Experts and Doctors on plant extracts in Mashhad, Razavi Khorasan, Iran


Locale: Mashhad, Razavi Khorasan, Iran
Topic: plant extracts

Top Publications

  1. Tashakori Sabzevar F, Ramezani M, Hosseinzadeh H, Parizadeh S, Movassaghi A, Ghorbani A, et al. Protective and hypoglycemic effects of celery seed on streptozotocin-induced diabetic rats: experimental and histopathological evaluation. Acta Diabetol. 2016;53:609-19 pubmed publisher
    ..The results indicated that celery seed extract can be effective in controlling hyperglycemia and hyperlipidemia in diabetic rats, and demonstrated its protective effects against pancreatic toxicity resulting from STZ-induction. ..
  2. Boskabady M, Alizadeh M, Jahanbin B. Bronchodilatory effect of Carum copticum in airways of asthmatic patients. Therapie. 2007;62:23-9 pubmed
    ..In conclusion, the results of the present study showed that Carum copticum has a relatively bronchodilatory effect on asthmatic airways which was comparable with the effect of theophylline at concentrations used. ..
  3. Behnam Rassouli F, Matin M, Iranshahi M, Bahrami A, Neshati V, Mollazadeh S, et al. Mogoltacin enhances vincristine cytotoxicity in human transitional cell carcinoma (TCC) cell line. Phytomedicine. 2009;16:181-7 pubmed publisher
    ..Results revealed that combination of 40 microg ml(-1) vincristine with 16 microg ml(-1) mogoltacin increased the cytotoxicity of vincristine after 48 h by 32.8%. ..
  4. Hosseinzadeh H, Sadeghnia H, Ziaee T, Danaee A. Protective effect of aqueous saffron extract (Crocus sativus L.) and crocin, its active constituent, on renal ischemia-reperfusion-induced oxidative damage in rats. J Pharm Pharm Sci. 2005;8:387-93 pubmed
    ..The aim of the present study was to assess the effect of aqueous saffron extract (Crocus sativus L.) and its active constituent, crocin, on oxidative stress following renal ischemia-reperfusion injury (IRI) in rats...
  5. Meshkini A. Acetone Extract of Almond Hulls Provides Protection against Oxidative Damage and Membrane Protein Degradation. J Acupunct Meridian Stud. 2016;9:134-42 pubmed publisher
    ..Overall, almond hull extract could be considered as a natural source of antioxidants, and its consumption could have a positive effect on human health. ..
  6. Boskabady M, Khatami A, Nazari A. Possible mechanism(s) for relaxant effects of Foeniculum vulgare on guinea pig tracheal chains. Pharmazie. 2004;59:561-4 pubmed
    ..However the results suggest a potassium channel opening effect for this plant, which may contribute on its relaxant effect on guinea pig tracheal chains. ..
  7. Ramezani M, Hosseinzadeh H, Mojtahedi K. Effects of Ferula gummosa Boiss. fractions on morphine dependence in mice. J Ethnopharmacol. 2001;77:71-5 pubmed
    ..The results of this study indicated that the plant extract contained component(s) that could be useful for the alleviation of morphine withdrawal syndrome. ..
  8. Hosseinzadeh H, Noraei N. Anxiolytic and hypnotic effect of Crocus sativus aqueous extract and its constituents, crocin and safranal, in mice. Phytother Res. 2009;23:768-74 pubmed publisher
    ..05 and 0.15 mL/kg) decreased some locomotion activity parameters. Safranal demonstrated no effects on motor coordination. The results showed that saffron aqueous extract and safranal have anxiolytic and hypnotic effects...
  9. Hosseinzadeh H, Parvardeh S. Anticonvulsant effects of thymoquinone, the major constituent of Nigella sativa seeds, in mice. Phytomedicine. 2004;11:56-64 pubmed
    ..These results indicate that thymoquinone may have anticonvulsant activity in the petit mal epilepsy probably through an opioid receptor-mediated increase in GABAergic tone. ..

More Information


  1. Tayarani Najaran Z, Mousavi S, Vahdati Mashhadian N, Emami S, Parsaee H. Scutellaria litwinowii induces apoptosis through both extrinsic and intrinsic apoptotic pathways in human promyelocytic leukemia cells. Nutr Cancer. 2012;64:80-8 pubmed publisher
    ..It could be concluded that S. litwinowii induced apoptosis in both apoptosis-proficient and apoptosis-resistant leukemic cells and it might be considered as a novel candidate in the treatment of hematological malignancies...
  2. Boskabady M, Shafei M, Parsaee H. Effects of aqueous and macerated extracts from Nigella sativa on guinea pig isolated heart activity. Pharmazie. 2005;60:943-8 pubmed
    ..The results of the present study may be due to calcium channel inhibitory or an opening effect for the plant on potassium channels of the isolated heart...
  3. Iranshahi M, Kalategi F, Rezaee R, Shahverdi A, Ito C, Furukawa H, et al. Cancer chemopreventive activity of terpenoid coumarins from Ferula species. Planta Med. 2008;74:147-50 pubmed publisher
    ..Our findings revealed that the presence of a prenyl moiety in the terpenoid coumarins plays an important role in anti-tumor promoting activity as previously reported for xanthones, coumarins, flavonoids and phenylpropanoids. ..
  4. Hanafi Bojd M, Iranshahi M, Mosaffa F, Tehrani S, Kalalinia F, Behravan J. Farnesiferol A from Ferula persica and galbanic acid from Ferula szowitsiana inhibit P-glycoprotein-mediated rhodamine efflux in breast cancer cell lines. Planta Med. 2011;77:1590-3 pubmed publisher
  5. Fatehi M, Farifteh F, Fatehi Hassanabad Z. Antispasmodic and hypotensive effects of Ferula asafoetida gum extract. J Ethnopharmacol. 2004;91:321-4 pubmed
  6. Cheraghi O, Dehghan G, Mahdavi M, Rahbarghazi R, Rezabakhsh A, Charoudeh H, et al. Potent anti-angiogenic and cytotoxic effect of conferone on human colorectal adenocarcinoma HT-29 cells. Phytomedicine. 2016;23:398-405 pubmed publisher
    ..In addition to anti-angiogenic properties of conferone, a profound decrease in migration capability of HT-29 cells was also evident. ..
  7. Hosseinzadeh H, Karimi G, Ameri M. Effects of Anethum graveolens L. seed extracts on experimental gastric irritation models in mice. BMC Pharmacol. 2002;2:21 pubmed
    ..The results suggest that A. graveolens seed extracts have significant mucosal protective and antisecretory effects of the gastric mucosa in mice. ..
  8. Yousefzadeh H, Mahmoudi M, Banihashemi M, Rastin M, Azad F. Investigation of dietary supplements prevalence as complementary therapy: Comparison between hospitalized psoriasis patients and non-psoriasis patients, correlation with disease severity and quality of life. Complement Ther Med. 2017;33:65-71 pubmed publisher
    ..21, r=-0.02). Self-medicating of MVM over last 30days was prevalent among studied psoriasis patients. They took dietary supplements in order to improve and maintain their health. ..
  9. Hadjzadeh M, Khoei A, Hadjzadeh Z, Parizady M. Ethanolic extract of nigella sativa L seeds on ethylene glycol-induced kidney calculi in rats. Urol J. 2007;4:86-90 pubmed
    ..The NS could also lower the urine concentration of calcium oxalate. We suggest further studies on the therapeutic and preventive effects of the NS on kidney calculus formation in human. ..
  10. Boskabady M, Javan H, Sajady M, Rakhshandeh H. The possible prophylactic effect of Nigella sativa seed extract in asthmatic patients. Fundam Clin Pharmacol. 2007;21:559-66 pubmed
    ..The results of phase I study generally suggest a prophylactic effect of N. sativa on asthma disease and warrant further research regarding this effect...
  11. Mirzaei Najafgholi H, Tarighi S, Golmohammadi M, Taheri P. The Effect of Citrus Essential Oils and Their Constituents on Growth of Xanthomonas citri subsp. citri. Molecules. 2017;22: pubmed publisher
    ..We introduced C. aurantifolia and C. aurantium EOs, and their constituents citral, ?-terpineol, citronellal, geraniol, and linalool as possible control agents for CBC. ..
  12. Hosseinzadeh H, Jahanian Z. Effect of Crocus sativus L. (saffron) stigma and its constituents, crocin and safranal, on morphine withdrawal syndrome in mice. Phytother Res. 2010;24:726-30 pubmed publisher
    ..But crocin and the dose of 400 mg/kg ethanolic extract showed no effect on activity in this test. It is concluded that the extracts and crocin may have interaction with the opioid system to reduce withdrawal syndrome...
  13. Hosseinzadeh H, Khooei A, Khashayarmanesh Z, Motamed Shariaty V. Antiurolithiatic activity of Pinus eldarica medw: fruits aqueous extract in rats. Urol J. 2010;7:232-7 pubmed
    ..Stone formation did not decrease in the treatment group. This study indicates that P. eldarica fruit extract prevents calcium oxalate deposition, without producing diuresis. ..
  14. Hosseinzadeh S, Soleimani M, Vossoughi M, Ranjbarvan P, Hamedi S, Zamanlui S, et al. Study of epithelial differentiation and protein expression of keratinocyte-mesenchyme stem cell co-cultivation on electrospun nylon/B. vulgaris extract composite scaffold. Mater Sci Eng C Mater Biol Appl. 2017;75:653-662 pubmed publisher
    ..To the best of our knowledge, findings of this study will introduce new way for the generation of novel biomaterials for the development of current skin tissue engineering. ..
  15. Boskabady M, Keyhanmanesh R, Khameneh S, Doostdar Y, Khakzad M. Potential immunomodulation effect of the extract of Nigella sativa on ovalbumin sensitized guinea pigs. J Zhejiang Univ Sci B. 2011;12:201-9 pubmed publisher
    ..001), except for the oedema in the sensitized group treated with low concentration of the extract, but an increased IFN-?. These results confirm a preventive effect of N. sativa extract on lung inflammation of sensitized guinea pigs...
  16. Hadizadeh F, Mohajeri S, Seifi M. Extraction and purification of crocin from saffron stigmas employing a simple and efficient crystallization method. Pak J Biol Sci. 2010;13:691-8 pubmed
    ..The purity of crystallized total crocin in this work was more than 97%. ..
  17. Vahdati Mashhadian N, Rakhshandeh H, Omidi A. An investigation on LD50 and subacute hepatic toxicity of Nigella sativa seed extracts in mice. Pharmazie. 2005;60:544-7 pubmed
    ..In conclusion, Nigella sativa extracts are relatively nontoxic in the acute toxicity test, but the possibility of hepatic damage with its aqueous extract should be considered...
  18. Boskabady M, Kiani S, Rakhshandah H. Relaxant effects of Rosa damascena on guinea pig tracheal chains and its possible mechanism(s). J Ethnopharmacol. 2006;106:377-82 pubmed
    ..These results showed a potent relaxant effect of Rosa damascena on tracheal chains of guinea pigs that was comparable to that of theophylline at concentrations used...
  19. Mosaffa F, Behravan J, Karimi G, Iranshahi M. Antigenotoxic effects of Satureja hortensis L. on rat lymphocytes exposed to oxidative stress. Arch Pharm Res. 2006;29:159-64 pubmed
    ..01) on H2O2 induced chromosomal damage. In conclusion both the ethanolic extract and the essential oil of the plant reversed the oxidative damage to rat lymphocytes induced by hydrogen peroxide...
  20. Rakhshandah H, Hosseini M. Potentiation of pentobarbital hypnosis by Rosa damascena in mice. Indian J Exp Biol. 2006;44:910-2 pubmed
    ..The results showed that the ethanolic and aqueous extracts in 500 and 1000 mg/kg doses significantly increased pentobarbital induced sleeping time which was comparable to diazepam. The chloroformic extract had no hypnotic effect. ..
  21. Hosseinzadeh H, Nourbakhsh M. Effect of Rosmarinus officinalis L. aerial parts extract on morphine withdrawal syndrome in mice. Phytother Res. 2003;17:938-41 pubmed
    ..Phytochemical study indicated that only the aqueous extract of R. officinalis has an alkaloid component. It is concluded that the aqueous and ethanol extracts of R. officinalis aerial parts could diminish morphine withdrawal syndrome...
  22. Hosseinzadeh H, Ramezani M, Shafaei H, Taghiabadi E. Anticonvulsant effect of Berberis integerrima L. root extracts in mice. J Acupunct Meridian Stud. 2013;6:12-7 pubmed publisher
    ..The present study, conducted in mice, indicated that B integerrima has anticonvulsant activity in PTZ-induced seizures. It is concluded that B integerrima may be useful in petit mal epilepsy...
  23. Hosseinzadeh H, Khoshdel M, Ghorbani M. Antinociceptive, anti-inflammatory effects and acute toxicity of aqueous and ethanolic extracts of Myrtus communis L. Aerial parts in mice. J Acupunct Meridian Stud. 2011;4:242-7 pubmed publisher
    ..015, and 0.03 g/kg) demonstrated anti-inflammatory effects against chronic inflammation. The aqueous and ethanolic extracts of the aerial parts of M communis L. showed antinociceptive effects and these may be mediated by opioid receptors...
  24. Hosseini M, Ghasemzadeh Rahbardar M, Sadeghnia H, Rakhshandeh H. Effects of different extracts of Rosa damascena on pentylenetetrazol-induced seizures in mice. Zhong Xi Yi Jie He Xue Bao. 2011;9:1118-24 pubmed
    ..In the present study, the effects of aqueous, ethanolic and chloroformic extracts of Rosa damascena on pentylenetetrazol (PTZ)-induced seizures were investigated in mice...
  25. Fatehi M, Saleh T, Fatehi Hassanabad Z, Farrokhfal K, Jafarzadeh M, Davodi S. A pharmacological study on Berberis vulgaris fruit extract. J Ethnopharmacol. 2005;102:46-52 pubmed
  26. Boskabady M, Rahbardar M, Jafari Z. The effect of safranal on histamine (H(1)) receptors of guinea pig tracheal chains. Fitoterapia. 2011;82:162-7 pubmed publisher
    ..05 to p < 0.001). The EC(50) obtained in the presence of all concentrations of safranal and maximum response of its two higher concentrations (1.25 and 2.5 ?g/mL) in group 2 were greater than in group 1 (p < 0.05 to p < 0.001). ..
  27. Mousavi S, Tavakkol Afshari J, Brook A, Jafari Anarkooli I. Role of caspases and Bax protein in saffron-induced apoptosis in MCF-7 cells. Food Chem Toxicol. 2009;47:1909-13 pubmed publisher
    ..Bax protein expression was also increased in saffron-treated cells. Thus saffron exerts proapoptotic effects in a breast cancer-derived cell line and could be considered as a potential chemotherapeutic agent in breast cancer. ..
  28. Tavakkol Afshari J, Brook A, Mousavi S. Study of cytotoxic and apoptogenic properties of saffron extract in human cancer cell lines. Food Chem Toxicol. 2008;46:3443-7 pubmed publisher
    ..Saffron could be also considered as a promising chemotherapeutic agent in cancer treatment in future. ..
  29. Akhondian J, Parsa A, Rakhshande H. The effect of Nigella sativa L. (black cumin seed) on intractable pediatric seizures. Med Sci Monit. 2007;13:CR555-9 pubmed
    ..The mean frequency of seizures decreased significantly during treatment with extract (p<0.05). It can be concluded that the water extract of Nigella sativa L. has antiepileptic effects in children with refractory seizures. ..
  30. Moallem S, Niapour M. Study of embryotoxicity of Perovskia abrotanoides, an adulterant in folk-medicine, during organogenesis in mice. J Ethnopharmacol. 2008;117:108-14 pubmed publisher
  31. Feizzadeh B, Afshari J, Rakhshandeh H, Rahimi A, Brook A, Doosti H. Cytotoxic effect of saffron stigma aqueous extract on human transitional cell carcinoma and mouse fibroblast. Urol J. 2008;5:161-7 pubmed
    ..Saffron has been suggested to have inhibitory effects on tumoral cells. We evaluated the cytotoxic effect of aqueous extract of saffron on human transitional cell carcinoma (TCC) and mouse non-neoplastic fibroblast cell lines...
  32. Ramezani M, Hosseinzadeh H, Daneshmand N. Antinociceptive effect of Elaeagnus angustifolia fruit seeds in mice. Fitoterapia. 2001;72:255-62 pubmed
  33. Momtazi A, Askari Khorasgani O, Abdollahi E, Sadeghi Aliabadi H, Mortazaeinezhad F, Sahebkar A. Phytochemical Analysis and Cytotoxicity Evaluation of Kelussia odoratissima Mozaff. J Acupunct Meridian Stud. 2017;10:180-186 pubmed publisher
    ..odoratissima leaf extract against human cancer cell lines. This activity of K. odoratissima may find application in combination with traditional herbal medicines to develop a new anticancer pharmacopuncture therapy. ..
  34. Mahyari S, Mahyari B, Emami S, Malaekeh Nikouei B, Jahanbakhsh S, Sahebkar A, et al. Evaluation of the efficacy of a polyherbal mouthwash containing Zingiber officinale, Rosmarinus officinalis and Calendula officinalis extracts in patients with gingivitis: A randomized double-blind placebo-controlled trial. Complement Ther Clin Pract. 2016;22:93-8 pubmed publisher
    ..Polyherbal mouthwash containing hydroalcoholic extracts of Z. officinale, R. officinalis and C. officinalis (5%) was effective in the treatment of gingivitis and its efficacy was comparable to that of chlorhexidine mouthwash. ..
  35. Hosseinzadeh H, Ziaee T, Sadeghi A. The effect of saffron, Crocus sativus stigma, extract and its constituents, safranal and crocin on sexual behaviors in normal male rats. Phytomedicine. 2008;15:491-5 pubmed
    ..increased MF, IF and EF behaviors and reduced EL, IL and ML parameters. Safranal did not show aphrodisiac effects. The present study reveals an aphrodisiac activity of saffron aqueous extract and its constituent crocin. ..
  36. Boskabady M, Tabanfar H, Gholamnezhad Z, Sadeghnia H. Inhibitory effect of Zataria multiflora Boiss and carvacrol on histamine (H(1) ) receptors of guinea-pig tracheal chains. Fundam Clin Pharmacol. 2012;26:609-20 pubmed publisher
    ..These results indicated an inhibitory effect of Z. multiflora and its constituent carvacrol on histamine H(1) receptors. ..
  37. Boskabady M, Keyhanmanesh R, Khamneh S, Ebrahimi M. The effect of Nigella sativa extract on tracheal responsiveness and lung inflammation in ovalbumin-sensitized guinea pigs. Clinics (Sao Paulo). 2011;66:879-87 pubmed
    ..To examine the preventive effect of a hydro-ethanolic extract of Nigella sativa on the tracheal responsiveness and white blood cell count in the lung lavage fluid of sensitized guinea pigs...
  38. Boskabady M, Aslani M, Kiani S. Relaxant effect of Thymus vulgaris on guinea-pig tracheal chains and its possible mechanism(s). Phytother Res. 2006;20:28-33 pubmed
    ..01 to p < 0.001). These results demonstrated a potent relaxant effect of Thymus vulgaris on guinea-pig tracheal chains that was comparable to theophylline at the concentrations used. ..
  39. Hosseinzadeh H, Abootorabi A, Sadeghnia H. Protective effect of Crocus sativus stigma extract and crocin (trans-crocin 4) on methyl methanesulfonate-induced DNA damage in mice organs. DNA Cell Biol. 2008;27:657-64 pubmed publisher
    ..69-fold for liver and 6.55-fold for spleen, 400 mg/Kg), in a dose-dependent manner. These data indicate that there is a genoprotective property in CSE and crocin, as revealed by the comet assay, in vivo...
  40. Mohaghegh M, Tafaghodi M. Dextran microspheres could enhance immune responses against PLGA nanospheres encapsulated with tetanus toxoid and Quillaja saponins after nasal immunization in rabbit. Pharm Dev Technol. 2011;16:36-43 pubmed publisher
    ..Co-encapsulation of QS and TT in PLGA nanospheres increased sIgA titers. In conclusion, the highest immune responses were observed by concomitant use of three adjuvants...
  41. Boskabady M, Farhadi J. The possible prophylactic effect of Nigella sativa seed aqueous extract on respiratory symptoms and pulmonary function tests on chemical war victims: a randomized, double-blind, placebo-controlled trial. J Altern Complement Med. 2008;14:1137-44 pubmed publisher
    ..In the present study, the prophylactic effect of a boiled aqueous extract of nigella seed on chemical war victims was examined...
  42. Hosseinzadeh H, Younesi H. Antinociceptive and anti-inflammatory effects of Crocus sativus L. stigma and petal extracts in mice. BMC Pharmacol. 2002;2:7 pubmed
    ..Crocus sativus L. (saffron) is used in folk medicine, for example as an antiedematogenic agent. We aimed to evaluate the antinociceptive and anti-inflammatory activity of saffron extracts in mice...
  43. Boskabady M, Shirmohammadi B, Jandaghi P, Kiani S. Possible mechanism(s) for relaxant effect of aqueous and macerated extracts from Nigella sativa on tracheal chains of guinea pig. BMC Pharmacol. 2004;4:3 pubmed
  44. Boskabady M, Jandaghi P, Kiani S, Hasanzadeh L. Antitussive effect of Carum copticum in guinea pigs. J Ethnopharmacol. 2005;97:79-82 pubmed
    ..These results indicated an antitussive effect of Carum copticum which was even greater than that of codeine at concentrations used. In addition the antitussive effect of Carum copticum was not due to its main constituent, carvacrol. ..
  45. Boskabady M, Aslani M. Relaxant effect of Crocus sativus (saffron) on guinea-pig tracheal chains and its possible mechanisms. J Pharm Pharmacol. 2006;58:1385-90 pubmed
    ..The results indicated that safranal was, at least in part, responsible for the relaxant effect of C. sativus. ..
  46. Hosseinzadeh H, Nassiri Asl M. Avicenna's (Ibn Sina) the Canon of Medicine and saffron (Crocus sativus): a review. Phytother Res. 2013;27:475-83 pubmed publisher
    ..This review indicates that the evaluation of plants based on ethnobotanical information and ancient books may be a valuable approach to finding new biological activities and compounds...
  47. Hadjzadeh M, Keshavarzi Z, Tabatabaee Yazdi S, Ghasem Shirazi M, Rajaei Z, Khajavi Rad A. Effect of alcoholic extract of Nigella sativa on cisplatin-induced toxicity in rat. Iran J Kidney Dis. 2012;6:99-104 pubmed
    ..The aim of this study was to test whether Nigella sativa (NS) seeds can reduce cisplatin-induced toxicity...
  48. Hosseinzadeh H, Sadeghnia H. Protective effect of safranal on pentylenetetrazol-induced seizures in the rat: involvement of GABAergic and opioids systems. Phytomedicine. 2007;14:256-62 pubmed
    ..c.v. and 2mg/kg body wt., i.p.). Results of this study demonstrated that safranal could exert anticonvulsant activity in the PTZ model and this effect may be mediated, at least partly, through GABA(A)-benzodiazepine receptor complex. ..
  49. Boskabady M, Ghasemzadeh Rahbardar M, Nemati H, Esmaeilzadeh M. Inhibitory effect of Crocus sativus (saffron) on histamine (H1) receptors of guinea pig tracheal chains. Pharmazie. 2010;65:300-5 pubmed
    ..These results indicated an inhibitory effect of Crocus sativus at histamine H1 receptors. ..
  50. Hosseinzadeh H, Ghenaati J. Evaluation of the antitussive effect of stigma and petals of saffron (Crocus sativus) and its components, safranal and crocin in guinea pigs. Fitoterapia. 2006;77:446-8 pubmed
    ..The ethanolic extract of C. sativus (100-800 mg/kg) and safranal (0.25-0.75 ml/kg) reduced the number of cough. The ethanolic and aqueous extracts of petal and crocin did not show antitussive activity...
  51. Tayarani Najaran Z, Mousavi S, Asili J, Emami S. Growth-inhibitory effect of Scutellaria lindbergii in human cancer cell lines. Food Chem Toxicol. 2010;48:599-604 pubmed publisher
    ..In conclusion, S. lindbergii exerts cytotoxic effects in different cancer cell lines in which apoptosis plays an important role. Thus S. lindbergii could be considered as a potential chemotherapeutic agent in cancer treatment...
  52. Imenshahidi M, Hosseinzadeh H, Javadpour Y. Hypotensive effect of aqueous saffron extract (Crocus sativus L.) and its constituents, safranal and crocin, in normotensive and hypertensive rats. Phytother Res. 2010;24:990-4 pubmed publisher
    ..It seems that safranal is more important than crocin for lowering down blood pressure of rats...
  53. Mousavi S, Tayarani N, Parsaee H. Protective effect of saffron extract and crocin on reactive oxygen species-mediated high glucose-induced toxicity in PC12 cells. Cell Mol Neurobiol. 2010;30:185-91 pubmed publisher
    ..Glucose toxicity was consistent with increased ROS production which reduced by saffron, crocin and GSH pretreatment. These results suggest saffron and its carotenoid crocin could be potentially useful in diabetic neuropathy treatment. ..
  54. Boskabady M, Shafei M, Shakiba A, Sefidi H. Effect of aqueous-ethanol extract from Crocus sativus (saffron) on guinea-pig isolated heart. Phytother Res. 2008;22:330-4 pubmed
    ..01 to p < 0.001). These results suggested a potent inhibitory effect of aqueous-ethanol extract from C. sativus on the calcium channel of guinea-pig heart...
  55. Panahi Y, Khalili N, Sahebi E, Namazi S, Reiner Z, Majeed M, et al. Curcuminoids modify lipid profile in type 2 diabetes mellitus: A randomized controlled trial. Complement Ther Med. 2017;33:1-5 pubmed publisher
    ..Therefore, curcuminoids supplementation could contribute to a reduced risk of cardiovascular events in dyslipidemic patients with T2D. ..
  56. Boskabady M, Mohsenpoor N, Takaloo L. Antiasthmatic effect of Nigella sativa in airways of asthmatic patients. Phytomedicine. 2010;17:707-13 pubmed publisher
    ..However, the effects of boiled extract of this plant on most measured PFTs was less than those of theophylline at concentrations used...
  57. Fatehi Hassanabad Z, Jafarzadeh M, Tarhini A, Fatehi M. The antihypertensive and vasodilator effects of aqueous extract from Berberis vulgaris fruit on hypertensive rats. Phytother Res. 2005;19:222-5 pubmed
    ..V. fruit. The present results suggest that the antihypertensive and vasodilatory effects of B.V. fruit extract are mainly endothelial-independent and it may be used to treat hypertension, a status with endothelial dysfunction...
  58. Hosseinzadeh H, Hosseini A, Nassiri Asl M, Sadeghnia H. Effect of Salvia leriifolia Benth. root extracts on ischemia-reperfusion in rat skeletal muscle. BMC Complement Altern Med. 2007;7:23 pubmed
    ..It is concluded that S. leriifolia root extracts have some protective effects on different markers of oxidative damage in muscle tissue injury caused by lower limb ischemia-reperfusion. ..
  59. Imanshahidi M, Hosseinzadeh H. The pharmacological effects of Salvia species on the central nervous system. Phytother Res. 2006;20:427-37 pubmed
  60. Hossein B, Nasim V, Sediqa A. The protective effect of Nigella sativa on lung injury of sulfur mustard-exposed Guinea pigs. Exp Lung Res. 2008;34:183-94 pubmed publisher
    ..05). These results showed a preventive effect of Nigella sativa on TR of SM-exposed guinea pigs. ..
  61. Mousavi S, Tayarani Najaran Z, Asghari M, Sadeghnia H. Protective effect of Nigella sativa extract and thymoquinone on serum/glucose deprivation-induced PC12 cells death. Cell Mol Neurobiol. 2010;30:591-8 pubmed publisher
    ..Our findings might raise the possibility of potential therapeutic application of N. sativa extract and TQ for managing cerebral ischemic and neurodegenerative disorders. ..
  62. Samarghandian S, Azimi Nezhad M, Borji A, Samini M, Farkhondeh T. Protective effects of carnosol against oxidative stress induced brain damage by chronic stress in rats. BMC Complement Altern Med. 2017;17:249 pubmed publisher
    ..The current research shows that the protective effects of carnosol may be accompanied with enhanced antioxidant defenses and decreased oxidative injury. ..
  63. Malek F, Boskabady M, Borushaki M, Tohidi M. Bronchodilatory effect of Portulaca oleracea in airways of asthmatic patients. J Ethnopharmacol. 2004;93:57-62 pubmed
    ..In conclusion, the results of the present study showed that Portulaca oleracea has a relatively potent but transient bronchodilatory effect on asthmatic airways...
  64. Hosseinzadeh H, Sadeghnia H, Ghaeni F, Motamedshariaty V, Mohajeri S. Effects of saffron (Crocus sativus L.) and its active constituent, crocin, on recognition and spatial memory after chronic cerebral hypoperfusion in rats. Phytother Res. 2012;26:381-6 pubmed publisher
    ..This study suggests that saffron extract and crocin improve spatial cognitive abilities following chronic cerebral hypoperfusion and that these effects may be related to the antioxidant effects of these compounds. ..
  65. Shamsa A, Hosseinzadeh H, Molaei M, Shakeri M, Rajabi O. Evaluation of Crocus sativus L. (saffron) on male erectile dysfunction: a pilot study. Phytomedicine. 2009;16:690-3 pubmed publisher
    ..15+/-1.44; after treatment 39.20+/-1.90, p<0.001). Saffron showed a positive effect on sexual function with increased number and duration of erectile events seen in patients with ED even only after taking it for ten days. ..
  66. Nemati H, Boskabady M, Ahmadzadef Vostakolaei H. Stimulatory effect of Crocus sativus (saffron) on beta2-adrenoceptors of guinea pig tracheal chains. Phytomedicine. 2008;15:1038-45 pubmed publisher
    ..A possible inhibitory effect of the plant on histamine (H(1)) receptors was also suggested...
  67. Behravan J, Mosafa F, Soudmand N, Taghiabadi E, Razavi B, Karimi G. Protective effects of aqueous and ethanolic extracts of Portulaca oleracea L. aerial parts on H2O2-induced DNA damage in lymphocytes by comet assay. J Acupunct Meridian Stud. 2011;4:193-7 pubmed publisher
    ..These data suggest that the aqueous extract of P. oleracea can prevent oxidative DNA damage to human lymphocytes, which is likely due to antioxidant constituents in the extract...
  68. Khajavi Rad A, Hadjzadeh M, Rajaei Z, Mohammadian N, Valiollahi S, Sonei M. The beneficial effect of cynodon dactylon fractions on ethylene glycol-induced kidney calculi in rats. Urol J. 2011;8:179-84 pubmed
    ..To assess the beneficial effect of different fractions of Cynodon dactylon (C. dactylon) on ethylene glycol-induced kidney calculi in rats...
  69. Boskabady M, Vahedi N, Amery S, Khakzad M. The effect of Nigella sativa alone, and in combination with dexamethasone, on tracheal muscle responsiveness and lung inflammation in sulfur mustard exposed guinea pigs. J Ethnopharmacol. 2011;137:1028-34 pubmed publisher
    ..ETHNOMEDICAL RELEVANCE: The anti-inflammatory activity of both systemic and local administrations of essential oil from Nigella sativa L. has been shown...