Experts and Doctors on aminopeptidases in Jerusalem, Israel
Locale: Jerusalem, Israel
Gilboa R, Greenblatt H, Perach M, Spungin Bialik A, Lessel U, Wohlfahrt G, et al
. Interactions of Streptomyces griseus aminopeptidase with a methionine product analogue: a structural study at 1.53 A resolution. Acta Crystallogr D Biol Crystallogr. 2000;56:551-8 pubmed
..The structural results are compared with a recent structure of AAP with an hydroxamate inhibitor in order to draw general functional conclusions which are relevant for this family of low molecular-weight aminopeptidases. ..
Gilboa R, Spungin Bialik A, Wohlfahrt G, Schomburg D, Blumberg S, Shoham G. Interactions of Streptomyces griseus aminopeptidase with amino acid reaction products and their implications toward a catalytic mechanism. Proteins. 2001;44:490-504 pubmed
..These structural results have been used for the simulation of several species along the reaction coordinate and for the suggestion of a general scheme for the proteolytic reaction catalyzed by SGAP...
Reiland V, Gilboa R, Spungin Bialik A, Schomburg D, Shoham Y, Blumberg S, et al
. Binding of inhibitory aromatic amino acids to Streptomyces griseus aminopeptidase. Acta Crystallogr D Biol Crystallogr. 2004;60:1738-46 pubmed
..These structural results correlate well with the results obtained for the complexes of SGAP with other inhibitory amino acids and support the general catalytic mechanism proposed for this and related enzymes. ..
Naamati A, Regev Rudzki N, Galperin S, Lill R, Pines O. Dual targeting of Nfs1 and discovery of its novel processing enzyme, Icp55. J Biol Chem. 2009;284:30200-8 pubmed publisher
..Intriguingly, Icp55 protease (like its substrate Nfs1) appears to be dual distributed between the nucleus and mitochondria. ..