Experts and Doctors on gene silencing in Haifa, Israel
Locale: Haifa, Israel
Topic: gene silencing
Rothem L, Aronheim A, Assaraf Y. Alterations in the expression of transcription factors and the reduced folate carrier as a novel mechanism of antifolate resistance in human leukemia cells. J Biol Chem. 2003;278:8935-41 pubmed
..These results establish a novel mechanism of antifolate resistance that is based on altered expression and function of transcription factors resulting in transcriptional silencing of the hRFC promoter. ..
Rothem L, Stark M, Kaufman Y, Mayo L, Assaraf Y. Reduced folate carrier gene silencing in multiple antifolate-resistant tumor cell lines is due to a simultaneous loss of function of multiple transcription factors but not promoter methylation. J Biol Chem. 2004;279:374-84 pubmed
Atar O, Levi B. PU.1 silencing leads to terminal differentiation of erythroleukemia cells. Biochem Biophys Res Commun. 2005;329:1288-92 pubmed
..1 gene is the immediate cause for maintaining the leukemic phenotype of the disease by retaining the self-renewal capacity of transformed erythroblastic cells and by blocking the terminal differentiation program towards erythrocytes. ..
Gonen N, Bram E, Assaraf Y. PCFT/SLC46A1 promoter methylation and restoration of gene expression in human leukemia cells. Biochem Biophys Res Commun. 2008;376:787-92 pubmed publisher
..The potential translational implications of the restoration of PCFT expression in chemotherapy of leukemia are discussed. ..
Fishman Jacob T, Reznichenko L, Youdim M, Mandel S. A sporadic Parkinson disease model via silencing of the ubiquitin-proteasome/E3 ligase component SKP1A. J Biol Chem. 2009;284:32835-45 pubmed publisher
..In summary, this new model has reproduced to a significant extent the molecular alterations described in sporadic PD at the cellular level, implicating Skp1 as a potential modifier in sporadic PD neurodegeneration. ..
Slomovic S, Fremder E, Staals R, Pruijn G, Schuster G. Addition of poly(A) and poly(A)-rich tails during RNA degradation in the cytoplasm of human cells. Proc Natl Acad Sci U S A. 2010;107:7407-12 pubmed publisher
..Together, these results suggest that a mechanism of RNA decay, involving transient polyadenylation, is present in the cytoplasm of human cells. ..
Kigel B, Rabinowicz N, Varshavsky A, Kessler O, Neufeld G. Plexin-A4 promotes tumor progression and tumor angiogenesis by enhancement of VEGF and bFGF signaling. Blood. 2011;118:4285-96 pubmed publisher
..Our results suggest that plexin-A4 may represent a target for the development of novel anti-angiogenic and anti-tumorigenic drugs. ..
Tattikota S, Rathjen T, McAnulty S, Wessels H, Akerman I, van de Bunt M, et al
. Argonaute2 mediates compensatory expansion of the pancreatic Î² cell. Cell Metab. 2014;19:122-34 pubmed publisher
..This study identifies the targeting of Ago2 by miR-184 as an essential component of the compensatory response to regulate proliferation according to insulin sensitivity. ..
Yu Z, Livnat Levanon N, Kleifeld O, Mansour W, Nakasone M, Castaneda C, et al
. Base-CP proteasome can serve as a platform for stepwise lid formation. Biosci Rep. 2015;35: pubmed publisher