Genomes and Genes
Experts and Doctors on mice in Rome, Latium, Italy
Locale: Rome, Latium, Italy
Publications458 found, 100 shown here
- Mucci N, Ianni A, Ursini C, Arzani D, Bhat N, Navarra P, et al. In vivo modulation of ETS genes induced by electromagnetic fields. In Vivo. 2001;15:489-94 pubmed..We observed an increase in ETS1 mRNA and protein expression, but a decrease in ETS2 protein levels. Preliminary results from this experimental model show in vivo evidence of the effect of EMF on ETS oncogene expression. ..
- Corbi N, Di Padova M, De Angelis R, Bruno T, Libri V, Iezzi S, et al. The alpha-like RNA polymerase II core subunit 3 (RPB3) is involved in tissue-specific transcription and muscle differentiation via interaction with the myogenic factor myogenin. FASEB J. 2002;16:1639-41 pubmed..These results indicate for the first time that the RPB3 pol II subunit is involved in the regulation of tissue-specific transcription. ..
- Aricò E, Robertson K, Belardelli F, Ferrantini M, Nash A. Vaccination with inactivated murine gammaherpesvirus 68 strongly limits viral replication and latency and protects type I IFN receptor knockout mice from a lethal infection. Vaccine. 2004;22:1433-40 pubmed..Of note, the inactivated MHV-68 vaccine completely protected type I IFN receptor knockout mice from the infection with a lethal dose of MHV-68. ..
- Galietta G, Giuliani G, Loizzo A, Amat A, Fumagalli E, De Feo V, et al. Neurophysiological studies of Heteropteris glabra Hok. & Arn. (Malpighiaceae) in DBA/2J mice. J Ethnopharmacol. 2005;97:415-9 pubmed
- Pasparakis M, Luedde T, Schmidt Supprian M. Dissection of the NF-kappaB signalling cascade in transgenic and knockout mice. Cell Death Differ. 2006;13:861-72 pubmed..Furthermore, inhibition or enforced activation of NF-kappaB in transgenic mice has uncovered the critical roles that NF-kappaB plays in the pathogenesis of various diseases such as liver failure, diabetes and cancer. ..
- Migliaccio A, Martelli F, Verrucci M, Migliaccio G, Vannucchi A, Ni H, et al. Altered SDF-1/CXCR4 axis in patients with primary myelofibrosis and in the Gata1 low mouse model of the disease. Exp Hematol. 2008;36:158-71 pubmed publisher..We suggest that these abnormalities contribute to the increased stem/progenitor cell trafficking observed in this mouse model as well as patients with PMF. ..
- Canettieri G, Di Marcotullio L, Greco A, Coni S, Antonucci L, Infante P, et al. Histone deacetylase and Cullin3-REN(KCTD11) ubiquitin ligase interplay regulates Hedgehog signalling through Gli acetylation. Nat Cell Biol. 2010;12:132-42 pubmed publisher..These data identify an integrated HDAC- and ubiquitin-mediated circuitry, where acetylation of Gli proteins functions as an unexpected key transcriptional checkpoint of Hedgehog signalling. ..
- Chiodi V, Uchigashima M, Beggiato S, Ferrante A, Armida M, Martire A, et al. Unbalance of CB1 receptors expressed in GABAergic and glutamatergic neurons in a transgenic mouse model of Huntington's disease. Neurobiol Dis. 2012;45:983-91 pubmed publisher..As a result, the balance between CB1Rs expressed by the two neuronal populations and, thus, the net effect of CB1R stimulation, is profoundly altered in HD mice...
- Guarguaglini G, Battistoni A, Pittoggi C, Di Matteo G, Di Fiore B, Lavia P. Expression of the murine RanBP1 and Htf9-c genes is regulated from a shared bidirectional promoter during cell cycle progression. Biochem J. 1997;325 ( Pt 1):277-86 pubmed..Together, the results suggest that the sharing of the regulatory region supports co-regulation of the Htf9-a/RanBP1 and Htf9-c genes in a common window of the cell cycle. ..
- Anastasi E, Campese A, Bellavia D, Bulotta A, Balestri A, Pascucci M, et al. Expression of activated Notch3 in transgenic mice enhances generation of T regulatory cells and protects against experimental autoimmune diabetes. J Immunol. 2003;171:4504-11 pubmed
- Monaco L, Passananti C, Fanciulli M. Genomic structure and transcriptional regulation of Che-1, a novel partner of Rb. Gene. 2003;321:57-63 pubmed..Importantly, we showed that Che-1 expression is regulated by a negative feedback mechanism, in which this protein is present on its own promoter repressing transcription. ..
- Confaloni A, Crestini A, Albani D, Piscopo P, Campeggi L, Terreni L, et al. Rat nicastrin gene: cDNA isolation, mRNA variants and expression pattern analysis. Brain Res Mol Brain Res. 2005;136:12-22 pubmed
- Tebano M, Martire A, Potenza R, Grò C, Pepponi R, Armida M, et al. Adenosine A(2A) receptors are required for normal BDNF levels and BDNF-induced potentiation of synaptic transmission in the mouse hippocampus. J Neurochem. 2008;104:279-86 pubmed..These results indicate that the tonic activation of A(2A)Rs is required for BDNF-induced potentiation of synaptic transmission and for sustaining a normal BDNF tone in the hippocampus. ..
- Giovanetti A, Deshpande T, Basso E. Persistence of genetic damage in mice exposed to low dose of X rays. Int J Radiat Biol. 2008;84:227-35 pubmed publisher..Results demonstrated that a single exposure to low-dose might induce long-term damage. Persistence of genetic damage might have relevant implications for estimating risk for low doses. ..
- DeMarch Z, Giampà C, Patassini S, Bernardi G, Fusco F. Beneficial effects of rolipram in the R6/2 mouse model of Huntington's disease. Neurobiol Dis. 2008;30:375-87 pubmed publisher..Our findings show that rolipram could be considered as a valid therapeutic approach for HD. ..
- Penitente R, Nicolò C, van den Elzen P, Di Sante G, Agrati C, Aloisi F, et al. Administration of PLP139-151 primes T cells distinct from those spontaneously responsive in vitro to this antigen. J Immunol. 2008;180:6611-22 pubmed..This "immunized" repertoire substitutes for the naive one and becomes dominant at the time of disease onset. ..
- Pagnini C, Corleto V, Hoang S, Saeed R, Cominelli F, Delle Fave G. Commensal bacteria and "oncologic surveillance": suggestions from an experimental model. J Clin Gastroenterol. 2008;42 Suppl 3 Pt 2:S193-6 pubmed publisher..Preliminary results suggest that colonic apoptosis induction, by commensal bacteria, could possibly represent a physiologic "oncologic surveillance" mechanism for colonic proliferative disease prevention. ..
- Cecconi F, Levine B. The role of autophagy in mammalian development: cell makeover rather than cell death. Dev Cell. 2008;15:344-57 pubmed publisher..Thus, autophagy is a process of cytosolic "renovation," crucial in cell fate decisions. ..
- Scaldaferri F, Vetrano S, Sans M, Arena V, Straface G, Stigliano E, et al. VEGF-A links angiogenesis and inflammation in inflammatory bowel disease pathogenesis. Gastroenterology. 2009;136:585-95.e5 pubmed publisher..VEGF-A appears to be a novel mediator of IBD by promoting intestinal angiogenesis and inflammation. Agents that block VEGF-A signaling might reduce intestinal inflammation in patients with IBD. ..
- Grisanti L, Falciatori I, Grasso M, Dovere L, Fera S, Muciaccia B, et al. Identification of spermatogonial stem cell subsets by morphological analysis and prospective isolation. Stem Cells. 2009;27:3043-52 pubmed publisher..Our data support the hypothesis of the existence of SSC subsets and reveal a previously unrecognized heterogeneity in the expression profile of As spermatogonia in vivo. ..
- Mancone C, Conti B, Amicone L, Bordoni V, Cicchini C, Calvo L, et al. Proteomic analysis reveals a major role for contact inhibition in the terminal differentiation of hepatocytes. J Hepatol. 2010;52:234-43 pubmed publisher..The hepatocyte terminal differentiation program requires a quiescent state maintained by cell-cell contact through the E-cadherin/beta-catenin pathway, rather than the inhibition of proliferation. ..
- Pittaluga E, Costa G, Krasnowska E, Brunelli R, Lundeberg T, Porpora M, et al. More than antioxidant: N-acetyl-L-cysteine in a murine model of endometriosis. Fertil Steril. 2010;94:2905-8 pubmed publisher..Also considering the lack of undesired side effects, including unaffected fertility potential, this suggests a beneficial use of NAC in endometriosis clinical treatment. ..
- Filomeni G, Cardaci S, da Costa Ferreira A, Rotilio G, Ciriolo M. Metabolic oxidative stress elicited by the copper(II) complex [Cu(isaepy)2] triggers apoptosis in SH-SY5Y cells through the induction of the AMP-activated protein kinase/p38MAPK/p53 signalling axis: evidence for a combined use with 3-bromopyruvate in. Biochem J. 2011;437:443-53 pubmed publisher..Overall, the results suggest that NADPH deriving from the pentose phosphate pathway contributes to PCN resistance to [Cu(isaepy)(2)] toxicity and propose its employment in combination with 3BrPA as possible tool for cancer treatment. ..
- Scaldaferri M, Fera S, Grisanti L, Sanchez M, Stefanini M, De Felici M, et al. Identification of side population cells in mouse primordial germ cells and prenatal testis. Int J Dev Biol. 2011;55:209-14 pubmed publisher..These findings provide evidence that the SP phenotype is a common feature of PGCs and identifies a subpopulation of fetal testis cells including prospermatogonia whose differentiation fate remains to be investigated. ..
- Barbagallo M, Di Martino M, Marcocci L, Pietrangeli P, De Carolis E, Casalino M, et al. A new piece of the Shigella Pathogenicity puzzle: spermidine accumulation by silencing of the speG gene [corrected]. PLoS ONE. 2011;6:e27226 pubmed publisher..Our observations fully support the pathoadaptive nature of speG inactivation in Shigella and reveal that the accumulation of spermidine is a key determinant in the pathogenicity strategy adopted by this microrganism...
- Bartucci M, Svensson S, Romania P, Dattilo R, Patrizii M, Signore M, et al. Therapeutic targeting of Chk1 in NSCLC stem cells during chemotherapy. Cell Death Differ. 2012;19:768-78 pubmed publisher..Taken together, these observations support the clinical evaluation of Chk1 inhibitors in combination with chemotherapy for a more effective treatment of NSCLC. ..
- Fabrizi C, Somma F, Pompili E, Biagioni F, Lenzi P, Fornai F, et al. Role of autophagy inhibitors and inducers in modulating the toxicity of trimethyltin in neuronal cell cultures. J Neural Transm (Vienna). 2012;119:1295-305 pubmed publisher..These data indicate that TMT neurotoxicity can be dramatically modified, at least in vitro, by lithium addition which seems to act through different mechanisms if acutely or chronically administered. ..
- Aquilano K, Baldelli S, Pagliei B, Cannata S, Rotilio G, Ciriolo M. p53 orchestrates the PGC-1?-mediated antioxidant response upon mild redox and metabolic imbalance. Antioxid Redox Signal. 2013;18:386-99 pubmed publisher..Such signaling axis could become the cornerstone for new pharmacological or dietary approaches for improving antioxidant response during ageing and human pathologies associated with oxidative stress. ..
- Rossi S, Sacchetti L, Napolitano F, De Chiara V, Motta C, Studer V, et al. Interleukin-1? causes anxiety by interacting with the endocannabinoid system. J Neurosci. 2012;32:13896-905 pubmed publisher..The present investigation identifies a previously unrecognized interaction between a major proinflammatory cytokine and the endocannabinoid system in the pathophysiology of anxiety. ..
- Farioli Vecchioli S, Cinà I, Ceccarelli M, Micheli L, Leonardi L, Ciotti M, et al. Tis21 knock-out enhances the frequency of medulloblastoma in Patched1 heterozygous mice by inhibiting the Cxcl3-dependent migration of cerebellar neurons. J Neurosci. 2012;32:15547-64 pubmed publisher..As Tis21 activates Cxcl3 transcription, our results suggest that Tis21 induces migration of GCPs through Cxcl3, which may represent a novel target for medulloblastoma therapy...
- Masuelli L, Benvenuto M, Fantini M, Marzocchella L, Sacchetti P, Di Stefano E, et al. Curcumin induces apoptosis in breast cancer cell lines and delays the growth of mammary tumors in neu transgenic mice. J Biol Regul Homeost Agents. 2013;27:105-19 pubmed..These findings support further studies on the therapeutic potential of CUR in combination with standard therapies in breast cancer patients. ..
- Del Vecchio S, MarbÃ N, Acosta A, Vignolo C, Traveset A. Effects of Posidonia oceanica beach-cast on germination, growth and nutrient uptake of coastal dune plants. PLoS ONE. 2013;8:e70607 pubmed publisher..3 fold in N and 2.5 fold in P; Elymus by 1.5 fold in N and 2 fold in P). Our results suggest a positive effect of seagrass litter for the enhancing of dune species, highlighting its role for the conservation of coastal dune ecosystems. ..
- Benvenuto M, Masuelli L, De Smaele E, Fantini M, Mattera R, Cucchi D, et al. In vitro and in vivo inhibition of breast cancer cell growth by targeting the Hedgehog/GLI pathway with SMO (GDC-0449) or GLI (GANT-61) inhibitors. Oncotarget. 2016;7:9250-70 pubmed publisher..These findings suggest that targeting the Hh pathway using antagonists that act downstream of SMO is a more efficient strategy than using antagonists that act upstream of SMO for interrupting Hh signaling in breast cancer. ..
- Iorio M, Frigeni V, Bowman E, Harris L, May E, Aceto M. Common stereospecificity of opioid and dopamine systems for N-butyrophenone prodine-like compounds. J Med Chem. 1991;34:194-7 pubmed..The results are remarkable in two respects, namely, the dextrorotatory isomer is consistently the most potent on all tests, and it acts on both opioid (mu) and neuroleptic (D2) receptors. ..
- Centonze D, Usiello A, Gubellini P, Pisani A, Borrelli E, Bernardi G, et al. Dopamine D2 receptor-mediated inhibition of dopaminergic neurons in mice lacking D2L receptors. Neuropsychopharmacology. 2002;27:723-6 pubmed..Thus, pharmacological compounds able to interfere selectively with presynaptic D2S receptors might constitute effective therapeutic strategies in neuropsychiatric disorders, by causing negligible side-effects. ..
- Cozzolino M, Amori I, Pesaresi M, Ferri A, Nencini M, Carri M. Cysteine 111 affects aggregation and cytotoxicity of mutant Cu,Zn-superoxide dismutase associated with familial amyotrophic lateral sclerosis. J Biol Chem. 2008;283:866-74 pubmed..These data are consistent with the view that the redox environment influences the oligomerization/aggregation pathway of mutSOD1 and point to Cys-111 as a key mediator of this process. ..
- Cipollone D, Carsetti R, Tagliani A, Rosado M, Borgiani P, Novelli G, et al. Folic acid and methionine in the prevention of teratogen-induced congenital defects in mice. Cardiovasc Pathol. 2009;18:100-9 pubmed publisher..Hereby, we analyzed the effects of nutritive therapy involving folic acid and methionine on teratogen-induced congenital defects in mice...
- De Leonibus E, Managò F, Giordani F, Petrosino F, Lopez S, Oliverio A, et al. Metabotropic glutamate receptors 5 blockade reverses spatial memory deficits in a mouse model of Parkinson's disease. Neuropsychopharmacology. 2009;34:729-38 pubmed publisher..Further, they demonstrate that mGluR5 blockade may also have beneficial effects on cognitive deficits induced by dopamine depletion. ..
- Adone R, Francia M, Pistoia C, Petrucci P, Pesciaroli M, Pasquali P. Protective role of antibodies induced by Brucella melitensis B115 against B. melitensis and Brucella abortus infections in mice. Vaccine. 2012;30:3992-5 pubmed publisher..This is the first study assessing the efficacy of antibodies directed to antigens other than O-PS in the course of brucellosis infection. ..
- Filesi I, Cardinale A, van der Sar S, Cowell I, Singh P, Biocca S. Loss of heterochromatin protein 1 (HP1) chromodomain function in mammalian cells by intracellular antibodies causes cell death. J Cell Sci. 2002;115:1803-13 pubmed
- Cipollone D, Amati F, Carsetti R, Placidi S, Biancolella M, D Amati G, et al. A multiple retinoic acid antagonist induces conotruncal anomalies, including transposition of the great arteries, in mice. Cardiovasc Pathol. 2006;15:194-202 pubmed..Transposition of the great arteries can be consistently reproduced in mice by administration of a retinoic acid competitive antagonist on 7.5 dpc. ..
- Farini D, La Sala G, Tedesco M, De Felici M. Chemoattractant action and molecular signaling pathways of Kit ligand on mouse primordial germ cells. Dev Biol. 2007;306:572-83 pubmed
- Restivo L, Roman F, Dumuis A, Bockaert J, Marchetti E, Ammassari Teule M. The promnesic effect of G-protein-coupled 5-HT4 receptors activation is mediated by a potentiation of learning-induced spine growth in the mouse hippocampus. Neuropsychopharmacology. 2008;33:2427-34 pubmed..These findings provide evidence that 5-HT(4)Rs stimulation selectively increases experience-dependent structural plasticity in learning-activated hippocampal circuits. ..
- Straface G, Aprahamian T, Flex A, Gaetani E, Biscetti F, Smith R, et al. Sonic hedgehog regulates angiogenesis and myogenesis during post-natal skeletal muscle regeneration. J Cell Mol Med. 2009;13:2424-35 pubmed publisher..These findings might constitute the foundation for new therapeutic approaches for muscular diseases in humans. ..
- Ferlini C, Cicchillitti L, Raspaglio G, Bartollino S, Cimitan S, Bertucci C, et al. Paclitaxel directly binds to Bcl-2 and functionally mimics activity of Nur77. Cancer Res. 2009;69:6906-14 pubmed publisher..This discovery could help in the development of novel anticancer agents with nontaxane skeleton as well as in identifying the clinical subsets responsive to paclitaxel-based therapy. ..
- Middei S, Roberto A, Berretta N, Panico M, Lista S, Bernardi G, et al. Learning discloses abnormal structural and functional plasticity at hippocampal synapses in the APP23 mouse model of Alzheimer's disease. Learn Mem. 2010;17:236-40 pubmed publisher..Thus, learning discloses mutation-related abnormalities regarding dendritic spine formation and LTP persistence, thereby suggesting that although unaltered in naïve synapses, plasticity becomes defective at the time it comes into play. ..
- Pajalunga D, Puggioni E, Mazzola A, Leva V, Montecucco A, Crescenzi M. DNA replication is intrinsically hindered in terminally differentiated myotubes. PLoS ONE. 2010;5:e11559 pubmed publisher..Furthermore, this trait might contribute to explain the inability of these cells to play a role in tissue repair, unlike their counterparts in extensively regenerating species. ..
- Guastadisegni C, Kelly F, Cassee F, Gerlofs Nijland M, Janssen N, Pozzi R, et al. Determinants of the proinflammatory action of ambient particulate matter in immortalized murine macrophages. Environ Health Perspect. 2010;118:1728-34 pubmed publisher..We found no evidence that PM collected from sites in close proximity to traffic sources displayed enhanced proinflammatory activity in RAW264.7 cells. ..
- Curcio L, Podda M, Leone L, Piacentini R, Mastrodonato A, Cappelletti P, et al. Reduced D-serine levels in the nucleus accumbens of cocaine-treated rats hinder the induction of NMDA receptor-dependent synaptic plasticity. Brain. 2013;136:1216-30 pubmed publisher..These results provide evidence for a critical role of D-serine signalling in synaptic plasticity relevant to cocaine addiction. ..
- Musella A, Mandolesi G, Gentile A, Rossi S, Studer V, Motta C, et al. Cladribine interferes with IL-1? synaptic effects in experimental multiple sclerosis. J Neuroimmunol. 2013;264:8-13 pubmed publisher..Cladribine possesses neuroprotective properties in experimental MS that are independent of its peripheral immunosuppressant action. ..
- Cippitelli M, Fionda C, Di Bona D, Di Rosa F, Lupo A, Piccoli M, et al. Negative regulation of CD95 ligand gene expression by vitamin D3 in T lymphocytes. J Immunol. 2002;168:1154-66 pubmed..These results place FasL as a novel target for the immunoregulatory activities of 1,25(OH)(2)D(3), and confirm the interest for a possible pharmacological use of this molecule and its derivatives. ..
- Pascucci T, Ventura R, Puglisi Allegra S, Cabib S. Deficits in brain serotonin synthesis in a genetic mouse model of phenylketonuria. Neuroreport. 2002;13:2561-4 pubmed..These results suggest that interference with brain 5-hydroxytryptophan synthesis may be the major cause of serotonin deficits in hyperphenylalaninemia. ..
- Brunori M, Giuffrè A, Nienhaus K, Nienhaus G, Scandurra F, Vallone B. Neuroglobin, nitric oxide, and oxygen: functional pathways and conformational changes. Proc Natl Acad Sci U S A. 2005;102:8483-8 pubmed
- De Nicola F, Bruno T, Iezzi S, Di Padova M, Floridi A, Passananti C, et al. The prolyl isomerase Pin1 affects Che-1 stability in response to apoptotic DNA damage. J Biol Chem. 2007;282:19685-91 pubmed..Our results establish Che-1 as a new Pin1 and HDM2 target and confirm its important role in the cellular response to DNA damage. ..
- Fimia G, Stoykova A, Romagnoli A, Giunta L, Di Bartolomeo S, Nardacci R, et al. Ambra1 regulates autophagy and development of the nervous system. Nature. 2007;447:1121-5 pubmed
- De Mori R, Straino S, Di Carlo A, Mangoni A, Pompilio G, Palumbo R, et al. Multiple effects of high mobility group box protein 1 in skeletal muscle regeneration. Arterioscler Thromb Vasc Biol. 2007;27:2377-83 pubmed..HMGB1 plays a role in skeletal muscle regeneration modulating, in an autocrine-paracrine manner, myoblast and endothelial cell functions. ..
- Manni L, Di Fausto V, Chaldakov G, Aloe L. Brain leptin and nerve growth factor are differently affected by stress in male and female mice: possible neuroendocrine and cardio-metabolic implications. Neurosci Lett. 2007;426:39-44 pubmed..The observation that the brain leptin and NGF receptors were altered by stress suggests a functional role for these molecules in neuroendocrine and cardiovascular response to stress events. ..
- Gabanella F, Butchbach M, Saieva L, Carissimi C, Burghes A, Pellizzoni L. Ribonucleoprotein assembly defects correlate with spinal muscular atrophy severity and preferentially affect a subset of spliceosomal snRNPs. PLoS ONE. 2007;2:e921 pubmed..These findings are consistent with the hypothesis that SMN deficiency affects the splicing machinery and in particular the minor splicing pathway of a rare class of introns in SMA. ..
- D Amelio M, Cavallucci V, Diamantini A, Cecconi F. Analysis of neuronal cell death in mammals. Methods Enzymol. 2008;446:259-76 pubmed publisher..The goal of this chapter is to provide readers with a scientific guide to proven methods that highlight the current strategies for detecting apoptosis in the nervous system. ..
- Mercatelli N, Coppola V, Bonci D, Miele F, Costantini A, Guadagnoli M, et al. The inhibition of the highly expressed miR-221 and miR-222 impairs the growth of prostate carcinoma xenografts in mice. PLoS ONE. 2008;3:e4029 pubmed publisher..These findings suggest that modulating miR-221/222 levels may have a therapeutic potential in prostate carcinoma. ..
- Sciamanna G, Bonsi P, Tassone A, Cuomo D, Tscherter A, Viscomi M, et al. Impaired striatal D2 receptor function leads to enhanced GABA transmission in a mouse model of DYT1 dystonia. Neurobiol Dis. 2009;34:133-45 pubmed publisher..Our findings demonstrate a disinhibition of striatal GABAergic synaptic activity, that can be at least partially attributed to a D2 DA receptor dysfunction. ..
- Gabellini C, Trisciuoglio D, Desideri M, Candiloro A, Ragazzoni Y, Orlandi A, et al. Functional activity of CXCL8 receptors, CXCR1 and CXCR2, on human malignant melanoma progression. Eur J Cancer. 2009;45:2618-27 pubmed publisher..Thus, blocking the CXCL8 signalling axis promises an improvement for the therapy of cancer and, in particular, of metastatic melanoma. ..
- De Santis R, Leoni B, Rosi A, Albertoni C, Forni G, Cojoca R, et al. AvidinOX for highly efficient tissue-pretargeted radionuclide therapy. Cancer Biother Radiopharm. 2010;25:143-8 pubmed publisher..Efficacy data, together with good tolerability results, indicate that AvidinOX is a highly innovative reagent for tissue-pretargeted radionuclide therapy. ..
- Ricci Vitiani L, Mollinari C, di Martino S, Biffoni M, Pilozzi E, Pagliuca A, et al. Thymosin beta4 targeting impairs tumorigenic activity of colon cancer stem cells. FASEB J. 2010;24:4291-301 pubmed publisher..In conclusion, T?4 may have important implications for therapeutic intervention for treatment of human colon carcinoma. ..
- Bruno T, Desantis A, Bossi G, Di Agostino S, Sorino C, De Nicola F, et al. Che-1 promotes tumor cell survival by sustaining mutant p53 transcription and inhibiting DNA damage response activation. Cancer Cell. 2010;18:122-34 pubmed publisher..Notably, loss of Che-1 activates DNA damage checkpoint response and induces transactivation of p73. Therefore, these findings underline the important role that Che-1 has in survival of cells expressing mutant p53. ..
- Nutini M, Frazzini V, Marini C, Spalloni A, Sensi S, Longone P. Zinc pre-treatment enhances NMDAR-mediated excitotoxicity in cultured cortical neurons from SOD1(G93A) mouse, a model of amyotrophic lateral sclerosis. Neuropharmacology. 2011;60:1200-8 pubmed publisher..This article is part of a Special Issue entitled 'Trends in neuropharmacology: in memory of Erminio Costa'. ..
- Schiavoni G, Sistigu A, Valentini M, Mattei F, Sestili P, Spadaro F, et al. Cyclophosphamide synergizes with type I interferons through systemic dendritic cell reactivation and induction of immunogenic tumor apoptosis. Cancer Res. 2011;71:768-78 pubmed publisher..These results disclose new perspectives for the development of targeted and more effective chemoimmunotherapy treatments of cancer patients. ..
- Fetoni A, Picciotti P, Paludetti G, Troiani D. Pathogenesis of presbycusis in animal models: a review. Exp Gerontol. 2011;46:413-25 pubmed publisher..This work aims to give a broad overview of the scientific findings related to presbycusis, focusing mainly on experimental studies in animal models...
- Vitullo P, Sciamanna I, Baiocchi M, Sinibaldi Vallebona P, Spadafora C. LINE-1 retrotransposon copies are amplified during murine early embryo development. Mol Reprod Dev. 2012;79:118-27 pubmed publisher..These findings support the conclusion that RT-dependent amplification of LINE-1 retrotransposons is a distinctive feature of early embryonic genomes. Its physiological involvement in preimplantation murine development is discussed. ..
- Di Bari M, Nonno R, Agrimi U. The mouse model for scrapie: inoculation, clinical scoring, and histopathological techniques. Methods Mol Biol. 2012;849:453-71 pubmed publisher..This chapter reviews the techniques used in transmission studies, from the preparation of the inocula to pathological investigations, with specific focus on the potential problems that may occur and how to solve them. ..
- Rinaldo C, Moncada A, Gradi A, Ciuffini L, D Eliseo D, Siepi F, et al. HIPK2 controls cytokinesis and prevents tetraploidization by phosphorylating histone H2B at the midbody. Mol Cell. 2012;47:87-98 pubmed publisher..Overall, our data uncover mechanisms of a critical HIPK2 function in cytokinesis and in the prevention of tetraploidization. ..
- Odorisio T, De Luca N, Vesci L, Luisi P, Stano P, Zambruno G, et al. The atypical retinoid E-3-(3'-Adamantan-1-yl-4'-methoxybiphenyl-4-yl)-2-propenoic acid (ST1898) displays comedolytic activity in the rhino mouse model. Eur J Dermatol. 2012;22:505-11 pubmed publisher..Our data indicate that ST1898 has strong comedolytic activity but modest topical side effects. ..
- Volonte C, Apolloni S, Skaper S, Burnstock G. P2X7 receptors: channels, pores and more. CNS Neurol Disord Drug Targets. 2012;11:705-21 pubmed..In this review we discuss current biology and pharmacology of the P2X7R, as well as insights into the role for this receptor in neurological/psychiatric diseases. ..
- Tonkin J, Temmerman L, Sampson R, Gallego Colon E, Barberi L, Bilbao D, et al. Monocyte/Macrophage-derived IGF-1 Orchestrates Murine Skeletal Muscle Regeneration and Modulates Autocrine Polarization. Mol Ther. 2015;23:1189-1200 pubmed publisher..These data establish local macrophage-derived IGF-1 as a key factor in inflammation resolution and macrophage polarization during muscle regeneration. ..
- Mao Y, Chen X, Xu M, Fujita K, Motoki K, Sasabe T, et al. Targeting TEAD/YAP-transcription-dependent necrosis, TRIAD, ameliorates Huntington's disease pathology. Hum Mol Genet. 2016;25:4749-4770 pubmed publisher..Collectively, we suggest approaches targeting the signalling pathway of TEAD/YAP-transcription-dependent necrosis (TRIAD) could lead to a therapeutic development against HD. ..
- Maroder M, Scarpa S, Screpanti I, Stigliano A, Meco D, Vacca A, et al. Human immunodeficiency virus type 1 tat protein modulates fibronectin expression in thymic epithelial cells and impairs in vitro thymocyte development. Cell Immunol. 1996;168:49-58 pubmed
- Bernassola F, Federici M, Corazzari M, Terrinoni A, Hribal M, De Laurenzi V, et al. Role of transglutaminase 2 in glucose tolerance: knockout mice studies and a putative mutation in a MODY patient. FASEB J. 2002;16:1371-8 pubmed..Collectively, these results identify TGase 2 as a potential candidate gene in type 2 diabetes. ..
- Fiorini M, Ballaro C, Sala G, Falcone G, Alema S, Segatto O. Expression of RALT, a feedback inhibitor of ErbB receptors, is subjected to an integrated transcriptional and post-translational control. Oncogene. 2002;21:6530-9 pubmed..Such an integrated transcriptional and post-translational control is likely to provide RALT with the ability to fluctuate timely in order to tune ErbB signals. ..
- Uccelletti D, De Jaco A, Farina F, Mancini P, Augusti Tocco G, Biagioni S, et al. Cell surface expression of a GPI-anchored form of mouse acetylcholinesterase in Klpmr1Delta cells of Kluyveromyces lactis. Biochem Biophys Res Commun. 2002;298:559-65 pubmed..lactis resulted in yeast cells displaying high AChE activity. This could be regarded as a novel sensing unit to be employed for detecting AChE inhibitors as pesticides. ..
- Puglisi R, Montanari M, Chiarella P, Stefanini M, Boitani C. Regulatory role of BMP2 and BMP7 in spermatogonia and Sertoli cell proliferation in the immature mouse. Eur J Endocrinol. 2004;151:511-20 pubmed..These findings suggest that BMPs are involved in physiological paracrine signalling during the first wave of spermatogenesis. ..
- Ammassari Teule M, Castellano C. Strains of rodents and the pharmacology of learning and memory. Neural Plast. 2004;11:205-16 pubmed..The second part focuses specifically on in-breeding. In conclusion, the advantages and the limits of a Mendelian pharmacogenetic approach of learning and memory are discussed. ..
- De Angelis L, Zhao J, Andreucci J, Olson E, Cossu G, McDermott J. Regulation of vertebrate myotome development by the p38 MAP kinase-MEF2 signaling pathway. Dev Biol. 2005;283:171-9 pubmed..Thus, we present novel evidence indicating a crucial role for p38 MAPK signaling to the MEF2 transcriptional regulators during early mammalian somite development and myotome formation. ..
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