Experts and Doctors on tumor cell line in Bari, Apulia, Italy


Locale: Bari, Apulia, Italy
Topic: tumor cell line

Top Publications

  1. Natalicchio A, De Stefano F, Orlando M, Melchiorre M, Leonardini A, Cignarelli A, et al. Exendin-4 prevents c-Jun N-terminal protein kinase activation by tumor necrosis factor-alpha (TNFalpha) and inhibits TNFalpha-induced apoptosis in insulin-secreting cells. Endocrinology. 2010;151:2019-29 pubmed publisher
    ..By inhibiting JNK phosphorylation in a PKA-dependent manner, exendin-4 counteracts TNFalpha-mediated apoptosis and reverses the inhibitory events in the IRS/Akt pathway, resulting in promotion of cell survival. ..
  2. Perosa F, Favoino E, Vicenti C, Guarnera A, Racanelli V, De Pinto V, et al. Two structurally different rituximab-specific CD20 mimotope peptides reveal that rituximab recognizes two different CD20-associated epitopes. J Immunol. 2009;182:416-23 pubmed
    ..Altogether, these results indicate that the two structurally different peptides are also conformationally different, and suggest that rituximab recognizes two different CD20-associated epitopes. ..
  3. Moro L, Arbini A, Marra E, Greco M. Mitochondrial DNA depletion reduces PARP-1 levels and promotes progression of the neoplastic phenotype in prostate carcinoma. Cell Oncol. 2008;30:307-22 pubmed
    ..Overall, these results provide novel evidence demonstrating that mtDNA depletion in early prostate carcinoma may contribute to the acquisition of a more invasive phenotype that is less sensitive to paclitaxel-induced apoptosis. ..
  4. Cassano G, Gasparre G, Niso M, Contino M, Scalera V, Colabufo N. F281, synthetic agonist of the sigma-2 receptor, induces Ca2+ efflux from the endoplasmic reticulum and mitochondria in SK-N-SH cells. Cell Calcium. 2009;45:340-5 pubmed publisher
    ..After the increase in [Ca(2+)](i) and within 10 min, we observed a sudden drop in metabolic activity and intracellular [ATP] leading to cell death. ..
  5. Lisi S, Sisto M, Soleti R, Saponaro C, Scagliusi P, D Amore M, et al. Fcgamma receptors mediate internalization of anti-Ro and anti-La autoantibodies from Sjögren's syndrome and apoptosis in human salivary gland cell line A-253. J Oral Pathol Med. 2007;36:511-23 pubmed
    ..We conclude that anti-Ro and anti-La autoantibodies have pathogenic effects that could depend on binding to Fcgamma receptors. ..
  6. Panaro M, Cianciulli A, Mitolo V, Mitolo C, Acquafredda A, Brandonisio O, et al. Caspase-dependent apoptosis of the HCT-8 epithelial cell line induced by the parasite Giardia intestinalis. FEMS Immunol Med Microbiol. 2007;51:302-9 pubmed
  7. Azzariti A, Colabufo N, Berardi F, Porcelli L, Niso M, Simone G, et al. Cyclohexylpiperazine derivative PB28, a sigma2 agonist and sigma1 antagonist receptor, inhibits cell growth, modulates P-glycoprotein, and synergizes with anthracyclines in breast cancer. Mol Cancer Ther. 2006;5:1807-16 pubmed
    ..In conclusion, we suggest that the sigma(2) agonist PB28 could be an interesting antitumor agent either in monotherapy or in combination with conventional drugs. ..
  8. Pisani L, Muncipinto G, Miscioscia T, Nicolotti O, Leonetti F, Catto M, et al. Discovery of a novel class of potent coumarin monoamine oxidase B inhibitors: development and biopharmacological profiling of 7-[(3-chlorobenzyl)oxy]-4-[(methylamino)methyl]-2H-chromen-2-one methanesulfonate (NW-1772) as a highly potent, selective, r. J Med Chem. 2009;52:6685-706 pubmed publisher
    ..On the basis of this preliminary preclinical profile, inhibitor 22b might be viewed as a promising clinical candidate for the treatment of neurodegenerative diseases. ..
  9. Ramires R, Caiaffa M, Tursi A, Haeggstrom J, Macchia L. Novel inhibitory effect on 5-lipoxygenase activity by the anti-asthma drug montelukast. Biochem Biophys Res Commun. 2004;324:815-21 pubmed
    ..5-Lipoxygenase inhibition by montelukast appears to be highly selective since the drug had no effects on other enzymes of the leukotriene cascade, viz. LTC4 synthase and LTA hydrolase. ..

More Information


  1. Margiotta N, Bergamo A, Sava G, Padovano G, De Clercq E, Natile G. Antiviral properties and cytotoxic activity of platinum(II) complexes with 1,10-phenanthrolines and acyclovir or penciclovir. J Inorg Biochem. 2004;98:1385-90 pubmed
    ..The greater cytotoxicity of compounds with Me(2)phen may result from a higher reactivity towards cellular components, such as glutathione, which could cause release of the diimine, known to be highly cytotoxic. ..
  2. Colabufo N, Berardi F, Perrone R, Rapposelli S, Digiacomo M, Vanni M, et al. Synthesis and biological evaluation of (hetero)arylmethyloxy- and arylmethylamine-phenyl derivatives as potent P-glycoprotein modulating agents. J Med Chem. 2008;51:1415-22 pubmed publisher
    ..The results demonstrated that only the amino derivatives 23- 27 displayed moderate BCRP inhibition activity...
  3. Mazzocca A, Fransvea E, Lavezzari G, Antonaci S, Giannelli G. Inhibition of transforming growth factor beta receptor I kinase blocks hepatocellular carcinoma growth through neo-angiogenesis regulation. Hepatology. 2009;50:1140-51 pubmed publisher
    ..Finally, LY2109761 does not show significant effects on physiological angiogenetic development. These data support the rationale for targeting TGF-beta signaling in patients with HCC. ..
  4. Polimeno L, Pesetti B, Lisowsky T, Iannone F, Resta L, Giorgio F, et al. Protective effect of augmenter of liver regeneration on hydrogen peroxide-induced apoptosis in SH-SY5Y human neuroblastoma cells. Free Radic Res. 2009;43:865-75 pubmed publisher
    ..The data demonstrate that Alrp improves SH-SY5Y cells survival in H(2)O(2)-induced apoptosis. It is speculated that this effect could be related to the Alrp enzymatic activity. ..
  5. De Giglio E, Cometa S, Ricci M, Zizzi A, Cafagna D, Manzotti S, et al. Development and characterization of rhVEGF-loaded poly(HEMA-MOEP) coatings electrosynthesized on titanium to enhance bone mineralization and angiogenesis. Acta Biomater. 2010;6:282-90 pubmed publisher
  6. Lefkimmiatis K, Caratozzolo M, Merlo P, D Erchia A, Navarro B, Levrero M, et al. p73 and p63 sustain cellular growth by transcriptional activation of cell cycle progression genes. Cancer Res. 2009;69:8563-71 pubmed publisher
    ..The elevated concentrations of p73 and p63 found in many cancers could cause the aberrant activation of cell growth progression genes and therefore contribute to cancer initiation or progression under certain conditions. ..
  7. Colucci S, Brunetti G, Mori G, Oranger A, Centonze M, Mori C, et al. Soluble decoy receptor 3 modulates the survival and formation of osteoclasts from multiple myeloma bone disease patients. Leukemia. 2009;23:2139-46 pubmed publisher
    ..The production of DcR3 by T lymphocytes confers these cells a role in the pathogenesis of bone disease associated with MM. ..
  8. Moro L, Arbini A, Yao J, di Sant agnese P, Marra E, Greco M. Loss of BRCA2 promotes prostate cancer cell invasion through up-regulation of matrix metalloproteinase-9. Cancer Sci. 2008;99:553-63 pubmed publisher
  9. Fransvea E, Mazzocca A, Antonaci S, Giannelli G. Targeting transforming growth factor (TGF)-betaRI inhibits activation of beta1 integrin and blocks vascular invasion in hepatocellular carcinoma. Hepatology. 2009;49:839-50 pubmed publisher
    ..TGF-beta1 promotes vascular invasion by activating beta1 integrin. This suggests a rationale for targeting TGF-betaRI in future clinical trials. ..
  10. Intini F, Boccarelli A, Francia V, Pacifico C, Sivo M, Natile G, et al. Platinum complexes with imino ethers or cyclic ligands mimicking imino ethers: synthesis, in vitro antitumour activity, and DNA interaction properties. J Biol Inorg Chem. 2004;9:768-80 pubmed
    ..This study demonstrates that ligand configuration modulates the activity of both trans and cis compounds, and supports the development of platinum drugs based on their coordination chemistry to combat cisplatin resistance. ..
  11. Ribatti D, Vacca A, Rusnati M, Presta M. The discovery of basic fibroblast growth factor/fibroblast growth factor-2 and its role in haematological malignancies. Cytokine Growth Factor Rev. 2007;18:327-34 pubmed
    ..This review describes its history, as well as its role in tumor angiogenesis associated with haematological malignancies, as traced by the main contributions to the international medical literature. ..
  12. Colabufo N, Berardi F, Abate C, Contino M, Niso M, Perrone R. Is the sigma2 receptor a histone binding protein?. J Med Chem. 2006;49:4153-8 pubmed
    ..1 histone (SwissProt accession number: P16403). These results disclosed a dual hypothesis about the sigma(2) receptor, that is, that it is formed by histones or that the sigma(2) ligands also bind histone proteins...
  13. Cardone R, Bagorda A, Bellizzi A, Busco G, Guerra L, Paradiso A, et al. Protein kinase A gating of a pseudopodial-located RhoA/ROCK/p38/NHE1 signal module regulates invasion in breast cancer cell lines. Mol Biol Cell. 2005;16:3117-27 pubmed
  14. Paradiso A, Cardone R, Bellizzi A, Bagorda A, Guerra L, Tommasino M, et al. The Na+-H+ exchanger-1 induces cytoskeletal changes involving reciprocal RhoA and Rac1 signaling, resulting in motility and invasion in MDA-MB-435 cells. Breast Cancer Res. 2004;6:R616-28 pubmed
    ..Our findings suggest that the reported antagonistic roles of RhoA and Rac1 in cell motility/invasion and cytoskeletal organization may be due, in part, to their concerted action on NHE1 activity as a convergence point. ..
  15. Virgintino D, Errede M, Girolamo F, Capobianco C, Robertson D, Vimercati A, et al. Fetal blood-brain barrier P-glycoprotein contributes to brain protection during human development. J Neuropathol Exp Neurol. 2008;67:50-61 pubmed
  16. Cardone R, Bellizzi A, Busco G, Weinman E, Dell Aquila M, Casavola V, et al. The NHERF1 PDZ2 domain regulates PKA-RhoA-p38-mediated NHE1 activation and invasion in breast tumor cells. Mol Biol Cell. 2007;18:1768-80 pubmed
    ..We conclude that NHERF1 overexpression enhances the invasive phenotype in breast cancer cells, both alone and in synergy with exposure to the tumor microenvironment, via the coordination of PKA-gated RhoA/p38 signaling. ..
  17. Quaranta M, Coviello M, Daniele A, Abbate I, Durrant L, Paradiso A, et al. MUC3 and MCA serum levels and steroid receptor content in breast cancer. Int J Biol Markers. 2004;19:109-14 pubmed
    ..Our results suggest that further investigations are necessary to establish whether progesterone can modulate MUC3 and MCA expression in breast cancer...