Genomes and Genes
Experts and Doctors on animals in Dublin, Leinster, Ireland
Locale: Dublin, Leinster, Ireland
Publications488 found, 100 shown here
- Dirks J, Taylor D. Fracture toughness of locust cuticle. J Exp Biol. 2012;215:1502-8 pubmed publisher..These findings thus might inspire the development of new biomimetic composite materials...
- Dunne E, Spring C, Reheman A, Jin W, Berndt M, Newman D, et al. Cadherin 6 has a functional role in platelet aggregation and thrombus formation. Arterioscler Thromb Vasc Biol. 2012;32:1724-31 pubmed publisher..This study demonstrates the role of cadherin 6 as a novel ligand for α(IIb)β(3) and highlights its function in thrombus formation. ..
- Doi T, Puri P, Bannigan J, Thompson J. Eya1 and Eya2 gene expression is down-regulated during somitic myogenesis in the cadmium-induced omphalocele chick model. J Pediatr Surg. 2012;47:1123-7 pubmed publisher..Down-regulation of Eya genes during the critical period of early embryogenesis may contribute to omphalocele phenotype in the Cd chick model, interfering with migration of embryonic body wall ventrally. ..
- O KEEFFE M, Crabbe P, Salden M, Wichers J, Van Peteghem C, Kohen F, et al. Preliminary evaluation of a lateral flow immunoassay device for screening urine samples for the presence of sulphamethazine. J Immunol Methods. 2003;278:117-26 pubmed..The LFIA device has been fabricated as a test kit for determining SMZ residues in animals produced for slaughter. ..
- Flannery O, Britton J, O Reilly P, Mahony N, Prendergast P, Kenny P. The threshold force required for femoral impaction grafting in revision hip surgery. Acta Orthop. 2010;81:303-7 pubmed publisher..28 mm. We achieved a stable construct without fracture. Further studies using human cadaveric femurs should be done to determine the threshold force required for femoral impaction grafting in revision hip surgery. ..
- McNeela E, Burke A, Neill D, Baxter C, Fernandes V, Ferreira D, et al. Pneumolysin activates the NLRP3 inflammasome and promotes proinflammatory cytokines independently of TLR4. PLoS Pathog. 2010;6:e1001191 pubmed publisher..Furthermore, NLRP3 was required for protective immunity against respiratory infection with S. pneumoniae. These results add significantly to our understanding of the interactions between PLY and the immune system. ..
- Sheridan G, Dev K. S1P1 receptor subtype inhibits demyelination and regulates chemokine release in cerebellar slice cultures. Glia. 2012;60:382-92 pubmed publisher..The study supports the concept that FTY720 attenuates demyelination by not only preventing S1PR-mediated T cell migration into the CNS but also by limiting cytokine communication between cells of the immune system and the CNS. ..
- Murphy N, Lynch M. Activation of the P2X? receptor induces migration of glial cells by inducing cathepsin B degradation of tissue inhibitor of metalloproteinase 1. J Neurochem. 2012;123:761-70 pubmed publisher..We also present data that indicate that ATP or cell damage induces glial cell migration, which is inhibited by P2X(7) antagonism, depletion of MMP-9 or inhibition of cathepsin B. ..
- Claro T, Widaa A, McDonnell C, Foster T, O Brien F, Kerrigan S. Staphylococcus aureus protein A binding to osteoblast tumour necrosis factor receptor 1 results in activation of nuclear factor kappa B and release of interleukin-6 in bone infection. Microbiology. 2013;159:147-54 pubmed publisher..Anti-inflammatory drug therapy could be used either alone or in conjunction with antibiotics to treat osteomyelitis or for prophylaxis in high-risk patients...
- McCarthy C, Lieggi N, Barry D, Mooney D, de Gaetano M, James W, et al. Macrophage PPAR gamma Co-activator-1 alpha participates in repressing foam cell formation and atherosclerosis in response to conjugated linoleic acid. EMBO Mol Med. 2013;5:1443-57 pubmed publisher..Importantly, macrophage specific deletion of PGC-1? accelerated atherosclerosis in the LDLR(-/-) mouse in vivo. These novel data support a functional role for PGC-1? in atheroprotection. ..
- Wu D, Sun D. Application of visible and near infrared hyperspectral imaging for non-invasively measuring distribution of water-holding capacity in salmon flesh. Talanta. 2013;116:266-76 pubmed publisher..The overall results show that the laborious, time-consuming, and destructive traditional techniques could be replaced by hyperspectral imaging to provide a rapid and non-invasive measurement of WHC distribution in salmon flesh...
- Selfridge A, Cavadas M, Scholz C, Campbell E, Welch L, Lecuona E, et al. Hypercapnia Suppresses the HIF-dependent Adaptive Response to Hypoxia. J Biol Chem. 2016;291:11800-8 pubmed publisher..Therefore, hypercapnia may play a key role in the pathophysiology of diseases where HIF is implicated. ..
- Taylor D. Fatigue of bone and bones: an analysis based on stressed volume. J Orthop Res. 1998;16:163-9 pubmed..Failure within 10(5) cycles is expected to occur at cyclic stresses of 23-30 MPa in human long bones and of 32-43 MPa in bovine bones. Repair is therefore needed to prevent failure at physiological stress levels. ..
- Lynn D, Lloyd A, O Farrelly C. In silico identification of components of the Toll-like receptor (TLR) signaling pathway in clustered chicken expressed sequence tags (ESTs). Vet Immunol Immunopathol. 2003;93:177-84 pubmed..We have identified in silico the full-length sequence for liver-expressed antimicrobial peptide 2 (LEAP-2). This is the first time a non-mammalian LEAP-2 has been described. ..
- Laffey J, Honan D, Hopkins N, Hyvelin J, Boylan J, McLoughlin P. Hypercapnic acidosis attenuates endotoxin-induced acute lung injury. Am J Respir Crit Care Med. 2004;169:46-56 pubmed..The beneficial actions of hypercapnic acidosis were not mediated by inhibition of peroxynitrite-induced nitration within proteins...
- Brint E, Xu D, Liu H, Dunne A, McKenzie A, O Neill L, et al. ST2 is an inhibitor of interleukin 1 receptor and Toll-like receptor 4 signaling and maintains endotoxin tolerance. Nat Immunol. 2004;5:373-9 pubmed..Thus, these results provide a molecular explanation for the function of ST2 in T(H)2 responses, as inhibition of TLRs promotes a T(H)2 response, and also identify ST2 as a key regulator of endotoxin tolerance. ..
- O Reilly S, Leonard M, Kieran N, Comerford K, Cummins E, Pouliot M, et al. Hypoxia induces epithelial amphiregulin gene expression in a CREB-dependent manner. Am J Physiol Cell Physiol. 2006;290:C592-600 pubmed..These data also further support a role for CREB as an HIF-independent hypoxia-responsive transcription factor in the regulation of intestinal epithelial gene expression. ..
- Taggart C, Cryan S, Weldon S, Gibbons A, Greene C, Kelly E, et al. Secretory leucoprotease inhibitor binds to NF-kappaB binding sites in monocytes and inhibits p65 binding. J Exp Med. 2005;202:1659-68 pubmed..Therefore, SLPI inhibition of NF-kappaB activation is mediated, in part, by competitive binding to the NF-kappaB consensus-binding site. ..
- De Waal D, Combrink M. Live vaccines against bovine babesiosis. Vet Parasitol. 2006;138:88-96 pubmed..Despite considerable research efforts into the development of alternative more consumer friendly vaccines, none is immediately forthcoming and the live attenuated babesiosis vaccines are still used in many countries. ..
- Parkinson M, O Neill S, Dalton J. Endemic human fasciolosis in the Bolivian Altiplano. Epidemiol Infect. 2007;135:669-74 pubmed..In Los Andes incidences of up to 67% of population cohorts were found, and prevalence is age-related with the highest infection rate in children aged 8-11 years. ..
- O Sullivan N, McGettigan P, Sheridan G, Pickering M, Conboy L, O Connor J, et al. Temporal change in gene expression in the rat dentate gyrus following passive avoidance learning. J Neurochem. 2007;101:1085-98 pubmed..Thus, the memory-associated transcriptional cascade supports the cardinal periods of synaptic loosening, reorganisation and selection thought to underpin the process of long-term memory consolidation in the hippocampus. ..
- Gao W, Ferguson G, Connell P, Walshe T, Murphy R, Birney Y, et al. High glucose concentrations alter hypoxia-induced control of vascular smooth muscle cell growth via a HIF-1alpha-dependent pathway. J Mol Cell Cardiol. 2007;42:609-19 pubmed..These results suggest that hypoxia-induced changes in vascular cell growth are altered by hyperglycemia via inhibition of HIF-1alpha expression and activity. ..
- Geraghty P, Rogan M, Greene C, Boxio R, Poiriert T, O Mahony M, et al. Neutrophil elastase up-regulates cathepsin B and matrix metalloprotease-2 expression. J Immunol. 2007;178:5871-8 pubmed..This has important implications for therapeutic intervention in protease-mediated diseases. ..
- Walsh C, Smith P, Fallon P. Role for CTLA-4 but not CD25+ T cells during Schistosoma mansoni infection of mice. Parasite Immunol. 2007;29:293-308 pubmed..This study illustrates the complexity of regulation of T cells in schistosome infection and highlights a specific role for CTLA-4+, but not CD25+ cells, in the regulation of Th2 responses in helminth infection. ..
- Zielak A, Canty M, Forde N, Coussens P, Smith G, Lonergan P, et al. Differential expression of genes for transcription factors in theca and granulosa cells following selection of a dominant follicle in cattle. Mol Reprod Dev. 2008;75:904-14 pubmed
- Montedonico S, Sugimoto K, Felle P, Bannigan J, Puri P. Prenatal treatment with retinoic acid promotes pulmonary alveologenesis in the nitrofen model of congenital diaphragmatic hernia. J Pediatr Surg. 2008;43:500-7 pubmed publisher..Our results demonstrate that prenatal treatment with retinoic acid stimulates alveologenesis in hypoplastic lungs in CDH. ..
- O Regan E, McCabe E, Burgess C, McGuinness S, Barry T, Duffy G, et al. Development of a real-time multiplex PCR assay for the detection of multiple Salmonella serotypes in chicken samples. BMC Microbiol. 2008;8:156 pubmed publisher..Thirty cultures blind tested were correctly identified by the real-time multiplex PCR method. Real-time PCR methodology can contribute to meet the need for rapid identification and detection methods in food testing laboratories. ..
- Graciet E, Walter F, Ó Maoiléidigh D, Pollmann S, Meyerowitz E, Varshavsky A, et al. The N-end rule pathway controls multiple functions during Arabidopsis shoot and leaf development. Proc Natl Acad Sci U S A. 2009;106:13618-23 pubmed publisher..Our results suggest that AtATE1 and AtATE2 act redundantly with AS1, but independently of auxin, in the control of leaf development. ..
- Cederlund M, Morrissey M, Baden T, Scholz D, Vendrell V, Lagnado L, et al. Zebrafish Tg(7.2mab21l2:EGFP)ucd2 transgenics reveal a unique population of retinal amacrine cells. Invest Ophthalmol Vis Sci. 2011;52:1613-21 pubmed publisher..CONCLUSIONS; The novel transgenic line Tg(7.2mab21l2:EGFP)ucd2 uncovers a unique subpopulation of retinal amacrine cells. ..
- Fitzpatrick S, Tambuwala M, Bruning U, Schaible B, Scholz C, Byrne A, et al. An intact canonical NF-?B pathway is required for inflammatory gene expression in response to hypoxia. J Immunol. 2011;186:1091-6 pubmed publisher..These results implicate an essential role for NF-?B signaling in inflammatory gene expression in response to hypoxia both through the regulation of HIF-1 and through direct effects upon target gene expression. ..
- Rakovich T, Boland C, Bernstein I, Chikwana V, Iwata Reuyl D, Kelly V. Queuosine deficiency in eukaryotes compromises tyrosine production through increased tetrahydrobiopterin oxidation. J Biol Chem. 2011;286:19354-63 pubmed publisher..Our data suggest that queuosine modification limits BH4 oxidation in vivo and thereby potentially impacts on numerous physiological processes in eukaryotes. ..
- Ennis C, McDowell D, Bolton D. The prevalence, distribution and characterization of Shiga toxin-producing Escherichia coli (STEC) serotypes and virulotypes from a cluster of bovine farms. J Appl Microbiol. 2012;113:1238-48 pubmed publisher..The data presented provide further evidence of the emergence of new STEC virulotypes of potential public health significance. ..
- Cullen S, Henry C, Kearney C, Logue S, Feoktistova M, Tynan G, et al. Fas/CD95-induced chemokines can serve as "find-me" signals for apoptotic cells. Mol Cell. 2013;49:1034-48 pubmed publisher..Thus, in addition to provoking apoptosis, Fas receptor stimulation can trigger the secretion of chemotactic factors and other immunologically active proteins that can influence immune responsiveness toward dying cells. ..
- Heilbronner S, Hanses F, Monk I, Speziale P, Foster T. Sortase A promotes virulence in experimental Staphylococcus lugdunensis endocarditis. Microbiology. 2013;159:2141-52 pubmed publisher..Mutants defective in single surface proteins Fbl or vWbl were not significantly different from the wild-type but showed trends towards reduced virulence. ..
- Furlong E, Keon N, Thornton F, Rein T, Martin F. Expression of a 74-kDa nuclear factor 1 (NF1) protein is induced in mouse mammary gland involution. Involution-enhanced occupation of a twin NF1 binding element in the testosterone-repressed prostate message-2/clusterin promoter. J Biol Chem. 1996;271:29688-97 pubmed
- Gormley E, Collins J. The development of wildlife control strategies for eradication of tuberculosis in cattle in Ireland. Tuber Lung Dis. 2000;80:229-36 pubmed..Any proposed vaccination programme would need to be undertaken against the background of an exhaustive investigation of the cattle and herd management-related factors, and take account of environmental issues. ..
- Fitzgerald K, Palsson McDermott E, Bowie A, Jefferies C, Mansell A, Brady G, et al. Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction. Nature. 2001;413:78-83 pubmed..Mal associates with TLR-4. Mal is therefore an adapter in TLR-4 signal transduction. ..
- Lynch A, Moore M, Craig S, Lonergan P, Martin D, Lynch M. Analysis of interleukin-1 beta-induced cell signaling activation in rat hippocampus following exposure to gamma irradiation. Protective effect of eicosapentaenoic acid. J Biol Chem. 2003;278:51075-84 pubmed..The data are consistent with the idea that EPA exerts anti-inflammatory and neuroprotective effects in the central nervous system. ..
- O Meara S, Kinsella B. The effect of the farnesyl protein transferase inhibitor SCH66336 on isoprenylation and signalling by the prostacyclin receptor. Biochem J. 2005;386:177-89 pubmed..These data confirm that the -CSLC motif of the IP is a direct target for inhibition by the FTI SCH66336, and in the presence of strong FTase inhibition, the IP does not undergo compensatory geranylgeranylation ..
- Maderna P, Yona S, Perretti M, Godson C. Modulation of phagocytosis of apoptotic neutrophils by supernatant from dexamethasone-treated macrophages and annexin-derived peptide Ac(2-26). J Immunol. 2005;174:3727-33 pubmed..In conclusion, these results emphasize the pivotal role of annexin 1 as mediator for clearance of apoptotic cells and expand its potential therapeutic role in controlling inflammatory diseases. ..
- Bell A, Monaghan P, Page A. Peptidyl-prolyl cis-trans isomerases (immunophilins) and their roles in parasite biochemistry, host-parasite interaction and antiparasitic drug action. Int J Parasitol. 2006;36:261-76 pubmed
- Rodriguez F, Rozas I, Kaiser M, Brun R, Nguyen B, Wilson W, et al. New bis(2-aminoimidazoline) and bisguanidine DNA minor groove binders with potent in vivo antitrypanosomal and antiplasmodial activity. J Med Chem. 2008;51:909-23 pubmed publisher..No correlation between antiplasmodial activity and in vitro inhibition of ferriprotoporphyrin IX biomineralisation was observed, suggesting that additional mechanism of action is likely to be involved. ..
- Lewis R, Behnke J, Stafford P, Holland C. Dose-dependent impact of larval Ascaris suum on host body weight in the mouse model. J Helminthol. 2009;83:1-5 pubmed publisher..These findings suggest that larval migratory ascariasis has a significant negative impact upon host growth and that this is related to infective dose and larval burden. ..
- Monahan A, Miller I, Nally J. Leptospirosis: risks during recreational activities. J Appl Microbiol. 2009;107:707-16 pubmed publisher..Molecular techniques can be used to provide risk assessments prior to competition, to supplement epidemiology, and to assess shedding of Leptospira in urine samples. ..
- Duffy M, McKiernan E, O Donovan N, McGowan P. The role of ADAMs in disease pathophysiology. Clin Chim Acta. 2009;403:31-6 pubmed..Further work is required in order to establish a causative role for ADAMs in rheumatoid arthritis, Alzheimer's disease, cardiac hypertrophy and asthma...
- Tivnan A, Foley N, Tracey L, Davidoff A, Stallings R. MicroRNA-184-mediated inhibition of tumour growth in an orthotopic murine model of neuroblastoma. Anticancer Res. 2010;30:4391-5 pubmed
- Cox R, Hernandez Santana A, Ramdass S, McMahon G, Harmey J, Morgan M. Microcalcifications in breast cancer: novel insights into the molecular mechanism and functional consequence of mammary mineralisation. Br J Cancer. 2012;106:525-37 pubmed publisher..Our findings point to the cells mineralisation potential and the microenvironment regulating it, as a significant feature of breast tumour development. ..
- Bowie R, Donatello S, Lyes C, Owens M, Babina I, Hudson L, et al. Lipid rafts are disrupted in mildly inflamed intestinal microenvironments without overt disruption of the epithelial barrier. Am J Physiol Gastrointest Liver Physiol. 2012;302:G781-93 pubmed publisher..Our data suggest for the first time that lipid raft disruption occurs early in the inflammatory cascade in murine and human colitis and, we speculate, may contribute to subsequent disruption of epithelial barrier function. ..
- Keegan J, Holland C. A comparison of Toxocara canis embryonation under controlled conditions in soil and hair. J Helminthol. 2013;87:78-84 pubmed publisher..In light of these findings the transmission of Toxocara spp. as a result of direct contact with well-cared-for owned dogs seems unlikely, but should not be ignored...
- Doolan P, Clarke C, Kinsella P, Breen L, Meleady P, Leonard M, et al. Transcriptomic analysis of clonal growth rate variation during CHO cell line development. J Biotechnol. 2013;166:105-13 pubmed publisher..Finally, we demonstrate the enrichment of predicted mRNA targets of miR17-92, a microRNA (miRNA) cluster known to be upregulated during rapid proliferation, within downregulated transcripts. ..
- Bonner C, Nyhan K, Bacon S, Kyithar M, Schmid J, Concannon C, et al. Identification of circulating microRNAs in HNF1A-MODY carriers. Diabetologia. 2013;56:1743-51 pubmed publisher..Furthermore, our study demonstrates that these miRNAs can be readily detected in the serum of HNF1A-MODY carriers. ..
- O Connell R, Carberry J, O Halloran K. Sternohyoid and diaphragm muscle form and function during postnatal development in the rat. Exp Physiol. 2013;98:1386-400 pubmed publisher..The accelerated maturation of the sternohyoid muscle relative to the diaphragm may have implications for the control of airway calibre in vivo. ..
- Gheorghescu A, Thompson J. Delayed vasculogenesis and impaired angiogenesis due to altered Ang-2 and VE-cadherin levels in the chick embryo model following exposure to cadmium. Pediatr Surg Int. 2016;32:175-86 pubmed publisher..Cd exposure inhibits normal development of extra-embryonic vasculature in line with growth retardation of the chick embryo in association with altered expression of Ang-2 and VE-cadherin. ..
- Budd K, Mitchell J, Keane O. Lineage associated expression of virulence traits in bovine-adapted Staphylococcus aureus. Vet Microbiol. 2016;189:24-31 pubmed publisher..aureus to draw conclusions regarding virulence or the host response to infection in unrelated lineages. ..
- Lajczak N, Saint Criq V, O Dwyer A, Perino A, Adorini L, Schoonjans K, et al. Bile acids deoxycholic acid and ursodeoxycholic acid differentially regulate human Î²-defensin-1 and -2 secretion by colonic epithelial cells. FASEB J. 2017;31:3848-3857 pubmed publisher..K., Saint-Criq, V., O'Dwyer, A. M., Perino, A., Adorini, L., Schoonjans, K., Keely, S. J. Bile acids deoxycholic acid and ursodeoxycholic acid differentially regulate human Î²-defensin-1 and -2 secretion by colonic epithelial cells. ..
- Floudas A, Saunders S, Moran T, Schwartz C, Hams E, Fitzgerald D, et al. IL-17 Receptor A Maintains and Protects the Skin Barrier To Prevent Allergic Skin Inflammation. J Immunol. 2017;199:707-717 pubmed publisher..This study describes a previously unappreciated protective role for IL-17RA signaling in regulation of the skin barrier and maintenance of skin immune homeostasis. ..
- Sadlier D, Connolly S, Kieran N, Roxburgh S, Brazil D, Kairaitis L, et al. Sequential extracellular matrix-focused and baited-global cluster analysis of serial transcriptomic profiles identifies candidate modulators of renal tubulointerstitial fibrosis in murine adriamycin-induced nephropathy. J Biol Chem. 2004;279:29670-80 pubmed..The further exploration of these complex gene networks should shed light on the core molecular pathways that underpin TIF in renal disease. ..
- O Mahony M, Healy A, Harte D, Walshe K, Torgerson P, Doherty M. Milk amyloid A: correlation with cellular indices of mammary inflammation in cows with normal and raised serum amyloid A. Res Vet Sci. 2006;80:155-61 pubmed..The results of the current study indicate that milk amyloid A exhibits good correlation with established cell-based indicators of intramammary inflammation. ..
- Feldman G, Kiely B, Martin N, Ryan G, McMorrow T, Ryan M. Role for TGF-beta in cyclosporine-induced modulation of renal epithelial barrier function. J Am Soc Nephrol. 2007;18:1662-71 pubmed..The results presented here suggest that the CsA-induced modulation of paracellular permeability may be mediated, at least in part, by an increase in TGF-beta production. ..
- Miranda CasoLuengo R, Prescott J, Vazquez Boland J, Meijer W. The intracellular pathogen Rhodococcus equi produces a catecholate siderophore required for saprophytic growth. J Bacteriol. 2008;190:1631-7 pubmed..Neither mutant was attenuated in vivo in a mouse infection model, indicating that the iupU- and iupS-encoded iron acquisition systems are primarily involved in iron uptake during saprophytic life...
- McBryan J, Howlin J, Napoletano S, Martin F. Amphiregulin: role in mammary gland development and breast cancer. J Mammary Gland Biol Neoplasia. 2008;13:159-69 pubmed publisher..Here we summarise our current understanding of amphiregulin's contribution to mammary gland development and breast cancer progression. ..
- Bexis S, McCormick P, Docherty J. Vascular actions of the prostacyclin receptor antagonist BAY 73-1449 in the portal hypertensive rat. Eur J Pharmacol. 2008;590:322-6 pubmed publisher..Portal pressure was similar in animals treated with vehicle or BAY 73-1449. It is concluded that the prostacyclin receptor antagonist BAY 73-1449 can acutely reduce shunt vessel blood flow in portal hypertensive rats. ..
- English J, Dicker P, Föcking M, Dunn M, Cotter D. 2-D DIGE analysis implicates cytoskeletal abnormalities in psychiatric disease. Proteomics. 2009;9:3368-82 pubmed publisher..The data presented here strongly suggest disruption of the cytoskeleton and its associated signal transduction proteins in schizophrenia, and to a lesser extent in bipolar disorder. ..
- Whelehan C, Meade K, Eckersall P, Young F, O Farrelly C. Experimental Staphylococcus aureus infection of the mammary gland induces region-specific changes in innate immune gene expression. Vet Immunol Immunopathol. 2011;140:181-9 pubmed publisher..05; DEFB4 and DEFB5 >9- and >27-fold respectively, P<0.05). Collectively, our data show both sentinel and effector immune functions throughout the mammary gland in response to S. aureus challenge. ..
- Okumu L, Fair T, Szekeres Bartho J, O Doherty A, Crowe M, Roche J, et al. Endometrial expression of progesterone-induced blocking factor and galectins-1, -3, -9, and -3 binding protein in the luteal phase and early pregnancy in cattle. Physiol Genomics. 2011;43:903-10 pubmed publisher..Additionally, LGALS9 and PIBF proteins were expressed in distinct uterine cell types. These results indicate that the galectins may be involved in uterine receptivity and/or implantation in heifers. ..
- Shore A, Deasy E, Slickers P, Brennan G, O Connell B, Monecke S, et al. Detection of staphylococcal cassette chromosome mec type XI carrying highly divergent mecA, mecI, mecR1, blaZ, and ccr genes in human clinical isolates of clonal complex 130 methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother. 2011;55:3765-73 pubmed publisher..aureus strains were predominantly from bovine sources. The highly divergent nature of SCCmec XI relative to other SCCmec elements indicates that it may have originated in another taxon. ..
- Zaitsev A, Anwyl R. Inhibition of the slow afterhyperpolarization restores the classical spike timing-dependent plasticity rule obeyed in layer 2/3 pyramidal cells of the prefrontal cortex. J Neurophysiol. 2012;107:205-15 pubmed publisher..These findings shed light on a fundamental question in the field of memory research regarding how environmental and behavioral stimuli influence LTP, thereby contributing to the modulation of memory. ..
- Burleigh S, van de Laar T, Stroop C, van Grunsven W, O Donoghue N, Rudd P, et al. Synergizing metabolic flux analysis and nucleotide sugar metabolism to understand the control of glycosylation of recombinant protein in CHO cells. BMC Biotechnol. 2011;11:95 pubmed publisher..This system advances our knowledge of the relationship between metabolic flux and the glycosylation of biotherapeutics in CHO cells and will be of benefit to the bioprocessing industry. ..
- Rajtak U, Boland F, Leonard N, Bolton D, Fanning S. Roles of diet and the acid tolerance response in survival of common Salmonella serotypes in feces of finishing pigs. Appl Environ Microbiol. 2012;78:110-9 pubmed publisher..Fecal survival and transmission of Salmonella in pig herds may be reduced by dietary approaches, but effects are highly dependent on environmental temperature...
- O Reilly V, Zeng S, Bricard G, Atzberger A, Hogan A, Jackson J, et al. Distinct and overlapping effector functions of expanded human CD4+, CD8?+ and CD4-CD8?- invariant natural killer T cells. PLoS ONE. 2011;6:e28648 pubmed publisher..Thus, subset composition of iNKT cells is a major determinant of function. Use of enriched CD8?(+), DN or CD4(+) iNKT cells may optimally harness the immunoregulatory properties of iNKT cells for treatment of disease. ..
- Nguyen L, Kolch W, Kholodenko B. When ubiquitination meets phosphorylation: a systems biology perspective of EGFR/MAPK signalling. Cell Commun Signal. 2013;11:52 pubmed publisher..We argue that given the overwhelming complexity arising from inter-connected PTMs, a quantitative framework based on systems biology and mathematical modelling is needed to efficiently understand their roles in cell signalling. ..
- Quesada R, Andaluz A, CÃ¡ceres M, Moll X, Iglesias M, Dorcaratto D, et al. Long-term evolution of acinar-to-ductal metaplasia and Î²-cell mass after radiofrequency-assisted transection of the pancreas in a controlled large animal model. Pancreatology. 2016;16:38-43 pubmed publisher..The endocrine mass showed a normal increase. RFAT in the pig seems to be an appropriate PDL model without restoration of pancreatic drainage or reduction of endocrine mass. ..
- Houpin E, McCarthy G, Ferrand M, de Waal T, O Neill E, Zintl A. Comparison of three methods for the detection of Angiostrongylus vasorum in the final host. Vet Parasitol. 2016;220:54-8 pubmed publisher..Agreement between the tests ranged from 45.6 to 79.7%. A novel nested PCR-RFLP for the detection and identification of canid lungworm spp. is described. ..
- Jefferies C, Bowie A, Brady G, Cooke E, Li X, O Neill L. Transactivation by the p65 subunit of NF-kappaB in response to interleukin-1 (IL-1) involves MyD88, IL-1 receptor-associated kinase 1, TRAF-6, and Rac1. Mol Cell Biol. 2001;21:4544-52 pubmed..A pathway emanating from MyD88 and involving IRAK-1, TRAF-6, and Rac1 is therefore involved in transactivation of gene expression by the p65 subunit of NF-kappaB in response to IL-1. ..
- Lawless M, Greene C, Mulgrew A, Taggart C, O Neill S, McElvaney N. Activation of endoplasmic reticulum-specific stress responses associated with the conformational disease Z alpha 1-antitrypsin deficiency. J Immunol. 2004;172:5722-6 pubmed..These findings have important implications for the design of future therapeutics for Z A1AT liver disease and may also impact on drug design for other conformational diseases. ..
- Vanattou Saïfoudine N, McNamara R, Harkin A. Mechanisms mediating the ability of caffeine to influence MDMA ('Ecstasy')-induced hyperthermia in rats. Br J Pharmacol. 2010;160:860-77 pubmed publisher..A combination of adenosine A(2A) receptor antagonism and PDE inhibition can account for the exacerbation of MDMA-induced hyperthermia by caffeine. ..
- Lyons A, Downer E, Costello D, Murphy N, Lynch M. Dok2 mediates the CD200Fc attenuation of A?-induced changes in glia. J Neuroinflammation. 2012;9:107 pubmed publisher..The findings suggest that activation of CD200R and Dok2 is a valuable strategy for modulating microglial activation and may have therapeutic potential in neurodegenerative conditions. ..
- Evans A, O Keeffe P, Mihm M, Roche J, Macmillan K, Boland M. Effect of oestradiol benzoate given after prostaglandin at two stages of follicle wave development on oestrus synchronisation, the LH surge and ovulation in heifers. Anim Reprod Sci. 2003;76:13-23 pubmed..In conclusion, the use of ODB advanced, but did not alter the temporal relationships among oestrus, the LH surge and ovulation, regardless of stage of follicle development at treatment. ..