Experts and Doctors on membrane transport proteins in New Delhi, NCT, India

Summary

Locale: New Delhi, NCT, India
Topic: membrane transport proteins

Top Publications

  1. Shukla S, Yadav V, Mukhopadhyay G, Prasad R. Ncb2 is involved in activated transcription of CDR1 in azole-resistant clinical isolates of Candida albicans. Eukaryot Cell. 2011;10:1357-66 pubmed publisher
    ..Taken together, our results show that Ncb2, in conjunction with Tac1, is involved in the transcriptional activation of CDR1, opening up new therapeutic possibilities to combat multidrug resistance (MDR) in C. albicans. ..
  2. Saini V, Raghuvanshi S, Khurana J, Ahmed N, Hasnain S, Tyagi A, et al. Massive gene acquisitions in Mycobacterium indicus pranii provide a perspective on mycobacterial evolution. Nucleic Acids Res. 2012;40:10832-50 pubmed publisher
  3. Mukherjee P, Prasad R. Purified arginine permease of Candida albicans is functionally active in a reconstituted system. Yeast. 1998;14:335-45 pubmed
    ..All the characteristic features of L-arginine transport displayed by the reconstituted system were similar to those observed in intact cells. Thus homogeneous purified arginine permease was also functionally active. ..
  4. Manoharlal R, Gorantala J, Sharma M, Sanglard D, Prasad R. PAP1 [poly(A) polymerase 1] homozygosity and hyperadenylation are major determinants of increased mRNA stability of CDR1 in azole-resistant clinical isolates of Candida albicans. Microbiology. 2010;156:313-26 pubmed publisher
  5. Prasad R, Shah A, Sanwal H, Kapoor K. Alanine scanning of all cysteines and construction of a functional cysteine-less Cdr1p, a multidrug ABC transporter of Candida albicans. Biochem Biophys Res Commun. 2012;417:508-13 pubmed publisher
  6. Prasad R, Goffeau A. Yeast ATP-binding cassette transporters conferring multidrug resistance. Annu Rev Microbiol. 2012;66:39-63 pubmed publisher
    ..Here, we review current achievements concerning the structure, molecular mechanism, and physiological functions of yeast Pdr transporters...
  7. Wahajuddin -, Taneja I, Arora S, Raju K, Siddiqui N. Disposition of pharmacologically active dietary isoflavones in biological systems. Curr Drug Metab. 2013;14:369-80 pubmed
    ..Further, the effects of these phytoestrogens on the activity and kinetics of drug metabolizing enzymes and various clinically relevant influx/efflux transporters and the resulting diet-drug interactions have also been discussed. ..
  8. Jan A, Azam M, Choi I, Ali A, Haq Q. Analysis for the presence of determinants involved in the transport of mercury across bacterial membrane from polluted water bodies of India. Braz J Microbiol. 2016;47:55-62 pubmed publisher
  9. Mónico A, Nim S, Duarte N, Rawal M, Prasad R, Di Pietro A, et al. Lathyrol and epoxylathyrol derivatives: Modulation of Cdr1p and Mdr1p drug-efflux transporters of Candida albicans in Saccharomyces cerevisiae model. Bioorg Med Chem. 2017;25:3278-3284 pubmed publisher

Scientific Experts

More Information

Publications15

  1. Rai V, Shukla S, Jha S, Komath S, Prasad R. Functional characterization of N-terminal nucleotide binding domain (NBD-1) of a major ABC drug transporter Cdr1p of Candida albicans: uncommon but conserved Trp326 of Walker B is important for ATP binding. Biochemistry. 2005;44:6650-61 pubmed
  2. Gaur M, Puri N, Manoharlal R, Rai V, Mukhopadhayay G, Choudhury D, et al. MFS transportome of the human pathogenic yeast Candida albicans. BMC Genomics. 2008;9:579 pubmed publisher
    ..Considering the clinical relevance of C. albicans and role of MFS members in antifungal resistance and nutrient transport, this analysis would pave way for identifying their physiological relevance. ..
  3. Ahmad A, Khan A, Manzoor N. Reversal of efflux mediated antifungal resistance underlies synergistic activity of two monoterpenes with fluconazole. Eur J Pharm Sci. 2013;48:80-6 pubmed publisher
    ..The selectively fungicidal characteristics and ability to restore FLC susceptibility in resistant isolates signify a promising candidature of THY and CARV as antifungal agents in combinational treatments for candidiasis. ..
  4. Kumar A, Sharma V, Khan M, Hindala M, Kumar S. Auxin transport inhibitor induced low complexity petiolated leaves and sessile leaf-like stipules and architectures of heritable leaf and stipule mutants in Pisum sativum suggest that its simple lobed stipules and compound leaf represent ancestral fo. J Genet. 2013;92:25-61 pubmed
    ..v) All forms of leaves, including simple leaf, probably have origins in a gene regulatory network of the kind present in P. sativum. ..
  5. Thomas E, Roman E, Claypool S, Manzoor N, Pla J, Panwar S. Mitochondria influence CDR1 efflux pump activity, Hog1-mediated oxidative stress pathway, iron homeostasis, and ergosterol levels in Candida albicans. Antimicrob Agents Chemother. 2013;57:5580-99 pubmed publisher
    ..Collectively, these findings reinforce the connection between functional mitochondria and azole tolerance, oxidant-mediated stress, and iron homeostasis in C. albicans. ..
  6. Gupta A, Thelma B. Identification of critical variants within SLC44A4, an ulcerative colitis susceptibility gene identified in a GWAS in north Indians. Genes Immun. 2016;17:105-9 pubmed publisher
    ..This highlights the importance of this gene in UC biology, thus confirming the finding of the GWAS and also warranting additional studies. ..