Experts and Doctors on cell differentiation in Okazaki, Aichi, Japan


Locale: Okazaki, Aichi, Japan
Topic: cell differentiation

Top Publications

  1. Hatanaka Y, Hisanaga S, Heizmann C, Murakami F. Distinct migratory behavior of early- and late-born neurons derived from the cortical ventricular zone. J Comp Neurol. 2004;479:1-14 pubmed
    ..Thus, there appear to be at least two distinct migratory phases of cortical neurons: one common to the early- and late-born neurons, and the other specific to late-born neurons and Cdk5-dependent. ..
  2. Paul Prasanth B, Bhandari R, Kobayashi T, Horiguchi R, Kobayashi Y, Nakamoto M, et al. Estrogen oversees the maintenance of the female genetic program in terminally differentiated gonochorists. Sci Rep. 2013;3:2862 pubmed publisher
    ..Gonochoristic fish maintain their sexual plasticity until adulthood and E2 plays a critical role in maintaining the female phenotype. ..
  3. Hara Y, Nagayama K, Yamamoto T, Matsumoto T, Suzuki M, Ueno N. Directional migration of leading-edge mesoderm generates physical forces: Implication in Xenopus notochord formation during gastrulation. Dev Biol. 2013;382:482-95 pubmed publisher
    ..We propose that the LEM may have a mechanical role in aiding the AM elongation through the rearrangement of force distribution in the dorsal marginal zone. ..
  4. Katsu Y, Kubokawa K, Urushitani H, Iguchi T. Estrogen-dependent transactivation of amphioxus steroid hormone receptor via both estrogen and androgen response elements. Endocrinology. 2010;151:639-48 pubmed publisher
    ..These results highlight the importance of comparative experimental approaches for the evolutionary study of endocrine systems. ..
  5. Goda T, Takagi C, Ueno N. Xenopus Rnd1 and Rnd3 GTP-binding proteins are expressed under the control of segmentation clock and required for somite formation. Dev Dyn. 2009;238:2867-76 pubmed publisher
    ..We also show that antisense morpholino oligonucleotides to Rnd1/3 inhibit somite segmentation and differentiation in Xenopus embryos. These results suggest that Rnd1/3 are required for Xenopus somitogenesis. ..
  6. Nakamura Y, Kagami H, Tagami T. Development, differentiation and manipulation of chicken germ cells. Dev Growth Differ. 2013;55:20-40 pubmed publisher
    ..This review will describe the development, migration, differentiation and manipulation of germ cells, and discuss the prospects that germ cell technologies offer for agriculture, biotechnology and academic research. ..
  7. Hata K, Araki M, Yamamori T. Ciliary neurotrophic factor inhibits differentiation of photoreceptor-like cells in rat pineal glands in vitro. Brain Res Dev Brain Res. 2003;143:179-87 pubmed
    ..These results suggest that CNTF plays an inhibitory role in the development of photoreceptor-like cells in early postnatal rat pineal glands. ..
  8. Ono K, Takebayashi H, Ikeda K, Furusho M, Nishizawa T, Watanabe K, et al. Regional- and temporal-dependent changes in the differentiation of Olig2 progenitors in the forebrain, and the impact on astrocyte development in the dorsal pallium. Dev Biol. 2008;320:456-68 pubmed publisher
    ..These observations indicate that embryonic Olig2+ progenitor cells change their differentiative properties during development, and also that Olig2 plays a role in astrocyte development in a region-specific manner. ..
  9. Shintani T, Ihara M, Sakuta H, Takahashi H, Watakabe I, Noda M. Eph receptors are negatively controlled by protein tyrosine phosphatase receptor type O. Nat Neurosci. 2006;9:761-9 pubmed
    ..Our findings explain the molecular mechanism that determines the threshold of the response of Eph receptors to ephrins in vivo. ..

More Information


  1. Hamada Y, Hiroe T, Suzuki Y, Oda M, Tsujimoto Y, Coleman J, et al. Notch2 is required for formation of the placental circulatory system, but not for cell-type specification in the developing mouse placenta. Differentiation. 2007;75:268-78 pubmed
    ..Thus, Notch2 is not cell autonomously required for the early cell fate determination of subtypes of trophoblast cells, but plays an indispensable role in the formation of maternal blood sinuses in the developing mouse placenta. ..
  2. Yoshida S. Elucidating the identity and behavior of spermatogenic stem cells in the mouse testis. Reproduction. 2012;144:293-302 pubmed publisher
    ..These features may lead to establishment of a more universal principle on stem cells that is shared by other systems...
  3. Shintani T, Maeda N, Noda M. Receptor-like protein tyrosine phosphatase gamma (RPTPgamma), but not PTPzeta/RPTPbeta, inhibits nerve-growth-factor-induced neurite outgrowth in PC12D cells. Dev Neurosci. 2001;23:55-69 pubmed
    ..These results indicate that RPTPgamma and PTPzeta have different substrate specificities, and RPTPgamma inhibits NGF-induced neurite outgrowth of PC12D cells through modulation of the p13(suc1) complex. ..
  4. Mochii M, Agata K, Kobayashi H, Yamamoto T, Eguchi G. Expression of gene coding for a melanosomal matrix protein transcriptionally regulated in the transdifferentiation of chick embryo pigmented epithelial cells. Cell Differ. 1988;24:67-74 pubmed
    ..The transcripts were detected in neither transdifferentiating, transdifferentiated lens cells nor bipotent dedifferentiated PECs, although the 2.6 kb transcript was vigorously synthesized by redifferentiating into PECs. ..
  5. Shimizu T, Kagawa T, Wada T, Muroyama Y, Takada S, Ikenaka K. Wnt signaling controls the timing of oligodendrocyte development in the spinal cord. Dev Biol. 2005;282:397-410 pubmed
    ..Addition of rmFz-8/Fc, a Wnt antagonist, increased the number of immature oligodendrocytes in the spinal cord explant culture, demonstrating that endogenous Wnt signaling controls oligodendrocyte development. ..
  6. Satou C, Kimura Y, Higashijima S. Generation of multiple classes of V0 neurons in zebrafish spinal cord: progenitor heterogeneity and temporal control of neuronal diversity. J Neurosci. 2012;32:1771-83 pubmed publisher
    ..These results suggest that multiple types of V0 neurons are produced by two distinct mechanisms; from heterogeneous p0 progenitors and from the same p0 progenitor, but in a time-dependent manner. ..
  7. Fujimori T. Preimplantation development of mouse: a view from cellular behavior. Dev Growth Differ. 2010;52:253-62 pubmed publisher
    ..Here, mouse preimplantation embryonic development is briefly summarized and our current understanding of this complex process based on recent observations is reviewed...
  8. Kondo T, Plaza S, Zanet J, Benrabah E, Valenti P, Hashimoto Y, et al. Small peptides switch the transcriptional activity of Shavenbaby during Drosophila embryogenesis. Science. 2010;329:336-9 pubmed publisher
    ..Our results demonstrate that during Drosophila embryogenesis, Pri sORF peptides provide a strict temporal control to the transcriptional program of epidermal morphogenesis. ..
  9. Kumada T, Hasegawa A, Iwasaki Y, Baba H, Ikenaka K. Isolation of cystatin C via functional cloning of astrocyte differentiation factors. Dev Neurosci. 2004;26:68-76 pubmed
    ..Although previous data showed that CysC is involved in the maintenance of adult neural stem cells, our data indicate that it is involved in astrocyte differentiation during mouse brain development. ..
  10. Yamanaka H, Yanagawa Y, Obata K. Development of stellate and basket cells and their apoptosis in mouse cerebellar cortex. Neurosci Res. 2004;50:13-22 pubmed
    ..Apoptosis of GABAergic interneurons was demonstrated in the ML and WM during the first two weeks. Their apoptotic loss will contribute to the adjustment of neuron number or elimination of any improper populations. ..
  11. Iwasaki Y, Hosoya T, Takebayashi H, Ogawa Y, Hotta Y, Ikenaka K. The potential to induce glial differentiation is conserved between Drosophila and mammalian glial cells missing genes. Development. 2003;130:6027-35 pubmed
    ..The mammalian homolog of Drosophila gcm, mouse Gcm1, exhibits the potential to induce gliogenesis, but may function in the generation of a minor subpopulation of glial cells. ..
  12. Mochii M, Mazaki Y, Mizuno N, Hayashi H, Eguchi G. Role of Mitf in differentiation and transdifferentiation of chicken pigmented epithelial cell. Dev Biol. 1998;193:47-62 pubmed
    ..The expression patterns of pax6 and Mitf are complementary both in vivo in vitro. Overexpression of Mitf inhibited expression of pax6 in cultured rPECs. These observations suggest that Mitf regulates pax6 expression negatively. ..
  13. Mochii M, Agata K, Eguchi G. Complete sequence and expression of a cDNA encoding a chicken 115-kDa melanosomal matrix protein. Pigment Cell Res. 1991;4:41-7 pubmed
    ..The presence of a specific sorting signal was suggested for localization of melanosomal proteins. Southern blot analysis has revealed that the homologues of the chicken MMP115 gene are found in many vertebrate genomes. ..
  14. Sawada K, Agata K, Eguchi G. Characterization of terminally differentiated cell state by categorizing cDNA clones derived from chicken lens fibers. Int J Dev Biol. 1996;40:531-5 pubmed
  15. Masahira N, Takebayashi H, Ono K, Watanabe K, Ding L, Furusho M, et al. Olig2-positive progenitors in the embryonic spinal cord give rise not only to motoneurons and oligodendrocytes, but also to a subset of astrocytes and ependymal cells. Dev Biol. 2006;293:358-69 pubmed
    ..These findings demonstrate that motoneurons and oligodendrocytes are not the only cell types originating from this domain. ..
  16. Hayashi Y, Hayashi M, Kobayashi S. Nanos suppresses somatic cell fate in Drosophila germ line. Proc Natl Acad Sci U S A. 2004;101:10338-42 pubmed
    ..We propose a model in which Nos establishes germ-line/soma dichotomy and is also required to maintain germ-line fate. ..
  17. Kinoshita N, Iioka H, Miyakoshi A, Ueno N. PKC delta is essential for Dishevelled function in a noncanonical Wnt pathway that regulates Xenopus convergent extension movements. Genes Dev. 2003;17:1663-76 pubmed
    ..Thus, PKC delta plays an essential role in the Wnt/JNK pathway by regulating the localization and activity of Dishevelled. ..
  18. Kimura T, Nagao Y, Hashimoto H, Yamamoto Shiraishi Y, Yamamoto S, Yabe T, et al. Leucophores are similar to xanthophores in their specification and differentiation processes in medaka. Proc Natl Acad Sci U S A. 2014;111:7343-8 pubmed publisher
    ..Our findings provide clues for revealing diverse evolutionary mechanisms of pigment cell formation in animals. ..
  19. Hyodo Miura J, Urushiyama S, Nagai S, Nishita M, Ueno N, Shibuya H. Involvement of NLK and Sox11 in neural induction in Xenopus development. Genes Cells. 2002;7:487-96 pubmed
    ..Our findings indicate that xNLK may play a role in neural development together with xSox11 during early Xenopus embryogenesis. ..
  20. Maeda N, Noda M. 6B4 proteoglycan/phosphacan is a repulsive substratum but promotes morphological differentiation of cortical neurons. Development. 1996;122:647-58 pubmed
    ..These results suggest that 6B4 proteoglycan/phosphacan modulates morphogenesis and differentiation of neurons dependent on its spatiotemporal distribution and the cell types in the brain. ..
  21. Gotoh H, Ono K, Takebayashi H, Harada H, Nakamura H, Ikenaka K. Genetically-defined lineage tracing of Nkx2.2-expressing cells in chick spinal cord. Dev Biol. 2011;349:504-11 pubmed publisher
    ..Moreover, the labeled OLs were found throughout the white matter in the spinal cord including the most dorsal spinal cord. Thus p3 domain directly generates spinal cord OLs in the chick spinal cord...
  22. Kubota Y, Shigematsu N, Karube F, Sekigawa A, Kato S, Yamaguchi N, et al. Selective coexpression of multiple chemical markers defines discrete populations of neocortical GABAergic neurons. Cereb Cortex. 2011;21:1803-17 pubmed publisher
    ..These observations support the existence of a limited number of functionally distinct subtypes of GABA cells in the neocortex. ..
  23. Inamura N, Ono K, Takebayashi H, Zalc B, Ikenaka K. Olig2 lineage cells generate GABAergic neurons in the prethalamic nuclei, including the zona incerta, ventral lateral geniculate nucleus and reticular thalamic nucleus. Dev Neurosci. 2011;33:118-29 pubmed publisher
  24. Oishi K, Nakagawa N, Tachikawa K, Sasaki S, Aramaki M, Hirano S, et al. Identity of neocortical layer 4 neurons is specified through correct positioning into the cortex. elife. 2016;5: pubmed publisher
    ..These results suggest that the L4 identity is not completely determined at the time of birth but ensured by the surrounding environment after appropriate positioning. ..
  25. Sugimoto R, Nabeshima Y, Yoshida S. Retinoic acid metabolism links the periodical differentiation of germ cells with the cycle of Sertoli cells in mouse seminiferous epithelium. Mech Dev. 2012;128:610-24 pubmed publisher
    ..Similar regulation by differentiating progeny through the modulation of local environment could also be involved in other stem cell systems...
  26. Kimura Y, Satou C, Higashijima S. V2a and V2b neurons are generated by the final divisions of pair-producing progenitors in the zebrafish spinal cord. Development. 2008;135:3001-5 pubmed publisher
    ..We report that the terminal division of pair-producing progenitor cells in vertebrate neurogenesis can reproducibly produce two distinct neurons through a mechanism that may not depend on the orientation of the division axis. ..
  27. Kodama T, Itsukaichi Nishida Y, Fukazawa Y, Wakamori M, Miyata M, Molnar E, et al. A CaV2.1 calcium channel mutation rocker reduces the number of postsynaptic AMPA receptors in parallel fiber-Purkinje cell synapses. Eur J Neurosci. 2006;24:2993-3007 pubmed
    ..These lines of evidence suggest that even a moderate dysfunction of CaV2.1 Ca2+ channel can cause substantial changes in postsynaptic molecular composition of the PF-PC synapses and dendritic structure of PCs...
  28. Furusho M, Ono K, Takebayashi H, Masahira N, Kagawa T, Ikeda K, et al. Involvement of the Olig2 transcription factor in cholinergic neuron development of the basal forebrain. Dev Biol. 2006;293:348-57 pubmed
    ..The present study provides the first direct evidence for involvement of the Olig2 gene in cholinergic differentiation in the basal forebrain. ..
  29. Ogawa Y, Takebayashi H, Takahashi M, Osumi N, Iwasaki Y, Ikenaka K. Gliogenic radial glial cells show heterogeneity in the developing mouse spinal cord. Dev Neurosci. 2005;27:364-77 pubmed
    ..This raises the idea that astrocytes generated from different domains along the dorsoventral axis in the mouse spinal cord have distinct characteristics. ..
  30. Katsu Y, Lubahn D, Iguchi T. Expression of a novel C-type lectin in the mouse vagina. Endocrinology. 2003;144:2597-605 pubmed
    ..Taken together, these data suggest that DDV10 encodes a novel, 17beta-estradiol-regulated, C-type lectin in the mouse vagina. DDV10 may play a role in the stratification and/or cornification of epithelial cells during differentiation. ..
  31. Shibuya H, Iwata H, Masuyama N, Gotoh Y, Yamaguchi K, Irie K, et al. Role of TAK1 and TAB1 in BMP signaling in early Xenopus development. EMBO J. 1998;17:1019-28 pubmed
    ..These results thus suggest that xTAK1 and xTAB1 function in the BMP signal transduction pathway in Xenopus embryos in a cooperative manner. ..
  32. Nishiyama T, Miyawaki K, Ohshima M, Thompson K, Nagashima A, Hasebe M, et al. Digital gene expression profiling by 5'-end sequencing of cDNAs during reprogramming in the moss Physcomitrella patens. PLoS ONE. 2012;7:e36471 pubmed publisher
    ..patens, although no exogenous phytohormone is applied in the moss system, suggesting that an intrinsic phytohormone regulatory system may be used in the moss. ..
  33. Kitadate Y, Shigenobu S, Arita K, Kobayashi S. Boss/Sev signaling from germline to soma restricts germline-stem-cell-niche formation in the anterior region of Drosophila male gonads. Dev Cell. 2007;13:151-9 pubmed
    ..Thus, we propose that signal transduction from germline to soma restricts expansion of the germline-stem-cell niche in the gonads. ..