Experts and Doctors on protein transport in Crete, Greece


Locale: Crete, Greece
Topic: protein transport

Top Publications

  1. Papanikou E, Karamanou S, Baud C, Frank M, Sianidis G, Keramisanou D, et al. Identification of the preprotein binding domain of SecA. J Biol Chem. 2005;280:43209-17 pubmed
    ..We propose that (a) PBD is a preprotein receptor and a physical bridge connecting bound preproteins to the DEAD motor, and (b) preproteins control the ATPase cycle via PBD. ..
  2. Alcock F, Grossmann J, Gentle I, Likic V, Lithgow T, Tokatlidis K. Conserved substrate binding by chaperones in the bacterial periplasm and the mitochondrial intermembrane space. Biochem J. 2008;409:377-87 pubmed
  3. Pozidis C, Chalkiadaki A, Gomez Serrano A, Stahlberg H, Brown I, Tampakaki A, et al. Type III protein translocase: HrcN is a peripheral ATPase that is activated by oligomerization. J Biol Chem. 2003;278:25816-24 pubmed publisher
    ..We propose that TTS ATPases catalyze protein translocation as activated homo-oligomers at the plasma membrane...
  4. Moschonas A, Kouraki M, Knox P, Thymiakou E, Kardassis D, Eliopoulos A. CD40 induces antigen transporter and immunoproteasome gene expression in carcinomas via the coordinated action of NF-kappaB and of NF-kappaB-mediated de novo synthesis of IRF-1. Mol Cell Biol. 2008;28:6208-22 pubmed publisher
  5. Gouridis G, Karamanou S, Gelis I, Kalodimos C, Economou A. Signal peptides are allosteric activators of the protein translocase. Nature. 2009;462:363-7 pubmed publisher
    ..A role for signal peptides and targeting sequences as allosteric activators may be universal in protein translocases. ..
  6. Sideris D, Petrakis N, Katrakili N, Mikropoulou D, Gallo A, Ciofi Baffoni S, et al. A novel intermembrane space-targeting signal docks cysteines onto Mia40 during mitochondrial oxidative folding. J Cell Biol. 2009;187:1007-22 pubmed publisher
  7. Kotzamani D, Plaitakis A. Alpha helical structures in the leader sequence of human GLUD2 glutamate dehydrogenase responsible for mitochondrial import. Neurochem Int. 2012;61:463-9 pubmed publisher
  8. Kourmouli N, Theodoropoulos P, Dialynas G, Bakou A, Politou A, Cowell I, et al. Dynamic associations of heterochromatin protein 1 with the nuclear envelope. EMBO J. 2000;19:6558-68 pubmed
    ..A His(6)-tagged peptide representing this region inhibited recruitment of LAP2beta and B-type lamins around the surfaces of condensed chromosomes, suggesting involvement of HP1 proteins in nuclear envelope reassembly. ..
  9. Vrontou E, Karamanou S, Baud C, Sianidis G, Economou A. Global co-ordination of protein translocation by the SecA IRA1 switch. J Biol Chem. 2004;279:22490-7 pubmed
    ..IRA1-mediated global co-ordination of SecA catalysis is essential for protein translocation. ..

More Information


  1. Hadjicharalambous C, Sheynis T, Jelinek R, Shanahan M, Ouellette A, Gizeli E. Mechanisms of alpha-defensin bactericidal action: comparative membrane disruption by Cryptdin-4 and its disulfide-null analogue. Biochemistry. 2008;47:12626-34 pubmed publisher
    ..6C/A)-Crp4, on the other hand, appears to induce greater membrane disintegration. ..
  2. Lionaki E, Aivaliotis M, Pozidis C, Tokatlidis K. The N-terminal shuttle domain of Erv1 determines the affinity for Mia40 and mediates electron transfer to the catalytic Erv1 core in yeast mitochondria. Antioxid Redox Signal. 2010;13:1327-39 pubmed publisher
    ..Finally, we reconstituted the system by adding in trans the N- and C- terminal domains of Erv1 together with its substrate Mia40. ..
  3. Kallergi E, Andreadaki M, Kritsiligkou P, Katrakili N, Pozidis C, Tokatlidis K, et al. Targeting and maturation of Erv1/ALR in the mitochondrial intermembrane space. ACS Chem Biol. 2012;7:707-14 pubmed publisher
    ..Both of these events must follow a specific sequential order to allow Erv1/ALR to reach the fully functional state, illustrating a new paradigm for protein maturation in the IMS...