Experts and Doctors on molecular sequence data in Brescia, Lombardy, Italy


Locale: Brescia, Lombardy, Italy
Topic: molecular sequence data

Top Publications

  1. Foiani M, Marini F, Gamba D, Lucchini G, Plevani P. The B subunit of the DNA polymerase alpha-primase complex in Saccharomyces cerevisiae executes an essential function at the initial stage of DNA replication. Mol Cell Biol. 1994;14:923-33 pubmed
    ..A model for the role of the B subunit in initiation of DNA replication at an origin is presented. ..
  2. Nicoli S, Gilardelli C, Pozzoli O, Presta M, Cotelli F. Regulated expression pattern of gremlin during zebrafish development. Gene Expr Patterns. 2005;5:539-44 pubmed
    ..Finally, grm transcript is strongly downregulated in fibroblast growth factor-8 (fgf8) and sonic hedgehog (shh) mutants, thus implicating a putative role of Fgf/Shh signalling loop in grm expression regulation. ..
  3. Camozzi M, Rusnati M, Bugatti A, Bottazzi B, Mantovani A, Bastone A, et al. Identification of an antiangiogenic FGF2-binding site in the N terminus of the soluble pattern recognition receptor PTX3. J Biol Chem. 2006;281:22605-13 pubmed
  4. Rovida F, Piralla A, Marzani F, Moreno A, Campanini G, Mojoli F, et al. Swine influenza A (H1N1) virus (SIV) infection requiring extracorporeal life support in an immunocompetent adult patient with indirect exposure to pigs, Italy, October 2016. Euro Surveill. 2017;22: pubmed publisher
    ..The sole risk factor for influenza was a body mass index?>?30 kg/m2. After a month of hospitalisation, the patient was discharged in good health. ..
  5. Mattioli S, Imberti L, Stellini R, Primi D. Mimicry of the immunodominant conformation-dependent antigenic site of hepatitis A virus by motifs selected from synthetic peptide libraries. J Virol. 1995;69:5294-9 pubmed
    ..Collectively, these data represent an additional important paradigm of a mimotope capable of mimicking an antigenic determinant with unknown tertiary structure. ..
  6. Lelli D, Papetti A, Sabelli C, Rosti E, Moreno A, Boniotti M. Detection of coronaviruses in bats of various species in Italy. Viruses. 2013;5:2679-89 pubmed publisher
  7. Giacopuzzi E, Bresciani R, Schauer R, Monti E, Borsani G. New insights on the sialidase protein family revealed by a phylogenetic analysis in metazoa. PLoS ONE. 2012;7:e44193 pubmed publisher
    ..Moreover, we further confirm findings on the catalytic residues and identified enzyme loop portions that behave as rapidly diverging regions and may be involved in the evolution of specific properties of sialidases...
  8. Fra A, Gooptu B, Ferrarotti I, Miranda E, Scabini R, Ronzoni R, et al. Three new alpha1-antitrypsin deficiency variants help to define a C-terminal region regulating conformational change and polymerization. PLoS ONE. 2012;7:e38405 pubmed publisher
    ..The new mutations cluster structurally, thus defining a region of the AAT molecule critical for regulating its conformational state. ..
  9. Giacopuzzi E, Barlati S, Preti A, Venerando B, Monti E, Borsani G, et al. Gallus gallus NEU3 sialidase as model to study protein evolution mechanism based on rapid evolving loops. BMC Biochem. 2011;12:45 pubmed publisher
    ..Giving the peculiar organization of the loop region identified in Gg NEU3, this protein can be considered of particular interest in such evolutionary studies and to get deeper insights in sialidase evolution. ..

More Information


  1. Chiarelli N, Ritelli M, Zoppi N, Benini A, Borsani G, Barlati S, et al. Characterization and expression pattern analysis of the facilitative glucose transporter 10 gene (slc2a10) in Danio rerio. Int J Dev Biol. 2011;55:229-36 pubmed publisher
    ..In later embryonic stages, slc2a10 mRNA was detected in the otic vesicles, hatching gland cells, pectoral fin, posterior tectum and swim bladder. Overall, these results suggest a wide role of slc2a10 during zebrafish development. ..
  2. Lanzi G, Ferrari S, Vihinen M, Caraffi S, Kutukculer N, Schiaffonati L, et al. Different molecular behavior of CD40 mutants causing hyper-IgM syndrome. Blood. 2010;116:5867-74 pubmed publisher
    ..These results give new important insights into the molecular pathogenesis of HIGM disease, and suggest that CD40 deficiency can also be regarded as an ER-storage disease. ..
  3. Luscieti S, Santambrogio P, Langlois d Estaintot B, Granier T, Cozzi A, Poli M, et al. Mutant ferritin L-chains that cause neurodegeneration act in a dominant-negative manner to reduce ferritin iron incorporation. J Biol Chem. 2010;285:11948-57 pubmed publisher
    ..The data support the hypothesis that hereditary ferritinopathies are due to alterations of ferritin functionality and provide new input on the mechanism of the function of isoferritins. ..
  4. Serana F, Sottini A, Caimi L, Palermo B, Natali P, Nistico P, et al. Identification of a public CDR3 motif and a biased utilization of T-cell receptor V beta and J beta chains in HLA-A2/Melan-A-specific T-cell clonotypes of melanoma patients. J Transl Med. 2009;7:21 pubmed publisher
  5. Salvi A, Bongarzone I, Miccichè F, Arici B, Barlati S, De Petro G. Proteomic identification of LASP-1 down-regulation after RNAi urokinase silencing in human hepatocellular carcinoma cells. Neoplasia. 2009;11:207-19 pubmed
    ..In summary, the proteomic identification of a set of uPA downstream proteins provides new insight into the function of uPA in HCC cells. ..
  6. Manzoni M, Colombi P, Papini N, Rubaga L, Tiso N, Preti A, et al. Molecular cloning and biochemical characterization of sialidases from zebrafish (Danio rerio). Biochem J. 2007;408:395-406 pubmed publisher
    ..Overall, the redundancy of sialidases together with their expression profile and their activity exerted on gangliosides of living cells indicate the biological relevance of this class of enzymes in zebrafish...
  7. Lanzi G, de Miranda J, Boniotti M, Cameron C, Lavazza A, Capucci L, et al. Molecular and biological characterization of deformed wing virus of honeybees (Apis mellifera L.). J Virol. 2006;80:4998-5009 pubmed publisher
    ..The genome organization, capsid morphology, and sequence comparison data indicate that DWV is a member of the recently established genus Iflavirus...
  8. Losi C, Silini A, Fiorini C, Soresina A, Meini A, Ferrari S, et al. Mutational analysis of human BAFF receptor TNFRSF13C (BAFF-R) in patients with common variable immunodeficiency. J Clin Immunol. 2005;25:496-502 pubmed
    ..These variants do not affect the expression of BAFF-R neither at the mRNA nor at the protein level, suggesting that these variants represent novel polymorphic variants of the BAFF-R gene. ..
  9. Monti E, Bassi M, Bresciani R, Civini S, Croci G, Papini N, et al. Molecular cloning and characterization of NEU4, the fourth member of the human sialidase gene family. Genomics. 2004;83:445-53 pubmed
    ..Immunofluorescence staining and Western blot analysis demonstrated the association of NEU4 with the inner cell membranes. ..
  10. Barbon A, Vallini I, Barlati S. Genomic organization of the human GRIK2 gene and evidence for multiple splicing variants. Gene. 2001;274:187-97 pubmed
  11. Parolini S, Bottino C, Falco M, Augugliaro R, Giliani S, Franceschini R, et al. X-linked lymphoproliferative disease. 2B4 molecules displaying inhibitory rather than activating function are responsible for the inability of natural killer cells to kill Epstein-Barr virus-infected cells. J Exp Med. 2000;192:337-46 pubmed
    ..As expected, in XLP-NK cells, 2B4 did not associate with SH2D1A, whereas similar to 2B4 molecules isolated from normal NK cells, it did associate with Src homology 2 domain-containing phosphatase 1. ..
  12. Monti E, Bassi M, Papini N, Riboni M, Manzoni M, Venerando B, et al. Identification and expression of NEU3, a novel human sialidase associated to the plasma membrane. Biochem J. 2000;349:343-51 pubmed
    ..8. Immunofluorescence staining of the transfected COS7 cells demonstrated the protein's localization in the plasma membrane. ..
  13. Borroni B, Archetti S, Del Bo R, Papetti A, Buratti E, Bonvicini C, et al. TARDBP mutations in frontotemporal lobar degeneration: frequency, clinical features, and disease course. Rejuvenation Res. 2010;13:509-17 pubmed publisher
    ..This work further supports the need for TARDBP screening in FTLD. Also intronic splicing that affects mutations should be considered as well. ..
  14. Zizioli D, Forlanelli E, Guarienti M, Nicoli S, Fanzani A, Bresciani R, et al. Characterization of the AP-1 ?1A and ?1B adaptins in zebrafish (Danio rerio). Dev Dyn. 2010;239:2404-12 pubmed publisher
    ..Development ceased at 7-8 dpf. ?1B is not expressed in murine liver, indicating loss of ?1B expression and establishment of alternative sorting mechanisms during mammalian development. ..
  15. Giagulli C, Marsico S, Magiera A, Bruno R, Caccuri F, Barone I, et al. Opposite effects of HIV-1 p17 variants on PTEN activation and cell growth in B cells. PLoS ONE. 2011;6:e17831 pubmed publisher
    ..Moreover, it provides the first evidence on the presence of a p17 natural variant mimicking the p17?36-induced signalling in B cells and displaying the capacity of promoting B cell growth and tumorigenesis. ..
  16. De Francesco M, Baronio M, Fiorentini S, Signorini C, Bonfanti C, Poiesi C, et al. HIV-1 matrix protein p17 increases the production of proinflammatory cytokines and counteracts IL-4 activity by binding to a cellular receptor. Proc Natl Acad Sci U S A. 2002;99:9972-7 pubmed
    ..Our results define a role for p17 in HIV-1 pathogenesis and contribute to our understanding of the molecular mechanism of HIV-1 infection and the development of additional antiviral therapeutic strategies. ..