Experts and Doctors on oxidoreductases in Milano, Lombardy, Italy


Locale: Milano, Lombardy, Italy
Topic: oxidoreductases

Top Publications

  1. Cabibbo A, Pagani M, Fabbri M, Rocchi M, Farmery M, Bulleid N, et al. ERO1-L, a human protein that favors disulfide bond formation in the endoplasmic reticulum. J Biol Chem. 2000;275:4827-33 pubmed
    ..ERO1-L is no longer functional when either one of the highly conserved Cys-394 or Cys-397 is mutated. These results strongly suggest that ERO1-L is involved in oxidative ER protein folding in mammalian cells. ..
  2. Mezghrani A, Fassio A, Benham A, Simmen T, Braakman I, Sitia R. Manipulation of oxidative protein folding and PDI redox state in mammalian cells. EMBO J. 2001;20:6288-96 pubmed
    ..Mutants in the Ero1-Lalpha CXXCXXC motif act as dominant negatives by limiting immunoglobulin oxidation. PDI-dependent oxidative folding in living cells can thus be manipulated by using hERO variants. ..
  3. Monti D, Ottolina G, Carrea G, Riva S. Redox reactions catalyzed by isolated enzymes. Chem Rev. 2011;111:4111-40 pubmed publisher
  4. Reniero D, Galli E, Barbieri P. Cloning and comparison of mercury- and organomercurial-resistance determinants from a Pseudomonas stutzeri plasmid. Gene. 1995;166:77-82 pubmed
    ..The presence of two inverted repeat-like elements, identical to those of Tn5053, upstream from merR suggests that the pPB broad-spectrum-gene cluster could be part of a transposon-like element. ..
  5. Pagani M, Fabbri M, Benedetti C, Fassio A, Pilati S, Bulleid N, et al. Endoplasmic reticulum oxidoreductin 1-lbeta (ERO1-Lbeta), a human gene induced in the course of the unfolded protein response. J Biol Chem. 2000;275:23685-92 pubmed
    ..Furthermore, only ERO1-Lbeta transcripts are induced in the course of the unfolded protein response. Our results suggest a complex regulation of ER redox homeostasis in mammalian cells. ..
  6. Bertoli G, Simmen T, Anelli T, Molteni S, Fesce R, Sitia R. Two conserved cysteine triads in human Ero1alpha cooperate for efficient disulfide bond formation in the endoplasmic reticulum. J Biol Chem. 2004;279:30047-52 pubmed
    ..These findings suggest that interactions between the two triads, dependent on Cys85 and Cys391, are important for Ero1alpha function, possibly stabilizing a platform for efficient PDI oxidation. ..
  7. Otsu M, Bertoli G, Fagioli C, Guerini Rocco E, Nerini Molteni S, Ruffato E, et al. Dynamic retention of Ero1alpha and Ero1beta in the endoplasmic reticulum by interactions with PDI and ERp44. Antioxid Redox Signal. 2006;8:274-82 pubmed
    ..PDI also prevents Ero1 aggregation and dimerization, thus chaperoning its own oxidase. This dynamic retention mechanism of Ero1 may be important for fine-tuning the regulation of ER redox homeostasis and quality control. ..
  8. Marzorati M, de Ferra F, Van Raemdonck H, Borin S, Allifranchini E, Carpani G, et al. A novel reductive dehalogenase, identified in a contaminated groundwater enrichment culture and in Desulfitobacterium dichloroeliminans strain DCA1, is linked to dehalogenation of 1,2-dichloroethane. Appl Environ Microbiol. 2007;73:2990-9 pubmed
    ..In conclusion, these data suggest that the newly described RDs are specifically adapted to 1,2-DCA dechlorination...
  9. Anelli T, Bergamelli L, Margittai E, Rimessi A, Fagioli C, Malgaroli A, et al. Ero1? regulates Ca(2+) fluxes at the endoplasmic reticulum-mitochondria interface (MAM). Antioxid Redox Signal. 2012;16:1077-87 pubmed publisher
    ..Taken together, our results indicate that the levels, subcellular localization, and activity of Ero1? coordinately regulate Ca(2+) and redox homeostasis and signaling in the early secretory compartment. ..

More Information


  1. Bendinelli P, Maroni P, Matteucci E, Luzzati A, Perrucchini G, Desiderio M. Hypoxia inducible factor-1 is activated by transcriptional co-activator with PDZ-binding motif (TAZ) versus WWdomain-containing oxidoreductase (WWOX) in hypoxic microenvironment of bone metastasis from breast cancer. Eur J Cancer. 2013;49:2608-18 pubmed publisher
    ..We gained clinical insight into HIF-1? and TAZ as candidate biomarkers for bone avidity, relevant for early-therapeutic intervention against bone metastasis. ..