Experts and Doctors on amino acid sequence in Brescia, Lombardy, Italy


Locale: Brescia, Lombardy, Italy
Topic: amino acid sequence

Top Publications

  1. Serana F, Sottini A, Caimi L, Palermo B, Natali P, Nistico P, et al. Identification of a public CDR3 motif and a biased utilization of T-cell receptor V beta and J beta chains in HLA-A2/Melan-A-specific T-cell clonotypes of melanoma patients. J Transl Med. 2009;7:21 pubmed publisher
  2. Bugatti A, Giagulli C, Urbinati C, Caccuri F, Chiodelli P, Oreste P, et al. Molecular interaction studies of HIV-1 matrix protein p17 and heparin: identification of the heparin-binding motif of p17 as a target for the development of multitarget antagonists. J Biol Chem. 2013;288:1150-61 pubmed publisher
    ..Here, we characterized at a molecular level the interaction of p17 with its cellular receptors, laying the basis for the development of heparin-mimicking p17 antagonists...
  3. Giacopuzzi E, Bresciani R, Schauer R, Monti E, Borsani G. New insights on the sialidase protein family revealed by a phylogenetic analysis in metazoa. PLoS ONE. 2012;7:e44193 pubmed publisher
    ..Moreover, we further confirm findings on the catalytic residues and identified enzyme loop portions that behave as rapidly diverging regions and may be involved in the evolution of specific properties of sialidases...
  4. Fra A, Gooptu B, Ferrarotti I, Miranda E, Scabini R, Ronzoni R, et al. Three new alpha1-antitrypsin deficiency variants help to define a C-terminal region regulating conformational change and polymerization. PLoS ONE. 2012;7:e38405 pubmed publisher
    ..The new mutations cluster structurally, thus defining a region of the AAT molecule critical for regulating its conformational state. ..
  5. Giacopuzzi E, Barlati S, Preti A, Venerando B, Monti E, Borsani G, et al. Gallus gallus NEU3 sialidase as model to study protein evolution mechanism based on rapid evolving loops. BMC Biochem. 2011;12:45 pubmed publisher
    ..Giving the peculiar organization of the loop region identified in Gg NEU3, this protein can be considered of particular interest in such evolutionary studies and to get deeper insights in sialidase evolution. ..
  6. Chiarelli N, Ritelli M, Zoppi N, Benini A, Borsani G, Barlati S, et al. Characterization and expression pattern analysis of the facilitative glucose transporter 10 gene (slc2a10) in Danio rerio. Int J Dev Biol. 2011;55:229-36 pubmed publisher
    ..In later embryonic stages, slc2a10 mRNA was detected in the otic vesicles, hatching gland cells, pectoral fin, posterior tectum and swim bladder. Overall, these results suggest a wide role of slc2a10 during zebrafish development. ..
  7. Lanzi G, Ferrari S, Vihinen M, Caraffi S, Kutukculer N, Schiaffonati L, et al. Different molecular behavior of CD40 mutants causing hyper-IgM syndrome. Blood. 2010;116:5867-74 pubmed publisher
    ..These results give new important insights into the molecular pathogenesis of HIGM disease, and suggest that CD40 deficiency can also be regarded as an ER-storage disease. ..
  8. Zizioli D, Forlanelli E, Guarienti M, Nicoli S, Fanzani A, Bresciani R, et al. Characterization of the AP-1 ?1A and ?1B adaptins in zebrafish (Danio rerio). Dev Dyn. 2010;239:2404-12 pubmed publisher
    ..Development ceased at 7-8 dpf. ?1B is not expressed in murine liver, indicating loss of ?1B expression and establishment of alternative sorting mechanisms during mammalian development. ..
  9. Luscieti S, Santambrogio P, Langlois d Estaintot B, Granier T, Cozzi A, Poli M, et al. Mutant ferritin L-chains that cause neurodegeneration act in a dominant-negative manner to reduce ferritin iron incorporation. J Biol Chem. 2010;285:11948-57 pubmed publisher
    ..The data support the hypothesis that hereditary ferritinopathies are due to alterations of ferritin functionality and provide new input on the mechanism of the function of isoferritins. ..

More Information


  1. Mattioli S, Imberti L, Stellini R, Primi D. Mimicry of the immunodominant conformation-dependent antigenic site of hepatitis A virus by motifs selected from synthetic peptide libraries. J Virol. 1995;69:5294-9 pubmed
    ..Collectively, these data represent an additional important paradigm of a mimotope capable of mimicking an antigenic determinant with unknown tertiary structure. ..
  2. Camozzi M, Rusnati M, Bugatti A, Bottazzi B, Mantovani A, Bastone A, et al. Identification of an antiangiogenic FGF2-binding site in the N terminus of the soluble pattern recognition receptor PTX3. J Biol Chem. 2006;281:22605-13 pubmed
  3. Losi C, Silini A, Fiorini C, Soresina A, Meini A, Ferrari S, et al. Mutational analysis of human BAFF receptor TNFRSF13C (BAFF-R) in patients with common variable immunodeficiency. J Clin Immunol. 2005;25:496-502 pubmed
    ..These variants do not affect the expression of BAFF-R neither at the mRNA nor at the protein level, suggesting that these variants represent novel polymorphic variants of the BAFF-R gene. ..
  4. Nicoli S, Gilardelli C, Pozzoli O, Presta M, Cotelli F. Regulated expression pattern of gremlin during zebrafish development. Gene Expr Patterns. 2005;5:539-44 pubmed
    ..Finally, grm transcript is strongly downregulated in fibroblast growth factor-8 (fgf8) and sonic hedgehog (shh) mutants, thus implicating a putative role of Fgf/Shh signalling loop in grm expression regulation. ..
  5. De Francesco M, Baronio M, Fiorentini S, Signorini C, Bonfanti C, Poiesi C, et al. HIV-1 matrix protein p17 increases the production of proinflammatory cytokines and counteracts IL-4 activity by binding to a cellular receptor. Proc Natl Acad Sci U S A. 2002;99:9972-7 pubmed
    ..Our results define a role for p17 in HIV-1 pathogenesis and contribute to our understanding of the molecular mechanism of HIV-1 infection and the development of additional antiviral therapeutic strategies. ..
  6. Barbon A, Vallini I, Barlati S. Genomic organization of the human GRIK2 gene and evidence for multiple splicing variants. Gene. 2001;274:187-97 pubmed
  7. Monti E, Bassi M, Papini N, Riboni M, Manzoni M, Venerando B, et al. Identification and expression of NEU3, a novel human sialidase associated to the plasma membrane. Biochem J. 2000;349:343-51 pubmed
    ..8. Immunofluorescence staining of the transfected COS7 cells demonstrated the protein's localization in the plasma membrane. ..
  8. Foiani M, Marini F, Gamba D, Lucchini G, Plevani P. The B subunit of the DNA polymerase alpha-primase complex in Saccharomyces cerevisiae executes an essential function at the initial stage of DNA replication. Mol Cell Biol. 1994;14:923-33 pubmed
    ..A model for the role of the B subunit in initiation of DNA replication at an origin is presented. ..
  9. Lanzi G, de Miranda J, Boniotti M, Cameron C, Lavazza A, Capucci L, et al. Molecular and biological characterization of deformed wing virus of honeybees (Apis mellifera L.). J Virol. 2006;80:4998-5009 pubmed publisher
    ..The genome organization, capsid morphology, and sequence comparison data indicate that DWV is a member of the recently established genus Iflavirus...
  10. Giagulli C, Marsico S, Magiera A, Bruno R, Caccuri F, Barone I, et al. Opposite effects of HIV-1 p17 variants on PTEN activation and cell growth in B cells. PLoS ONE. 2011;6:e17831 pubmed publisher
    ..Moreover, it provides the first evidence on the presence of a p17 natural variant mimicking the p17?36-induced signalling in B cells and displaying the capacity of promoting B cell growth and tumorigenesis. ..
  11. Monti E, Bassi M, Bresciani R, Civini S, Croci G, Papini N, et al. Molecular cloning and characterization of NEU4, the fourth member of the human sialidase gene family. Genomics. 2004;83:445-53 pubmed
    ..Immunofluorescence staining and Western blot analysis demonstrated the association of NEU4 with the inner cell membranes. ..