Experts and Doctors on prostatic neoplasms in Bari, Apulia, Italy
Locale: Bari, Apulia, Italy
Topic: prostatic neoplasms
Moro L, Greco M, Ditonno P, Battaglia M, Marra E, Perlino E. Transcriptional regulation of the beta1C integrin splice variant in human prostate adenocarcinoma. Int J Oncol. 2003;23:1601-6 pubmed
..Moreover, the decrease in transcriptional activity of the beta1 integrin gene directly correlates to the reduction of beta1C integrin steady-state mRNA levels (r=0.78). ..
Moro L, Arbini A, Yao J, di Sant agnese P, Marra E, Greco M. Loss of BRCA2 promotes prostate cancer cell invasion through up-regulation of matrix metalloproteinase-9. Cancer Sci. 2008;99:553-63 pubmed publisher
Moro L, Arbini A, Yao J, di Sant Agnese P, Marra E, Greco M. Mitochondrial DNA depletion in prostate epithelial cells promotes anoikis resistance and invasion through activation of PI3K/Akt2. Cell Death Differ. 2009;16:571-83 pubmed publisher
..Taken together, these results provide novel mechanistic evidence supporting the notion that mtDNA mutations may confer survival and migratory advantage to prostate cancer cells through Akt2 signaling. ..
Pagliarulo V, Bracarda S, Eisenberger M, Mottet N, Schroder F, Sternberg C, et al
. Contemporary role of androgen deprivation therapy for prostate cancer. Eur Urol. 2012;61:11-25 pubmed publisher
..Implementation of ADT should be evidence based, with special consideration to adverse events and the risk-benefit ratio. ..
de Bari L, Moro L, Passarella S. Prostate cancer cells metabolize d-lactate inside mitochondria via a D-lactate dehydrogenase which is more active and highly expressed than in normal cells. FEBS Lett. 2013;587:467-73 pubmed publisher
..D-Lactate can enter prostate mitochondria and cause the export of newly synthesized malate in a carrier-mediated manner, with the rate of malate efflux from mitochondria twofold higher in cancer. ..