Genomes and Genes
Experts and Doctors on amino acid sequence in Kolkata, West Bengal, India
Locale: Kolkata, West Bengal, India
Topic: amino acid sequence
- Pal A, Panigrahi R, Biswas A, Datta S, Sarkar N, Guha S, et al. Influence of HIV-associated degree of immune suppression on molecular heterogeneity of hepatitis B virus among HIV co-infected patients. Virology. 2013;436:134-42 pubmed publisher..Interestingly, genetic diversity in HBV/A1, the next common subgenotype, was modified in the opposite manner. Together our results underscore the need for proper HBV molecular monitoring in HIV co-infection. ..
- Khamrui S, Majumder S, Dasgupta J, Dattagupta J, Sen U. Identification of a novel set of scaffolding residues that are instrumental for the inhibitory property of Kunitz (STI) inhibitors. Protein Sci. 2010;19:593-602 pubmed publisher..Additionally, we rationalize why the loop-scaffold swapping is not permitted even among the members of highly homologous inhibitors, which might be important in the light of inhibitor design. ..
- Giri N, Bhowmik P, Bhattacharya B, Mitra M, Das Gupta S. The mycobacteriophage D29 gene 65 encodes an early-expressed protein that functions as a structure-specific nuclease. J Bacteriol. 2009;191:959-67 pubmed publisher..Given its mode of action, it is very likely that gp65 is involved in processing branched replication intermediates formed during the replication of phage DNA. ..
- Chatterjee A, Majee M, Ghosh S, Majumder A. sll1722, an unassigned open reading frame of Synechocystis PCC 6803, codes for L-myo-inositol 1-phosphate synthase. Planta. 2004;218:989-98 pubmed..Comparison of the sll1722 sequences with other MIPS sequences and its phylogenetic analysis revealed that the Synechocystis MIPS gene is quite divergent from the others. ..
- GhoshDastidar K, Chatterjee A, Chatterjee A, Majumder A. Evolutionary divergence of L-myo-inositol 1-phosphate synthase: significance of a "core catalytic structure". Subcell Biochem. 2006;39:315-40 pubmed
- Das A, Ghosh J, Bhattacharya A, Samanta D, Das D, Das Gupta C. Involvement of mitochondrial ribosomal proteins in ribosomal RNA-mediated protein folding. J Biol Chem. 2011;286:43771-81 pubmed publisher..The RNA2 or large subunit proteins probably introduce some allosteric change in the peptidyl transferase loop to enable it to release proteins in FCS. ..
- Bhattacharya A, Biswas A, Das P. Identification of a protein kinase A regulatory subunit from Leishmania having importance in metacyclogenesis through induction of autophagy. Mol Microbiol. 2012;83:548-64 pubmed publisher..The study, for the first time, reports the identification of a functional cAMP-binding effector molecule from Leishmania that may modulate important cytological events affecting metacyclogenesis. ..
- Dutta S, Choudhury D, Dattagupta J, Biswas S. C-Terminal extension of a plant cysteine protease modulates proteolytic activity through a partial inhibitory mechanism. FEBS J. 2011;278:3012-24 pubmed publisher..These data suggest that the CT-extension has an inhibitory role in the proteolytic activity of ervatamin-C but does not have a major role either in stabilizing the enzyme or in its folding mechanism. ..
- Chanda P, Mondal R, Sau K, Sau S. Antibiotics, arsenate and H2O2 induce the promoter of Staphylococcus aureus cspC gene more strongly than cold. J Basic Microbiol. 2009;49:205-11 pubmed publisher..Their roles in S. aureus cold shock gene expression have been discussed elaborately. ..
- Majumder S, Schmidt G, Lohia A, Aktories K. EhRho1, a RhoA-like GTPase of Entamoeba histolytica, is modified by clostridial glucosylating cytotoxins. Appl Environ Microbiol. 2006;72:7842-8 pubmed..Lethal toxin from Clostridium sordellii did not glucosylate EhRho1 but labeled several other substrate proteins in lysates from Entamoeba histolytica in the presence of UDP-[14C]glucose. ..
- Sengupta T, Mukherjee M, Das A, Mandal C, Das R, Mukherjee T, et al. Characterization of the ATPase activity of topoisomerase II from Leishmania donovani and identification of residues conferring resistance to etoposide. Biochem J. 2005;390:419-26 pubmed..Taken together, these results provide an insight for the development of newer therapeutic agents with specific selectivity. ..
- Chatterjee A, Dastidar K, Maitra S, Das Chatterjee A, Dihazi H, Eschrich K, et al. sll1981, an acetolactate synthase homologue of Synechocystis sp. PCC6803, functions as L-myo-inositol 1-phosphate synthase. Planta. 2006;224:367-79 pubmed..It is probable that sll1981 may code for a bifunctional enzyme protein having conserved domains for both MIPS and acetolactate synthase (ALS) activities. ..
- Jana B, Sau S. The helix located between the two domains of a mip-like peptidyl-prolyl cis-trans isomerase is crucial for its structure, stability, and protein folding ability. Biochemistry. 2012;51:7930-9 pubmed publisher..The data together suggest that length of helix ?3 contributes significantly to the preservation of the structure, function, and stability of E. coli FKBP22. ..
- Thakurta P, Biswas S, Chakrabarti C, Sundd M, Jagannadham M, Dattagupta J. Structural basis of the unusual stability and substrate specificity of ervatamin C, a plant cysteine protease from Ervatamia coronaria. Biochemistry. 2004;43:1532-40 pubmed
- Majumder S, Khamrui S, Dasgupta J, Dattagupta J, Sen U. Role of remote scaffolding residues in the inhibitory loop pre-organization, flexibility, rigidification and enzyme inhibition of serine protease inhibitors. Biochim Biophys Acta. 2012;1824:882-90 pubmed publisher..B-factor analysis indicates that the amount of inhibitory loop rigidification varies between different inhibitor families. ..
- Majee M, Maitra S, Dastidar K, Pattnaik S, Chatterjee A, Hait N, et al. A novel salt-tolerant L-myo-inositol-1-phosphate synthase from Porteresia coarctata (Roxb.) Tateoka, a halophytic wild rice: molecular cloning, bacterial overexpression, characterization, and functional introgression into tobacco-conferring salt tole. J Biol Chem. 2004;279:28539-52 pubmed..MIPS protein isolated from PINO1 transgenics showed salt-tolerant property in vitro confirming functional expression in planta of the PINO1 gene. To our knowledge, this is the first report of a salt-tolerant MIPS from any source. ..
- Majumder A, Chatterjee A, Ghosh Dastidar K, Majee M. Diversification and evolution of L-myo-inositol 1-phosphate synthase. FEBS Lett. 2003;553:3-10 pubmed..However, conservation of a 'core catalytic structure' among the MIPS proteins implies an essential function of the enzyme in cellular metabolism throughout the biological kingdom. ..
- Banerjee M, Datta M, Majumder P, Mukhopadhyay D, Bhattacharyya N. Transcription regulation of caspase-1 by R393 of HIPPI and its molecular partner HIP-1. Nucleic Acids Res. 2010;38:878-92 pubmed publisher..Taking together, we are able to show the importance of R393 of HIPPI and the role of HIPPI-HIP-1 heterodimer in the transcription regulation of caspase-1. ..
- Manna M, Mukhopadhyay C. Cholesterol driven alteration of the conformation and dynamics of phospholamban in model membranes. Phys Chem Chem Phys. 2011;13:20188-98 pubmed publisher..Altogether, our results highlight atomistic details of protein-lipid interplay and provide new insights into the possible effects of cholesterol on conformational dynamics of phospholamban in membrane bilayers...
- Ray S, Patra B, Das Chatterjee A, Ganguli A, Majumder A. Identification and organization of chloroplastic and cytosolic L-myo-inositol 1-phosphate synthase coding gene(s) in Oryza sativa: comparison with the wild halophytic rice, Porteresia coarctata. Planta. 2010;231:1211-27 pubmed publisher..Nucleotide divergence among the different Oryza and Porteresia INO1 genes were calculated and compared. ..
- Datta P, Dasgupta A, Bhakta S, Basu J. Interaction between FtsZ and FtsW of Mycobacterium tuberculosis. J Biol Chem. 2002;277:24983-7 pubmed..tuberculosis. The findings assume particular significance in view of the global efforts to explore new targets in M. tuberculosis for chemotherapeutic intervention. ..
- Sharma K, Mukherjee C, Roy S, De D, Bhattacharyya D. Human placental extract mediated inhibition of proteinase K: implications of heparin and glycoproteins in wound physiology. J Cell Physiol. 2014;229:1212-23 pubmed publisher..Comprehensive analysis of this inhibitory property of placental extract partly explains its efficacy in curing wounds with common bacterial infections. ..
- Iqbal M, Siddiqui A, Alam A, Goyal M, Banerjee C, Sarkar S, et al. Expression, purification and characterization of Plasmodium falciparum vacuolar protein sorting 29. Protein Expr Purif. 2016;120:7-15 pubmed publisher..This study provides purification, biophysical characterization and subcellular localization of PfVPS29 in different asexual stages of P. falciparum. ..
- Kundu S, Roy D. Structural considerations for designing adenosine analogs as selective inhibitors of Trichomonas sp. glyceraldehyde-3- phosphate dehydrogenase. In Silico Biol. 2007;7:583-93 pubmed..This study could further be extended for future anti-trichomonal drug design strategies in order to control trichomoniasis. ..
- Datta A, Roy S, Parrack P. Role of C-terminal residues in oligomerization and stability of lambda CII: implications for lysis-lysogeny decision of the phage. J Mol Biol. 2005;345:315-24 pubmed publisher..The implications of tetrameric organization, essential for CII activity, on the recognition of the direct repeat sequence is discussed...
- Mandal M, Saha S, Ghosh A, Majumder G. Identification and characterization of a sperm motility promoting glycoprotein from buffalo blood serum. J Cell Physiol. 2006;209:353-62 pubmed
- Mondal H, Chakraborti D, Majumder P, Roy P, Roy A, Bhattacharya S, et al. Allergenicity assessment of Allium sativum leaf agglutinin, a potential candidate protein for developing sap sucking insect resistant food crops. PLoS ONE. 2011;6:e27716 pubmed publisher..This is the first report regarding the monitoring of the allergenicity of any mannose-binding monocot lectin having insecticidal efficacy against hemipteran insects. ..
- Bhattacharya R, Sahoo G, Nayak M, Saha D, Sur D, Naik T, et al. Molecular epidemiology of human picobirnaviruses among children of a slum community in Kolkata, India. Infect Genet Evol. 2006;6:453-8 pubmed
- Dasgupta S, Manna D, Basu G. Structural and functional consequences of mutating a proteobacteria-specific surface residue in the catalytic domain of Escherichia coli GluRS. FEBS Lett. 2012;586:1724-30 pubmed publisher..In contrast, most non-proteobacterial GluRS contain Leu, and never Arg, at this position. Our results imply a unique strategy of glutamylation of tRNA(Glu) in proteobacteria under phylum-specific evolutionary compulsions...
- Majumdar S, Ghatak J, Mukherji S, Bhattacharjee H, Bhaduri A. UDPgalactose 4-epimerase from Saccharomyces cerevisiae. A bifunctional enzyme with aldose 1-epimerase activity. Eur J Biochem. 2004;271:753-9 pubmed..cerevisiae UDPgalactose 4-epimerase is a bifunctional enzyme with aldose 1-epimerase activity. The active sites for these two enzymatic activities are located in different regions of the epimerase holoenzyme. ..
- Roy D, Sengupta S. Structural features of a cold-adapted Alaskan bacterial lipase. J Biomol Struct Dyn. 2007;24:463-70 pubmed..Our study may help in understanding the structural features of a cold-adapted lipase and can further be used in engineering lipase that can function at or near extreme temperatures with considerable biotechnological potential. ..
- Roy S, Sarkar S, Singh S, Sengupta D. A dideoxynucleotide-sensitive DNA polymerase activity characterized from endoreduplicating cells of mungbean (Vigna radiata L.) during ontogeny of cotyledons. FEBS J. 2007;274:2005-23 pubmed
- Nandi S, Ghosh P, Roy S. Expression of PITX2 homeodomain transcription factor during rat gonadal development in a sexually dimorphic manner. Cell Physiol Biochem. 2011;27:159-70 pubmed publisher..All the evidences suggest that the differential expression of PITX2 might be associated with sex-specific embryonic and postnatal gonadal development and the physiological processes. ..
- Bhattacharyya M, Ray S, Bhattacharya S, Chakrabarti A. Chaperone activity and prodan binding at the self-associating domain of erythroid spectrin. J Biol Chem. 2004;279:55080-8 pubmed..There are other patches of sequences also in both the spectrin polypeptides, at the other termini as well as in the middle of the rod domain having significant homology with well known chaperone proteins...
- Kundu S, Roy D. Computational study of glyceraldehyde-3-phosphate dehydrogenase of Entamoeba histolytica: implications for structure-based drug design. J Biomol Struct Dyn. 2007;25:25-33 pubmed..In the absence of a crystal structure, our study provides an early insight into the structure of major drug target EhGAPDH, thus, facilitating the inhibitor design. ..
- Basu S, Roy A, Ghosh A, Bera A, Chattopadhyay D, Chakrabarti K. Arg²³? is an essential catalytic residue of Bacillus pumilus DKS1 pectate lyase to degum ramie fibre. Biodegradation. 2011;22:153-61 pubmed publisher..Site directed mutagenesis confirmed that arginine is an essential catalytic residue of DKS1 pectate lyase...
- Roy A, Bera S, Patra S, Ray S, Ray M. A novel D-glyceraldehyde-3-phosphate binding protein, a truncated albumin, with D-glyceraldehyde-3-phosphate dehydrogenase inhibitory property. IUBMB Life. 2009;61:995-1000 pubmed publisher..The implication of this protein in the control of glycolysis has been discussed...
- Chaudhuri P, Basu A, Ghosh A. Aggregation dependent enhancement of trehalose-6-phosphate synthase activity in Saccharomyces cerevisiae. Biochim Biophys Acta. 2008;1780:289-97 pubmed publisher..The association of the active complex was also found to be governed by ionic interactions. ..
- Singh S, Banerjee P. Nucleotide sequence analysis of cryptic plasmid pAM5 from Acidiphilium multivorum. Plasmid. 2007;58:101-14 pubmed publisher..In its natural host, A. multivorum JCM-8867, pAM5 maintains a copy number of 50-60, and its derivative pSK2 maintains a comparatively, higher copy number in E. coli than in acidophiles...
- Acharya M, Mookherjee S, Bhattacharjee A, Thakur S, Bandyopadhyay A, Sen A, et al. Evaluation of the OPTC gene in primary open angle glaucoma: functional significance of a silent change. BMC Mol Biol. 2007;8:21 pubmed..Our study suggests OPTC as a candidate gene for POAG. Further, it highlights the importance of investigating the 'silent' variations for functional implication that might not be apparent from only in silico analysis. ..
- Gomes A, Bhattacharya S, Mukherjee S, Gomes A. Inhibition of toxic actions of phospholipase A2 isolated & characterized from the Indian Banded Krait (Bungarus fasciatus) venom by synthetic herbal compounds. Indian J Med Res. 2012;136:40-5 pubmed
- Mukhopadhyay A, Talukdar S, Bhattacharjee A, Ray K. Bioinformatic approaches for identification and characterization of olfactomedin related genes with a potential role in pathogenesis of ocular disorders. Mol Vis. 2004;10:304-14 pubmed..Noelin 1 and Noelin 2 could be tested as candidate genes for eye diseases based on their expressions in the eye and shared olfactomedin domains with Myocilin in the C-termini of the respective proteins. ..
- Roy S, Choudhury S, Singh S, Das K. Functional analysis of light-regulated promoter region of AtPol? gene. Planta. 2012;235:411-32 pubmed publisher..Overall, our results provide novel information on the role of light signaling in regulation of expression of an important component of DNA repair machinery in plants. ..
- Das S, Raychaudhuri M, Sen U, Mukhopadhyay D. Functional implications of the conformational switch in AICD peptide upon binding to Grb2-SH2 domain. J Mol Biol. 2011;414:217-30 pubmed publisher..Our results reveal the significance of a specific interaction of the two molecules to optimize the rapid transport of AICD inside endosomal vesicles presumably to reduce the cytotoxic load. ..
- Bagchi A, Ghosh T. Structural insight into the interactions of SoxV, SoxW and SoxS in the process of transport of reductants during sulfur oxidation by the novel global sulfur oxidation reaction cycle. Biophys Chem. 2006;119:7-13 pubmed..Our study provides a rational basis to interpret the molecular mechanism of the biochemistry of sulfur anion oxidation reactions by these ecologically important organisms...
- Banerjee R, Nath S, Ranjan A, Khamrui S, Pani B, Sen R, et al. The first structure of polarity suppression protein, Psu from enterobacteria phage P4, reveals a novel fold and a knotted dimer. J Biol Chem. 2012;287:44667-75 pubmed publisher..This structure would help to explain the functional properties of the protein and can be used as a template to design a minimal peptide fragment that can be used as a drug against Rho-dependent transcription termination in bacteria...
- Das D, Samanta D, Hasan S, Das A, Bhattacharya A, Dasgupta S, et al. Identical RNA-protein interactions in vivo and in vitro and a scheme of folding the newly synthesized proteins by ribosomes. J Biol Chem. 2012;287:37508-21 pubmed publisher..Based on this observation, we propose a model here for the nucleation of folding of the nascent protein chain by the PTC...
- Kobayashi H, Otsubo T, Teraoka F, Ikeda K, Seike S, Takahashi E, et al. Involvement of the Arg566 residue of Aeromonas sobria serine protease in substrate specificity. PLoS ONE. 2017;12:e0186392 pubmed publisher..We therefore conclude that the Arg-566 residue of ASP is likely responsible for the selection of substrates. ..
- Mondal G, Baral R, Roychoudhury S. A new Mad2-interacting domain of Cdc20 is critical for the function of Mad2-Cdc20 complex in the spindle assembly checkpoint. Biochem J. 2006;396:243-53 pubmed..Further, we have identified a unique polyhistidine motif with metal binding property adjacent to this second binding domain that may be important for maintaining the overall conformation of Cdc20 for its binding to Mad2. ..
- Pan D, Bera A, De S, Bandyopadhyay S, Das S, Manna B, et al. Relative expression of the 14-3-3 gene in different morphotypes of cysts of Echinococcus granulosus isolated from the Indian buffalo. J Helminthol. 2010;84:394-7 pubmed publisher..The uniform expression of actin II conclusively proves the survivability of the harvested organisms. ..
- Singh S, Roy S, Choudhury S, Sengupta D. DNA repair and recombination in higher plants: insights from comparative genomics of Arabidopsis and rice. BMC Genomics. 2010;11:443 pubmed publisher..These results, altogether, provide a useful framework for further experimental studies in these organisms. ..
- Sinha A, Mandal S, Banerjee S, Ghosh A, Ganguly S, Sil A, et al. Identification and characterization of a FYVE domain from the early diverging eukaryote Giardia lamblia. Curr Microbiol. 2011;62:1179-84 pubmed publisher..lamblia FYVE domain in S. cerevisiae, displays its selective localization to PtdIns(3)P-enriched endosomes. This is the first study to characterize a PtdIns(3)P effector protein in this early-diverged eukaryote. ..
- Singh A, Haldar R, Mandal D, Kundu M. Analysis of the topology of Vibrio cholerae NorM and identification of amino acid residues involved in norfloxacin resistance. Antimicrob Agents Chemother. 2006;50:3717-23 pubmed publisher..Except for D(155), C(196), and Y(384), all of these residues are located in periplasmic loops...
- Goyal M, Alam A, Iqbal M, Dey S, Bindu S, Pal C, et al. Identification and molecular characterization of an Alba-family protein from human malaria parasite Plasmodium falciparum. Nucleic Acids Res. 2012;40:1174-90 pubmed publisher..ChIP and ChIP ReChIP analyses further confirmed that PfAlba3 binds to the telomeric and subtelomeric regions as well as to var gene promoter...
- Bhowmick R, Ghosal A, Das B, Koley H, Saha D, Ganguly S, et al. Intestinal adherence of Vibrio cholerae involves a coordinated interaction between colonization factor GbpA and mucin. Infect Immun. 2008;76:4968-77 pubmed publisher..cholerae...
- Chaki M, Sengupta M, Mukhopadhyay A, Subba Rao I, Majumder P, Das M, et al. OCA1 in different ethnic groups of india is primarily due to founder mutations in the tyrosinase gene. Ann Hum Genet. 2006;70:623-30 pubmed..Direct detection of the mutations prevalent in specific ethnic groups could be used for carrier detection and genetic counselling. ..
- Bagchi A, Roy P. Structural insight into SoxC and SoxD interaction and their role in electron transport process in the novel global sulfur cycle in Paracoccus pantotrophus. Biochem Biophys Res Commun. 2005;331:1107-13 pubmed..The putative active site geometries of these two proteins as well as the structural basis of the involvements of these proteins in electron transport process during the oxidation of sulfur anions are also investigated...
- Kundu M, Sen P, Das K. Structure, stability, and chaperone function of alphaA-crystallin: role of N-terminal region. Biopolymers. 2007;86:177-92 pubmed..Detailed analysis showed that the most important role of N-terminal region is to control the oligomerization, which is crucial for the stability and in vivo survival of this protein molecule. ..
- Das B, Pal R, Bag S, Bhadra R. Stringent response in Vibrio cholerae: genetic analysis of spoT gene function and identification of a novel (p)ppGpp synthetase gene. Mol Microbiol. 2009;72:380-98 pubmed publisher..Analysis of a V. choleraeDeltarelADeltaspoTDeltarelV triple mutant confirmed that apart from canonical relA and spoT genes, relV is a novel gene in V. cholerae responsible for (p)ppGpp synthesis...
- Sabui S, Ghosal A, Dutta S, Ghosh A, Ramamurthy T, Nataro J, et al. Allelic variation in colonization factor CS6 of enterotoxigenic Escherichia coli isolated from patients with acute diarrhoea and controls. J Med Microbiol. 2010;59:770-9 pubmed publisher..Thus, CS6 variants are formed as a result of different allelic combinations of CssA and CssB, and these changes at the functional level might be important in the development of an effective ETEC vaccine. ..
- Sengupta M, Chaki M, Arti N, Ray K. SLC45A2 variations in Indian oculocutaneous albinism patients. Mol Vis. 2007;13:1406-11 pubmed..Interestingly, in almost 31% of the cases, the second mutation has never been found. The purpose of this study was to investigate the molecular basis of OCA among Indians using SLC45A2 as the candidate gene...
- Sengupta S, Banerjee S, Lahiri S, Dutta T, Dhar T, Ghosh A. Purification, characterization, sequencing and molecular cloning of a novel cysteine methyltransferase that regulates trehalose-6-phosphate synthase from Saccharomyces cerevisiae. Biochim Biophys Acta. 2014;1840:1861-71 pubmed publisher..cerevisiae. This is the first report about a cysteine methyltransferase which performs S methylation at cysteine residue regulating TPS activity by 50%, which resulted in an increase of the intercellular stress sugar, trehalose. ..
- Maiti S, Paul S, Pal A. Isolation, characterization, and structure analysis of a non-TIR-NBS-LRR encoding candidate gene from MYMIV-resistant Vigna mungo. Mol Biotechnol. 2012;52:217-33 pubmed publisher..mungo plants from MYMIV. This suggests involvement of CYR1 in recognizing MYMIV-effector molecule thus contributing to incompatible interaction. This study is the first stride to understand molecular mechanism of MYMIV resistance. ..
- Mandal D, Moitra P, Basu J. Mapping of a spectrin-binding domain of human erythrocyte membrane protein 4.2. Biochem J. 2002;364:841-7 pubmed..2 confirmed that these residues are crucial in mediating protein 4.2-spectrin interactions. ..
- Datta A, Bhattacharyya D, Singh S, Ghosh A, Schmidtchen A, Malmsten M, et al. Role of Aromatic Amino Acids in Lipopolysaccharide and Membrane Interactions of Antimicrobial Peptides for Use in Plant Disease Control. J Biol Chem. 2016;291:13301-17 pubmed publisher..We thus present key structural aspects of KYE28, constituting an aromatic zipper, of potential importance for the development of novel plant protection agents and therapeutic agents. ..
- Raychaudhuri S, Majumder P, Sarkar S, Giri K, Mukhopadhyay D, Bhattacharyya N. Huntingtin interacting protein HYPK is intrinsically unstructured. Proteins. 2008;71:1686-98 pubmed
- Maulik A, Ghosh H, Basu S. Comparative study of protein-protein interaction observed in PolyGalacturonase-Inhibiting Proteins from Phaseolus vulgaris and Glycine max and PolyGalacturonase from Fusarium moniliforme. BMC Genomics. 2009;10 Suppl 3:S19 pubmed publisher..Docking studies reveal that PvPGIP2 and GmPGIP3 interact with the residues constituting the active site of FmPG with implications that the proteins bind/block FmPG at its active site and thereby inhibit the enzyme. ..