Experts and Doctors on hela cells in Cork, Munster, Ireland


Locale: Cork, Munster, Ireland
Topic: hela cells

Top Publications

  1. O Riordan T, Fitzgerald K, Ponomarev G, Mackrill J, Hynes J, Taylor C, et al. Sensing intracellular oxygen using near-infrared phosphorescent probes and live-cell fluorescence imaging. Am J Physiol Regul Integr Comp Physiol. 2007;292:R1613-20 pubmed
  2. Wallace D, Lindsay A, Hendrick A, McCaffrey M. Rab11-FIP4 interacts with Rab11 in a GTP-dependent manner and its overexpression condenses the Rab11 positive compartment in HeLa cells. Biochem Biophys Res Commun. 2002;299:770-9 pubmed
    ..It is likely that Rab11-FIP4 serves as a Rab11 effector in a Rab11 mediated function other than transferrin recycling. ..
  3. Horgan C, Walsh M, Zurawski T, McCaffrey M. Rab11-FIP3 localises to a Rab11-positive pericentrosomal compartment during interphase and to the cleavage furrow during cytokinesis. Biochem Biophys Res Commun. 2004;319:83-94 pubmed
    ..It is likely that Rab11-FIP3 is involved in trafficking events other than Tfn trafficking; these may include the transport of endosomally derived membrane to the cleavage furrow during cytokinesis. ..
  4. Lindsay A, McCaffrey M. Characterisation of the Rab binding properties of Rab coupling protein (RCP) by site-directed mutagenesis. FEBS Lett. 2004;571:86-92 pubmed
    ..Our results indicate that Rab11, rather than Rab4, mediates the intracellular localisation of RCP, and that the class I Rab11-FIPs compete for binding to Rab11. ..
  5. Favre C, Zhdanov A, Leahy M, Papkovsky D, O CONNOR R. Mitochondrial pyrimidine nucleotide carrier (PNC1) regulates mitochondrial biogenesis and the invasive phenotype of cancer cells. Oncogene. 2010;29:3964-76 pubmed publisher
  6. Lindsay A, McCaffrey M. Myosin Va is required for P body but not stress granule formation. J Biol Chem. 2011;286:11519-28 pubmed publisher
  7. Foley K, Young P. An analysis of splicing, actin-binding properties, heterodimerization and molecular interactions of the non-muscle ?-actinins. Biochem J. 2013;452:477-88 pubmed publisher
    ..This significantly alters our view of non-muscle actinin function. ..
  8. Lindsay A, Hendrick A, Cantalupo G, Senic Matuglia F, Goud B, Bucci C, et al. Rab coupling protein (RCP), a novel Rab4 and Rab11 effector protein. J Biol Chem. 2002;277:12190-9 pubmed
    ..RCP is a homologue of Rip11 and therefore belongs to the recently described Rab11-FIP family. ..
  9. Lindsay A, McCaffrey M. The C2 domains of the class I Rab11 family of interacting proteins target recycling vesicles to the plasma membrane. J Cell Sci. 2004;117:4365-75 pubmed
    ..We propose that the C2 domains of the class I Rab11-FIPs function to target these proteins to 'docking sites' in the plasma membrane that are enriched in PtdIns(3,4,5)P3 and phosphatidic acid. ..

More Information


  1. Dmitriev R, Zhdanov A, Ponomarev G, Yashunski D, Papkovsky D. Intracellular oxygen-sensitive phosphorescent probes based on cell-penetrating peptides. Anal Biochem. 2010;398:24-33 pubmed publisher
    ..They provide a simple and versatile tool for O(2) monitoring in live cells and in tissue, and an alternative to the existing O(2) probes which require facilitated transport into the cell. ..
  2. Kelly E, Giordano F, Horgan C, Jollivet F, Raposo G, McCaffrey M. Rab30 is required for the morphological integrity of the Golgi apparatus. Biol Cell. 2012;104:84-101 pubmed publisher
    ..Many Rabs have been extensively characterised whereas others, such as Rab30, have to date received relatively little attention...
  3. Pettigrew C, Clerkin J, Cotter T. DUOX enzyme activity promotes AKT signalling in prostate cancer cells. Anticancer Res. 2012;32:5175-81 pubmed
    ..This report shows that ROS levels in PC3 cells are constitutively maintained by DUOX enzymes, and these ROS positively regulate AKT signalling through inactivating phosphatases, leading to increased resistance to apoptosis. ..
  4. Horgan C, Hanscom S, McCaffrey M. GRAB is a binding partner for the Rab11a and Rab11b GTPases. Biochem Biophys Res Commun. 2013;441:214-9 pubmed publisher
    ..These data identify GRAB as a dual Rab-binding protein that could potentially link Rab3 and Rab11 and/or Rab8 and Rab11-mediated intracellular trafficking processes. ..
  5. Taglauer E, Artemiuk P, Hanscom S, Lindsay A, Wuebbolt D, Breathnach F, et al. Rab11 family expression in the human placenta: Localization at the maternal-fetal interface. PLoS ONE. 2017;12:e0184864 pubmed publisher
    ..Overall these findings highlight the expression of the Rab11 family within the human placenta, with novel localization at the maternal-fetal interface. ..
  6. Lindsay A, McCaffrey M. Rab11-FIP2 functions in transferrin recycling and associates with endosomal membranes via its COOH-terminal domain. J Biol Chem. 2002;277:27193-9 pubmed
    ..This phenotype cannot be reversed by excess wild-type Rab11, or dominant-positive Rab11 (Rab11Q70L), suggesting that Rab11-FIP2 functions downstream of Rab11 in endosomal trafficking. ..