGG element plays an important role in the sucrose-inducible expression of a group of plant genes. ..
  17. Sobue S, Hagiwara K, Banno Y, Tamiya Koizumi K, Suzuki M, Takagi A, et al. Transcription factor specificity protein 1 (Sp1) is the main regulator of nerve growth factor-induced sphingosine kinase 1 gene expression of the rat pheochromocytoma cell line, PC12. J Neurochem. 2005;95:940-9 pubmed
    ..These results suggest the signal transduction pathway from NGF receptor TrkA to transcription factor Sp1 protein binding to the promoter Sp1-like motif in NGF-induced rat SPHK1 gene expression. ..
  18. Aki Y, Kondo A, Nakamura H, Togari A. Lysophosphatidic acid-stimulated interleukin-6 and -8 synthesis through LPA1 receptors on human osteoblasts. Arch Oral Biol. 2008;53:207-13 pubmed
    ..These findings suggest that extracellular LPA-induced IL-6 and IL-8 synthesis occurred through Edg-2 (LPA(1) receptor) and the activation of PLC and IP(3)-mediated intracellular calcium release in SaM-1 cells. ..
  19. Hamaguchi A, Yamashino T, Koizumi N, Kiba T, Kojima M, Sakakibara H, et al. A small subfamily of Arabidopsis RADIALIS-LIKE SANT/MYB genes: a link to HOOKLESS1-mediated signal transduction during early morphogenesis. Biosci Biotechnol Biochem. 2008;72:2687-96 pubmed
    ..These results are discussed in the context of the possibility that RSM1 is implicated in HLS1-mediated auxin signaling, which is responsible for regulation of the early photomorphogenesis of Arabidopsis thaliana. ..
  20. Akaza N, Akamatsu H, Kishi M, Mizutani H, Ishii I, Nakata S, et al. Effects of Propionibacterium acnes on various mRNA expression levels in normal human epidermal keratinocytes in vitro. J Dermatol. 2009;36:213-23 pubmed publisher
    ..Moreover, it was considered that the reaction of NHEK to P. acnes may be different depending on the type of bacteria...
  21. Murase T, Hattori T, Ohtake M, Abe M, Amakusa Y, Takatsu M, et al. Cardiac remodeling and diastolic dysfunction in DahlS.Z-Lepr(fa)/Lepr(fa) rats: a new animal model of metabolic syndrome. Hypertens Res. 2012;35:186-93 pubmed publisher
    ..These animals also develop salt-sensitive hypertension and LV diastolic dysfunction as well as LV hypertrophy and fibrosis, and these changes are associated with increased cardiac oxidative stress and inflammation. ..
  22. Sugihara Y, Sadohara E, Yonezawa K, Kugo M, Oshima K, Matsuda T, et al. Identification and expression of an autosomal paralogue of ribosomal protein S4, X-linked, in mice: potential involvement of testis-specific ribosomal proteins in translation and spermatogenesis. Gene. 2013;521:91-9 pubmed publisher
  23. Hamada S, Urakawa H, Kozawa E, Arai E, Ikuta K, Sakai T, et al. Characteristics of cultured desmoid cells with different CTNNB1 mutation status. Cancer Med. 2016;5:352-60 pubmed publisher
    ..Isolated and cultured desmoid tumor cells harboring any one of the CTNNB1 mutation status had unique characteristics, and could be useful to investigate desmoid tumors with different mutation status of CTNNB1. ..
  24. Kobayashi S, Nagino M, Komatsu S, Naruse K, Nimura Y, Nakanishi M, et al. Stretch-induced IL-6 secretion from endothelial cells requires NF-kappaB activation. Biochem Biophys Res Commun. 2003;308:306-12 pubmed
    ..In conclusion, continuous stretch induces IL-6 secretion from ECs, most likely through sequential activation of IKKs and NF-kappaB. ..
  25. Sugito N, Ishiguro H, Kuwabara Y, Kimura M, Mitsui A, Kurehara H, et al. RNASEN regulates cell proliferation and affects survival in esophageal cancer patients. Clin Cancer Res. 2006;12:7322-8 pubmed
    ..The relationship between the RNASEN expression and the prognosis of the ESCC patients warrants a further study on the role of miRNA and tumor progression. ..
  26. Tokumoto M, Satoh M. [Cadmium induces p53-dependent apoptosis through the inhibition of Ube2d family gene expression]. Nihon Eiseigaku Zasshi. 2012;67:472-7 pubmed
    ..Thus, the Ube2d family genes may be one of the key targets of renal toxicity caused by Cd. ..
  27. Yamaguchi M, Yoshida H, Hirose F, Inoue Y, Hayashi Y, Yamagishi M, et al. Ectopic expression of BEAF32A in the Drosophila eye imaginal disc inhibits differentiation of photoreceptor cells and induces apoptosis. Chromosoma. 2001;110:313-21 pubmed
    ..The transgenic flies established in this study should be useful to identify targets of BEAF32A and its positive or negative regulators in Drosophila. ..
  28. Kanbe E, Abe A, Towatari M, Kawabe T, Saito H, Emi N. DR1-like element in human topoisomerase IIalpha gene involved in enhancement of etoposide-induced apoptosis by PPARgamma ligand. Exp Hematol. 2003;31:300-8 pubmed
  29. Yasuo S, Watanabe M, Okabayashi N, Ebihara S, Yoshimura T. Circadian clock genes and photoperiodism: Comprehensive analysis of clock gene expression in the mediobasal hypothalamus, the suprachiasmatic nucleus, and the pineal gland of Japanese Quail under various light schedules. Endocrinology. 2003;144:3742-8 pubmed
    ..In contrast, expression patterns of clock genes in the MBH were stable under various light conditions, which enables animals to keep a steady-state photoinducible phase. ..
  30. Kikuchi Y, Verkade H, Reiter J, Kim C, Chitnis A, Kuroiwa A, et al. Notch signaling can regulate endoderm formation in zebrafish. Dev Dyn. 2004;229:756-62 pubmed
    ..Altogether, these results suggest that Notch signaling plays a role in the formation of the endoderm, possibly in its segregation from the mesoderm. ..
  31. Xu J, Nagata K, Obata K, Ichihara S, Izawa H, Noda A, et al. Nicorandil promotes myocardial capillary and arteriolar growth in the failing heart of Dahl salt-sensitive hypertensive rats. Hypertension. 2005;46:719-24 pubmed
    ..Nicorandil may prove beneficial for the treatment of hypertensive heart failure as well as of ischemic heart disease. ..
  32. Iwamoto N, Abe Dohmae S, Ayaori M, Tanaka N, Kusuhara M, Ohsuzu F, et al. ATP-binding cassette transporter A1 gene transcription is downregulated by activator protein 2alpha. Doxazosin inhibits activator protein 2alpha and increases high-density lipoprotein biogenesis independent of alpha1-adrenoceptor blockade. Circ Res. 2007;101:156-65 pubmed
    ..Doxazosin inhibits AP2alpha activity independent of alpha(1)-adrenoceptor blockade and increases the ABCA1 expression and HDL biogenesis. AP2alpha is a potent pharmacological target for the increase of HDL...
  33. Kim T, Misumi S, Jung C, Masuda T, Isobe Y, Furuyama F, et al. Increase in dopaminergic neurons from mouse embryonic stem cell-derived neural progenitor/stem cells is mediated by hypoxia inducible factor-1alpha. J Neurosci Res. 2008;86:2353-62 pubmed publisher
    ..These data suggest that enhanced differentiation into DAergic neurons from ES cell-derived NPCs was induced by C-Mix or L-Oxy mediated by HIF-1alpha. ..
  34. Bautista M, Miyata T, Miura K, Tanaka T. RNA interference-mediated knockdown of a cytochrome P450, CYP6BG1, from the diamondback moth, Plutella xylostella, reduces larval resistance to permethrin. Insect Biochem Mol Biol. 2009;39:38-46 pubmed publisher
    ..xylostella strain did not lead to changes in the level of resistance to permethrin, supporting further the specific involvement of CYP6BG1 in the resistance. ..
  35. Laurent T, Murase D, Tsukioka S, Matsuura T, Nagamori S, Oda H. A novel human hepatoma cell line, FLC-4, exhibits highly enhanced liver differentiation functions through the three-dimensional cell shape. J Cell Physiol. 2012;227:2898-906 pubmed publisher
    ..In conclusion, differentiation of FLC-4 human hepatoma cell line can be enhanced to a human liver-like level through the three-dimensional cell shape in a microtubule-dependent manner. ..
  36. Sun Y, Tomura T, Sato J, Iizuka T, Fudou R, Ojika M. Isolation and Biosynthetic Analysis of Haliamide, a New PKS-NRPS Hybrid Metabolite from the Marine Myxobacterium Haliangium ochraceum. Molecules. 2016;21:59 pubmed publisher
    ..The sulfotransferase (ST)-thioesterase (TE) domains encoded in hlaB appears to be responsible for the terminal alkene formation via decarboxylation. ..
  37. Nomoto S, Ito S, Yang L, Kiuchi K. Molecular cloning and expression analysis of GFR alpha-3, a novel cDNA related to GDNFR alpha and NTNR alpha. Biochem Biophys Res Commun. 1998;244:849-53 pubmed
    ..These results indicate that the tissue distribution of GFR alpha-3 mRNA is different from that of GDNFR alpha or NTNR alpha mRNA, and suggest that GFR alpha-3 may function in differentiation of embryonic cells expressing its mRNA. ..
  38. Inagaki M, Schmelzle T, Yamaguchi K, Irie K, Hall M, Matsumoto K. PDK1 homologs activate the Pkc1-mitogen-activated protein kinase pathway in yeast. Mol Cell Biol. 1999;19:8344-52 pubmed
    ..The Pkh2 phosphorylation site in Pkc1 (Thr-983) is part of a conserved PDK1 target motif and essential for Pkc1 function. Thus, the yeast PDK1 homologs activate Pkc1 and the Pkc1-effector MAPK pathway. ..
  39. Sawada A, Fritz A, Jiang Y, Yamamoto A, Yamasu K, Kuroiwa A, et al. Zebrafish Mesp family genes, mesp-a and mesp-b are segmentally expressed in the presomitic mesoderm, and Mesp-b confers the anterior identity to the developing somites. Development. 2000;127:1691-702 pubmed
    ..These observations suggest that zebrafish mesp genes are involved in anteroposterior specification within the presumptive somites, by regulating the essential signalling pathways mediated by Notch-Delta and FGFR. ..
  40. Saishin Y, Ishikawa R, Ugawa S, Guo W, Ueda T, Morimura H, et al. Retinal fascin: functional nature, subcellular distribution, and chromosomal localization. Invest Ophthalmol Vis Sci. 2000;41:2087-95 pubmed
    ..These results suggest that retinal fascin may play a role in formation of unique morphologic structures of the photoreceptor cells and is a candidate gene for retinal degenerative disorders. ..
  41. Kuno A, Yamada T, Masuda K, Ogawa K, Sogawa M, Nakamura S, et al. Angiotensin-converting enzyme inhibitor attenuates pancreatic inflammation and fibrosis in male Wistar Bonn/Kobori rats. Gastroenterology. 2003;124:1010-9 pubmed
    ..We propose that an ACE inhibitor may be useful for treating chronic pancreatitis. ..
  42. Senda M, Ito A, Tsuchida A, Hagiwara T, Kaneda T, Nakamura Y, et al. Identification and expression of a sialyltransferase responsible for the synthesis of disialylgalactosylgloboside in normal and malignant kidney cells: downregulation of ST6GalNAc VI in renal cancers. Biochem J. 2007;402:459-70 pubmed
    ..All these findings indicated that DSGG was suppressed during the malignant transformation of the proximal tubules as a maturation arrest of glycosylation. ..
  43. Suzuki D, Murata Y, Oda S. Changes in Ucp1, D2 (Dio2) and Glut4 (Slc2a4) mRNA expression in response to short-term cold exposure in the house musk shrew (Suncus murinus). Exp Anim. 2007;56:279-88 pubmed
    ..These findings suggest that the responsiveness of mRNA regulation is weak and thus may be involved in cold-intolerance in suncus. ..
  44. Ogasawara N, Tsukamoto T, Mizoshita T, Inada K, Ban H, Kondo S, et al. RUNX3 expression correlates with chief cell differentiation in human gastric cancers. Histol Histopathol. 2009;24:31-40 pubmed publisher
    ..RUNX3 is strongly associated with chief cell phenotypic expression in human gastric cancers, as well as in normal gastric mucosa, and could be considered to play an important role in maintaining the chief cell phenotype...
  45. Kawaji A, Ohnaka Y, Osada S, Nishizuka M, Imagawa M. Gelsolin, an actin regulatory protein, is required for differentiation of mouse 3T3-L1 cells into adipocytes. Biol Pharm Bull. 2010;33:773-9 pubmed
    ..Gelsolin plays a crucial role in the differentiation of 3T3-L1 cells into adipocytes. ..
  46. Tokizane K, Konishi H, Yasui M, Ogawa T, Sasaki K, Minamino N, et al. Continuous stress promotes expression of VGF in melanotroph via suppression of dopamine. Mol Cell Endocrinol. 2013;372:49-56 pubmed publisher
    ..In vitro, dopamine dose-dependently decreased the mRNA levels in cultured melanotrophs. These findings suggest that VGF expression under CS is negatively regulated by dopaminergic neurons projecting from the hypothalamus. ..
  47. Suzuki Y, Tsutsumi K, Miyamoto T, Yamamura H, Imaizumi Y. Heterodimerization of two pore domain K+ channel TASK1 and TALK2 in living heterologous expression systems. PLoS ONE. 2017;12:e0186252 pubmed publisher
    ..These results suggested that heterodimerization of TASK1 and TALK2 provides cells with the ability to make multiple responses to a variety of physiological and pharmacological stimuli. ..
  48. Kato S, Yuzawa Y, Tsuboi N, Maruyama S, Morita Y, Matsuguchi T, et al. Endotoxin-induced chemokine expression in murine peritoneal mesothelial cells: the role of toll-like receptor 4. J Am Soc Nephrol. 2004;15:1289-99 pubmed
    ..The results provide a candidate molecular target in prevention of it. ..
  49. Itoh Y, Kojima Y, Yasui T, Tozawa K, Sasaki S, Kohri K. Examination of alpha 1 adrenoceptor subtypes in the human ureter. Int J Urol. 2007;14:749-53 pubmed
    ..According to our results, we should try the alpha 1d AR antagonist for the conservative expulsive therapy of distal ureteral stones in the highest region of alpha 1d subtype distribution. ..
  50. Mizushima T, Sasaki M, Ando T, Wada T, Tanaka M, Okamoto Y, et al. Blockage of angiotensin II type 1 receptor regulates TNF-alpha-induced MAdCAM-1 expression via inhibition of NF-kappaB translocation to the nucleus and ameliorates colitis. Am J Physiol Gastrointest Liver Physiol. 2010;298:G255-66 pubmed publisher
    ..Furthermore, inhibition of AT1R ameliorates colitis in a mouse colitis model. Therefore, AT1R might be one of new therapeutic target of IBD via regulation of MAdCAM-1. ..
  51. Hiromatsu T, Yajima T, Matsuguchi T, Nishimura H, Wajjwalku W, Arai T, et al. Overexpression of interleukin-15 protects against Escherichia coli-induced shock accompanied by inhibition of tumor necrosis factor-alpha-induced apoptosis. J Infect Dis. 2003;187:1442-51 pubmed
    ..coli challenge. These results suggest that IL-15 overexpression can prevent TNF-alpha-induced apoptosis and protect against E. coli-induced shock, indicating a possible therapeutic application of IL-15 for septic shock. ..
  52. Iwamura K, Furukawa K, Uchikawa M, Sojka B, Kojima Y, Wiels J, et al. The blood group P1 synthase gene is identical to the Gb3/CD77 synthase gene. A clue to the solution of the P1/P2/p puzzle. J Biol Chem. 2003;278:44429-38 pubmed
    ..Differences in the transcriptional regulation in erythrocytes might be a major factor determining P1/P2. ..
  53. Asahina S, Sato C, Matsuno M, Matsuda T, Colley K, Kitajima K. Involvement of the alpha2,8-polysialyltransferases II/STX and IV/PST in the biosynthesis of polysialic acid chains on the O-linked glycoproteins in rainbow trout ovary. J Biochem. 2006;140:687-701 pubmed publisher
    ..rtSTX-em was not expressed in ovary. These results suggest that the enhanced expression of rtSTX-ov under the co-expression with rtPST may be important for the biosynthesis of polySia on O-linked glycans of PSGP...
  54. Nakatani H, Aoki N, Nadano D, Matsuda T. Transplantation of a mammary stromal cell line into a mammary fat pad: development of the site-specific in vivo analysis system for mammary stromal cells. Biosci Biotechnol Biochem. 2011;75:550-5 pubmed
    ..Finally, we discuss the application of transplantation procedure for in vivo studies of the mammary stromal tissue development and stromal-epithelial interactions. ..
  55. Kagawa N. Efficient expression of human aromatase (CYP19) in E. coli. Methods Mol Biol. 2011;705:109-22 pubmed publisher
    ..Therefore, the expression methods for the two forms of human aromatase as well as a method for the determination of the reduced CO-difference spectrum will be described. ..
  56. Saka M, Obata K, Ichihara S, Cheng X, Kimata H, Noda A, et al. Attenuation of ventricular hypertrophy and fibrosis in rats by pitavastatin: potential role of the RhoA-extracellular signal-regulated kinase-serum response factor signalling pathway. Clin Exp Pharmacol Physiol. 2006;33:1164-71 pubmed
  57. Hagiwara S, Murakumo Y, Sato T, Shigetomi T, Mitsudo K, Tohnai I, et al. Up-regulation of CD109 expression is associated with carcinogenesis of the squamous epithelium of the oral cavity. Cancer Sci. 2008;99:1916-23 pubmed publisher
    ..These findings suggest that CD109 plays a role in the development of oral cancers, and is a useful prognostic marker to predict malignant transformation of premalignant lesions. ..
  58. Koiwai O, Hasada K, Yasui Y, Sakai Y, Sato H, Watanabe T. Isolation of cDNAs for mouse phenol and bilirubin UDP-glucuronosyltransferases and mapping of the mouse gene for phenol UDP-glucuronosyltransferase (Ugtla1) to chromosome 1 by restriction fragment length variations. Biochem Genet. 1995;33:111-22 pubmed
    ..We also detected duplication of the gene for phenol UDPGT in all mouse strains examined with the exception of MOL-MIT and SUB-SHH. ..
  59. Zhang Z, Yamashita H, Toyama T, Yamamoto Y, Kawasoe T, Iwase H. Reduced expression of the breast cancer metastasis suppressor 1 mRNA is correlated with poor progress in breast cancer. Clin Cancer Res. 2006;12:6410-4 pubmed
    ..Our results also suggest that measuring BRMS1 expression will help to identify those breast cancer patients with worse disease-free survival. ..
  60. Ramdhan D, Kamijima M, Wang D, Ito Y, Naito H, Yanagiba Y, et al. Differential response to trichloroethylene-induced hepatosteatosis in wild-type and PPARalpha-humanized mice. Environ Health Perspect. 2010;118:1557-63 pubmed publisher
    ..However, human PPARalpha may afford only weak protection against TRI-mediated effects compared with mouse PPARalpha. ..
  61. Ujiie A, Nakano H, Iwasaki Y. Extracellular production of Pseudozyma (Candida) antarctica lipase B with genuine primary sequence in recombinant Escherichia coli. J Biosci Bioeng. 2016;121:303-9 pubmed publisher
    ..This is the first example of E. coli-based extracellular production of a CALB enzyme without extra amino acid residues. ..
  62. Kitamoto N, Yoshino Yasuda S, Ohmiya K, Tsukagoshi N. Sequence analysis and overexpression of a pectin lyase gene (pel1) from Aspergillus oryzae KBN616. Biosci Biotechnol Biochem. 2001;65:209-12 pubmed
    ..The pel1 gene was successfully overexpressed under the promoter of the A. oryzae TEF1 gene. The molecular mass of the recombinant pectin lyase substantially coincided with that calculated based on nucleotide sequence. ..
  63. Asamoto M, Hokaiwado N, Murasaki T, Shirai T. Connexin 32 dominant-negative mutant transgenic rats are resistant to hepatic damage by chemicals. Hepatology. 2004;40:205-10 pubmed
    ..In conclusion, gap junctional intercellular communication (GJIC) plays an important role in toxic effects of chemicals; damage or death signals may pass through gap junctions in the rat liver in vivo. ..
  64. Matsumoto M, Sakae K, Hashikawa S, Torii K, Hasegawa T, Horii T, et al. Close correlation of streptococcal DNase B (sdaB) alleles with emm genotypes in Streptococcus pyogenes. Microbiol Immunol. 2005;49:925-9 pubmed
    ..The distribution of each allele was generally emm genotype-specific. Only sdaB7 was found in both emm2 and emm4. The promoter region was highly conserved and DNase B protein was similarly expressed in all alleles. ..
  65. Ohno M, Komakine J, Suzuki E, Nishizuka M, Osada S, Imagawa M. Repression of the promoter activity mediated by liver receptor homolog-1 through interaction with ku proteins. Biol Pharm Bull. 2010;33:784-91 pubmed
    ..Ku proteins may function as corepressors for various nuclear receptors including LRH-1. ..
  66. Kako E, Kaneko N, Aoyama M, Hida H, Takebayashi H, Ikenaka K, et al. Subventricular zone-derived oligodendrogenesis in injured neonatal white matter in mice enhanced by a nonerythropoietic erythropoietin derivative. Stem Cells. 2012;30:2234-47 pubmed publisher
    ..These results demonstrate the limitation and potential of endogenous OPCs in the pSVZ as a therapeutic target for treating neonatal white-matter injury. ..
  67. Ujita M, Katsuno Y, Kawachi I, Ueno Y, Banno Y, Fujii H, et al. Glucan-binding activity of silkworm 30-kDa apolipoprotein and its involvement in defense against fungal infection. Biosci Biotechnol Biochem. 2005;69:1178-85 pubmed
    ..mori. These results suggest that 6G1 lipoprotein plays a role in the protection of B. mori against invading fungi. ..
  68. Ito A, Asamoto M, Hokaiwado N, Takahashi S, Shirai T. Tbx3 expression is related to apoptosis and cell proliferation in rat bladder both hyperplastic epithelial cells and carcinoma cells. Cancer Lett. 2005;219:105-12 pubmed
  69. Saito K, Sakaguchi M, Iioka H, Matsui M, Nakanishi H, Huh N, et al. Coxsackie and adenovirus receptor is a critical regulator for the survival and growth of oral squamous carcinoma cells. Oncogene. 2014;33:1274-86 pubmed publisher
    ..Thus, CAR substantially has an impact on growth and survival of oral SCC cells as a negative regulator of ROCK in vitro and in vivo. ..
  70. Seto M, Yamamoto K, Iida S, Akao Y, Utsumi K, Kubonishi I, et al. Gene rearrangement and overexpression of PRAD1 in lymphoid malignancy with t(11;14)(q13;q32) translocation. Oncogene. 1992;7:1401-6 pubmed
  71. Mizuno K, Kojima Y, Kurokawa S, Maruyama T, Sasaki S, Kohri K, et al. Identification of differentially expressed genes in human cryptorchid testes using suppression subtractive hybridization. J Urol. 2009;181:1330-7; discussion 1337 pubmed publisher
    ..Changes in the expression levels of these genes in the testes might enable novel evaluation of spermatogenic failure caused by cryptorchidism. ..
  72. Morishima S, Kashiwase K, Matsuo K, Azuma F, Yabe T, Sato Otsubo A, et al. High-risk HLA alleles for severe acute graft-versus-host disease and mortality in unrelated donor bone marrow transplantation. Haematologica. 2016;101:491-8 pubmed publisher
  73. Tsuda L, Inoue Y, Yoo M, Mizuno M, Hata M, Lim Y, et al. A protein kinase similar to MAP kinase activator acts downstream of the raf kinase in Drosophila. Cell. 1993;72:407-14 pubmed
    ..Our genetic results demonstrate the connection between raf and the highly conserved protein kinase cascade involving MAP kinase in vivo. ..
  74. Kitamoto N, Yoshino S, Ohmiya K, Tsukagoshi N. Sequence analysis, overexpression, and antisense inhibition of a beta-xylosidase gene, xylA, from Aspergillus oryzae KBN616. Appl Environ Microbiol. 1999;65:20-4 pubmed
    ..The partial-length antisense xylA gene expressed under control of the A. oryzae TEF1 promoter decreased the beta-xylosidase level in A. oryzae to about 20% of that of the host strain. ..
  75. Shimizu H, Matsuguchi T, Fukuda Y, Nakano I, Hayakawa T, Takeuchi O, et al. Toll-like receptor 2 contributes to liver injury by Salmonella infection through Fas ligand expression on NKT cells in mice. Gastroenterology. 2002;123:1265-77 pubmed
    ..TLR2 may contribute to liver injury induced by Salmonella infection via FasL induction on liver NKT cells. ..
  76. Xu Y, Takahashi Y, Wang Y, Hama A, Nishio N, Muramatsu H, et al. Downregulation of GATA-2 and overexpression of adipogenic gene-PPARgamma in mesenchymal stem cells from patients with aplastic anemia. Exp Hematol. 2009;37:1393-9 pubmed publisher
    ..Decreased expression of GATA-2 might be responsible for the pathogenesis and development of the clinical features of the disease. ..
  77. Katsumata Y, Nomura S, Ino K, Iwanaga K, Kurosawa N, Ito T, et al. Progesterone stimulates the expression of aminopeptidase A/angiotensinase in human choriocarcinoma cells. Placenta. 2001;22:831-6 pubmed
    ..These findings may serve as a useful model to study the effects of progesterone on angiotensin II metabolism in placenta, although the physiological validity of these studies remains to be clarified. ..
  78. Masayama A, Hamasaki K, Urakami K, Shimamoto S, Kato S, Makino S, et al. Expression of germination-related enzymes, CspA, CspB, CspC, SleC, and SleM, of Clostridium perfringens S40 in the mother cell compartment of sporulating cells. Genes Genet Syst. 2006;81:227-34 pubmed
    ..These results suggested that CspABC, SleC, and SleM are synthesized in the mother cell compartment of sporulating cells, probably at stages II approximately III of sporulation, and that the expression of cspABC genes is tricistronic. ..
  79. Yamamoto M, Maruyama D, Endo T, Nishikawa S. Arabidopsis thaliana has a set of J proteins in the endoplasmic reticulum that are conserved from yeast to animals and plants. Plant Cell Physiol. 2008;49:1547-62 pubmed publisher
    ..These results suggest that A. thaliana has a set of ER J proteins structurally and functionally conserved from yeast to plants. ..
  80. Takeshita K, Yamamoto K, Ito M, Kondo T, Matsushita T, Hirai M, et al. Increased expression of plasminogen activator inhibitor-1 with fibrin deposition in a murine model of aging, "Klotho" mouse. Semin Thromb Hemost. 2002;28:545-54 pubmed
    ..These observations suggest that in the process of aging the PAI-1 gene expression is increased, contributing to the development of thrombosis. ..
  81. Lu R, Niida H, Nakanishi M. Human SAD1 kinase is involved in UV-induced DNA damage checkpoint function. J Biol Chem. 2004;279:31164-70 pubmed
    ..The identification of this new kinase suggests the existence of an alternative checkpoint pathway other than those of ATR-Chk1 and p38MAPK. ..
  82. Ugawa S, Ueda T, Takahashi E, Hirabayashi Y, Yoneda T, Komai S, et al. Cloning and functional expression of ASIC-beta2, a splice variant of ASIC-beta. Neuroreport. 2001;12:2865-9 pubmed
    ..When expressed in Xenopus oocytes, ASIC-beta2 was inactive by itself. However, it associated with ASIC-beta to form heteromers, which display lower affinity for protons than ASIC-beta alone. ..
  83. Sun X, Chen Z, Hayashi Y, Kanou Y, Takagishi Y, Oda S, et al. Insertion of an intracisternal A particle retrotransposon element in plasma membrane calcium ATPase 2 gene attenuates its expression and produces an ataxic phenotype in joggle mutant mice. Gene. 2008;411:94-102 pubmed publisher
    ..Thus, we attributed ataxia in joggle mice to reduced expression of Pmca2, resulting from insertion of the IAP element. ..
  84. Horiba M, Kadomatsu K, Nakamura E, Muramatsu H, Ikematsu S, Sakuma S, et al. Neointima formation in a restenosis model is suppressed in midkine-deficient mice. J Clin Invest. 2000;105:489-95 pubmed
    ..These results indicate that MK plays a critical role in neointima formation at least in part owing to its ability to mediate leukocyte recruitment. ..
  85. Fujii M, Toyoda T, Nakanishi H, Yatabe Y, Sato A, Matsudaira Y, et al. TGF-? synergizes with defects in the Hippo pathway to stimulate human malignant mesothelioma growth. J Exp Med. 2012;209:479-94 pubmed publisher
    ..These data suggest that CTGF is an important modulator of MM growth and pathology and represents a novel therapeutic target for this disease. ..
  86. Uchiya K, Tohsuji M, Nikai T, Sugihara H, Sasakawa C. Identification and characterization of phoN-Sf, a gene on the large plasmid of Shigella flexneri 2a encoding a nonspecific phosphatase. J Bacteriol. 1996;178:4548-54 pubmed
  87. Ohya S, Tanaka M, Oku T, Asai Y, Watanabe M, Giles W, et al. Molecular cloning and tissue distribution of an alternatively spliced variant of an A-type K+ channel alpha-subunit, Kv4.3 in the rat. FEBS Lett. 1997;420:47-53 pubmed
    ..The longer splice variant is very weakly expressed in brain, but is the major product in heart. ..
  88. Fujii T, Nakao F, Shibata Y, Shioi G, Kodama E, Fujisawa H, et al. Caenorhabditis elegans PlexinA, PLX-1, interacts with transmembrane semaphorins and regulates epidermal morphogenesis. Development. 2002;129:2053-63 pubmed
  89. Bessho Y, Oguri T, Ozasa H, Uemura T, Sakamoto H, Miyazaki M, et al. ABCC10/MRP7 is associated with vinorelbine resistance in non-small cell lung cancer. Oncol Rep. 2009;21:263-8 pubmed
    ..Moreover, we detected the expression of ABCC10/MRP7 in 12 of 17 NSCLC cells, whereas ABCB1/MDR1 was detected in only 3 of 17 NSCLC cells. These results indicate that ABCC10/MRP7 may confer VNB resistance in NSCLC. ..
  90. Yokoi H, Mizukami H, Nagatsu A, Tanabe H, Inoue M. Hydroxy monounsaturated fatty acids as agonists for peroxisome proliferator-activated receptors. Biol Pharm Bull. 2010;33:854-61 pubmed
    ..In conclusion, (9Z)-11-HOE derived from alday seeds and hydroxy MUFAs with a chain length of 16 or 18 acted as PPAR agonists. Hydroxylation of MUFAs may change these compounds from silent PPAR ligands to active PPAR agonists...
  91. Momonoi K, Tsuji T, Kazuma K, Yoshida K. Specific expression of the vacuolar iron transporter, TgVit, causes iron accumulation in blue-colored inner bottom segments of various tulip petals. Biosci Biotechnol Biochem. 2012;76:319-25 pubmed
    ..TgVit1-dependent iron accumulation in the bottom segments of the inner perianth might be controlled by an unknown system that differentiated the upper parts and bottom segments of the inner perianth...
  92. Iwata E, Ikeda S, Abe N, Kobayashi A, Kurata M, Matsunaga S, et al. Roles of GIG1 and UVI4 in genome duplication in Arabidopsis thaliana. Plant Signal Behav. 2012;7:1079-81 pubmed publisher
    ..These findings suggest that endomitosis and endoreplication are regulated by similar molecular mechanisms, in which two related proteins, GIG1 and UVI4, may inhibit APC/C in different ways. ..