Experts and Doctors on middle aged in Hong Kong, Central and Western, Hong Kong


Locale: Hong Kong, Central and Western, Hong Kong
Topic: middle aged

Top Publications

  1. Pang C, Baum L, Chan W, Lau T, Poon P, Lam D. The apolipoprotein E epsilon4 allele is unlikely to be a major risk factor of age-related macular degeneration in Chinese. Ophthalmologica. 2000;214:289-91 pubmed
    ..Thus we cannot exclude a possible effect of this allele on ARMD risk, but we can conclude that this allele is likely not a major factor influencing ARMD risk in the Chinese. ..
  2. Ng F, Wong W, Wong B, Kng C, Wong S, Lai K, et al. Sequential intravenous/oral antibiotic vs. continuous intravenous antibiotic in the treatment of pyogenic liver abscess. Aliment Pharmacol Ther. 2002;16:1083-90 pubmed
    ..A sequential intravenous/oral antibiotic regime is a safe and effective treatment for pyogenic liver abscess. This reduces the cost of therapy and the length of hospital stay. ..
  3. Lau H, Patil N, Yuen W, Lee F. Management of peritoneal tear during endoscopic extraperitoneal inguinal hernioplasty. Surg Endosc. 2002;16:1474-7 pubmed
    ..Its occurrence significantly prolongs the length of operation. Endoscopic stapling and pretied suture loop ligation are safe and quick techniques for the closure of peritoneal tear during TEP. ..
  4. Lau H, Patil N, Yuen W, Lee F. Laparoscopic incisional hernioplasty utilising on-lay expanded polytetrafluoroethylene DualMesh: prospective study. Hong Kong Med J. 2002;8:413-7 pubmed
    ..Extensive adhesion, which does not allow the establishment of pneumoperitoneum, is a condition that precludes the safe performance of laparoscopic repair. ..
  5. Sy S, Wong N, Mok T, Tsao M, Lee T, Tse G, et al. Genetic alterations of lung adenocarcinoma in relation to smoking and ethnicity. Lung Cancer. 2003;41:91-9 pubmed
    ..006). In particular, regional over-representations of 13q21-q34 (P=0.044), 17q25 (P=0.015), 19q13.1 (P=0.044) and 22q (P=0.044) may have implications for the pathologic pathways associated with the tobacco-related lung adenocarcinoma. ..
  6. Chim C, Hu W, Loong F, Ooi G, Liang R. GI manifestations of mantle cell lymphoma. Gastrointest Endosc. 2003;58:931-3 pubmed
  7. Tse G, Lui P, Lee C, Kung F, Scolyer R, Law B, et al. Stromal expression of vascular endothelial growth factor correlates with tumor grade and microvessel density in mammary phyllodes tumors: a multicenter study of 185 cases. Hum Pathol. 2004;35:1053-7 pubmed
    ..Assessment of stromal VEGF may be useful as an adjunctive diagnostic criterion in the histologic assessment of malignancy in phyllodes tumors. ..
  8. Chan K, Cheng V, Woo P, Lau S, Poon L, Guan Y, et al. Serological responses in patients with severe acute respiratory syndrome coronavirus infection and cross-reactivity with human coronaviruses 229E, OC43, and NL63. Clin Diagn Lab Immunol. 2005;12:1317-21 pubmed
    ..There is a need for awareness of cross-reactive antibody responses between coronaviruses when interpreting IF serology. ..
  9. Yu A, Critchley L, Lee A, Gin T. Alfentanil dosage when inserting the classic laryngeal mask airway. Anesthesiology. 2006;105:684-8 pubmed
    ..The optimum dose for alfentanil, when coadministered with 2.5 mg/kg propofol, was 10 microg/kg. ..

More Information

Publications345 found, 100 shown here

  1. Chen G, Ho R, Wong J, Lee K, Lai P. Single nucleotide polymorphism in the promoter region of human alpha-fetoprotein (AFP) gene and its significance in hepatocellular carcinoma (HCC). Eur J Surg Oncol. 2007;33:882-6 pubmed
    ..The novel polymorphisms identified in the promoter region of the AFP gene may be pathologically significant in HCC. ..
  2. Chan S, Mo F, Johnson P, Hui E, Ma B, Ho W, et al. New utility of an old marker: serial alpha-fetoprotein measurement in predicting radiologic response and survival of patients with hepatocellular carcinoma undergoing systemic chemotherapy. J Clin Oncol. 2009;27:446-52 pubmed publisher
    ..Incorporation of AFP response into the criteria evaluating treatment outcome should be considered in clinical practice and clinical trials of novel agents in HCC. ..
  3. Cheung A, Fung T, Fan A, Wan T, Chow H, Leung J, et al. Successful engraftment by leukemia initiating cells in adult acute lymphoblastic leukemia after direct intrahepatic injection into unconditioned newborn NOD/SCID mice. Exp Hematol. 2010;38:3-10 pubmed publisher
    ..In this study, we reported an undescribed model in which adult ALL cells were injected into unconditioned newborn nonobese diabetic severe combined immunodeficient mice via an intrahepatic route...
  4. You J, Wong R, Waye M, Mu Y, Lim C, Choi K, et al. Warfarin dosing algorithm using clinical, demographic and pharmacogenetic data from Chinese patients. J Thromb Thrombolysis. 2011;31:113-8 pubmed publisher
    ..In conclusion, a genotype-guided dosing algorithm for warfarin therapy was developed for Chinese patients to explain 68% of dosage variation. The predicted doses differed from the actual doses by no more than 20% in 50% of patients. ..
  5. Lao X, Thomas G, Jiang C, Zhang W, Adab P, Lam T, et al. Obesity, high-sensitive C-reactive protein and snoring in older Chinese: the Guangzhou Biobank Cohort Study. Respir Med. 2010;104:1750-6 pubmed publisher
    ..We therefore investigated whether snoring may mediate the increased vascular risk directly through increased inflammation as indicated by HsCRP levels or if other determinants predominated in a large older Chinese population...
  6. Or C, Karsh B, Severtson D, Burke L, Brown R, Brennan P. Factors affecting home care patients' acceptance of a web-based interactive self-management technology. J Am Med Inform Assoc. 2011;18:51-9 pubmed publisher
  7. Yan E, Wu A, Ho P, Pearson V. Older Chinese men and women's experiences and understanding of sexuality. Cult Health Sex. 2011;13:983-99 pubmed publisher
    ..The lack of an appropriate partner due to widowhood, the partner's physical condition or a poor spousal relationship apparently accounted for the low levels of sexual activity reported by informants. ..
  8. Chan G, Leung A, Wong A, Chan K, Kwong Y, Lai K, et al. Quantification of BK viral load in asymptomatic renal allograft recipients. Ren Fail. 2012;34:550-4 pubmed publisher
    ..Our findings may guide optimal immunosuppressive modulation in PVAN cases, where judicious manipulation of immunosuppression is required without inciting allograft rejection. ..
  9. Wong K, Kumta S, Sze K, Wong C. Use of a patient-specific CAD/CAM surgical jig in extremity bone tumor resection and custom prosthetic reconstruction. Comput Aided Surg. 2012;17:284-93 pubmed publisher
    ..Further assessment in a larger population is necessary to determine the clinical efficacy of the technique...
  10. Li K, Yang L, Pang J, Chan A, Zhou L, Mao Y, et al. MIR-137 suppresses growth and invasion, is downregulated in oligodendroglial tumors and targets CSE1L. Brain Pathol. 2013;23:426-39 pubmed publisher
    ..Overall, our data suggest that miR-137 regulates growth of glioma cells and targets CSE1L, providing further understanding in the tumorigenesis of gliomas. ..
  11. Leung K, Yeoh G, Cheung H, Fong F, Chan K. Prevalence of abnormal Papanicolaou smears in female sex workers in Hong Kong. Hong Kong Med J. 2013;19:203-6 pubmed publisher
  12. Wong D, Watanabe T, Tanaka Y, Seto W, Lee C, Fung J, et al. Role of HLA-DP polymorphisms on chronicity and disease activity of hepatitis B infection in Southern Chinese. PLoS ONE. 2013;8:e66920 pubmed publisher
    ..HLA-DP SNPs rs3077, rs9277378 and rs3128917 were associated with chronicity of HBV disease in the Chinese. Further studies are required to determine whether these SNPs influence the disease endemicity in different ethnic populations. ..
  13. Lee J, Wong R, Chan J, Wong I, Lai J. Differences in corneal parameters between normal tension glaucoma and primary open-angle glaucoma. Int Ophthalmol. 2015;35:67-72 pubmed publisher
    ..2,530.0 ± 320.4 cells/mm(2), p = 0.04). There were no significant differences in the spherical equivalent or CCT between the NTG and POAG groups. A significantly lower corneal endothelial cell count was found in NTG compared to POAG. ..
  14. Chang W, Hui C, Chan S, Lee E, Chen E. Impact of avolition and cognitive impairment on functional outcome in first-episode schizophrenia-spectrum disorder: a prospective one-year follow-up study. Schizophr Res. 2016;170:318-21 pubmed publisher
    ..Our findings indicate the central role of in determining longitudinal functional status in the early illness stage. ..
  15. Moots R, Xavier R, Mok C, Rahman M, Tsai W, Al Maini M, et al. The impact of anti-drug antibodies on drug concentrations and clinical outcomes in rheumatoid arthritis patients treated with adalimumab, etanercept, or infliximab: Results from a multinational, real-world clinical practice, non-interventional study. PLoS ONE. 2017;12:e0175207 pubmed publisher
    ..ADA were detected in ADL- and IFX-treated but not ETN-treated patients. Patients without ADA generally showed numerically better clinical outcomes than those with ADA. This study was registered on (NCT01981473). ..
  16. Tsang W, Chan J, Ng C. Kikuchi's lymphadenitis. A morphologic analysis of 75 cases with special reference to unusual features. Am J Surg Pathol. 1994;18:219-31 pubmed
  17. Fu W, Wu W, Ip F. Concomitant tuberculosis and pyogenic infection of the cervical spine. A case report. Spine (Phila Pa 1976). 1998;23:139-43 pubmed
    ..Examination of biopsy samples for histologic and bacteriologic findings is important to confirm this diagnosis. Radical debridement and combination therapy are strongly recommended to treat patients with this combination of infections. ..
  18. Tse G, Putti T, Lui P, Lo A, Scolyer R, Law B, et al. Increased c-kit (CD117) expression in malignant mammary phyllodes tumors. Mod Pathol. 2004;17:827-31 pubmed
    ..This provides strong evidence that c-kit receptor mediated tyrosine kinase involvement in the pathogenesis of phyllodes tumors, and the therapeutic agent, STI571, Glivec, may be a potentially useful drug for its management. ..
  19. Ko F, Lau C, Leung T, Wong G, Lam C, Hui D. Exhaled breath condensate levels of 8-isoprostane, growth related oncogene alpha and monocyte chemoattractant protein-1 in patients with chronic obstructive pulmonary disease. Respir Med. 2006;100:630-8 pubmed
    ..8-isoprostane level, but not GROalpha and MCP-1, in EBC was increased in COPD patients with poorer lung function. This suggests an increased oxidative stress in the airway in patients with more severe COPD. ..
  20. Lui P, Tse G, Tan P, Jayaram G, Putti T, Chaiwun B, et al. Fine-needle aspiration cytology of metaplastic carcinoma of the breast. J Clin Pathol. 2007;60:529-33 pubmed
    ..Metaplastic carcinoma of the breast encompasses a heterogeneous group of tumours with variable components of sarcomatoid, squamous or poorly differentiated carcinomas...
  21. Chan K, Ching J, Xu M, Cheung A, Yip S, Yam L, et al. Association of ICAM3 genetic variant with severe acute respiratory syndrome. J Infect Dis. 2007;196:271-80 pubmed
    ..31 [95% confidence interval {CI}, 1.37-13.56]) and lower total white blood cell counts (P=.022; OR, 0.30 [95% CI, 0.10-0.89]) on admission. These findings support the role of ICAM3 in the immunopathogenesis of SARS. ..
  22. Ho S, Chan S, Yip Y, Chan C, Woo J, Sham A. Change in bone mineral density and its determinants in pre- and perimenopausal Chinese women: the Hong Kong Perimenopausal Women Osteoporosis Study. Osteoporos Int. 2008;19:1785-96 pubmed publisher
    ..Higher baseline LM was also protective for neck of femur BMD. Maintenance of body weight and physical fitness were observed to have a protective effect on for bone loss in Chinese perimenopausal women. ..
  23. Cheung C, Tso A, Cheung B, Xu A, Ong K, Fong C, et al. Obesity susceptibility genetic variants identified from recent genome-wide association studies: implications in a chinese population. J Clin Endocrinol Metab. 2010;95:1395-403 pubmed publisher
    ..Further functional and fine-mapping studies to elucidate the roles of these putative obesity-related genes and genetic variants are warranted. ..
  24. Tomlinson B, Hu M, Lee V, Lui S, Chu T, Poon E, et al. ABCG2 polymorphism is associated with the low-density lipoprotein cholesterol response to rosuvastatin. Clin Pharmacol Ther. 2010;87:558-62 pubmed publisher
    ..As compared with subjects with the c.421CC genotype, those with the c.421AA genotype showed a 6.9% greater reduction in LDL-C level, which would be equivalent to the effect obtained by doubling the dose of rosuvastatin...
  25. Mok E, Wong F, Wong D. The meaning of spirituality and spiritual care among the Hong Kong Chinese terminally ill. J Adv Nurs. 2010;66:360-70 pubmed publisher
    ..For dying individuals to experience love and for them to be understood as valuable even when no longer economically productive are both experiences of healing. ..
  26. Chan C, Alvarez Bognar F, Wong K, Leung C, Tam C, Chan K, et al. The epidemiology and clinical manifestations of human immunodeficiency virus-associated tuberculosis in Hong Kong. Hong Kong Med J. 2010;16:192-8 pubmed
    ..Continual surveillance of both conditions is imperative, especially in view of a possible link between human immunodeficiency virus and multidrug-resistant tuberculosis. ..
  27. Leung T, Yip S, Lam C, Chan T, Lam W, Siu D, et al. Genetic predisposition of white matter infarction with protein S deficiency and R355C mutation. Neurology. 2010;75:2185-9 pubmed publisher
    ..The findings substantiate an association between PSD and stroke. Study of the mechanism underlying this association may improve our understanding of premature cryptogenic white matter infarction. ..
  28. Chan K, Brownridge D, Fong D, Tiwari A, Leung W, Ho P. Violence against pregnant women can increase the risk of child abuse: a longitudinal study. Child Abuse Negl. 2012;36:275-84 pubmed publisher
    ..This underscores the importance of screening pregnant women for IPV in order to prevent CAN at an early stage. Home visitations are suggested to break the cycle of violence within a nuclear family. ..
  29. Kam A, Sung J, Lee T, Wong T, Van Hasselt A. Clinical evaluation of a computerized self-administered hearing test. Int J Audiol. 2012;51:606-10 pubmed publisher
    ..The results suggest that the computerized self-administered hearing test is a reliable and valid measure of unmasked air-conduction hearing thresholds. ..
  30. Wen C, Cui J, Lee M, Mak K, Luk K, Hu Y. Quantitative analysis of fiber tractography in cervical spondylotic myelopathy. Spine J. 2013;13:697-705 pubmed publisher
    ..316, p=.684). The quantitative analysis of fiber tractography is a reliable approach to detect cervical spondylotic myelopathic lesions compared with healthy spinal cords. It could be employed to delineate the severity of CSM. ..
  31. Leung Y, Lee T, Ho S, Cheung L. Trigeminal neurosensory deficit and patient reported outcome measures: the effect on life satisfaction and depression symptoms. PLoS ONE. 2013;8:e72891 pubmed publisher
    ..02). Individuals with permanent trigeminal neurosensory deficit after lower third molar surgery have worse life satisfaction and more depressive symptoms when compared to those who did not suffer from the surgical complication. ..
  32. Tsang J, Kwok Y, Chan K, Ni Y, Chow W, Lau K, et al. Expression and clinical significance of carcinoembryonic antigen-related cell adhesion molecule 6 in breast cancers. Breast Cancer Res Treat. 2013;142:311-22 pubmed publisher
    ..Within this group, CEACAM6 was associated with adverse high nodal stage patient outcome. Given the wide expression of CEACAM6 in all breast cancers, its roles as prognostic marker and therapeutic target warrant further evaluation. ..
  33. Seto W, Cheung K, Wong D, Huang F, Fung J, Liu K, et al. Hepatitis B surface antigen seroclearance during nucleoside analogue therapy: surface antigen kinetics, outcomes, and durability. J Gastroenterol. 2016;51:487-95 pubmed publisher
    ..NA-treated patients achieving HBsAg seroclearance uniquely maintained high rates of HBsAg reduction throughout treatment, with HBsAg seroclearance durable in most of the patients after treatment cessation. ..
  34. Chan D, Luk A, So W, Kong A, Chow F, Ma R, et al. Natural history and outcome in Chinese patients with gastroenteropancreatic neuroendocrine tumours: - a 17-year retrospective analysis. BMC Endocr Disord. 2016;16:12 pubmed publisher
    ..Multidisciplinary approach in the management of patients with GEP-NETs may help improve the treatment efficacy and outcome. ..
  35. Cheung K, Yung S, Chau M, Yap D, Chan K, Lee C, et al. Annexin II-binding immunoglobulins in patients with lupus nephritis and their correlation with disease manifestations. Clin Sci (Lond). 2017;131:653-671 pubmed publisher
    ..The co-localization of annexin II and p11 expression with immune deposition in the kidney suggests pathogenic relevance. ..
  36. Haycock P, Burgess S, Nounu A, Zheng J, Okoli G, Bowden J, et al. Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases: A Mendelian Randomization Study. JAMA Oncol. 2017;3:636-651 pubmed publisher
    ..28-0.61]) and interstitial lung disease (OR, 0.09 [95% CI, 0.05-0.15]). It is likely that longer telomeres increase risk for several cancers but reduce risk for some non-neoplastic diseases, including cardiovascular diseases. ..
  37. Chong L, Lo K. Cutaneous tuberculosis in Hong Kong: a 10-year retrospective study. Int J Dermatol. 1995;34:26-9 pubmed
    ..Tuberculosis verrucosa cutis was the commonest type. Because the last survey was carried out 25 years ago, it was thought necessary to find out the new incidence and pattern of this important disease in this locality...
  38. Chu F, Li T, Lui V, Newsome P, Chow R, Cheung L. Prevalence of impacted teeth and associated pathologies--a radiographic study of the Hong Kong Chinese population. Hong Kong Med J. 2003;9:158-63 pubmed
    ..Caries and periodontal diseases were commonly seen in relation to the impacted third molars, whereas cystic pathology and root resorption were rarely observed. ..
  39. Lee A, Ciocca V, Whitehill T. Acoustic correlates of hypernasality. Clin Linguist Phon. 2003;17:259-64 pubmed
    ..This study showed that one-third-octave analysis has high intrajudge reliability and is applicable to the speech of adults with hypernasality due to different etiologies. ..
  40. Liu S, Leung R, Chan K, Chiu P, Cheung A, Tam K, et al. p73 expression is associated with the cellular radiosensitivity in cervical cancer after radiotherapy. Clin Cancer Res. 2004;10:3309-16 pubmed
    ..Our findings suggested that p73 expression was related to the radiosensitivity of cervical cancer cells and may play an important role in the regulation of cellular radiosensitivity. ..
  41. Lam W, Chu W, Tang A, Tse G, Ma T. Role of radiologic features in the management of papillary lesions of the breast. AJR Am J Roentgenol. 2006;186:1322-7 pubmed
    ..Fine-needle aspiration and core biopsy have pitfalls, and the need for surgical excision of all papillary lesions should be revisited. ..
  42. Chan W, Lai T, Wong A, Liu D, Lam D. Combined photodynamic therapy and intravitreal triamcinolone injection for the treatment of choroidal neovascularisation secondary to pathological myopia: a pilot study. Br J Ophthalmol. 2007;91:174-9 pubmed
    ..To assess the efficacy and safety of combined intravitreal triamcinolone (IVTA) and photodynamic therapy (PDT) with verteporfin in the treatment of choroidal neovascularisation (CNV) secondary to pathological myopia...
  43. Tam L, Tomlinson B, Chu T, Li M, Leung Y, Kwok L, et al. Cardiovascular risk profile of patients with psoriatic arthritis compared to controls--the role of inflammation. Rheumatology (Oxford). 2008;47:718-23 pubmed publisher
    ..These data support the hypothesis that PsA may be associated with obesity, hypertension, dyslipidaemia and insulin resistance because of the shared inflammatory pathway. ..
  44. Chan C, Cheng A, Leung C, Cheung C, Yung A, Gong B, et al. Quantitative assessment of optic nerve head morphology and retinal nerve fibre layer in non-arteritic anterior ischaemic optic neuropathy with optical coherence tomography and confocal scanning laser ophthalmoloscopy. Br J Ophthalmol. 2009;93:731-5 pubmed publisher
    ..A larger sample size is necessary to demonstrate if disc size affects the risk of developing NAION. The NAION-affected eyes' OCT RNFLT correlated with HVF mean deviation but the HRT RNFLT did not. ..
  45. Wong V, Yu J, Cheng A, Wong G, Chan H, Chu E, et al. High serum interleukin-6 level predicts future hepatocellular carcinoma development in patients with chronic hepatitis B. Int J Cancer. 2009;124:2766-70 pubmed publisher
    ..This may assist clinicians in selecting high-risk patients for HCC surveillance program. ..
  46. Chim C, Fung T, Liang R. Methylation of cyclin-dependent kinase inhibitors, XAF1, JUNB, CDH13 and soluble Wnt inhibitors in essential thrombocythaemia. J Clin Pathol. 2010;63:518-21 pubmed publisher
    ..Whether differential methylation may occur in the progenitor or mature blood cell compartments remains to be verified. Our study contributes to the literature on methylation in chronic myeloproliferatve diseases. ..
  47. Jin O, Kavikondala S, Mok M, Sun L, Gu J, Fu R, et al. Abnormalities in circulating plasmacytoid dendritic cells in patients with systemic lupus erythematosus. Arthritis Res Ther. 2010;12:R137 pubmed publisher
    ..We suggest circulating pDCs may be pathogenically relevant in SLE. ..
  48. Mok C, Ho L, Leung H, Wong L. Performance of anti-C1q, antinucleosome, and anti-dsDNA antibodies for detecting concurrent disease activity of systemic lupus erythematosus. Transl Res. 2010;156:320-5 pubmed publisher
    ..The anti-C1q antibody, however, is more specific than anti-dsDNA for both active renal and extrarenal lupus. The absence of both anti-dsDNA and anti-C1q has a high NPV for renal activity. ..
  49. Yu S, Leung T, Hung E, Lee K, Wong L. Angioplasty and stenting for intracranial atherosclerotic stenosis with nitinol stent: factors affecting technical success and patient safety. Neurosurgery. 2012;70:104-13 pubmed publisher
    ..Procedure-related factors could be identified and lead to improvements in patient safety and technical outcome. Tortuous vascular morphology is a key factor to be overcome. ..
  50. Gu J, Chan T, Zhang J, Leung A, Kwong Y, Khong P. Whole-body diffusion-weighted imaging: the added value to whole-body MRI at initial diagnosis of lymphoma. AJR Am J Roentgenol. 2011;197:W384-91 pubmed publisher
    ..With technical optimization, whole-body MRI with DWI, as a nonionizing imaging modality, may potentially be useful as an alternative method to PET/CT in the management of malignant lymphoma. ..
  51. Law S, Ma K, Li K. The clinical characteristics of lupus related protein-losing enteropathy in Hong Kong Chinese population: 10 years of experience from a regional hospital. Lupus. 2012;21:840-7 pubmed publisher
    ..There appears to be increasing prevalence of SLE related PLE. A diagnosis can be made using 99m Tc-labeled HSA scintigraphy. PLE generally responds well to immunosuppressive therapy. ..
  52. Tsang J, Lai M, Wong K, Chan S, Lam C, Tsang A, et al. ?B-crystallin is a useful marker for triple negative and basal breast cancers. Histopathology. 2012;61:378-86 pubmed publisher
    ..crystallin also demonstrated a high specificity (92.9%) and an even higher sensitivity (56.5%) for BLBCs. The findings indicated that ?B-crystallin was a highly sensitive and specific marker for TNBCs and BLBCs. ..
  53. Ren S, Cheng A, To K, Tong J, Li M, Shen J, et al. Host immune defense peptide LL-37 activates caspase-independent apoptosis and suppresses colon cancer. Cancer Res. 2012;72:6512-23 pubmed publisher
    ..Collectively, our findings show that LL-37 activates a GPCR-p53-Bax/Bak/Bcl-2 signaling cascade that triggers AIF/EndoG-mediated apoptosis in colon cancer cells. ..
  54. Yiu Y, Yiu K, Siu C, Chan Y, Li S, Wong L, et al. Randomized controlled trial of vitamin D supplement on endothelial function in patients with type 2 diabetes. Atherosclerosis. 2013;227:140-6 pubmed publisher
    ..05). In patients with type 2 DM, 12 weeks oral supplementation of vitamin D did not significantly affect vascular function or serum biomarkers of inflammation and oxidative stress. HKCTR-867, ..
  55. Yau T, Tang V, Yao T, Fan S, Lo C, Poon R. Development of Hong Kong Liver Cancer staging system with treatment stratification for patients with hepatocellular carcinoma. Gastroenterology. 2014;146:1691-700.e3 pubmed publisher
    ..The HKLC system should be validated in non-Asian patient populations and in patients with different etiologies of HCC. ..
  56. Liu R, Hu B, Li Q, Jing X, Zhong C, Chang Y, et al. Novel genes and variants associated with IgA nephropathy by co-segregating with the disease phenotypes in 10 IgAN families. Gene. 2015;571:43-51 pubmed publisher
    ..We discovered 6 deleterious variants in 4 genes associated with familial IgAN. These genes are good candidate genes that appear to be causally related to IgAN and warrant further study. ..
  57. Ramalingam S, O Byrne K, Boyer M, Mok T, Jänne P, Zhang H, et al. Dacomitinib versus erlotinib in patients with EGFR-mutated advanced nonsmall-cell lung cancer (NSCLC): pooled subset analyses from two randomized trials. Ann Oncol. 2016;27:423-9 pubmed publisher
    ..An ongoing phase III study will compare dacomitinib to gefitinib in first-line therapy of patients with NSCLC harboring common activating EGFR mutations (ARCHER 1050; NCT01774721). ARCHER 1009 (NCT01360554) and A7471028 (NCT00769067). ..
  58. Thøgersen Ntoumani C, Ng J, Ntoumanis N, Chatzisarantis N, Vlachopoulos S, Katartzi E, et al. 'Mum's the word': Predictors and outcomes of weight concerns in pre-adolescent and early adolescent girls. Body Image. 2016;16:107-12 pubmed publisher
    ..Daughters' concerns with their weight were a strong predictor of eating restraint, but not exercise behavior. ..
  59. Wang B, Lv K, Chen W, Zhao J, Luo J, Wu J, et al. miR-375 and miR-205 Regulate the Invasion and Migration of Laryngeal Squamous Cell Carcinoma Synergistically via AKT-Mediated EMT. Biomed Res Int. 2016;2016:9652789 pubmed publisher
  60. Lee H, Lo K, Wei W, Tsao S, Chung G, Ibrahim M, et al. Oncogenic S1P signalling in EBV-associated nasopharyngeal carcinoma activates AKT and promotes cell migration through S1P receptor 3. J Pathol. 2017;242:62-72 pubmed publisher
    ..Copyright © 2017 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. ..
  61. Mak P, Irwin M, Ooi C, Chow B. Incidence of diaphragmatic paralysis following supraclavicular brachial plexus block and its effect on pulmonary function. Anaesthesia. 2001;56:352-6 pubmed
    ..All patients remained asymptomatic throughout, with normal oxygen saturation on room air. ..
  62. Lee C, Leung Y, Chow W. Transcatheter closure of the patent ductus arteriosus using an Amplatzer duct occluder in adults. Jpn Heart J. 2001;42:533-7 pubmed
    ..Our initial experience with an of ADO in an adult population appears to be encouraging and as good as in paediatric patients. ..
  63. Lo K, Cheung T, Yim S, Chung T. Hysteroscopic dissemination of endometrial carcinoma using carbon dioxide and normal saline: a retrospective study. Gynecol Oncol. 2002;84:394-8 pubmed
    ..This report emphasizes the need for prospective evaluation for further clarification of this hypothesis. The clinical significance of the dissemination awaits the long-term follow-up of these patients. ..
  64. Wong K, Liu Y, Ng P, Young B, Lee S. Epidemiology of hepatitis A and hepatitis E infection and their determinants in adult Chinese community in Hong Kong. J Med Virol. 2004;72:538-44 pubmed
    ..001). The increasing proportion of susceptible population to enterically transmitted viral hepatitis has implications to future prevention and control programmes, including vaccination strategies...
  65. Wong T, Yau J, Chan C, Kwong R, Ho S, Lau C, et al. The psychological impact of severe acute respiratory syndrome outbreak on healthcare workers in emergency departments and how they cope. Eur J Emerg Med. 2005;12:13-8 pubmed
    ..Overall, the more frequently adopted coping strategies were acceptance, active coping, and positive framing. ..
  66. Leung C, Tham C, Mohammed S, Li E, Leung K, Chan W, et al. In vivo measurements of macular and nerve fibre layer thickness in retinal arterial occlusion. Eye (Lond). 2007;21:1464-8 pubmed
    ..To investigate the structure-function relationship in patients with retinal arterial occlusion by measuring the macular and the peripapillary retinal nerve fibre layer (RNFL) thickness and the visual sensitivity...
  67. Yau T, Chan K, Chant M, Lau H, Soong I, Cheung P, et al. Wide local excision and radiotherapy for the treatment of ductal carcinoma in situ of the breast: the Hong Kong experience. Clin Oncol (R Coll Radiol). 2006;18:447-52 pubmed
    ..We conducted a single-centre retrospective study to examine the clinical outcome of women in Hong Kong...
  68. Kwok P, Ho K, Ma C, Chung S, Tse C, Tang P, et al. The short-to-midterm results of endovascular stent grafting for acute thoracic aortic diseases in Chinese patients. Hong Kong Med J. 2006;12:355-60 pubmed
    ..However, the large size of the stent graft introducer set imposes a high risk of access artery injury, for which further improvements are necessary. ..
  69. Lau J, Kim J, Tsui H, Griffiths S. Perceptions related to bird-to-human avian influenza, influenza vaccination, and use of face mask. Infection. 2008;36:434-43 pubmed publisher
    ..Perceptions related to human avian influenza were associated with IV and mask use behaviors. This can potentially be turned into opportunities of promoting desirable public health behaviors. ..
  70. Ha J, Tsui K, Tang C, Siu W, Fung K, Li M. Cholecystectomy or not after percutaneous cholecystostomy for acute calculous cholecystitis in high-risk patients. Hepatogastroenterology. 2008;55:1497-502 pubmed
    ..However, the limited survival of these patients because of their old age and medical co-morbidities should be taken into consideration. ..
  71. Chim C, Hwang Y, Pang C, Shek T. Restoration of chemosensitivity by bortezomib: implications for refractory myeloma. Nat Rev Clin Oncol. 2009;6:237-40 pubmed publisher
    ..Salvage chemotherapy regimens including bortezomib plus steroid, alkylators plus steroid, bortezomib plus anthracycline and radiotherapy, and combined bortezomib, cyclophosphamide, melphalan and steroid therapy. ..
  72. Chan V, So L, Lam J, Lau K, Chan C, Lin A, et al. Major haemoptysis in Hong Kong: aetiologies, angiographic findings and outcomes of bronchial artery embolisation. Int J Tuberc Lung Dis. 2009;13:1167-73 pubmed
    ..In Hong Kong, about one tenth of admissions due to haemoptysis were life-threatening. PTB and bronchiectasis were the major causes. Complications due to BAE were uncommon and self-limiting, with super-selective catheters. ..
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    ..In addition to age and GCS score, the CT patterns of bilateral haematomas, temporal haematomas and associated subdural haematomas were suggestive of poor outcome or mortality...
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    ..The diagnosis was confirmed after a histopathological examination. This case highlights the obstacles to making a preoperative diagnosis of immunoglobulin G4-associated sclerosing cholangitis. ..
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    ..Results suggest that OSG participation may offer some benefits for those living with HIV/AIDS. ..
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    ..IVIM can reflect diffusion and perfusion information of IFI lesions separately. • Perfusion characteristics of IFI lesions could help differentiate treatment response. • An initial low f may predict unfavourable response in IFI. ..
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    ..The most desirable costs of the Highly Effective DAAs would be below US$43,553 if Sofosbuvir-PR rescue therapy is used and below US$56,985 if Boceprevir-PR therapy is used. ..
  78. Guo D, Zhang J, Yuen S, Tsui W, Chan A, Ho C, et al. Reduced expression of EphB2 that parallels invasion and metastasis in colorectal tumours. Carcinogenesis. 2006;27:454-64 pubmed
    ..EphB2 may achieve its tumour suppressor function through regulation of cell survival, adhesion and migration. ..
  79. Tam C, Ho J, Wang Y, Lee H, Lam V, Germer S, et al. Common polymorphisms in MTNR1B, G6PC2 and GCK are associated with increased fasting plasma glucose and impaired beta-cell function in Chinese subjects. PLoS ONE. 2010;5:e11428 pubmed publisher
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    ..2% sensitivity, 83.8% specificity and 73% accuracy for malignancy. Improvements in reliability and accuracy of real-time qualitative ultrasound elastography are required for it to be adopted into routine clinical practice. ..
  81. Lam K, Lau K, So K, Tam C, Wu Y, Cheung G, et al. Can botulinum toxin decrease carer burden in long term care residents with upper limb spasticity? A randomized controlled study. J Am Med Dir Assoc. 2012;13:477-84 pubmed publisher
    ..The treatment was also associated with improved scores on patient-centered outcome measures. ..
  82. Wong H, Ong K, Leung R, Lam T, Thomas G, Lam K, et al. A single nucleotide polymorphism of interleukin-6 gene is related to plasma adrenomedullin levels. Clin Endocrinol (Oxf). 2013;79:504-9 pubmed publisher
    ..Plasma ADM levels are related to the SNP rs17147230 in IL6 gene. The effect of the polymorphism on inflammation and cardiovascular disease remains to be determined. ..
  83. Lo E, Schwarz E. Determinants for dental visit behavior among Hong Kong Chinese in a longitudinal study. J Public Health Dent. 1998;58:220-7 pubmed
    ..The expanded Andersen and Newman model was useful as a theoretical framework in studying the dental services utilization behaviors of the Hong Kong adults. ..
  84. Au W, Ma S, Kwong Y. Disseminated hepatosplenic mycobacterial infection masking myeloproliferative diseases as leukemoid reaction: a diagnostic pitfall. Leuk Lymphoma. 2001;42:805-8 pubmed
    ..Clinicians and hematologist should be aware of such a predisposition and possible dual pathology for proper diagnosis, therapy and monitoring of both the infection and the myeloproliferation...
  85. Wu J, Lai A, Wong S, Chan F, Leung W, Sung J. Dysfunction of oesophageal motility in Helicobacter pylori-infected patients with reflux oesophagitis. Aliment Pharmacol Ther. 2001;15:1913-9 pubmed
    ..Oesophageal motor dysfunction probably plays a dominant role in the development of gastro-oesophageal reflux disease in patients with H. pylori infection. ..
  86. Ng W, Poon C, Kong J. Fine needle aspiration cytology of ductal breast carcinoma with neuroendocrine differentiation. Review of eight cases with histologic correlation. Acta Cytol. 2002;46:325-31 pubmed
    ..Recognition of this entity is important in order to avoid the misdiagnosis of neuroendocrine tumor metastatic to the breast. ..
  87. Yuen A, Fan Y, Fung C, Hung K. Endoscopic-assisted cranionasal resection of olfactory neuroblastoma. Head Neck. 2005;27:488-93 pubmed
    ..There were no local recurrences. Two patients died of lung metastasis. Cranionasal resection is a safe and adequate procedure. Postoperative radiotherapy is not necessary after clear resection of Kadesh A and B tumors. ..
  88. Wong C, Bao Y, Wong E, Leung P, Fung K, Lam C. Immunomodulatory activities of Yunzhi and Danshen in post-treatment breast cancer patients. Am J Chin Med. 2005;33:381-95 pubmed
    ..05). Therefore, the regular oral consumption of Yunzhi-Danshen capsules could be beneficial for promoting immunological function in post-treatment of breast cancer patients. ..
  89. Tong P, Ko G, Chan W, Ma R, So W, Lo M, et al. The efficacy and tolerability of fosinopril in Chinese type 2 diabetic patients with moderate renal insufficiency. Diabetes Obes Metab. 2006;8:342-7 pubmed
    ..Fosinopril treatment reduced albuminuria and rate of decline in renal function in type 2 diabetic patients with moderate renal insufficiency and did not increase the incidence of adverse events. ..
  90. Ip D, Ip F. Elderly patients with two episodes of fragility hip fractures form a special subgroup. J Orthop Surg (Hong Kong). 2006;14:245-8 pubmed
    ..Elderly patients with 2 episodes of fragility hip fractures form a special subgroup among geriatric hip fracture patients. Fall prevention programmes and treatment for osteoporosis are recommended. ..
  91. Wang T, Wong S. Streptobacillus moniliformis septic arthritis: a clinical entity distinct from rat-bite fever?. BMC Infect Dis. 2007;7:56 pubmed
    ..Streptobacillus moniliformis is a zoonotic agent associated with rodent contacts. Although it is more commonly reported to cause rat-bite fever with reactive arthritides, it can also lead to pyogenic infection of the joints...
  92. Fung B, Chan K, Lam L, Cheung S, Choy N, Chu K, et al. Study of wrist posture, loading and repetitive motion as risk factors for developing carpal tunnel syndrome. Hand Surg. 2007;12:13-8 pubmed
    ..Adjustment was made for age, sex, BMI, smoking and psychosocial stress. Our study confirms that frequent flexion, extension and sustained force of the wrist increase the risk of developing CTS. ..