Experts and Doctors on cadherins in Nagoya, Aichi, Japan


Locale: Nagoya, Aichi, Japan
Topic: cadherins

Top Publications

  1. Saito K, Sakaguchi M, Iioka H, Matsui M, Nakanishi H, Huh N, et al. Coxsackie and adenovirus receptor is a critical regulator for the survival and growth of oral squamous carcinoma cells. Oncogene. 2014;33:1274-86 pubmed publisher
    ..Thus, CAR substantially has an impact on growth and survival of oral SCC cells as a negative regulator of ROCK in vitro and in vivo. ..
  2. Suda K, Tomizawa K, Fujii M, Murakami H, Osada H, Maehara Y, et al. Epithelial to mesenchymal transition in an epidermal growth factor receptor-mutant lung cancer cell line with acquired resistance to erlotinib. J Thorac Oncol. 2011;6:1152-61 pubmed publisher
    ..Our results indicate that it would be important to consider the influence of EMT in the development of treatments against acquired resistance to gefitinib or erlotinib. ..
  3. Takeyama Y, Sato M, Horio M, Hase T, Yoshida K, Yokoyama T, et al. Knockdown of ZEB1, a master epithelial-to-mesenchymal transition (EMT) gene, suppresses anchorage-independent cell growth of lung cancer cells. Cancer Lett. 2010;296:216-24 pubmed publisher
    ..These results suggest that inhibiting ZEB1 function may be an attractive target for NSCLC therapeutic development. ..
  4. Sato K, Watanabe T, Wang S, Kakeno M, Matsuzawa K, Matsui T, et al. Numb controls E-cadherin endocytosis through p120 catenin with aPKC. Mol Biol Cell. 2011;22:3103-19 pubmed publisher
    ..Thus, we propose that aPKC phosphorylates Numb to prevent its binding to p120 and ?-adaptin, thereby attenuating E-cadherin endocytosis to maintain apicobasal polarity. ..
  5. Osada H, Tomida S, Yatabe Y, Tatematsu Y, Takeuchi T, Murakami H, et al. Roles of achaete-scute homologue 1 in DKK1 and E-cadherin repression and neuroendocrine differentiation in lung cancer. Cancer Res. 2008;68:1647-55 pubmed publisher
  6. Sugimoto M, Inoko A, Shiromizu T, Nakayama M, Zou P, Yonemura S, et al. The keratin-binding protein Albatross regulates polarization of epithelial cells. J Cell Biol. 2008;183:19-28 pubmed publisher
    ..We propose that keratins and the keratin-binding protein Albatross are important for epithelial cell polarization...
  7. Rahman M, Senga T, Ito S, Hyodo T, Hasegawa H, Hamaguchi M. S-nitrosylation at cysteine 498 of c-Src tyrosine kinase regulates nitric oxide-mediated cell invasion. J Biol Chem. 2010;285:3806-14 pubmed publisher
    ..These results identify a novel signaling pathway that links NO and Src family kinases to cancer cell invasion and metastasis. ..
  8. Asano T, Yamada S, Fuchs B, Takami H, Hayashi M, Sugimoto H, et al. Clinical implication of Frizzled 2 expression and its association with epithelial-to-mesenchymal transition in hepatocellular carcinoma. Int J Oncol. 2017;50:1647-1654 pubmed publisher
    ..Furthermore, Stat3 might be controlled by both the Wnt5/Fzd2 and IL-6/Jak2 signaling pathways and play an important role in EMT. ..
  9. Yamada S, Fuchs B, Fujii T, Shimoyama Y, Sugimoto H, Nomoto S, et al. Epithelial-to-mesenchymal transition predicts prognosis of pancreatic cancer. Surgery. 2013;154:946-54 pubmed publisher
    ..The aim of this study was to evaluate the association between EMT and the prognoses for patients with pancreatic cancer...

More Information


  1. Nakashima H, Hashimoto N, Aoyama D, Kohnoh T, Sakamoto K, Kusunose M, et al. Involvement of the transcription factor twist in phenotype alteration through epithelial-mesenchymal transition in lung cancer cells. Mol Carcinog. 2012;51:400-10 pubmed publisher
    ..Our present analysis of twist expression in lung cancer provide clues to comprehensive understanding of the mechanisms, by which metastasis often develops in lung cancer. ..
  2. Imura H, Yamada T, Mishima K, Fujiwara K, Kawaki H, Hirata A, et al. Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin suggests abnormal palate development after palatal fusion. Congenit Anom (Kyoto). 2010;50:77-84 pubmed publisher
    ..A decrease in E-cadherin expression was observed in this mass of cells, indicating its involvement in the development of cleft palate...
  3. Fukuoka T, Hibi K, Nakao A. Aberrant methylation is frequently observed in advanced esophageal squamous cell carcinoma. Anticancer Res. 2006;26:3333-5 pubmed
    ..ESCC with methylation-positive genes showed a trend towards larger tumor size and deeper invasion (p = 0.139 and p = 0.0664, respectively). Thus, the methylation of the p16, HLTF and CDH13 genes is a high malignancy factor in ESCC. ..
  4. Hibi K, Kodera Y, Ito K, Akiyama S, Nakao A. Methylation pattern of CDH13 gene in digestive tract cancers. Br J Cancer. 2004;91:1139-42 pubmed
    ..These results suggested that CDH13 might play a variety of roles depending on the tissue type. ..
  5. Dohda T, Nakamura Y, Kamihira M, Iijima S. Functional role of RhoA in growth regulation of primary hepatocytes. J Biochem. 2004;135:631-7 pubmed
    ..The Clostridium botulinum C3 enzyme inhibited hepatocyte growth with stimulation by HGF. These results suggest that RhoA has a crucial role in hepatocyte growth control. ..
  6. Hibi K, Nakayama H, Kodera Y, Ito K, Akiyama S, Nakao A. CDH13 promoter region is specifically methylated in poorly differentiated colorectal cancer. Br J Cancer. 2004;90:1030-3 pubmed
  7. Kubota E, Kataoka H, Aoyama M, Mizoshita T, Mori Y, Shimura T, et al. Role of ES cell-expressed Ras (ERas) in tumorigenicity of gastric cancer. Am J Pathol. 2010;177:955-63 pubmed publisher
    ..These data suggest that ERas is activated in a significant population of gastric cancer, where it may play a crucial role in gastric cancer cell survival and metastases to liver via down-regulation of E-cadherin. ..
  8. Horio M, Sato M, Takeyama Y, Elshazley M, Yamashita R, Hase T, et al. Transient but not stable ZEB1 knockdown dramatically inhibits growth of malignant pleural mesothelioma cells. Ann Surg Oncol. 2012;19 Suppl 3:S634-45 pubmed publisher
  9. Izawa I, Nishizawa M, Ohtakara K, Inagaki M. Densin-180 interacts with delta-catenin/neural plakophilin-related armadillo repeat protein at synapses. J Biol Chem. 2002;277:5345-50 pubmed
    ..Densin-180 co-localized with delta-catenin/NPRAP at synapses in delta-catenin/NPRAP and may be involved in organization of the synaptic cell-cell junction through interaction with the delta-catenin/NPRAP-N-cadherin complex. ..