Experts and Doctors on zebrafish proteins in Tel Aviv, Israel


Locale: Tel Aviv, Israel
Topic: zebrafish proteins

Top Publications

  1. Tovin A, Alon S, Ben Moshe Z, Mracek P, Vatine G, Foulkes N, et al. Systematic identification of rhythmic genes reveals camk1gb as a new element in the circadian clockwork. PLoS Genet. 2012;8:e1003116 pubmed publisher
    ..Therefore, it appears that camk1gb plays a role in linking the pineal master clock with the periphery...
  2. Pillar N, Pleniceanu O, Fang M, Ziv L, Lahav E, Botchan S, et al. A rare variant in the FHL1 gene associated with X-linked recessive hypoparathyroidism. Hum Genet. 2017;136:835-845 pubmed publisher
    ..Altogether, our data suggest that FHL1 is a novel regulator of calcium homeostasis and implicate it as the causative gene for X-linked recessive hypoparathyroidism. ..
  3. Zilberberg A, Yaniv A, Gazit A. The low density lipoprotein receptor-1, LRP1, interacts with the human frizzled-1 (HFz1) and down-regulates the canonical Wnt signaling pathway. J Biol Chem. 2004;279:17535-42 pubmed
    ..However, whereas some members of the LDLR family, such as LRP5/6, interact with Fz and serve as Wnt coreceptors, others negatively regulate Wnt signaling, presumably by sequestering Fz. ..
  4. Ziv L, Gothilf Y. Circadian time-keeping during early stages of development. Proc Natl Acad Sci U S A. 2006;103:4146-51 pubmed
    ..The 24-h rhythm is then maintained throughout rapid proliferation and, remarkably, differentiation...
  5. Appelbaum L, Vallone D, Anzulovich A, Ziv L, Tom M, Foulkes N, et al. Zebrafish arylalkylamine-N-acetyltransferase genes - targets for regulation of the circadian clock. J Mol Endocrinol. 2006;36:337-47 pubmed
  6. Dresner E, Malishkevich A, Arviv C, Leibman Barak S, Alon S, Ofir R, et al. Novel evolutionary-conserved role for the activity-dependent neuroprotective protein (ADNP) family that is important for erythropoiesis. J Biol Chem. 2012;287:40173-85 pubmed publisher
    ..Taken together, our results reveal an ancestral role for the ADNP protein family in maturation and differentiation of the erythroid lineage, associated with direct regulation of ?-globin expression. ..
  7. Golan T, Yaniv A, Bafico A, Liu G, Gazit A. The human Frizzled 6 (HFz6) acts as a negative regulator of the canonical Wnt. beta-catenin signaling cascade. J Biol Chem. 2004;279:14879-88 pubmed
  8. Palevitch O, Abraham E, Borodovsky N, Levkowitz G, Zohar Y, Gothilf Y. Nasal embryonic LHRH factor plays a role in the developmental migration and projection of gonadotropin-releasing hormone 3 neurons in zebrafish. Dev Dyn. 2009;238:66-75 pubmed publisher
    ..These results suggest that Nelf is an important factor in the developmental migration and projection of GnRH3 neurons in zebrafish. ..
  9. Smadja Storz S, Tovin A, Mracek P, Alon S, Foulkes N, Gothilf Y. Casein kinase 1? activity: a key element in the zebrafish circadian timing system. PLoS ONE. 2013;8:e54189 pubmed publisher
    ..Furthermore, the effect of CK1? inhibition on rhythmic locomotor activity may reflect its effect on the function of the central clock in the pineal gland as well as its regulation of peripheral clocks...

More Information


  1. Gazit A, Yaniv A, Bafico A, Pramila T, Igarashi M, Kitajewski J, et al. Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response. Oncogene. 1999;18:5959-66 pubmed
    ..All of these findings provide strong evidence that Hfz1 is a functional partner for certain Wnts in inducing TCF dependent transcription. ..
  2. Ziv L, Levkovitz S, Toyama R, Falcon J, Gothilf Y. Functional development of the zebrafish pineal gland: light-induced expression of period2 is required for onset of the circadian clock. J Neuroendocrinol. 2005;17:314-20 pubmed
    ..These experiments indicated that light-induced zper2 expression is crucial for establishment of the clock-controlled zfaanat2 rhythm in the zebrafish pineal gland. ..
  3. Ziv L, Gothilf Y. Period2 expression pattern and its role in the development of the pineal circadian clock in zebrafish. Chronobiol Int. 2006;23:101-12 pubmed
    ..Thus, a possible role for early photoreception and light-induced zper2 expression in the development of clock-controlled rhythms remains to be investigated. ..
  4. Palevitch O, Abraham E, Borodovsky N, Levkowitz G, Zohar Y, Gothilf Y. Cxcl12a-Cxcr4b signaling is important for proper development of the forebrain GnRH system in zebrafish. Gen Comp Endocrinol. 2010;165:262-8 pubmed publisher
    ..The results of this study suggest that the Cxcl12a-Cxcr4b ligand-receptor pair are involved in the migration of GnRH3 neurons in zebrafish, and are therefore crucial for the development of this system. ..
  5. Ben Moshe Z, Vatine G, Alon S, Tovin A, Mracek P, Foulkes N, et al. Multiple PAR and E4BP4 bZIP transcription factors in zebrafish: diverse spatial and temporal expression patterns. Chronobiol Int. 2010;27:1509-31 pubmed publisher
    ..This study, in the genetically accessible zebrafish model, lays the foundation for further research regarding the involvement and specific roles of PAR and E4BP4 transcription factors in the vertebrate circadian clock mechanism. ..
  6. Keren Kaplan T, Attali I, Motamedchaboki K, Davis B, Tanner N, Reshef Y, et al. Synthetic biology approach to reconstituting the ubiquitylation cascade in bacteria. EMBO J. 2012;31:378-90 pubmed publisher
    ..Characterization of several ubiquitylated proteins demonstrated the integrity, specificity and fidelity of the system, and revealed new biological findings. ..