Experts and Doctors on caenorhabditis elegans proteins in Haifa, Israel


Locale: Haifa, Israel
Topic: caenorhabditis elegans proteins

Top Publications

  1. Podbilewicz B. ADM-1, a protein with metalloprotease- and disintegrin-like domains, is expressed in syncytial organs, sperm, and sheath cells of sensory organs in Caenorhabditis elegans. Mol Biol Cell. 1996;7:1877-93 pubmed
    ..ADM-1 expression in the hypodermis, pharynx, vulva, and mature sperm is consistent with a putative role in somatic and gamete cell fusions. ..
  2. Shemer G, Suissa M, Kolotuev I, Nguyen K, Hall D, Podbilewicz B. EFF-1 is sufficient to initiate and execute tissue-specific cell fusion in C. elegans. Curr Biol. 2004;14:1587-91 pubmed
    ..Surprisingly, eff-1 is not required to fuse the gonadal anchor cell to uterine cells. Thus, eff-1 is sufficient and essential for most but not all cell fusion events during C. elegans development. ..
  3. Podbilewicz B, Leikina E, Sapir A, Valansi C, Suissa M, Shemer G, et al. The C. elegans developmental fusogen EFF-1 mediates homotypic fusion in heterologous cells and in vivo. Dev Cell. 2006;11:471-81 pubmed
    ..Thus, although EFF-1-mediated fusion shares characteristics with viral and intracellular fusion, including an apparent hemifusion step, it differs from these reactions in the homotypic organization of the fusion machinery. ..
  4. Gattegno T, Mittal A, Valansi C, Nguyen K, Hall D, Chernomordik L, et al. Genetic control of fusion pore expansion in the epidermis of Caenorhabditis elegans. Mol Biol Cell. 2007;18:1153-66 pubmed
    ..The first cell fusion does not trigger a wave of orderly fusions in either direction. Ultrastructural studies show that epidermal syncytiogenesis require eff-1 activities to initiate and expand membrane merger...
  5. Sapir A, Choi J, Leikina E, Avinoam O, Valansi C, Chernomordik L, et al. AFF-1, a FOS-1-regulated fusogen, mediates fusion of the anchor cell in C. elegans. Dev Cell. 2007;12:683-98 pubmed
    ..Thus, FOS-1 links cell invasion and fusion in a developmental cascade. ..
  6. Oren Suissa M, Hall D, Treinin M, Shemer G, Podbilewicz B. The fusogen EFF-1 controls sculpting of mechanosensory dendrites. Science. 2010;328:1285-8 pubmed publisher
    ..Neuronal pruning appeared to involve EFF-1-dependent branch retraction and neurite-neurite autofusion. Thus, EFF-1 activities may act as a quality control mechanism during the sculpting of dendritic trees...
  7. Avinoam O, Fridman K, Valansi C, Abutbul I, Zeev Ben Mordehai T, Maurer U, et al. Conserved eukaryotic fusogens can fuse viral envelopes to cells. Science. 2011;332:589-92 pubmed publisher
    ..Thus, FF proteins are part of an ancient family of cellular fusogens that can promote fusion when expressed on a viral particle. ..
  8. PĂ©rez Vargas J, Krey T, Valansi C, Avinoam O, Haouz A, Jamin M, et al. Structural basis of eukaryotic cell-cell fusion. Cell. 2014;157:407-419 pubmed publisher
  9. Smurova K, Podbilewicz B. RAB-5- and DYNAMIN-1-Mediated Endocytosis of EFF-1 Fusogen Controls Cell-Cell Fusion. Cell Rep. 2016;14:1517-1527 pubmed publisher
    ..Downregulation of dynamin or RAB-5 caused EFF-1 mislocalization to all apical membrane domains and excessive fusion. Thus, internalization of EFF-1 is a safety mechanism preventing excessive cell fusion. ..

More Information


  1. Oren Suissa M, Gattegno T, Kravtsov V, Podbilewicz B. Extrinsic Repair of Injured Dendrites as a Paradigm for Regeneration by Fusion in Caenorhabditis elegans. Genetics. 2017;206:215-230 pubmed publisher
    ..EFF-1 is essential for dendritic pruning after injury and extrinsic AFF-1 mediates dendrite fusion to bypass injuries. ..
  2. Kravtsov V, Oren Suissa M, Podbilewicz B. The fusogen AFF-1 can rejuvenate the regenerative potential of adult dendritic trees by self-fusion. Development. 2017;144:2364-2374 pubmed publisher
    ..Thus, ectopic expression of the fusogen AFF-1 in the PVD and mutations in daf-2 differentially rejuvenate some aspects of dendritic regeneration following injury. ..