Experts and Doctors on mitosis in Rome, Latium, Italy


Locale: Rome, Latium, Italy
Topic: mitosis

Top Publications

  1. Sorino C, Bruno T, Desantis A, Di Certo M, Iezzi S, De Nicola F, et al. Centrosomal Che-1 protein is involved in the regulation of mitosis and DNA damage response by mediating pericentrin (PCNT)-dependent Chk1 protein localization. J Biol Chem. 2013;288:23348-57 pubmed publisher
    ..Our results reinforce the notion that Che-1 plays an important role in DDR and that its contribution seems to be relevant for the spindle assembly checkpoint. ..
  2. Asteriti I, Rensen W, Lindon C, Lavia P, Guarguaglini G. The Aurora-A/TPX2 complex: a novel oncogenic holoenzyme?. Biochim Biophys Acta. 2010;1806:230-9 pubmed publisher
    ..We also suggest that some of the roles that are conventionally attributed to Aurora-A in cell transformation and tumorigenesis could in fact be a consequence of the oncogenic activation of this unit. ..
  3. Roscioli E, Bolognesi A, Guarguaglini G, Lavia P. Ran control of mitosis in human cells: gradients and local signals. Biochem Soc Trans. 2010;38:1709-14 pubmed publisher
  4. Roscioli E, Di Francesco L, Bolognesi A, Giubettini M, Orlando S, Harel A, et al. Importin-? negatively regulates multiple aspects of mitosis including RANGAP1 recruitment to kinetochores. J Cell Biol. 2012;196:435-50 pubmed publisher
    ..These results reveal previously unrecognized importin-? functions at kinetochores exerted via RANBP2 and opposed by CRM1. ..
  5. Lupari E, Ventura I, Marcon F, Aquilina G, Dogliotti E, Fortini P. Pol kappa partially rescues MMR-dependent cytotoxicity of O6-methylguanine. DNA Repair (Amst). 2012;11:579-86 pubmed publisher
  6. Siriaco G, Cenci G, Haoudi A, Champion L, Zhou C, Gatti M, et al. Telomere elongation (Tel), a new mutation in Drosophila melanogaster that produces long telomeres. Genetics. 2002;160:235-45 pubmed
    ..Associations between metaphase chromosomes are resolved during anaphase, suggesting that they are mediated by either proteinaceous links or DNA hydrogen bonding, rather than covalent DNA-DNA bonds. ..
  7. Di Fiore B, Ciciarello M, Mangiacasale R, Palena A, Tassin A, Cundari E, et al. Mammalian RanBP1 regulates centrosome cohesion during mitosis. J Cell Sci. 2003;116:3399-411 pubmed
    ..These data indicate that overexpressed RanBP1 interferes with crucial factor(s) that control structural and dynamic features of centrosomes during mitosis and contribute to uncover novel mitotic functions downstream of the Ran network. ..
  8. Verni F, Gandhi R, Goldberg M, Gatti M. Genetic and molecular analysis of wings apart-like (wapl), a gene controlling heterochromatin organization in Drosophila melanogaster. Genetics. 2000;154:1693-710 pubmed
  9. Giansanti M, Farkas R, Bonaccorsi S, Lindsley D, Wakimoto B, Fuller M, et al. Genetic dissection of meiotic cytokinesis in Drosophila males. Mol Biol Cell. 2004;15:2509-22 pubmed

More Information


  1. Ciciarello M, Mangiacasale R, Thibier C, Guarguaglini G, Marchetti E, Di Fiore B, et al. Importin beta is transported to spindle poles during mitosis and regulates Ran-dependent spindle assembly factors in mammalian cells. J Cell Sci. 2004;117:6511-22 pubmed
    ..Targeting of TPX2/importin-beta complexes to poles is a key aspect in Ran-dependent control of the mitotic apparatus in mammalian cells. ..
  2. Tedeschi A, Ciciarello M, Mangiacasale R, Roscioli E, Rensen W, Lavia P. RANBP1 localizes a subset of mitotic regulatory factors on spindle microtubules and regulates chromosome segregation in human cells. J Cell Sci. 2007;120:3748-61 pubmed
  3. Vernarecci S, Ornaghi P, Bâgu A, Cundari E, Ballario P, Filetici P. Gcn5p plays an important role in centromere kinetochore function in budding yeast. Mol Cell Biol. 2008;28:988-96 pubmed
    ..Our findings offer a key insight into a Gcn5p-dependent epigenetic regulation at centromere/kinetochore in mitosis. ..
  4. Gurtner A, Fuschi P, Magi F, Colussi C, Gaetano C, Dobbelstein M, et al. NF-Y dependent epigenetic modifications discriminate between proliferating and postmitotic tissue. PLoS ONE. 2008;3:e2047 pubmed publisher
  5. Rensen W, Mangiacasale R, Ciciarello M, Lavia P. The GTPase Ran: regulation of cell life and potential roles in cell transformation. Front Biosci. 2008;13:4097-121 pubmed
    ..In this review we summarize growing evidence suggesting that deregulated activity of Ran or its effectors can contribute to pathways of cell transformation and facilitate tumor progression. ..
  6. De Luca M, Brunetto L, Asteriti I, Giubettini M, Lavia P, Guarguaglini G. Aurora-A and ch-TOG act in a common pathway in control of spindle pole integrity. Oncogene. 2008;27:6539-49 pubmed publisher
    ..These results indicate a novel function of Aurora-A, the regulation of ch-TOG and MCAK localization, and highlight a common pathway involving the three factors in control of spindle pole integrity. ..
  7. Cadot B, Brunetti M, Coppari S, Fedeli S, De Rinaldis E, Dello Russo C, et al. Loss of histone deacetylase 4 causes segregation defects during mitosis of p53-deficient human tumor cells. Cancer Res. 2009;69:6074-82 pubmed publisher
    ..We therefore suggest that systemic selective interference with the expression or function of HDAC4 is expected to have a significant therapeutic window, in particular, for p53-deficient tumors. ..
  8. Torosantucci L, De Santis Puzzonia M, Cenciarelli C, Rens W, Degrassi F. Aneuploidy in mitosis of PtK1 cells is generated by random loss and nondisjunction of individual chromosomes. J Cell Sci. 2009;122:3455-61 pubmed publisher
    ..Our findings imply random missegregation of chromosomes as the initial event in the generation of aneuploidy in mammalian somatic cells...
  9. La Rosa P, Pesiri V, Marino M, Acconcia F. 17?-Estradiol-induced cell proliferation requires estrogen receptor (ER) ? monoubiquitination. Cell Signal. 2011;23:1128-35 pubmed publisher
    ..Altogether these data demonstrate an inherent role for monoUbq in ER? signaling and point to the physiological function of ER? monoUbq in the regulation of E2-induced cell proliferation. ..
  10. Mattiuzzo M, Vargiu G, Totta P, Fiore M, Ciferri C, Musacchio A, et al. Abnormal kinetochore-generated pulling forces from expressing a N-terminally modified Hec1. PLoS ONE. 2011;6:e16307 pubmed publisher
    ..Overall, our findings support a model in which centrosome integrity is influenced by the pathways regulating kinetochore-microtubule attachment stability. ..
  11. Bonaccorsi S, Giansanti M, Gatti M. Spindle assembly in Drosophila neuroblasts and ganglion mother cells. Nat Cell Biol. 2000;2:54-6 pubmed
  12. Pajalunga D, Puggioni E, Mazzola A, Leva V, Montecucco A, Crescenzi M. DNA replication is intrinsically hindered in terminally differentiated myotubes. PLoS ONE. 2010;5:e11559 pubmed publisher
    ..Furthermore, this trait might contribute to explain the inability of these cells to play a role in tissue repair, unlike their counterparts in extensively regenerating species. ..
  13. Fulco M, Costanzo A, Merlo P, Mangiacasale R, Strano S, Blandino G, et al. p73 is regulated by phosphorylation at the G2/M transition. J Biol Chem. 2003;278:49196-202 pubmed
    ..Together these results indicate that M phase-specific phosphorylation of p73 by p34cdc2-cyclin B is associated with negative regulation of its transcriptional activating function. ..
  14. Lotti L, Ottini L, D Amico C, Gradini R, Cama A, Belleudi F, et al. Subcellular localization of the BRCA1 gene product in mitotic cells. Genes Chromosomes Cancer. 2002;35:193-203 pubmed
    ..These results are consistent with an involvement of BRCA1 in the dynamics of the mitotic spindle and in the segregation of duplicated chromosomes. ..
  15. Dolci S, Levati L, Pellegrini M, Faraoni I, Graziani G, Di Carlo A, et al. Stem cell factor activates telomerase in mouse mitotic spermatogonia and in primordial germ cells. J Cell Sci. 2002;115:1643-9 pubmed
    ..Our data suggest that the induction of telomerase by Kitl may contribute to the self-renewing potential of male germ cells and of PGCs. ..
  16. Cenci G, Rawson R, Belloni G, Castrillon D, Tudor M, Petrucci R, et al. UbcD1, a Drosophila ubiquitin-conjugating enzyme required for proper telomere behavior. Genes Dev. 1997;11:863-75 pubmed
    ..We therefore suggest that at least one of the targets of UbcD1 ubiquitination is a telomere-associated polypeptide that may help maintain proper chromosomal orientation during interphase. ..
  17. Cimini D, Mattiuzzo M, Torosantucci L, Degrassi F. Histone hyperacetylation in mitosis prevents sister chromatid separation and produces chromosome segregation defects. Mol Biol Cell. 2003;14:3821-33 pubmed
  18. Manni I, Tunici P, Cirenei N, Albarosa R, Colombo B, Roz L, et al. Mxi1 inhibits the proliferation of U87 glioma cells through down-regulation of cyclin B1 gene expression. Br J Cancer. 2002;86:477-84 pubmed
    ..Thus, our findings indicate that Mxi1 can act as a tumour suppressor in human glioblastomas through a molecular mechanism involving the transcriptional down-regulation of cyclin B1 gene expression. ..
  19. Colicchia V, Petroni M, Guarguaglini G, Sardina F, Sahún Roncero M, Carbonari M, et al. PARP inhibitors enhance replication stress and cause mitotic catastrophe in MYCN-dependent neuroblastoma. Oncogene. 2017;36:4682-4691 pubmed publisher
    ..These data highlight a novel route for cell death induction by PARP inhibitors and support their introduction, together with CHK1 inhibitors, in therapeutic approaches for neuroblastomas with high MYC(N) activity. ..