Experts and Doctors on hepatocytes in Jena, Thuringia, Germany


Locale: Jena, Thuringia, Germany
Topic: hepatocytes

Top Publications

  1. Ufelmann H, Krüger T, Luckas B, Schrenk D. Human and rat hepatocyte toxicity and protein phosphatase 1 and 2A inhibitory activity of naturally occurring desmethyl-microcystins and nodularins. Toxicology. 2012;293:59-67 pubmed publisher
    ..Thus, a variety of naturally occurring desmethylated MC and NOD congeners have to be considered as being at least as toxic as the corresponding fully methylated derivatives. ..
  2. Lupp A, Lucas N, Tralls M, Fuchs U, Danz M. Effects of different mitogens on intrasplenic liver tissue transplants in comparison to orthotopic liver. Exp Toxicol Pathol. 2003;54:449-65 pubmed
    ..The results of the present investigation show that characteristic effects of mitogens on orthotopic liver occur with certain differences also in ectopic liver cell transplants. ..
  3. Liu A, Jin H, Dirsch O, Deng M, Huang H, Bröcker Preuss M, et al. Release of danger signals during ischemic storage of the liver: a potential marker of organ damage?. Mediators Inflamm. 2010;2010:436145 pubmed publisher
    ..Furthermore, HMGB1 and MIF are more sensitive than liver enzymes to detect the additional mechanical damage inflicted on the organ graft during surgical manipulation. ..
  4. Herzog N, Hansen M, Miethbauer S, Schmidtke K, Anderer U, Lupp A, et al. Primary-like human hepatocytes genetically engineered to obtain proliferation competence display hepatic differentiation characteristics in monolayer and organotypical spheroid cultures. Cell Biol Int. 2016;40:341-53 pubmed publisher
    ..In conclusion, HepaFH3 cells and related primary-like hepatocyte lines seem to be promising tools for in vitro research of liver functions and as test system in drug development and toxicology analysis. ..
  5. Sauerbrei A, Schacke M, Schultz U, Egerer R, Merkle I, Glebe D, et al. Alternative methods for validation of cell culture infection with duck hepatitis B virus. J Virol Methods. 2005;129:178-85 pubmed
    ..Infection of cell cultures was most efficient 4 days after plating. The best identification of infected cultures was possible 6 days after infection with immunofluorescence using an antiserum against DHBV surface antigen...
  6. Orthaus S, Biskup C, Hoffmann B, Hoischen C, Ohndorf S, Benndorf K, et al. Assembly of the inner kinetochore proteins CENP-A and CENP-B in living human cells. Chembiochem. 2008;9:77-92 pubmed
    ..On the other hand, no FRET was detected between CENP-A and H2A.1 or H3.1. Our data support the view that two CENP-A molecules are packed with H4, but not with H3, in a single centromeric nucleosome. ..
  7. Schleicher J, Guthke R, Dahmen U, Dirsch O, Holzhuetter H, Schuster S. A theoretical study of lipid accumulation in the liver-implications for nonalcoholic fatty liver disease. Biochim Biophys Acta. 2014;1841:62-9 pubmed publisher
    ..The reversibility corresponds to the observation that caloric restriction can reduce the lipid content in the liver. ..
  8. Kondylis V, Polykratis A, Ehlken H, Ochoa Callejero L, Straub B, Krishna Subramanian S, et al. NEMO Prevents Steatohepatitis and Hepatocellular Carcinoma by Inhibiting RIPK1 Kinase Activity-Mediated Hepatocyte Apoptosis. Cancer Cell. 2015;28:582-598 pubmed publisher
    ..Collectively, these results show that NEMO prevents hepatocarcinogenesis by inhibiting RIPK1 kinase activity-driven hepatocyte apoptosis through NF-κB-dependent and -independent functions. ..
  9. Gröger M, Rennert K, Giszas B, Weiß E, Dinger J, Funke H, et al. Monocyte-induced recovery of inflammation-associated hepatocellular dysfunction in a biochip-based human liver model. Sci Rep. 2016;6:21868 pubmed publisher
    ..We therefore conclude that this human liver organoid model is a valuable tool to investigate sepsis-related liver dysfunction and subsequent immune cell-related tissue repair/remodeling processes. ..

More Information


  1. Birringer M, Lington D, Vertuani S, Manfredini S, Scharlau D, Glei M, et al. Proapoptotic effects of long-chain vitamin E metabolites in HepG2 cells are mediated by oxidative stress. Free Radic Biol Med. 2010;49:1315-22 pubmed publisher
    ..Taken together, these results indicate that long-chain metabolites may be responsible for antiproliferative properties of vitamin E vitamers...
  2. Kan C, Liu A, Fang H, Dirsch O, Dahmen U, Boettcher M. Induction of autophagy reduces ischemia/reperfusion injury in steatotic rat livers. J Surg Res. 2017;216:207-218 pubmed publisher
    ..Simultaneous modulation of GSK3b and ERK1/2 pathways might be an interesting strategy to reduce IRI in steatotic livers with an impairment of autophagy. ..