Experts and Doctors on membrane glycoproteins in Haifa, Israel


Locale: Haifa, Israel
Topic: membrane glycoproteins

Top Publications

  1. Azulay Debby H, Edry E, Melamed D. CpG DNA stimulates autoreactive immature B cells in the bone marrow. Eur J Immunol. 2007;37:1463-75 pubmed
    ..These results suggest that mitogenic signals provided by CpG DNA stimulate nontolerant immature B cells in the bone marrow and have the potential to interfere with central tolerance. ..
  2. Seagal J, Edry E, Keren Z, Leider N, Benny O, Machluf M, et al. A fail-safe mechanism for negative selection of isotype-switched B cell precursors is regulated by the Fas/FasL pathway. J Exp Med. 2003;198:1609-19 pubmed
    ..This developmental pathway, however, is strictly controlled by Fas/FasL interaction to prevent B cell autoimmunity. ..
  3. Dyugovskaya L, Lavie P, Hirsh M, Lavie L. Activated CD8+ T-lymphocytes in obstructive sleep apnoea. Eur Respir J. 2005;25:820-8 pubmed
    ..These results are compatible with the current authors' hypothesis of atherogenic sequelae in obstructive sleep apnoea. ..
  4. Schwartz M, Groshar D, Inzelberg R, Hocherman S. Dopamine-transporter imaging and visuo-motor testing in essential tremor, practical possibilities for detection of early stage Parkinson's disease. Parkinsonism Relat Disord. 2004;10:385-9 pubmed
    ..A significant correlation between ligand uptake and VMC was observed. Impaired VMC is a pertinent indication for further SPECT imaging in patients with ET, in order to establish a diagnosis of incipient PD. ..
  5. Fisher Lavie A, Zeidan A, Stern M, Garner C, Ziv N. Use dependence of presynaptic tenacity. J Neurosci. 2011;31:16770-80 pubmed publisher
    ..These findings also indicate, however, that neither AZ size nor SV content set points are particularly stable, questioning the long-term tenacity of presynaptic specializations. ..
  6. Munichor M, Cohen H, Sarid R, Manov I, Iancu T. Human herpesvirus 8 in primary effusion lymphoma in an HIV-seronegative male. A case report. Acta Cytol. 2004;48:425-30 pubmed
    ..To our knowledge, this is the first case in which immunostaining for anti-HHV-8 monoclonal antibodies was used to support the diagnosis. ..
  7. Seagal J, Leider N, Wildbaum G, Karin N, Melamed D. Increased plasma cell frequency and accumulation of abnormal syndecan-1plus T-cells in Igmu-deficient/lpr mice. Int Immunol. 2003;15:1045-52 pubmed
    ..Our results, therefore, suggest that in the muMT/lpr mouse model a small population of isotype-switched B cells is sufficient for the initiation and propagation of Th1-regulated murine lupus. ..
  8. Yaniv G, Shilkrut M, Lotan R, Berke G, Larisch S, Binah O. Hypoxia predisposes neonatal rat ventricular myocytes to apoptosis induced by activation of the Fas (CD95/Apo-1) receptor: Fas activation and apoptosis in hypoxic myocytes. Cardiovasc Res. 2002;54:611-23 pubmed
    ..By upregulating Fas expression and key proapoptotic proteins, and by downregulating antiapoptotic proteins, hypoxia predisposes ventricular myocytes to Fas-induced apoptosis. ..
  9. Podbilewicz B. ADM-1, a protein with metalloprotease- and disintegrin-like domains, is expressed in syncytial organs, sperm, and sheath cells of sensory organs in Caenorhabditis elegans. Mol Biol Cell. 1996;7:1877-93 pubmed
    ..ADM-1 expression in the hypodermis, pharynx, vulva, and mature sperm is consistent with a putative role in somatic and gamete cell fusions. ..

More Information


  1. Gattegno T, Mittal A, Valansi C, Nguyen K, Hall D, Chernomordik L, et al. Genetic control of fusion pore expansion in the epidermis of Caenorhabditis elegans. Mol Biol Cell. 2007;18:1153-66 pubmed
    ..The first cell fusion does not trigger a wave of orderly fusions in either direction. Ultrastructural studies show that epidermal syncytiogenesis require eff-1 activities to initiate and expand membrane merger...
  2. Varshavsky A, Kessler O, Abramovitch S, Kigel B, Zaffryar S, Akiri G, et al. Semaphorin-3B is an angiogenesis inhibitor that is inactivated by furin-like pro-protein convertases. Cancer Res. 2008;68:6922-31 pubmed publisher
    ..These results suggest that up-regulation of furin-like pro-protein convertases in malignant cells may enable tumors to evade the antiangiogenic effects of sema3B. ..
  3. Abassi Z, Shalabi A, Sohotnik R, Nativ O, Awad H, Bishara B, et al. Urinary NGAL and KIM-1: biomarkers for assessment of acute ischemic kidney injury following nephron sparing surgery. J Urol. 2013;189:1559-66 pubmed publisher
    ..Renal injury severity after nephron sparing surgery could be quantitatively assessed by measuring urinary NGAL and KIM-1. ..
  4. Oren Suissa M, Gattegno T, Kravtsov V, Podbilewicz B. Extrinsic Repair of Injured Dendrites as a Paradigm for Regeneration by Fusion in Caenorhabditis elegans. Genetics. 2017;206:215-230 pubmed publisher
    ..EFF-1 is essential for dendritic pruning after injury and extrinsic AFF-1 mediates dendrite fusion to bypass injuries. ..
  5. PĂ©rez Vargas J, Krey T, Valansi C, Avinoam O, Haouz A, Jamin M, et al. Structural basis of eukaryotic cell-cell fusion. Cell. 2014;157:407-419 pubmed publisher
  6. Podbilewicz B, Leikina E, Sapir A, Valansi C, Suissa M, Shemer G, et al. The C. elegans developmental fusogen EFF-1 mediates homotypic fusion in heterologous cells and in vivo. Dev Cell. 2006;11:471-81 pubmed
    ..Thus, although EFF-1-mediated fusion shares characteristics with viral and intracellular fusion, including an apparent hemifusion step, it differs from these reactions in the homotypic organization of the fusion machinery. ..
  7. Berko D, Herkon O, Braunstein I, Isakov E, David Y, Ziv T, et al. Inherent asymmetry in the 26S proteasome is defined by the ubiquitin receptor RPN13. J Biol Chem. 2014;289:5609-18 pubmed publisher
    ..Our data point to a potential new role for ubiquitin receptors as directionality factors that may participate in the prevention of simultaneous substrates translocation into the 20S from both 19S caps...
  8. Smurova K, Podbilewicz B. RAB-5- and DYNAMIN-1-Mediated Endocytosis of EFF-1 Fusogen Controls Cell-Cell Fusion. Cell Rep. 2016;14:1517-1527 pubmed publisher
    ..Downregulation of dynamin or RAB-5 caused EFF-1 mislocalization to all apical membrane domains and excessive fusion. Thus, internalization of EFF-1 is a safety mechanism preventing excessive cell fusion. ..
  9. Avinoam O, Fridman K, Valansi C, Abutbul I, Zeev Ben Mordehai T, Maurer U, et al. Conserved eukaryotic fusogens can fuse viral envelopes to cells. Science. 2011;332:589-92 pubmed publisher
    ..Thus, FF proteins are part of an ancient family of cellular fusogens that can promote fusion when expressed on a viral particle. ..
  10. Oren Suissa M, Hall D, Treinin M, Shemer G, Podbilewicz B. The fusogen EFF-1 controls sculpting of mechanosensory dendrites. Science. 2010;328:1285-8 pubmed publisher
    ..Neuronal pruning appeared to involve EFF-1-dependent branch retraction and neurite-neurite autofusion. Thus, EFF-1 activities may act as a quality control mechanism during the sculpting of dendritic trees...
  11. Shemer G, Suissa M, Kolotuev I, Nguyen K, Hall D, Podbilewicz B. EFF-1 is sufficient to initiate and execute tissue-specific cell fusion in C. elegans. Curr Biol. 2004;14:1587-91 pubmed
    ..Surprisingly, eff-1 is not required to fuse the gonadal anchor cell to uterine cells. Thus, eff-1 is sufficient and essential for most but not all cell fusion events during C. elegans development. ..
  12. Seagal J, Melamed D. Contribution of alphabeta and gammadelta T cells to the generation of primary immunoglobulin G-driven autoimmune response in immunoglobulin- mu-deficient/lpr mice. Immunology. 2004;112:265-73 pubmed
  13. Kraizer Y, Mawasi N, Seagal J, Paizi M, Assy N, Spira G. Vascular endothelial growth factor and angiopoietin in liver regeneration. Biochem Biophys Res Commun. 2001;287:209-15 pubmed
    ..We now report similar effect using VEGF121, further demonstrating the benefit of manipulating growth factors where such an intervention is required. ..
  14. Felzen B, Shilkrut M, Less H, Sarapov I, Maor G, Coleman R, et al. Fas (CD95/Apo-1)-mediated damage to ventricular myocytes induced by cytotoxic T lymphocytes from perforin-deficient mice: a major role for inositol 1,4,5-trisphosphate. Circ Res. 1998;82:438-50 pubmed
    ..We conclude that a Fas-based perforin-independent mechanism of CTL action can account for the immunopathology seen in the allotransplanted heart, myocarditis, and dilated cardiomyopathy. ..