Experts and Doctors on neoplasm invasiveness in Bari, Apulia, Italy


Locale: Bari, Apulia, Italy
Topic: neoplasm invasiveness

Top Publications

  1. Ria R, Vacca A, Ribatti D, Di Raimondo F, Merchionne F, Dammacco F. Alpha(v)beta(3) integrin engagement enhances cell invasiveness in human multiple myeloma. Haematologica. 2002;87:836-45 pubmed
  2. Paradiso A, Cardone R, Bellizzi A, Bagorda A, Guerra L, Tommasino M, et al. The Na+-H+ exchanger-1 induces cytoskeletal changes involving reciprocal RhoA and Rac1 signaling, resulting in motility and invasion in MDA-MB-435 cells. Breast Cancer Res. 2004;6:R616-28 pubmed
    ..Our findings suggest that the reported antagonistic roles of RhoA and Rac1 in cell motility/invasion and cytoskeletal organization may be due, in part, to their concerted action on NHE1 activity as a convergence point. ..
  3. Cardone R, Bagorda A, Bellizzi A, Busco G, Guerra L, Paradiso A, et al. Protein kinase A gating of a pseudopodial-located RhoA/ROCK/p38/NHE1 signal module regulates invasion in breast cancer cell lines. Mol Biol Cell. 2005;16:3117-27 pubmed
  4. Giannelli G, Bergamini C, Fransvea E, Sgarra C, Antonaci S. Laminin-5 with transforming growth factor-beta1 induces epithelial to mesenchymal transition in hepatocellular carcinoma. Gastroenterology. 2005;129:1375-83 pubmed
    ..Our study shows that Ln-5 and TGF-beta1 cooperatively induce EMT in HCC, suggesting the microenvironment as a potential target for new biological therapies. ..
  5. Cardone R, Bellizzi A, Busco G, Weinman E, Dell Aquila M, Casavola V, et al. The NHERF1 PDZ2 domain regulates PKA-RhoA-p38-mediated NHE1 activation and invasion in breast tumor cells. Mol Biol Cell. 2007;18:1768-80 pubmed
    ..We conclude that NHERF1 overexpression enhances the invasive phenotype in breast cancer cells, both alone and in synergy with exposure to the tumor microenvironment, via the coordination of PKA-gated RhoA/p38 signaling. ..
  6. Moro L, Arbini A, Yao J, di Sant agnese P, Marra E, Greco M. Loss of BRCA2 promotes prostate cancer cell invasion through up-regulation of matrix metalloproteinase-9. Cancer Sci. 2008;99:553-63 pubmed publisher
  7. Passantino L, Passantino G, Cianciotta A, Ribaud M, Lo Presti G, Ranieri G, et al. Expression of proto-oncogene C-kit and correlation with morphological evaluations in canine cutaneous mast cell tumors. Immunopharmacol Immunotoxicol. 2008;30:609-21 pubmed publisher
    ..Our results confirm that a more aggressive biologic behavior of canine MCT is associated with the increased c-kit expression, further suggesting a new role for c-kit, as a useful marker, in diagnostic pathology and in tumor progression. ..
  8. Malfettone A, Saponaro C, Paradiso A, Simone G, Mangia A. Peritumoral vascular invasion and NHERF1 expression define an immunophenotype of grade 2 invasive breast cancer associated with poor prognosis. BMC Cancer. 2012;12:106 pubmed publisher
    ..These observations support the idea of the PVI+/membranous NHERF1- expression immunophenotype as a useful marker, which could improve the accuracy of predicting clinical outcome in grade 2 tumors. ..
  9. Malfettone A, Silvestris N, Paradiso A, Mattioli E, Simone G, Mangia A. Overexpression of nuclear NHERF1 in advanced colorectal cancer: association with hypoxic microenvironment and tumor invasive phenotype. Exp Mol Pathol. 2012;92:296-303 pubmed publisher
    ..Our results support the oncogenic role of NHERF1 and promote nuclear NHERF1 as a potential new biomarker of advanced CRC. ..

More Information


  1. Cardone R, Greco M, Capulli M, Weinman E, Busco G, Bellizzi A, et al. NHERF1 acts as a molecular switch to program metastatic behavior and organotropism via its PDZ domains. Mol Biol Cell. 2012;23:2028-40 pubmed publisher
  2. Antelmi E, Cardone R, Greco M, Rubino R, Di Sole F, Martino N, et al. ß1 integrin binding phosphorylates ezrin at T567 to activate a lipid raft signalsome driving invadopodia activity and invasion. PLoS ONE. 2013;8:e75113 pubmed publisher