Experts and Doctors on kinesin in Rome, Latium, Italy


Locale: Rome, Latium, Italy
Topic: kinesin

Top Publications

  1. Di Fiore B, Ciciarello M, Mangiacasale R, Palena A, Tassin A, Cundari E, et al. Mammalian RanBP1 regulates centrosome cohesion during mitosis. J Cell Sci. 2003;116:3399-411 pubmed
    ..These data indicate that overexpressed RanBP1 interferes with crucial factor(s) that control structural and dynamic features of centrosomes during mitosis and contribute to uncover novel mitotic functions downstream of the Ran network. ..
  2. Macioce P, Gambara G, Bernassola M, Gaddini L, Torreri P, Macchia G, et al. Beta-dystrobrevin interacts directly with kinesin heavy chain in brain. J Cell Sci. 2003;116:4847-56 pubmed
    ..Our findings suggest a novel function for dystrobrevin as a motor protein receptor that might play a major role in the transport of components of the dystrophin-associated protein complex to specific sites in the cell. ..
  3. Giansanti M, Farkas R, Bonaccorsi S, Lindsley D, Wakimoto B, Fuller M, et al. Genetic dissection of meiotic cytokinesis in Drosophila males. Mol Biol Cell. 2004;15:2509-22 pubmed
  4. De Luca M, Brunetto L, Asteriti I, Giubettini M, Lavia P, Guarguaglini G. Aurora-A and ch-TOG act in a common pathway in control of spindle pole integrity. Oncogene. 2008;27:6539-49 pubmed publisher
    ..These results indicate a novel function of Aurora-A, the regulation of ch-TOG and MCAK localization, and highlight a common pathway involving the three factors in control of spindle pole integrity. ..
  5. Asteriti I, Giubettini M, Lavia P, Guarguaglini G. Aurora-A inactivation causes mitotic spindle pole fragmentation by unbalancing microtubule-generated forces. Mol Cancer. 2011;10:131 pubmed publisher
    ..This study therefore highlights a novel role of the Aurora-A kinase in regulating the balance between microtubule forces during bipolar spindle assembly. ..
  6. Fratini F, Macchia G, Torreri P, Matteucci A, Salzano A, Crescenzi M, et al. Phosphorylation on threonine 11 of ?-dystrobrevin alters its interaction with kinesin heavy chain. FEBS J. 2012;279:4131-44 pubmed publisher
    ..Thr11 was phosphorylated by protein kinase C, suggesting that this represents a key residue modified by the activation of different signaling pathways. ..
  7. Lepre T, Cascella R, Ragazzo M, Galli E, Novelli G, Giardina E. Association of KIF3A, but not OVOL1 and ACTL9, with atopic eczema in Italian patients. Br J Dermatol. 2013;168:1106-8 pubmed publisher
    ..77 (95% CI 1.66-4.61). We failed to reveal association between AE and the other two SNPs tested. Our study indicated KIF3A as a novel gene implicated in the development of AE in the Italian population. ..
  8. Kaji S, Kawarai T, Miyamoto R, Nodera H, Pedace L, Orlacchio A, et al. Late-onset spastic paraplegia type 10 (SPG10) family presenting with bulbar symptoms and fasciculations mimicking amyotrophic lateral sclerosis. J Neurol Sci. 2016;364:45-9 pubmed publisher
    ..Given that our cases showed pseudobulbar palsy, fasciculation and altered penetrance, KIF5A-SPG10 might well be considered as a differential diagnosis of sporadic ALS. ..
  9. Ceccarini M, Torreri P, Lombardi D, Macchia G, Macioce P, Petrucci T. Molecular basis of dystrobrevin interaction with kinesin heavy chain: structural determinants of their binding. J Mol Biol. 2005;354:872-82 pubmed
    ..Phosphorylation events could have a regulatory role in this context. ..

More Information


  1. Marra E, Palombo F, Ciliberto G, Aurisicchio L. Kinesin spindle protein SiRNA slows tumor progression. J Cell Physiol. 2013;228:58-64 pubmed publisher
    ..Our results show that intratumoral electro-transfer of siRNA is feasible and KSP-specific siRNA may provide a novel strategy for therapeutic intervention. ..