Genomes and Genes
Experts and Doctors on signal transduction in Dublin, Leinster, Ireland
Locale: Dublin, Leinster, Ireland
Topic: signal transduction
Publications182 found, 100 shown here
- Hazenberg J, Hentunen T, Heino T, Kurata K, Lee T, Taylor D. Microdamage detection and repair in bone: fracture mechanics, histology, cell biology. Technol Health Care. 2009;17:67-75 pubmed publisher..Here we show that microcrack accumulation causes damage to the network of cellular processes, resulting in the release of RANKL which stimulates the differentiation of cells specialising in repair. ..
- Babar M, Ryan A, Anderson L, Segurado R, Turner G, Murray L, et al. Genes of the interleukin-18 pathway are associated with susceptibility to Barrett's esophagus and esophageal adenocarcinoma. Am J Gastroenterol. 2012;107:1331-41 pubmed publisher..As both of these SNPs have been demonstrated as expression quantitative trait loci affecting expression of the respective genes, this strongly implicates IL-18 signaling in susceptibility to BE and EAC. ..
- Mori A, Oleszycka E, Sharp F, Coleman M, Ozasa Y, Singh M, et al. The vaccine adjuvant alum inhibits IL-12 by promoting PI3 kinase signaling while chitosan does not inhibit IL-12 and enhances Th1 and Th17 responses. Eur J Immunol. 2012;42:2709-19 pubmed publisher..Therefore, chitosan is an attractive alternative to alum in adjuvants for vaccines where potent cell-mediated immunity is required. ..
- Duffy D, Krstic A, Halasz M, Schwarzl T, Fey D, Iljin K, et al. Integrative omics reveals MYCN as a global suppressor of cellular signalling and enables network-based therapeutic target discovery in neuroblastoma. Oncotarget. 2015;6:43182-201 pubmed publisher..Importantly, this work describes a systems-level approach to systematically uncovering network based vulnerabilities and therapeutic targets for multifactorial diseases by integrating disparate omic data types. ..
- Crean J, Furlong F, Finlay D, Mitchell D, Murphy M, Conway B, et al. Connective tissue growth factor [CTGF]/CCN2 stimulates mesangial cell migration through integrated dissolution of focal adhesion complexes and activation of cell polarization. FASEB J. 2004;18:1541-3 pubmed..These findings begin to shed mechanistic light on the renal diabetic milieu, where increased CTGF expression in the glomerulus contributes to cellular dysfunction. ..
- Rehm M, Huber H, Dussmann H, Prehn J. Systems analysis of effector caspase activation and its control by X-linked inhibitor of apoptosis protein. EMBO J. 2006;25:4338-49 pubmed..Our study supports the hypothesis that high levels of XIAP control caspase activation and substrate cleavage, and may promote apoptosis resistance and sublethal caspase activation in vivo. ..
- Nee L, Tuite N, Ryan M, McMorrow T. TNF-alpha and IL-1 beta-mediated regulation of MMP-9 and TIMP-1 in human glomerular mesangial cells. Nephron Exp Nephrol. 2007;107:e73-86 pubmed..This suggests an important role for pro-inflammatory cytokines in renal disease progression. ..
- Mac Mullan P, Peace A, Madigan A, Tedesco A, Kenny D, McCarthy G. Platelet hyper-reactivity in active inflammatory arthritis is unique to the adenosine diphosphate pathway: a novel finding and potential therapeutic target. Rheumatology (Oxford). 2010;49:240-5 pubmed publisher..Patients with active IA demonstrate enhanced platelet reactivity, unique to the ADP pathway. This potential pro-thrombotic bias may contribute to their increased cardiovascular risk. ..
- Reynolds C, Roche H. Conjugated linoleic acid and inflammatory cell signalling. Prostaglandins Leukot Essent Fatty Acids. 2010;82:199-204 pubmed publisher..Whist CLA may ameliorate certain aspects of the inflammatory response, particularly within cellular and animal models, the relevance of this has yet to be clarified within the context of human health. ..
- Lanigan F, Gremel G, Hughes R, Brennan D, Martin F, Jirstrom K, et al. Homeobox transcription factor muscle segment homeobox 2 (Msx2) correlates with good prognosis in breast cancer patients and induces apoptosis in vitro. Breast Cancer Res. 2010;12:R59 pubmed publisher..We conclude that increased Msx2 expression results in improved outcome for breast cancer patients, possibly by increasing the likelihood of tumour cell death by apoptosis. ..
- Thomas W, Harvey B. Mechanisms underlying rapid aldosterone effects in the kidney. Annu Rev Physiol. 2011;73:335-57 pubmed publisher..This review describes current knowledge regarding the mechanisms and targets of rapid aldosterone action in the nephron and how aldosterone integrates these responses into the regulation of renal physiology. ..
- Keogh B, Parker A. Toll-like receptors as targets for immune disorders. Trends Pharmacol Sci. 2011;32:435-42 pubmed publisher..This review paper outlines the recent advances in the understanding of TLR biology and highlights novel TLR agonists and antagonists in development for the treatment of immune diseases. ..
- Simpson J, Joggerst B, Laketa V, Verissimo F, Cetin C, Erfle H, et al. Genome-wide RNAi screening identifies human proteins with a regulatory function in the early secretory pathway. Nat Cell Biol. 2012;14:764-74 pubmed publisher..This work provides an important resource for an integrative understanding of global cellular organization and regulation of the secretory pathway in mammalian cells...
- Russell S, Moore A, Fallon P, Walsh P. Soluble IL-2R? (sCD25) exacerbates autoimmunity and enhances the development of Th17 responses in mice. PLoS ONE. 2012;7:e47748 pubmed publisher..These data identify the ability of sCD25 to promote autoimmune disease pathogenesis and enhance Th17 responses through its ability to sequester local IL-2. ..
- Scholz C, Taylor C. Hydroxylase-dependent regulation of the NF-?B pathway. Biol Chem. 2013;394:479-93 pubmed publisher..Developing our understanding of the role of hydroxylases in hypoxic inflammation may identify novel therapeutic approaches in chronic inflammatory disease. ..
- Li B, Ní Chonghaile T, Fan Y, Madden S, Klinger R, O Connor A, et al. Therapeutic Rationale to Target Highly Expressed CDK7 Conferring Poor Outcomes in Triple-Negative Breast Cancer. Cancer Res. 2017;77:3834-3845 pubmed publisher..i>Cancer Res; 77(14); 3834-45. Â©2017 AACR. ..
- Brady G, Boggan L, Bowie A, O Neill L. Schlafen-1 causes a cell cycle arrest by inhibiting induction of cyclin D1. J Biol Chem. 2005;280:30723-34 pubmed..Finally, overexpression of Slfn-1 inhibited the activation of the cyclin D1 promoter. Slfn-1 therefore causes a cell cycle arrest during G1 by inhibiting induction of cyclin D1 by mitogens. ..
- Hart O, Athié Morales V, O Connor G, Gardiner C. TLR7/8-mediated activation of human NK cells results in accessory cell-dependent IFN-gamma production. J Immunol. 2005;175:1636-42 pubmed..Therefore, although NK cells can be directly activated by TLRs, accessory cells play an important and sometimes essential role in the activation of effector functions such as IFN-gamma production and cytotoxicity. ..
- Takayasu H, Nakazawa N, Montedonico S, Puri P. Down-regulation of Wnt signal pathway in nitrofen-induced hypoplastic lung. J Pediatr Surg. 2007;42:426-30 pubmed..These data suggest that the down-regulation of Wnt signaling pathway may disrupt branching lung morphogenesis, resulting in pulmonary hypoplasia in the nitrofen rat model of congenital diaphragmatic hernia. ..
- Gao W, Ferguson G, Connell P, Walshe T, Murphy R, Birney Y, et al. High glucose concentrations alter hypoxia-induced control of vascular smooth muscle cell growth via a HIF-1alpha-dependent pathway. J Mol Cell Cardiol. 2007;42:609-19 pubmed..These results suggest that hypoxia-induced changes in vascular cell growth are altered by hyperglycemia via inhibition of HIF-1alpha expression and activity. ..
- Gill C, Walsh S, Morrissey C, Fitzpatrick J, Watson R. Resveratrol sensitizes androgen independent prostate cancer cells to death-receptor mediated apoptosis through multiple mechanisms. Prostate. 2007;67:1641-53 pubmed..Use of resveratrol or inhibition of Akt phosphorylation may represent an important therapeutic approach in combination with conventional therapies for the treatment of prostate cancer. ..
- O Neill L. The interleukin-1 receptor/Toll-like receptor superfamily: 10 years of progress. Immunol Rev. 2008;226:10-8 pubmed publisher..This area has therefore proved very fruitful in terms of improving our knowledge of the molecular basis for innate immunity and inflammation, and we can anticipate further discoveries in the coming years. ..
- Kiely A, Robinson A, McClenaghan N, Flatt P, Newsholme P. Toll-like receptor agonist induced changes in clonal rat BRIN-BD11 beta-cell insulin secretion and signal transduction. J Endocrinol. 2009;202:365-73 pubmed publisher..Further incubation for 24 h in the absence of LPS resulted in the recovery of chronic insulin secretion. The negative beta-cell effects of LPS may contribute to hyperglycaemia in vivo. ..
- Hellwig C, Ludwig Galezowska A, Concannon C, Litchfield D, Prehn J, Rehm M. Activity of protein kinase CK2 uncouples Bid cleavage from caspase-8 activation. J Cell Sci. 2010;123:1401-6 pubmed publisher..We conclude that caspase-8 activation and Bid cleavage are temporally uncoupled events, providing transient tolerance to caspase-8 activities. ..
- Kholodenko B, Hancock J, Kolch W. Signalling ballet in space and time. Nat Rev Mol Cell Biol. 2010;11:414-26 pubmed publisher..They reveal design principles of spatiotemporal organization that are crucial for network function and cell fate decisions. ..
- Ni Ainle F, O Donnell J, Johnson J, Brown L, Gleeson E, Smith O, et al. Activated protein C N-linked glycans modulate cytoprotective signaling function on endothelial cells. J Biol Chem. 2011;286:1323-30 pubmed publisher..Furthermore, our data suggest that plasma ?-protein C, characterized by aberrant N-linked glycosylation at Asn-329, may be particularly important for maintenance of APC cytoprotective functions in vivo. ..
- Sai S, Holland L, McGee C, Lynch D, Butler G. Evolution of mating within the Candida parapsilosis species group. Eukaryot Cell. 2011;10:578-87 pubmed publisher..It is therefore likely either that mating of C. orthopsilosis takes place under certain unidentified conditions or that the mating pathway has been adapted for other functions, such as cross-species communication. ..
- Hogan A, Tobin A, Ahern T, Corrigan M, Gaoatswe G, Jackson R, et al. Glucagon-like peptide-1 (GLP-1) and the regulation of human invariant natural killer T cells: lessons from obesity, diabetes and psoriasis. Diabetologia. 2011;54:2745-54 pubmed publisher..The clinical effect observed and the direct interaction between GLP-1 and the immune system raise the possibility of therapeutic applications for GLP-1 in inflammatory conditions such as psoriasis. ..
- Marignol L, Rivera Figueroa K, Lynch T, Hollywood D. Hypoxia, notch signalling, and prostate cancer. Nat Rev Urol. 2013;10:405-13 pubmed publisher..Evidence to date suggests similar, therapeutically exploitable, behaviour of notch-activated and hypoxic prostate cancer cells. ..
- Zhao Z, Liao G, Zhou Q, Lv D, Holthfer H, Zou H. Sulforaphane Attenuates Contrast-Induced Nephropathy in Rats via Nrf2/HO-1 Pathway. Oxid Med Cell Longev. 2016;2016:9825623 pubmed publisher..SFN increased cell viability and attenuated ROS level in vitro. Conclusions. SFN attenuates experimental CIN in vitro and in vivo. This effect is suggested to activate the Nrf2 antioxidant defenses pathway. ..
- Mills E, Kelly B, O Neill L. Mitochondria are the powerhouses of immunity. Nat Immunol. 2017;18:488-498 pubmed publisher..These discoveries are revealing mitochondrial targets that could potentially be exploited for therapeutic gain in inflammation and cancer. ..
- Sadiku P, Willson J, Dickinson R, Murphy F, Harris A, Lewis A, et al. Prolyl hydroxylase 2 inactivation enhances glycogen storage and promotes excessive neutrophilic responses. J Clin Invest. 2017;127:3407-3420 pubmed publisher..These results demonstrate the therapeutic potential of targeting metabolic pathways in the treatment of inflammatory disease. ..
- Inder S, O Rourke S, McDermott N, Manecksha R, Finn S, Lynch T, et al. The Notch-3 receptor: A molecular switch to tumorigenesis?. Cancer Treat Rev. 2017;60:69-76 pubmed publisher..Molecular profiling strategies are increasingly incorporated into clinical decision making. This review aims to evaluate the clinical potential of Notch-3 within this new era of personalised medicine. ..
- Farrelly A, Wobser H, Bonner C, Anguissola S, Rehm M, Concannon C, et al. Early loss of mammalian target of rapamycin complex 1 (mTORC1) signalling and reduction in cell size during dominant-negative suppression of hepatic nuclear factor 1-alpha (HNF1A) function in INS-1 insulinoma cells. Diabetologia. 2009;52:136-44 pubmed publisher..Our data suggest that mTOR kinase and signalling through mTORC1 are highly sensitive to suppression of HNF1A function, and may contribute to disturbance of cell-size regulation and cell-cycle progression in HNF1A-MODY. ..
- Cummins E, Oliver K, Lenihan C, Fitzpatrick S, Bruning U, Scholz C, et al. NF-?B links CO2 sensing to innate immunity and inflammation in mammalian cells. J Immunol. 2010;185:4439-45 pubmed publisher..These results suggest the existence of a molecular CO(2) sensor in mammalian cells that is linked to the regulation of genes involved in innate immunity and inflammation. ..
- Lawless M, Greene C, Mulgrew A, Taggart C, O Neill S, McElvaney N. Activation of endoplasmic reticulum-specific stress responses associated with the conformational disease Z alpha 1-antitrypsin deficiency. J Immunol. 2004;172:5722-6 pubmed..These findings have important implications for the design of future therapeutics for Z A1AT liver disease and may also impact on drug design for other conformational diseases. ..
- DiPerna G, Stack J, Bowie A, Boyd A, Kotwal G, Zhang Z, et al. Poxvirus protein N1L targets the I-kappaB kinase complex, inhibits signaling to NF-kappaB by the tumor necrosis factor superfamily of receptors, and inhibits NF-kappaB and IRF3 signaling by toll-like receptors. J Biol Chem. 2004;279:36570-8 pubmed..Furthermore, N1L inhibited IRF3 signaling, which is also regulated by TBK1. These studies define a role for N1L as an immunomodulator of innate immunity by targeting components of NF-kappaB and IRF3 signaling pathways. ..
- Ryan S, McNicholas W, Taylor C. A critical role for p38 map kinase in NF-kappaB signaling during intermittent hypoxia/reoxygenation. Biochem Biophys Res Commun. 2007;355:728-33 pubmed..Furthermore, depletion of p38 using siRNA significantly reduces IHR-induced NF-kappaB activity. Thus, IHR activates NF-kappaB in an IKK-dependent manner signaled at least in part via activation of p38 MAPK. ..
- Blacque O, Cevik S, Kaplan O. Intraflagellar transport: from molecular characterisation to mechanism. Front Biosci. 2008;13:2633-52 pubmed..Here we present a comprehensive review of IFT, with particular emphasis on its molecular composition and mechanism of action. ..
- Wikström K, Kavanagh D, Reid H, Kinsella B. Differential regulation of RhoA-mediated signaling by the TPalpha and TPbeta isoforms of the human thromboxane A2 receptor: independent modulation of TPalpha signaling by prostacyclin and nitric oxide. Cell Signal. 2008;20:1497-512 pubmed publisher..Data herein provide essential new insights into the physiologic roles of TPalpha and TPbeta and, through studies in AoSMCs, reveal an additional mode of regulation of VSM contractile responses by TXA(2). ..
- Kenny E, Talbot S, Gong M, Golenbock D, Bryant C, O Neill L. MyD88 adaptor-like is not essential for TLR2 signaling and inhibits signaling by TLR3. J Immunol. 2009;183:3642-51 pubmed publisher..An inhibitory role for Mal in TLR3 signaling to JNK was also demonstrated. ..
- Carpenter S, Wochal P, Dunne A, O Neill L. Toll-like receptor 3 (TLR3) signaling requires TLR4 Interactor with leucine-rich REPeats (TRIL). J Biol Chem. 2011;286:38795-804 pubmed publisher..Most accessory molecules identified to date, such as CD14, gp96, PRAT4a, and Unc93B, all play roles in multiple TLR signaling pathways, and we now show that this is also the case for TRIL. ..
- O Boyle N, Meegan M. Designed multiple ligands for cancer therapy. Curr Med Chem. 2011;18:4722-37 pubmed..The review also provides brief commentaries on the biological processes and proteins that are currently targeted in cancer therapy and the potential for dual or triple targeting of these with designed multiple ligands. ..
- Cathcart M, O Byrne K, Reynolds J, O Sullivan J, Pidgeon G. COX-derived prostanoid pathways in gastrointestinal cancer development and progression: novel targets for prevention and intervention. Biochim Biophys Acta. 2012;1825:49-63 pubmed publisher..I. cancers will also be discussed. Finally, we will highlight the latest pre-clinical technologies as well as avenues for future investigation in this highly topical research field. ..
- Cathcart M, Lysaght J, Pidgeon G. Eicosanoid signalling pathways in the development and progression of colorectal cancer: novel approaches for prevention/intervention. Cancer Metastasis Rev. 2011;30:363-85 pubmed publisher..Finally, novel approaches targeting these arachidonic acid-derived eicosanoids (using pharmacological or natural agents) for chemoprevention and/or treatment of colorectal cancer are outlined. ..
- Ding C, Vidanes G, Maguire S, Guida A, Synnott J, Andes D, et al. Conserved and divergent roles of Bcr1 and CFEM proteins in Candida parapsilosis and Candida albicans. PLoS ONE. 2011;6:e28151 pubmed publisher..parapsilosis. Our data suggest that the role of the CFEM family in iron acquisition is conserved between C. albicans and C. parapsilosis, but their role in biofilm formation is not. ..
- Brennan K, McSherry E, Hudson L, Kay E, Hill A, Young L, et al. Junctional adhesion molecule-A is co-expressed with HER2 in breast tumors and acts as a novel regulator of HER2 protein degradation and signaling. Oncogene. 2013;32:2799-804 pubmed publisher..Furthermore, we speculate that JAM-A may regulate HER2 proteasomal degradation and activity, potentially offering a promise as a therapeutic target in HER2-positive breast cancers. ..
- Stevenson N, Bourke N, Ryan E, Binder M, Fanning L, Johnston J, et al. Hepatitis C virus targets the interferon-? JAK/STAT pathway by promoting proteasomal degradation in immune cells and hepatocytes. FEBS Lett. 2013;587:1571-8 pubmed publisher..These findings show that HCV inhibits IFN-? responses in a broad spectrum of cells via proteasomal degradation of JAK/STAT pathway components. ..
- Sanchez N, Gallagher M, Lao N, Gallagher C, Clarke C, Doolan P, et al. MiR-7 triggers cell cycle arrest at the G1/S transition by targeting multiple genes including Skp2 and Psme3. PLoS ONE. 2013;8:e65671 pubmed publisher..This work provides further mechanistic insight into the role of miR-7 as a regulator of cell growth in times of cellular stress. ..
- Heavey S, O Byrne K, Gately K. Strategies for co-targeting the PI3K/AKT/mTOR pathway in NSCLC. Cancer Treat Rev. 2014;40:445-56 pubmed publisher..The identification of appropriate patient cohorts who will benefit from PI3K co-targeted inhibition strategies will be key to the success of these inhibitors. ..
- Nguyen L, Kholodenko B. Feedback regulation in cell signalling: Lessons for cancer therapeutics. Semin Cell Dev Biol. 2016;50:85-94 pubmed publisher..We discuss mechanisms of drug resistance caused by network adaptations and suggest that development of effective drug combinations requires understanding of how feedback loops modulate drug responses. ..
- Viel S, MarÃ§ais A, Guimaraes F, Loftus R, Rabilloud J, Grau M, et al. TGF-Î² inhibits the activation and functions of NK cells by repressing the mTOR pathway. Sci Signal. 2016;9:ra19 pubmed publisher..Moreover, we propose that boosting the metabolic activity of antitumor lymphocytes could be an effective strategy to promote immune-mediated tumor suppression. ..
- Kinsella S, König H, Prehn J. Bid Promotes K63-Linked Polyubiquitination of Tumor Necrosis Factor Receptor Associated Factor 6 (TRAF6) and Sensitizes to Mutant SOD1-Induced Proinflammatory Signaling in Microglia. Eneuro. 2016;3: pubmed publisher..Bid promotes TLR4-NF-?B signaling by interacting with TRAF6 and promoting TRAF6 K63-linked polyubiquitination in microglia. ..
- English J, Dicker P, Föcking M, Dunn M, Cotter D. 2-D DIGE analysis implicates cytoskeletal abnormalities in psychiatric disease. Proteomics. 2009;9:3368-82 pubmed publisher..The data presented here strongly suggest disruption of the cytoskeleton and its associated signal transduction proteins in schizophrenia, and to a lesser extent in bipolar disorder. ..
- Duggan S, Behan F, Kirca M, Smith S, Reynolds J, Long A, et al. An integrative genomic approach in oesophageal cells identifies TRB3 as a bile acid responsive gene, downregulated in Barrett's oesophagus, which regulates NF-kappaB activation and cytokine levels. Carcinogenesis. 2010;31:936-45 pubmed publisher..This study identifies mechanisms through which bile acids such as DCA, in conjunction with the loss of key signalling molecules, could regulate oesophageal metaplasticity. ..
- ROONEY B, O Donovan H, Gaffney A, Browne M, Faherty N, Curran S, et al. CTGF/CCN2 activates canonical Wnt signalling in mesangial cells through LRP6: implications for the pathogenesis of diabetic nephropathy. FEBS Lett. 2011;585:531-8 pubmed publisher..Catenin is increased in type 1 diabetic and UUO mice and in in vitro models of hyperglycaemia and hypertension. These findings suggest that Wnt/CCN2 signalling plays a role in the pathogenesis of diabetic nephropathy. ..
- Cahill E, Costello C, Rowan S, Harkin S, Howell K, Leonard M, et al. Gremlin plays a key role in the pathogenesis of pulmonary hypertension. Circulation. 2012;125:920-30 pubmed publisher..High levels of basal gremlin expression in the lung may account for the unique vulnerability of the pulmonary circulation to heterozygous mutations of BMP type 2 receptor in pulmonary arterial hypertension. ..
- Egan B, Zierath J. Exercise metabolism and the molecular regulation of skeletal muscle adaptation. Cell Metab. 2013;17:162-84 pubmed publisher..Here, we review the metabolic responses and molecular mechanisms that underpin the adaptatation of skeletal muscle to acute exercise and exercise training. ..
- Lynch J, Meehan M, Crean J, Copeland J, Stallings R, Bray I. Metastasis suppressor microRNA-335 targets the formin family of actin nucleators. PLoS ONE. 2013;8:e78428 pubmed publisher..We conclude that miR-335 is a master regulator of tumour cell migration and invasion by directly targeting a plethora of genes that effectively control cell migratory processes. ..
- Corcionivoschi N, Alvarez L, Sharp T, Strengert M, Alemka A, Mantell J, et al. Mucosal reactive oxygen species decrease virulence by disrupting Campylobacter jejuni phosphotyrosine signaling. Cell Host Microbe. 2012;12:47-59 pubmed publisher..Thus, epithelial NADPH oxidases are an early antibacterial defense system in the intestinal mucosa that modifies virulence by disrupting bacterial signaling. ..
- Charmsaz S, Hughes E, Bane F, Tibbitts P, McIlroy M, Byrne C, et al. S100? as a serum marker in endocrine resistant breast cancer. BMC Med. 2017;15:79 pubmed publisher..ClinicalTrials.gov, NCT01840293 ). Registered on 23 April 2013. Retrospectively registered. ..
- Nolan C, McCarthy K, Eivers E, Jirtle R, Byrnes L. Mannose 6-phosphate receptors in an ancient vertebrate, zebrafish. Dev Genes Evol. 2006;216:144-51 pubmed..Our study establishes zebrafish as a novel, genetically tractable model for in vivo studies of MPR function and lysosome biogenesis. ..
- Cathcart M, Reynolds J, O Byrne K, Pidgeon G. The role of prostacyclin synthase and thromboxane synthase signaling in the development and progression of cancer. Biochim Biophys Acta. 2010;1805:153-66 pubmed publisher..Finally, we discuss current therapeutic strategies aimed at targeting these enzymes for the prevention/treatment of cancer. ..
- Costello D, Watson M, Cowley T, Murphy N, Murphy Royal C, Garlanda C, et al. Interleukin-1alpha and HMGB1 mediate hippocampal dysfunction in SIGIRR-deficient mice. J Neurosci. 2011;31:3871-9 pubmed publisher..These findings highlight the functional role of SIGIRR in regulating inflammatory-mediated synaptic and cognitive decline, and describe evidence of the key role of HMGB1 in this process. ..
- Stack J, Bowie A. Poxviral protein A46 antagonizes Toll-like receptor 4 signaling by targeting BB loop motifs in Toll-IL-1 receptor adaptor proteins to disrupt receptor:adaptor interactions. J Biol Chem. 2012;287:22672-82 pubmed publisher..This study provides the molecular basis for pathogen subversion of TLR4 signaling and clarifies the importance of TIR motif BB loops, which have been selected for viral antagonism, in the formation of the TLR4 complex...
- Murphy A, O Keeffe K, Lalor S, Maher B, Mills K, McLoughlin R. Staphylococcus aureus infection of mice expands a population of memory ?? T cells that are protective against subsequent infection. J Immunol. 2014;192:3697-708 pubmed publisher..aureus, in a fashion analogous to that associated with classical ?? T cells, and suggest that induction of IL-17-expressing ?? T cells may be an important property of a protective vaccine against S. aureus...
- Looby E, Abdel Latif M, Athié Morales V, Duggan S, Long A, Kelleher D. Deoxycholate induces COX-2 expression via Erk1/2-, p38-MAPK and AP-1-dependent mechanisms in esophageal cancer cells. BMC Cancer. 2009;9:190 pubmed publisher..DCA regulates both apoptosis and COX-2-regulated cell survival in esophageal cells suggesting that the balance between these two opposing signals may determine the transformation potential of DCA as a component of the refluxate. ..
- Dean J, Hashimoto K, Tsuji T, Gautier V, Hall W, Sheehy N. Functional interaction of HTLV-1 tax protein with the POZ domain of the transcriptional repressor BCL6. Oncogene. 2009;28:3723-34 pubmed publisher..This suggests that the expression of BCL6 in HTLV infected cells may contribute to the silencing of viral gene expression and to the long clinical latency associated with HTLV infection...
- McEneaney V, Dooley R, Harvey B, Thomas W. Protein kinase D stabilizes aldosterone-induced ERK1/2 MAP kinase activation in M1 renal cortical collecting duct cells to promote cell proliferation. J Steroid Biochem Mol Biol. 2010;118:18-28 pubmed publisher..This sub-cellular distribution of ERK1/2 was inhibited in cells suppressed in the expression of PKD1. ..
- Elgendy M, Sheridan C, Brumatti G, Martin S. Oncogenic Ras-induced expression of Noxa and Beclin-1 promotes autophagic cell death and limits clonogenic survival. Mol Cell. 2011;42:23-35 pubmed publisher..Thus, Ras-induced expression of Noxa and Beclin-1 promotes autophagic cell death, which represents a mechanism to limit the oncogenic potential of deregulated Ras signals. ..
- Saber T, Veale D, Balogh E, McCormick J, Nicanultaigh S, Connolly M, et al. Toll-like receptor 2 induced angiogenesis and invasion is mediated through the Tie2 signalling pathway in rheumatoid arthritis. PLoS ONE. 2011;6:e23540 pubmed publisher..This study investigates the effect of TLR2 on angiogenesis, EC adhesion and invasion using microvascular endothelial cells and RA whole tissue synovial explants ex-vivo...
- Montedonico S, Nakazawa N, Puri P. Congenital diaphragmatic hernia and retinoids: searching for an etiology. Pediatr Surg Int. 2008;24:755-61 pubmed publisher..Finally, we describe the existing evidence of a disruption of the retinoid-signaling pathway in CDH. ..
- Brennan K, Bowie A. Activation of host pattern recognition receptors by viruses. Curr Opin Microbiol. 2010;13:503-7 pubmed publisher..Another novel mechanism of viral DNA recognition unveiled, leading to proinflammatory cytokine production, involves the PYHIN family member AIM2. ..
- Mullen A, Loscher C, Roche H. Anti-inflammatory effects of EPA and DHA are dependent upon time and dose-response elements associated with LPS stimulation in THP-1-derived macrophages. J Nutr Biochem. 2010;21:444-50 pubmed publisher..Immune responses are dynamic, and the present study suggests a nutrient sensitive window of LPS activation at which EPA and DHA are strongly anti-inflammatory. ..
- Doi T, Puri P, Bannigan J, Thompson J. Disruption of calreticulin-mediated cellular adhesion signaling in the cadmium-induced omphalocele in the chick model. Pediatr Surg Int. 2010;26:91-5 pubmed publisher..05). There were no significant differences at 8H. Downregulation of CRT, E-cadherin and beta-catenin genes may cause omphalocele in the Cd chick model by disrupting CRT-mediated Ca(2+) signaling and AJs. ..
- Hams E, McCarron M, Amu S, Yagita H, Azuma M, Chen L, et al. Blockade of B7-H1 (programmed death ligand 1) enhances humoral immunity by positively regulating the generation of T follicular helper cells. J Immunol. 2011;186:5648-55 pubmed publisher..This finding has direct implications for investigations examining the feasibility of therapeutically manipulating this pathway and reveals new insights into the regulation of the humoral immune response. ..
- Sweeney C, Morrow D, Birney Y, Coyle S, Hennessy C, Scheller A, et al. Notch 1 and 3 receptor signaling modulates vascular smooth muscle cell growth, apoptosis, and migration via a CBF-1/RBP-Jk dependent pathway. FASEB J. 2004;18:1421-3 pubmed..Notch signaling, therefore, represents a novel therapeutic target for disease states in which changes in vascular cell fate occur in vivo. ..
- Dunne A, Carpenter S, Brikos C, Gray P, Strelow A, Wesche H, et al. IRAK1 and IRAK4 promote phosphorylation, ubiquitination, and degradation of MyD88 adaptor-like (Mal). J Biol Chem. 2010;285:18276-82 pubmed publisher..We therefore conclude that Mal is a substrate for IRAK1 and IRAK4 with phosphorylation promoting ubiquitination and degradation of Mal. This process may serve to negatively regulate signaling by TLR2 and TLR4. ..
- Tegtmeyer N, Wessler S, Backert S. Role of the cag-pathogenicity island encoded type IV secretion system in Helicobacter pylori pathogenesis. FEBS J. 2011;278:1190-202 pubmed publisher..The contribution of these signalling pathways to pathogenesis during H. pylori infections is discussed. ..
- Forde H, Harper E, Davenport C, Rochfort K, Wallace R, Murphy R, et al. The beneficial pleiotropic effects of tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) within the vasculature: A review of the evidence. Atherosclerosis. 2016;247:87-96 pubmed publisher..To this end, extensive in vitro, in vivo, and clinical studies will be reviewed and critical findings highlighted. ..
- Murphy M, Docherty N, Griffin B, Howlin J, McArdle E, McMahon R, et al. IHG-1 amplifies TGF-beta1 signaling and is increased in renal fibrosis. J Am Soc Nephrol. 2008;19:1672-80 pubmed publisher..In summary, IHG-1, which increases in diabetic nephropathy, may enhance the actions of TGF-beta1 and contribute to the development of tubulointerstitial fibrosis. ..