Experts and Doctors on crocus in Tehrān, Iran


Locale: Tehrān, Iran
Topic: crocus

Top Publications

  1. Kiani S, Minaei S. Potential application of machine vision technology to saffron (Crocus sativus L.) quality characterization. Food Chem. 2016;212:392-4 pubmed publisher
    ..Expert algorithms can be made available for prediction of saffron characteristics such as color as well as for product classification. ..
  2. Aliakbarzadeh G, Sereshti H, Parastar H. Pattern recognition analysis of chromatographic fingerprints of Crocus sativus L. secondary metabolites towards source identification and quality control. Anal Bioanal Chem. 2016;408:3295-307 pubmed publisher
    ..Finally, the individual contribution of each biomarker to the classes was determined by the counter propagation artificial neural network (CPANN) method. ..
  3. Akhondzadeh S, Sabet M, Harirchian M, Togha M, Cheraghmakani H, Razeghi S, et al. Saffron in the treatment of patients with mild to moderate Alzheimer's disease: a 16-week, randomized and placebo-controlled trial. J Clin Pharm Ther. 2010;35:581-8 pubmed publisher
    ..This double-blind, placebo-controlled study suggests that at least in the short-term, saffron is both safe and effective in mild to moderate AD. Larger confirmatory randomized controlled trials are called for. ..
  4. Tahvilzadeh M, Hajimahmoodi M, Toliyat T, Karimi M, Rahimi R. An evidence-based approach to medicinal plants for the treatment of sperm abnormalities in traditional Persian medicine. Andrologia. 2016;48:860-79 pubmed publisher
    ..Further studies are recommended for obtaining more conclusive results about the efficacy and safety of the mentioned medicinal plants. ..
  5. Ashrafi M, Bathaie S, Taghikhani M, Moosavi Movahedi A. The effect of carotenoids obtained from saffron on histone H1 structure and H1-DNA interaction. Int J Biol Macromol. 2005;36:246-52 pubmed
    ..These observations led to the suggesting a mechanism in which the H1 depletion may promote transcription. ..
  6. Akhondzadeh S, Shafiee Sabet M, Harirchian M, Togha M, Cheraghmakani H, Razeghi S, et al. A 22-week, multicenter, randomized, double-blind controlled trial of Crocus sativus in the treatment of mild-to-moderate Alzheimer's disease. Psychopharmacology (Berl). 2010;207:637-43 pubmed publisher
    ..This trial is registered with the Iranian Clinical Trials Registry (IRCT138711051556N1). ..
  7. Kashani L, Raisi F, Saroukhani S, Sohrabi H, Modabbernia A, Nasehi A, et al. Saffron for treatment of fluoxetine-induced sexual dysfunction in women: randomized double-blind placebo-controlled study. Hum Psychopharmacol. 2013;28:54-60 pubmed publisher
    ..has shown beneficial aphrodisiac effects in some animal and human studies. The aim of the present study was to assess the safety and efficacy of saffron on selective serotonin reuptake inhibitor-induced sexual dysfunction in women...
  8. Safarinejad M, Shafiei N, Safarinejad S. A prospective double-blind randomized placebo-controlled study of the effect of saffron (Crocus sativus Linn.) on semen parameters and seminal plasma antioxidant capacity in infertile men with idiopathic oligoasthenoteratozoospermia. Phytother Res. 2011;25:508-16 pubmed publisher
    ..If medical professionals want to prescribe herbal remedies for male infertility, previous rigorous scientific investigations, documenting their safety and efficacy are required...
  9. Ghoshooni H, Daryaafzoon M, Sadeghi Gharjehdagi S, Zardooz H, Sahraei H, Tehrani S, et al. Saffron (Crocus sativus) ethanolic extract and its constituent, safranal, inhibits morphine-induced place preference in mice. Pak J Biol Sci. 2011;14:939-44 pubmed
    ..The same results were obtained when safranal (1, 5 and 10 mg kg(-1), i.p.) was used. It may be concluded that both ethanolic saffron extract and safranal can inhibit the acquisition and expression of morphine-induced CPP in the mice...

More Information


  1. Amini M, Ghoranneviss M, Abdijadid S. Effect of cold plasma on crocin esters and volatile compounds of saffron. Food Chem. 2017;235:290-293 pubmed publisher
    ..There was no trans-2G, cis-4GG or cis-3Gg compounds observed after the Ar/10% O2 cold plasma treatment at 12kV. ..
  2. Keyhani E, Sattarahmady N. Catalytic properties of three L-lactate dehydrogenases from saffron corms (Crocus sativus L). Mol Biol Rep. 2002;29:163-6 pubmed
    ..9, 1.0 and 0.4 min(-1), respectively at pH 5.5, 7.5 and 9.5. Pseudo first order rate constant was also different under the three pH conditions. Malate was an inhibitor for the isoenzyme active at pH 9.5, but had no effect on the others...
  3. Bolhassani A, Khavari A, Bathaie S. Saffron and natural carotenoids: Biochemical activities and anti-tumor effects. Biochim Biophys Acta. 2014;1845:20-30 pubmed publisher
    ..In this mini-review, we briefly describe biochemical and immunological activities and chemo-preventive properties of saffron and natural carotenoids as an anticancer drug. ..
  4. Modabbernia A, Akhondzadeh S. Saffron, passionflower, valerian and sage for mental health. Psychiatr Clin North Am. 2013;36:85-91 pubmed publisher
    ..This article discusses clinically relevant scientific information on medicinal extracts of 4 herbs: saffron, passionflower, valerian, and sage...
  5. Modabbernia A, Sohrabi H, Nasehi A, Raisi F, Saroukhani S, Jamshidi A, et al. Effect of saffron on fluoxetine-induced sexual impairment in men: randomized double-blind placebo-controlled trial. Psychopharmacology (Berl). 2012;223:381-8 pubmed
    ..005). Frequency of side effects were similar between the two groups. Saffron is a tolerable and efficacious treatment for fluoxetine-related erectile dysfunction. ..
  6. Hooshmandi Z, Rohani A, Eidi A, Fatahi Z, Golmanesh L, Sahraei H. Reduction of metabolic and behavioral signs of acute stress in male Wistar rats by saffron water extract and its constituent safranal. Pharm Biol. 2011;49:947-54 pubmed publisher
    ..Moreover, the involvement of the amygdala in this observation can be ruled out. ..
  7. Ajami M, Eghtesadi S, Pazoki Toroudi H, Habibey R, Ebrahimi S. Effect of crocus sativus on gentamicin induced nephrotoxicity. Biol Res. 2010;43:83-90 pubmed publisher
    ..05, p<0.001, p<0.05, and p<0.001 respectively). In conclusion, our results suggest that saffron treatment reduces gentamicin-induced nephrotoxicity and this effect seems to be dose dependent. ..
  8. Bathaie S, Mousavi S. New applications and mechanisms of action of saffron and its important ingredients. Crit Rev Food Sci Nutr. 2010;50:761-86 pubmed publisher
    ..Our study concludes that saffron has a wide range of usefulness in medicine, cosmetics, and coloring industries, so it can be used for new drug designs. However, more research about its mechanism of action is needed. ..
  9. Agha Hosseini M, Kashani L, Aleyaseen A, Ghoreishi A, Rahmanpour H, Zarrinara A, et al. Crocus sativus L. (saffron) in the treatment of premenstrual syndrome: a double-blind, randomised and placebo-controlled trial. BJOG. 2008;115:515-9 pubmed publisher
    ..The aim of this double-blind and placebo-controlled trial was to investigate whether saffron (stigma of Crocus sativus L.) could relieve symptoms of premenstrual syndrome (PMS)...
  10. Ghamsari L, Keyhani E, Golkhoo S. Kinetics properties of guaiacol peroxidase activity in Crocus sativus L. corm during rooting. Iran Biomed J. 2007;11:137-146 pubmed
    ..Guaiacol peroxidases (GP) are haem-containing enzymes participating in many physiological processes in plants. The expression pattern of these enzymes is organ-specific and developmentally regulated...
  11. Noorbala A, Akhondzadeh S, Tahmacebi Pour N, Jamshidi A. Hydro-alcoholic extract of Crocus sativus L. versus fluoxetine in the treatment of mild to moderate depression: a double-blind, randomized pilot trial. J Ethnopharmacol. 2005;97:281-4 pubmed
    ..The results of this study indicate the efficacy of Crocus sativus in the treatment of mild to moderate depression. A large-scale trial is justified. ..
  12. Safarinejad M, Shafiei N, Safarinejad S. An open label, randomized, fixed-dose, crossover study comparing efficacy and safety of sildenafil citrate and saffron (Crocus sativus Linn.) for treating erectile dysfunction in men naïve to treatment. Int J Impot Res. 2010;22:240-50 pubmed publisher
    ..4 vs 25.4, P=0.001). Mean per patient 'yes' responses to GEQ was 91.2 and 4.2% for sildenafil and saffron, respectively (P=0.0001). These findings do not support a beneficial effect of saffron administration in men with ED. ..
  13. Bathaie S, Bolhasani A, Hoshyar R, Ranjbar B, Sabouni F, Moosavi Movahedi A. Interaction of saffron carotenoids as anticancer compounds with ctDNA, Oligo (dG.dC)15, and Oligo (dA.dT)15. DNA Cell Biol. 2007;26:533-40 pubmed
    ..In conclusion, the results show that saffron and its carotenoids interact with DNA and induce some conformational changes in it. Of these carotenoids, the order of potential of interaction with DNA is crocetin > DMC > crocin...
  14. Samadi L, Shahsavan Behboodi B. Fusaric acid induces apoptosis in saffron root-tip cells: roles of caspase-like activity, cytochrome c, and H2O2. Planta. 2006;225:223-34 pubmed
  15. Akhondzadeh S, Fallah Pour H, Afkham K, Jamshidi A, Khalighi Cigaroudi F. Comparison of Crocus sativus L. and imipramine in the treatment of mild to moderate depression: a pilot double-blind randomized trial [ISRCTN45683816]. BMC Complement Altern Med. 2004;4:12 pubmed
    ..To the best of our knowledge this is the first clinical trial that supports this indication for saffron. A large-scale trial with placebo control is warranted. ..