Experts and Doctors on neuraminidase in Brescia, Lombardy, Italy
Locale: Brescia, Lombardy, Italy
Monti E, Bassi M, Papini N, Riboni M, Manzoni M, Venerando B, et al
. Identification and expression of NEU3, a novel human sialidase associated to the plasma membrane. Biochem J. 2000;349:343-51 pubmed
..8. Immunofluorescence staining of the transfected COS7 cells demonstrated the protein's localization in the plasma membrane. ..
Zanchetti G, Colombi P, Manzoni M, Anastasia L, Caimi L, Borsani G, et al
. Sialidase NEU3 is a peripheral membrane protein localized on the cell surface and in endosomal structures. Biochem J. 2007;408:211-9 pubmed
..Overall, these results provide important information about the biology of NEU3, the most studied member of the mammalian sialidase family. ..
Stoppani E, Rossi S, Marchesini S, Preti A, Fanzani A. Defective myogenic differentiation of human rhabdomyosarcoma cells is characterized by sialidase Neu2 loss of expression. Cell Biol Int. 2009;33:1020-5 pubmed publisher
Giacopuzzi E, Barlati S, Preti A, Venerando B, Monti E, Borsani G, et al
. Gallus gallus NEU3 sialidase as model to study protein evolution mechanism based on rapid evolving loops. BMC Biochem. 2011;12:45 pubmed publisher
..Giving the peculiar organization of the loop region identified in Gg NEU3, this protein can be considered of particular interest in such evolutionary studies and to get deeper insights in sialidase evolution. ..
Fanzani A, Giuliani R, Colombo F, Zizioli D, Presta M, Preti A, et al
. Overexpression of cytosolic sialidase Neu2 induces myoblast differentiation in C2C12 cells. FEBS Lett. 2003;547:183-8 pubmed
..The results indicate that Neu2 upregulation per se is sufficient to trigger myoblast differentiation in C2C12 cells. ..
Monti E, Bassi M, Bresciani R, Civini S, Croci G, Papini N, et al
. Molecular cloning and characterization of NEU4, the fourth member of the human sialidase gene family. Genomics. 2004;83:445-53 pubmed
..Immunofluorescence staining and Western blot analysis demonstrated the association of NEU4 with the inner cell membranes. ..
Manzoni M, Colombi P, Papini N, Rubaga L, Tiso N, Preti A, et al
. Molecular cloning and biochemical characterization of sialidases from zebrafish (Danio rerio). Biochem J. 2007;408:395-406 pubmed publisher
..Overall, the redundancy of sialidases together with their expression profile and their activity exerted on gangliosides of living cells indicate the biological relevance of this class of enzymes in zebrafish...
Fanzani A, Giuliani R, Colombo F, Rossi S, Stoppani E, Martinet W, et al
. The enzymatic activity of sialidase Neu2 is inversely regulated during in vitro myoblast hypertrophy and atrophy. Biochem Biophys Res Commun. 2008;370:376-81 pubmed publisher
..Overall, we may conclude that Neu2 enzymatic activity is causally linked to proper muscle differentiation and growth. ..
Giacopuzzi E, Bresciani R, Schauer R, Monti E, Borsani G. New insights on the sialidase protein family revealed by a phylogenetic analysis in metazoa. PLoS ONE. 2012;7:e44193 pubmed publisher
..Moreover, we further confirm findings on the catalytic residues and identified enzyme loop portions that behave as rapidly diverging regions and may be involved in the evolution of specific properties of sialidases...